Author | Lightnews

MedChemExpress @medchemexpress.bsky.social · 9h

📚MedChemExpress Digest | #JAKSTAT in #AutoimmuneDiseases
💊JAK inhibitors & cytokine antibodies offer safer, long-lasting remission vs. broad immunosuppressants.
🔹Cytokine → STAT: #IL12→#STAT4 | #IL4→#STAT6 | #IL6/#IL23→#STAT3 | #IL2→#STAT5
🔗https://ow.ly/eaHu50Xmfho

MedChemExpress @medchemexpress.bsky.social · 14h

📰New & Featured | New in Science Translational Medicine:
Blocking #IL-4Rα (#dupilumab) or #IL-33 (#itepekimab) modulates distinct yet overlapping pathways in asthma.
Dual blockade helps resolve severe mixed inflammation, guiding precision biologic therapy.
#Asthma #Immunology #Cytokine

MedChemExpress @medchemexpress.bsky.social · 16h

🔥Hot Off the Press | 🧫 New in #Cell: Researchers uncover that intracellular #symbiotic bacteria living in cereal weevils build membranous #tubenets that channel sugars from the insect host directly into #bacterial cells.
#Microbiology #Endosymbionts

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MedChemExpress @medchemexpress.bsky.social · 19h

💊#FDA Approval Update | Contepo (fosfomycin)
🔸For #cUTI, including acute #pyelonephritis
🔸Caused by 𝘌𝘴𝘤𝘩𝘦𝘳𝘪𝘤𝘩𝘪𝘢 𝘤𝘰𝘭𝘪 and 𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦
⚙️Disrupts bacterial cell wall synthesis
⚙️Blocks the synthesis of peptidoglycan
#UTI #AcutePyelonephritis #antibacterial

MedChemExpress @medchemexpress.bsky.social · 4d

🎃Spooky Fun with #MedChemExpress!
👻Happy #Halloween! Cece is all dressed up, and our lab is buzzing with tricks, candies, and a dash of science magic! Tell us — what’s your favorite Halloween lab snack? 🍬

#LabLife #HalloweenVibes #ScienceFun #TrickOrTreat #SpookyScience #HalloweenMood #LabHalloween

MedChemExpress @medchemexpress.bsky.social · 4d

🤝MedChemExpress on the Move in the US | #ADDC 2025
🎈We sincerely thank everyone for the enthusiastic conversations at our poster and booth. We are excited to continue supporting your work with high-quality products and services in drug discovery. 👉 ow.ly/HW5W50Xk7m0

MedChemExpress @medchemexpress.bsky.social · 5d

🔥Hot Off the Press | Nature (2025): New insights into PDAC heterogeneity and signaling
🔹Epithelial ↔ Mesenchymal cell interplay
🔹Drives diversity & drug resistance
🔹Targeting these transitions = new therapy avenue
#PancreaticCancer #CancerTherapy #Oncology

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MedChemExpress @medchemexpress.bsky.social · 5d

📰New & Featured | New in #Cell: The #fetal #immune system is systemically active and self-regulating.
He et al. reveals cross-organ T cell memory, #ARG1⁺ neutrophil–mediated tolerance, and widespread #hematopoiesis across fetal organs.
#Immunology #DevelopmentalBiology #TCells

MedChemExpress @medchemexpress.bsky.social · 5d

🤝MedChemExpress on the Move in US | #Pennington Biomedical Research Center at #LSU-Baton Rouge
👻It was a treat having you visit our #Halloween-themed booth! 🎃 We’re proud to stand behind your experiments and discoveries. 🔬💡

MedChemExpress @medchemexpress.bsky.social · 6d

📰New & Featured | 🧠 New #Cell study: Cancer hijacks pain-sensing neurons to suppress #immunity.
Through the #ATF4-SLIT2-CGRP pathway, tumors reprogram lymph nodes into an immune-suppressed state.
Blocking this loop or using migraine drug rimegepant can restore #anti-tumor immunity.
#CancerResearch

MedChemExpress @medchemexpress.bsky.social · 6d

💊#FDA Approval Update | #Lynkuet® (#elinzanetant) is now approved for moderate to severe menopausal hot flashes — the first dual #NK1,3 receptor antagonist.
⚙️By blocking NK1,3 signaling on #KNDy neurons, it helps regulate thermoregulation and reduce hot flashes.
✔️Backed by Phase III OASIS trials

MedChemExpress @medchemexpress.bsky.social · 7d

📰New & Featured | 🧬New study in Cell Metabolism reveals that Hormone-Sensitive Lipase (#HSL) isn’t just a fat-burning enzyme — it also acts inside the nucleus of fat cells to regulate gene expression and maintain #adipose tissue. This dual role reshapes our understanding of #fat #metabolism.

MedChemExpress @medchemexpress.bsky.social · 7d

💡 Join Our Upcoming Webinar | #Antimalarial
📅 Wed, Oct 29, 2025 (Online via Zoom)
🎙️ Brad Sleebs, PhD — Laboratory Head, Walter & Eliza Hall Institute
🔗 www.medchemexpress.com/webinar-Brad...
🦠 #Malaria remains a global challenge, intensified by drug resistance.

