Manuel F. Navedo
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mfnavedo.bsky.social
Manuel F. Navedo
@mfnavedo.bsky.social
140 followers 54 following 25 posts
Our mission is to understand fundamental processes in vascular biology through creative thinking and scientific excellence.

navedolab.faculty.ucdavis.edu; @ucdavis.bsky.social
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mfnavedo.bsky.social
Happy Halloween and Happy Fluorescence Friday 🎃✨

#ScienceCostumes #FluorescenceFriday #SuperResolution #PALMSTORM #LabLife
October 31, 2025 at 6:05 PM
Reposted by Manuel F. Navedo
elisazhang.bsky.social
🚨 We are recruiting postdocs! If you're interested in reproductive, stem cell/developmental biology, and/or women's health, please apply! 📝 Please repost! 🚩
More info here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Postdoctoral Scientist - Zhang Lab
Primary Work Address: One Shields Avenue, Davis, CA, 95616 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and s...
hhmi.wd1.myworkdayjobs.com
October 24, 2025 at 4:23 PM
mfnavedo.bsky.social
The third episode of our podcast series just dropped:

navedolab.faculty.ucdavis.edu/podcasts/

This one focuses on our recent study examining vascular Panx1 channels and their role in vascular complications during diabetic hyperglycemia.

Get the paper here:

pubmed.ncbi.nlm.nih.gov/40636957/
Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia - PubMed
These results suggest a key role for Panx1 in controlling ATP signaling through the P2Y<sub>11L</sub>/AC5/AKAP5/PKA/Ca<sub>V</sub>1.2 axis in arterial myocytes. This Panx1-led complex modulates cAMP levels, Ca<sub>V</sub>1.2 activity, and vascular reactivity in response to diabetic hyperglycemia. Th …
pubmed.ncbi.nlm.nih.gov
October 23, 2025 at 4:44 PM
mfnavedo.bsky.social
Excited and honored to present this webinar. Please join!

🎙️Webinar!
Unlocking vascular disease connection through ion channel signaling

🗓 September 29th, 2025
🕒 Time: PDT 17:00 / CDT 19:00 / EDT 20:00
Register: tinyurl.com/yoluxuwf
#VascularDisease #IonChannels #Webinar
Welcome! You are invited to join a webinar: Unlocking vascular disease connection through ion channel signaling. After registering, you will receive a confirmation email about joining the webinar.
Welcome! You are invited to join a webinar: Unlocking vascular disease connection through ion channel signaling. After registering, you will receive a confirmation email about joining the webinar.
tinyurl.com
September 27, 2025 at 4:34 PM
mfnavedo.bsky.social
The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social

www.ahajournals.org/doi/10.1161/...
Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research
BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...
www.ahajournals.org
August 15, 2025 at 2:18 PM
mfnavedo.bsky.social
A little bit late but I’m honored and humbled to have been selected back in May as the recipient of the 2025
@ucdavis.bsky.social, @ucdavishealth.bsky.social Research Award! This recognition belongs to the M&M Lab members!
July 28, 2025 at 9:46 PM
Reposted by Manuel F. Navedo
lfsantana68.bsky.social
Manning & Rivera et al. (www.jacc.org/doi/10.1016/...) show that pruning just a few capillaries in the SA node plunges the heart’s pacemaker into metabolic overdraft—slowing the rate and jacking up beat-to-beat variability. The physiological equivalent of running on fumes. @jaccjournals.bsky.social
Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF
www.jacc.org
July 23, 2025 at 6:06 PM
mfnavedo.bsky.social
Great way to start the week with the release of this collaborative work with students and Drs. Horne & Hell
@ucdavispharm.bsky.social, @ucdavis.bsky.social. Get your copy now!

www.cell.com/cell-reports...
Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity
Lee et al. show that OCT3 and PMAT transport norepinephrine (NE) into neurons to stimulate β2ARs that are in their interior. The ensuing phosphorylation of GluA1 on S845 by PKA drives AMPARs to the su...
www.cell.com
July 21, 2025 at 2:52 PM
mfnavedo.bsky.social
Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @brantisakson.bsky.social and Xiang Lab
July 10, 2025 at 7:37 PM
Reposted by Manuel F. Navedo
miguelmab.bsky.social
Check our latest work from the M&M lab on the role of SMC Pannexin 1 in diabetic hyperglycemia! And thanks to everyone involved in this! Ole 💃 www.ahajournals.org/doi/10.1161/...
Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research
BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...
www.ahajournals.org
July 10, 2025 at 7:08 PM
Reposted by Manuel F. Navedo
ucdavispharm.bsky.social
United in discovery, stronger together!!! Great science happens when we gather to learn, support each other, & celebrate the power of collaboration & community at our Departmental Annual Retreat!

Shout out to organizers Deborah, Elva, Nate, Hai, Matthew, Christina & Charlotte!
July 1, 2025 at 1:44 PM
Reposted by Manuel F. Navedo
mcipucd.bsky.social
Discover the inspiring story of Jeff Hill, a
@ucdavis.bsky.social alum who leveraged the training he received in #physiology to support USA Air Force pilots.

MCIP provides the training so more people follow on Jeff's steps.

youtu.be/KuM4RIB98T8?...
My 100: Jeffrey Hill, M.S. '79
YouTube video by UC Davis Graduate Studies
youtu.be
June 4, 2025 at 10:41 PM
mfnavedo.bsky.social
The second episode of our podcast series just dropped.

navedolab.faculty.ucdavis.edu/podcasts/

This one highlights efforts of the Nieves-Cintron group to understand the effects of nicotine and tobacco products on vascular function.

