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Manuel F. Navedo @mfnavedo.bsky.social · 12d

Excited and honored to present this webinar. Please join!

🎙️Webinar!
Unlocking vascular disease connection through ion channel signaling

🗓 September 29th, 2025
🕒 Time: PDT 17:00 / CDT 19:00 / EDT 20:00
Register: tinyurl.com/yoluxuwf
#VascularDisease #IonChannels #Webinar

Welcome! You are invited to join a webinar: Unlocking vascular disease connection through ion channel signaling. After registering, you will receive a confirmation email about joining the webinar.

tinyurl.com

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Manuel F. Navedo @mfnavedo.bsky.social · Aug 15

The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social

www.ahajournals.org/doi/10.1161/...

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

www.ahajournals.org

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Manuel F. Navedo @mfnavedo.bsky.social · Jul 28

A little bit late but I’m honored and humbled to have been selected back in May as the recipient of the 2025
@ucdavis.bsky.social, @ucdavishealth.bsky.social Research Award! This recognition belongs to the M&M Lab members!

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Reposted by Manuel F. Navedo

Fernando Santana @lfsantana68.bsky.social · Jul 23

Manning & Rivera et al. (www.jacc.org/doi/10.1016/...) show that pruning just a few capillaries in the SA node plunges the heart’s pacemaker into metabolic overdraft—slowing the rate and jacking up beat-to-beat variability. The physiological equivalent of running on fumes. @jaccjournals.bsky.social

Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF

www.jacc.org

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Manuel F. Navedo @mfnavedo.bsky.social · Jul 21

Great way to start the week with the release of this collaborative work with students and Drs. Horne & Hell
@ucdavispharm.bsky.social, @ucdavis.bsky.social. Get your copy now!

www.cell.com/cell-reports...

Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity

Lee et al. show that OCT3 and PMAT transport norepinephrine (NE) into neurons to stimulate β2ARs that are in their interior. The ensuing phosphorylation of GluA1 on S845 by PKA drives AMPARs to the su...

www.cell.com

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Manuel F. Navedo @mfnavedo.bsky.social · Jul 11

Thank you for all the help and support! This story could not have happened without your timely and exeptional research skills and knowledge of the field. Much appreciated!

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Manuel F. Navedo @mfnavedo.bsky.social · Jul 10

Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @brantisakson.bsky.social and Xiang Lab

Miguel Martín-Aragón Baudel @miguelmab.bsky.social · Jul 10

Check our latest work from the M&M lab on the role of SMC Pannexin 1 in diabetic hyperglycemia! And thanks to everyone involved in this! Ole 💃 www.ahajournals.org/doi/10.1161/...

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

www.ahajournals.org

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Reposted by Manuel F. Navedo

Miguel Martín-Aragón Baudel @miguelmab.bsky.social · Jul 10

Check our latest work from the M&M lab on the role of SMC Pannexin 1 in diabetic hyperglycemia! And thanks to everyone involved in this! Ole 💃 www.ahajournals.org/doi/10.1161/...

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

www.ahajournals.org

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Reposted by Manuel F. Navedo

UC Davis Pharmacology @ucdavispharm.bsky.social · Jul 1

United in discovery, stronger together!!! Great science happens when we gather to learn, support each other, & celebrate the power of collaboration & community at our Departmental Annual Retreat!

Shout out to organizers Deborah, Elva, Nate, Hai, Matthew, Christina & Charlotte!

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Reposted by Manuel F. Navedo

MCIP at UC Davis @mcipucd.bsky.social · Jun 4

Discover the inspiring story of Jeff Hill, a
@ucdavis.bsky.social alum who leveraged the training he received in #physiology to support USA Air Force pilots.

MCIP provides the training so more people follow on Jeff's steps.

youtu.be/KuM4RIB98T8?...

My 100: Jeffrey Hill, M.S. '79

YouTube video by UC Davis Graduate Studies

youtu.be

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Manuel F. Navedo @mfnavedo.bsky.social · May 24

Oh these amazing things!!! Will need to place an order for deliver to Cali 😅

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Manuel F. Navedo @mfnavedo.bsky.social · May 20

The second episode of our podcast series just dropped.

navedolab.faculty.ucdavis.edu/podcasts/

This one highlights efforts of the Nieves-Cintron group to understand the effects of nicotine and tobacco products on vascular function.

