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mattiaubertini.bsky.social
Mattia Ubertini
@mattiaubertini.bsky.social
96 followers 150 following 1 posts
Postdoc at FMI - studying chromosome folding and dynamics in relation to transcriptional regulation, using live-cell imaging and polymer modeling.
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Reposted by Mattia Ubertini
djost-physbiol.bsky.social
Daniel Jost - Physical Biology of Chromatin group @djost-physbiol.bsky.social · 13d
New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social
www.biorxiv.org/content/10.1...
Loop extrusion provides mechanical robustness to chromatin
Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...
www.biorxiv.org
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mattiaubertini.bsky.social
Mattia Ubertini @mattiaubertini.bsky.social · 17d
If you are curious about how cohesin regulates chromosome contact dynamics and its role in enhancer-promoter communication, check out our latest work. It’s been really fun to work with @nesslfy.bsky.social and @lucagiorgetti.bsky.social. Hope you enjoy reading it!
lucagiorgetti.bsky.social
Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 17d
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
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Reposted by Mattia Ubertini
lucagiorgetti.bsky.social
Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 17d
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
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Reposted by Mattia Ubertini
elphegenoralab.bsky.social
Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · Aug 16
New preprint with @gfudenberg.bsky.social

We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.

This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇

www.biorxiv.org/content/10.1...
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
www.biorxiv.org
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Reposted by Mattia Ubertini
lucagiorgetti.bsky.social
Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · Mar 29
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
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