Check out the paper here:

pubmed.ncbi.nlm.nih.gov/38805589/
Podcasts – Welcome to the M&M Lab
navedolab.faculty.ucdavis.edu
May 20, 2025 at 4:36 PM
Reposted by Manuel F. Navedo
dablab.bsky.social
🎉 Excited to share our new paper in Science Signaling on #brain #pericytes constriction and TRPC3 channel—now published, featured on the cover, and highlighted in a Focus by
@vesselman.bsky.social

🧠🧪 Check it out: www.science.org/toc/signalin...
@cuanschutz.bsky.social
April 30, 2025 at 3:43 AM
mfnavedo.bsky.social
Honored and humbled to have received the Berne Distinguished Lectureship Award from the @apsphysiology.bsky.social CV Section this past weekend. Thanks to all current and former M&M Lab members, collaborators, @ucdavis.bsky.social, @ucdavishealth.bsky.social, #NIH_NHLBI & @americanheart.bsky.social
April 28, 2025 at 3:23 AM
Reposted by Manuel F. Navedo
ucd-physiology.bsky.social
A great start to the Basic Sciences Symposium celebrating Women’s History Month! Keynote speaker Dr. Martina Anto-Ocrah with event organizers! @roseedixon.bsky.social @hannahvoorhees.bsky.social @ucdavis.bsky.social
March 24, 2025 at 6:06 PM
Reposted by Manuel F. Navedo
ucd-physiology.bsky.social
We’re excited to announce the launch of our new PMB podcast on Spotify, titled Physiology Talks. This channel utilizes AI podcasters and is designed to showcase the incredible research happening in PMB @ucdavis.bsky.social . Tune in to the Premier episode!🎤🔬
open.spotify.com/episode/1LwV...
Premier Episode
UC Davis PMB—Physiology Talks · Episode
open.spotify.com
March 4, 2025 at 1:30 AM
mfnavedo.bsky.social
We are trying something new to help our community understand the impact of the science they generously support.

Check out Episode 1 of a new podcast series: navedolab.faculty.ucdavis.edu/podcasts/

Disclaimer: generated by AI, but I think you will thank me as I will be terrible at this 😆
Podcasts – Welcome to the M&M Lab
navedolab.faculty.ucdavis.edu
March 4, 2025 at 5:04 PM
Reposted by Manuel F. Navedo
ucdavispharm.bsky.social
Great audience and energy as we start the 8th
@ucdavis.bsky.social Cardiovascular Symposium!!!
February 13, 2025 at 9:09 PM
Reposted by Manuel F. Navedo
ucdavispharm.bsky.social
Excited to share this comprehensive review paper by Department Faculty on mechanotransduction in the #heart!
@ucdavis.bsky.social

The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect | Annual Reviews - go.shr.lc/42PlLtB
The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect | Annual Reviews
The Frank-Starling law and Anrep effect describe two intrinsic mechanisms that regulate contraction force in the heart. Based on recent advancements and the historical literature, we propose new persp...
go.shr.lc
February 11, 2025 at 2:15 AM
Reposted by Manuel F. Navedo
ucdavispharm.bsky.social
Faculty is on 🔥 this week! This comprehensive review highlights sex differences in the #heart!
@elegrand.bsky.social, @ucdavis.bsky.social, @ucdavishealth.bsky.social

Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation | Annual Reviews - go.shr.lc/3UpL3cq
Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation | Annual Reviews
The importance of biological sex on disease etiology and outcomes has long been underinvestigated. While recent focus on characterizing sex differences in cardiac pathophysiology has led to improved i...
go.shr.lc
February 11, 2025 at 2:17 AM
Reposted by Manuel F. Navedo
ucdavispharm.bsky.social
We are proud to host the 8th @ucdavis.bsky.social Cardiovascular Symposium Feb 13-14th!!! basicscience.ucdmc.ucdavis.edu/UCDavisCardi...

If you want to join us via webcast, please use the following link to register: na.eventscloud.com/ereg/index.p...
Home | UC Davis Cardiovascular Symposium
basicscience.ucdmc.ucdavis.edu
February 11, 2025 at 7:59 PM
mfnavedo.bsky.social
Check out this editorial written for a beautiful work by MArk Nelson's Lab on electro-calcium coupling and control of the neurovascular unit.

www.pnas.org/doi/10.1073/...
Electrifying the brain capillary Ca2+ signal | PNAS
Electrifying the brain capillary Ca2+ signal
www.pnas.org
January 21, 2025 at 3:50 PM
Reposted by Manuel F. Navedo
mcipucd.bsky.social
Great news piece about our Nate Herreras path from research to teaching!!! Check it out!

@ucdavis.bsky.social, @ucdavispharm.bsky.social

biology.ucdavis.edu/news/researc...
From Researcher to Educator: One Grad Student’s Path to Teaching
Graduate student Nathaniel (Nate) Herrera has used his last year at UC Davis to springboard a career in STEM teaching. Herrera, who joined UC Davis in 2021, studies sex differences in cardiac physiolo...
biology.ucdavis.edu
January 10, 2025 at 10:46 PM
mfnavedo.bsky.social
Very proud of all these @mcipucd.bsky.social students and their mentors. Once more, demonstrating their commitment to achieving their goals and the quality of science and training they receive in our graduate program.

@ucdavis.bsky.social, @ucdavispharm.bsky.social
mcipucd.bsky.social MCIP at UC Davis @mcipucd.bsky.social · Dec 21
We are pleased to announce
@americanheart.bsky.social
Pre-doctoral awards to several of our students:

Victor Alencar from Bers Lab
Sherif Bahriz from Xiang Lab
Woori Choi from Vorobyov Lab
Sophia Salbato from Nieves-Cintron Lab
Victoria Salemme from Xiang Lab

Congrats to all!!!
December 21, 2024 at 4:27 PM