MedChemExpress @medchemexpress.bsky.social · 7d

🔥Hot Off the Press | Nature: A PSMA-targeted #Nano-PROTAC using self-assembling nanotech can simultaneously degrade AR & HSP90, suppressing castration-resistant prostate cancer (#CRPC) and prolonging survival. MedChemExpress offers biological and chemical products to generate diverse disease models.

MedChemExpress @medchemexpress.bsky.social · 8d

👑 The crown jewel of antifungal research has everyone talking. At the #museum of #biochemistry, all eyes are on the crown jewel of antifungal research: #Fluconazole (HY-B0101). A powerful #antifungal featured in 17 research publications.
🔗 www.medchemexpress.com/Fluconazole....

MedChemExpress @medchemexpress.bsky.social · 10d

🔥Hot Off the Press | New in Science Advances: Early #VCAM-1 expression in kidney tubules flags nephrons headed for loss. It marks failed repair, recruits #PDGFRβ⁺ cells & precedes fibrosis + #CKD.
👉 A potential early biomarker & target to stop #AKI → CKD transition.

MedChemExpress @medchemexpress.bsky.social · 10d

🚀From Bench to Paper | Research in Signal Transduction and Targeted Therapy highlights a promising #Nano-PROTAC for castration-resistant prostate cancer (#CRPC). This PSMA-targeted agent degrades #AR, its chaperone #HSP90, and resistant #AR-V7 (a splice variant).
A new way to beat CRPC resistance.

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MedChemExpress @medchemexpress.bsky.social · 10d

📰New & Featured | Science Signaling: Cxcl12 and Shh/Ihh act as injury-induced niche factors that coordinate suture stem cell activation and bone regeneration.
➡️ Cxcl12-Cxcr4 signaling guides Gli1⁺ stem cell migration
➡️ Shh/Ihh promote osteogenic differentiation
#CranialRepair #Osteogenesis

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MedChemExpress @medchemexpress.bsky.social · 11d

✨More from “Magic Cece’s Island Day” Blind Box!
Cece’s found the perfect lookout spot! 🌺🌴
The Explorer & Coconut Cabin come together for double the fun (and coconuts 🥥).
#MedChemExpress #BlindBox #MiniatureWorld #MiniatureArt #BeachVibes #MiniScene #Lab #CollectibleToys

MedChemExpress @medchemexpress.bsky.social · 11d

“Magic Cece’s Island Day” #BlindBox is Here!
Music, pastries, and a beachside bonfire.
🎸+🍞 = the sweetest duet
Cece’s Guitar Poet and Bakery Van can be assembled into one perfect beach night.
Collect them both and complete the scene
#MiniatureWorld #MiniatureArt #MiniScene #LabMerch #CollectibleToys

MedChemExpress @medchemexpress.bsky.social · 11d

✨ “Magic Cece’s Island Day” Blind Box
Meet Dali’s Sunset 🌅💜 Chasing sunsets and dreams
#MedChemExpress #BlindBox #MiniatureWorld #MiniatureArt #BeachVibes #MiniScene #Lab #CollectibleToys

MedChemExpress @medchemexpress.bsky.social · 11d

🔥Hot Off the Press | #Tumor #CRATERs: Hotspots of #CD8⁺ T Cell Power
🐟Using a #zebrafish #melanoma model, researchers captured CD8⁺ T cells forming “CRATERs” — #Cancer Regions of Antigen presentation & T cell Engagement and Retention.
🔗 ow.ly/m3At50XgGwE
#Tcells #CancerResearch #CheckpointBlockade

MedChemExpress @medchemexpress.bsky.social · 11d

📚MedChemExpress Digest | Targeting #Lipid #Metabolism in #Cancer
🔬Cancer cells reprogram lipid uptake, synthesis & oxidation to fuel growth, survive stress & evade immunity. These pathways (#CD36, #FASN, #ACLY, #ACC, #SREBP) offers promising anticancer strategies. 👉Discover more: ow.ly/8RmS50XgbgE

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MedChemExpress @medchemexpress.bsky.social · 11d

🚀From Bench to Paper | 🧬Science: #MTAP-deficient tumors resist STING agonists by silencing #IRF3 signaling—but this can be reversed via polyamine metabolism targeting.
#E7766, a synthetic cyclic dinucleotide #STING agonist, helped reveal this mechanism.
🌟Get E7766 at MedChemExpress.

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MedChemExpress @medchemexpress.bsky.social · 12d

👨🔬👩🔬 We're thrilled to announce that #MedChemExpress will be exhibiting at the #AACR-NCI-EORTC International Conference on Molecular Targets and #Cancer Therapeutics.
📆 October 22–26, 2025
📍 Hynes Convention Center, Boston, MA.
🔽 For More Information:
lnkd.in/gEWR25pd
#ADC #TargetedTherapies