Check out the paper here:

pubmed.ncbi.nlm.nih.gov/38805589/

Podcasts – Welcome to the M&M Lab

navedolab.faculty.ucdavis.edu

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Reposted by Manuel F. Navedo

Fabrice Dabertrand @dablab.bsky.social · Apr 30

🎉 Excited to share our new paper in Science Signaling on #brain #pericytes constriction and TRPC3 channel—now published, featured on the cover, and highlighted in a Focus by
@vesselman.bsky.social

🧠🧪 Check it out: www.science.org/toc/signalin...
@cuanschutz.bsky.social

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Manuel F. Navedo @mfnavedo.bsky.social · Apr 28

Honored and humbled to have received the Berne Distinguished Lectureship Award from the @apsphysiology.bsky.social CV Section this past weekend. Thanks to all current and former M&M Lab members, collaborators, @ucdavis.bsky.social, @ucdavishealth.bsky.social, #NIH_NHLBI & @americanheart.bsky.social

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Reposted by Manuel F. Navedo

UC Davis Physiology @ucd-physiology.bsky.social · Mar 24

A great start to the Basic Sciences Symposium celebrating Women’s History Month! Keynote speaker Dr. Martina Anto-Ocrah with event organizers! @roseedixon.bsky.social @hannahvoorhees.bsky.social @ucdavis.bsky.social

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Reposted by Manuel F. Navedo

UC Davis Physiology @ucd-physiology.bsky.social · Mar 4

We’re excited to announce the launch of our new PMB podcast on Spotify, titled Physiology Talks. This channel utilizes AI podcasters and is designed to showcase the incredible research happening in PMB @ucdavis.bsky.social . Tune in to the Premier episode!🎤🔬
open.spotify.com/episode/1LwV...

Premier Episode

UC Davis PMB—Physiology Talks · Episode

open.spotify.com

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Manuel F. Navedo @mfnavedo.bsky.social · Mar 4

The paper that is the subject of this podcast can be found here: pubmed.ncbi.nlm.nih.gov/39377203/

α1C S1928 Phosphorylation of CaV1.2 Channel Controls Vascular Reactivity and Blood Pressure - PubMed

Results suggest an essential role for α1<sub>C</sub> S1928 phosphorylation in regulating channel distribution, activity and gating modality, and vascular function during angiotensin II signaling and h...

pubmed.ncbi.nlm.nih.gov

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Manuel F. Navedo @mfnavedo.bsky.social · Mar 4

We are trying something new to help our community understand the impact of the science they generously support.

Check out Episode 1 of a new podcast series: navedolab.faculty.ucdavis.edu/podcasts/

Disclaimer: generated by AI, but I think you will thank me as I will be terrible at this 😆

Podcasts – Welcome to the M&M Lab

navedolab.faculty.ucdavis.edu

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Manuel F. Navedo @mfnavedo.bsky.social · Feb 15

Thanks for actively participating and supporting the symposium, and for the visit. Always awesome to see you!

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Reposted by Manuel F. Navedo

UC Davis Pharmacology @ucdavispharm.bsky.social · Feb 13

Great audience and energy as we start the 8th
@ucdavis.bsky.social Cardiovascular Symposium!!!

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Reposted by Manuel F. Navedo

UC Davis Pharmacology @ucdavispharm.bsky.social · Feb 11

Excited to share this comprehensive review paper by Department Faculty on mechanotransduction in the #heart!
@ucdavis.bsky.social

The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect | Annual Reviews - go.shr.lc/42PlLtB

The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect | Annual Reviews

The Frank-Starling law and Anrep effect describe two intrinsic mechanisms that regulate contraction force in the heart. Based on recent advancements and the historical literature, we propose new persp...

go.shr.lc

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Reposted by Manuel F. Navedo

UC Davis Pharmacology @ucdavispharm.bsky.social · Feb 11

Faculty is on 🔥 this week! This comprehensive review highlights sex differences in the #heart!
@elegrand.bsky.social, @ucdavis.bsky.social, @ucdavishealth.bsky.social

Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation | Annual Reviews - go.shr.lc/3UpL3cq

Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation | Annual Reviews

The importance of biological sex on disease etiology and outcomes has long been underinvestigated. While recent focus on characterizing sex differences in cardiac pathophysiology has led to improved i...

go.shr.lc

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Reposted by Manuel F. Navedo

UC Davis Pharmacology @ucdavispharm.bsky.social · Feb 11

We are proud to host the 8th @ucdavis.bsky.social Cardiovascular Symposium Feb 13-14th!!! basicscience.ucdmc.ucdavis.edu/UCDavisCardi...

If you want to join us via webcast, please use the following link to register: na.eventscloud.com/ereg/index.p...

Home | UC Davis Cardiovascular Symposium

basicscience.ucdmc.ucdavis.edu

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Manuel F. Navedo @mfnavedo.bsky.social · Jan 21

Check out this editorial written for a beautiful work by MArk Nelson's Lab on electro-calcium coupling and control of the neurovascular unit.

www.pnas.org/doi/10.1073/...

Electrifying the brain capillary Ca2+ signal | PNAS

Electrifying the brain capillary Ca2+ signal

www.pnas.org

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Reposted by Manuel F. Navedo

MCIP at UC Davis @mcipucd.bsky.social · Jan 10

Great news piece about our Nate Herreras path from research to teaching!!! Check it out!

@ucdavis.bsky.social, @ucdavispharm.bsky.social

biology.ucdavis.edu/news/researc...

From Researcher to Educator: One Grad Student’s Path to Teaching

Graduate student Nathaniel (Nate) Herrera has used his last year at UC Davis to springboard a career in STEM teaching. Herrera, who joined UC Davis in 2021, studies sex differences in cardiac physiolo...

biology.ucdavis.edu

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