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#AASLD

How do we translate novel steatotic liver disease definitions into usable classifications for clinical research using EMR data? In this study in @aga-cgh.bsky.social we tested 7 different approaches to distinguish MetALD from ALD in Veterans with cirrhosis and compared clinical outcomes.

Wondering what I’m doing wrong (or right?!) that I (human hepatologist) have been asked to review an article about canine brucellosis…

(usually given at age 4-5, ie before school) is not a “booster” (does not need to be timed close to school) but to catch the 5-7% who didn’t respond to the first dose. The second dose can be given sooner as long as it’s 28 days apart. Our pediatrician was very happy to do so for our 3 year old.

As a parent who follows the recommended vaccination schedule I didn’t recall that the first MMR dose is given between 12-15 months of age - so all infants including those who received all recommended vaccines are not protected from measles. I also didn’t know that the second dose

Children get their first dose of MMR at 12-15 months in the routine vaccine schedule - I think most people including parents don’t realize that ALL infants are unprotected until that first dose. The second dose at age 4 is to catch non-responders to the first dose (not a booster), so can give early!

❗️Veterans with both very high cardiometabolic risk and heavy alcohol burden had clinical outcomes closer to MetALD than ALD.
❓Should we be classifying everyone with a certain threshold of alcohol use as ALD regardless of other clinical traits?
(4/4)

Classification of SLD varied *dramatically* depending on our choices as investigators.

❗️Beware misclassifying SLD based on absent/missing information about alcohol.
❗️⬆️ triglycerides and ⬇️ HDL are metabolic effects of alcohol use, and can be misleading in classifying SLD
(3/4)

Medical records are notoriously bad (biased, non-standardized) at capturing routine alcohol consumption. At the VA, alcohol use is measured annually for all primary care patients.
We compared 7 different SLD classification systems with varying alcohol and metabolic risk thresholds.
(2/4)

How do we apply the new SLD definitions in research? To study outcomes and implement trials for different SLD subtypes, we first need to be able to accurately identify each clinical entity using medical records/registry data.
www.cghjournal.org/article/S154...

@amergastroassn.bsky.social

In the United States, HCC deaths may have plateaued and soon be on the decline due to successful HCV elimination

However, persistent increases in MASLD and ALD-related HCC threaten these trends

AASLD #TLM24 #Liversky

#TLM24, a San Diego snack story

Hopeful #TLM24 will help this platform take off as the new home for liver lovers! @ebtapper.bsky.social @jonathanstinemd.bsky.social
@mash-and-coffee.bsky.social