Marson Lab
@marsonlab.bsky.social
News from Dr. Alex Marson's lab UCSF & Gladstone Institutes, focusing on advances in immunology, CRISPR & genomics.
Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social
December 15, 2025 at 2:02 PM
Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social
Reposted by Marson Lab
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
www.nature.com
December 11, 2025 at 5:54 PM
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...
December 10, 2025 at 10:57 PM
Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...
Happy to share our latest paper in Nature Biotech, led by graduate student Laine Goudy, joint with Luke Gilbert at Arc, developing CRISPRon/off technology for epigenetic programming of human T cells.
Integrated epigenetic and genetic programming of primary human T cells
Nature Biotechnology - Multiplexed editing in primary human T cells generates enhanced immune cell therapies.
rdcu.be
October 22, 2025 at 4:07 PM
Happy to share our latest paper in Nature Biotech, led by graduate student Laine Goudy, joint with Luke Gilbert at Arc, developing CRISPRon/off technology for epigenetic programming of human T cells.