McWilliams School of Biomedical Informatics
@mcwlliamssbmi.bsky.social
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Educating leaders in health informatics since 1997. Located in the Texas Medical Center at Houston, TX.
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mcwlliamssbmi.bsky.social
Some informatics challenges that are being noticed include:
- Interpretation of genomics (Variant calling and interpretation of copy number changes, etc.)
- Tracking clinical trial opportunities
- Matching based on molecular profile
- Analytic pipeline for genomics
#Healthcare #UTHealth #MSBMI
mcwlliamssbmi.bsky.social
Genomic profiling is now a standard part of managing advanced cancers, but this is constantly changing.
Interpreting complex genomic results and staying current with the latest findings is becoming a challenge for clinicians and researchers alike. #MSBMI #PrecisionOncology #UTHealth #Healthcare
mcwlliamssbmi.bsky.social
What is an Actionable Gene?
A genomic alteration can be considered "actionable" if that:
- Predicts therapy response (sensitivity or resistance)
- Is a germline alteration that predicts drug metabolism and/or adverse effects
Along with many more ways. #Healthcare #UTHealth #MSBMI #PrecisionOncology
mcwlliamssbmi.bsky.social
Reporting from this week’s research seminar with Funda Meric-Bernstam, MD.

Title: Genomically Informed Therapy: Advances and Informatics Challenges

This seminar will show how genomic profiling is changing cancer care and the challenges of using this data effectively in clinical settings.
mcwlliamssbmi.bsky.social
Please visit: www.uth.edu/big-tcr/inde... to learn more about the program details.

#BIGTCR #MSBMI #MyUTHealth #McWilliamsSBMI #Predoctoral #Postdoctoral #UTHealth

Application forms for both predoctoral and postdoctoral fellowships are now available.
Biomedical Informatics, Genomics and Translational Cancer Research
www.uth.edu
mcwlliamssbmi.bsky.social
By connecting O-GlcNAcylation patterns to clinical outcomes, this study highlights new opportunities for identifying therapeutic targets and prognostic tools.

Tune in next Wednesday to hear about the next MSBMI research seminar! #MSBMI #TranslationalScience #Healthcare #UTHealth #MolecularOncology
mcwlliamssbmi.bsky.social
Both pan-cancer and cancer-specific signatures were identified through this research. This helps distinguish between common mechanisms across cancer types and those that are unique to a particular diagnosis. #MSBMI #CancerGenomics #Healthcare #UTHealth
mcwlliamssbmi.bsky.social
Cancer-specific gene clusters emerged from a network analysis. These clusters showed strong associations with patient survival following disease progression, highlighting their potential clinical relevance. #MSBMI #PrecisionOncology #UTHealth #Researchseminar #Healthcare #CardiovascularDisease
mcwlliamssbmi.bsky.social
Their team built functional gene networks using curated O-GlcNAcylated proteins. Instead of looking at isolated genes, they analyzed how these proteins interact to influence disease processes at the network level. #MSBMI #SystemsBiology #Healthcare #UTHealth #ResearchSeminar #CardiovascularDisease
mcwlliamssbmi.bsky.social
This research uses OGT and OGA expression data from TCGA to measure the extent of O-GlcNAcylation dysregulation.
This provides a way to observe how subtle molecular changes might signal cancer-related activity across large datasets. #MSBMI #Bioinformatics #CancerResearch #Healthcare #UTHealth
mcwlliamssbmi.bsky.social
O-GlcNAcylation is a post-translational modification involved in important cellular functions. When dysregulated, it can interfere with cell cycle control, metabolism, and stress response. These factors contribute to cancer progression. #MSBMI #CancerResearch #Msbmiresearchseminar #Healthcare #Data
mcwlliamssbmi.bsky.social
Reporting from the MSBMI research seminar!

We’re joined by Venkat Keshav Chivukula, PhD, who is presenting: "Can Computational Modeling Provide Insights into Cardiovascular Disease Therapy?"

#MSBMI #CardiovascularResearch #BiomedicalInformatics #Msbmiresearchseminar #Researchseminar #Healthcare
mcwlliamssbmi.bsky.social
Stanford Researchers Introduced MedAgentBench: A Real-World Benchmark for Healthcare AI Agents #healthAI #AI #LLM #healthcareAI #healthcare #EHR #FHIR #EHRdata

www.marktechpost.com/2025/09/16/s...
Reposted by McWilliams School of Biomedical Informatics
healthcareittoday.com
T2: Who are the health IT people you listen to the most whether it’s at HIMSS, online, or other conferences? #HIMSS25 #HITsm