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mikesleutel.bsky.social @mikesleutel.bsky.social · Aug 16

For over 100 years, Bt spores have been used to protect crops from caterpillars. These spores bear mysterious hair-like ENAs. Thanks to cryoEM, we now know ENAs are robust protein fibers that cluster spores like grappling hooks. Read more in Nature Communications.

www.nature.com/articles/s41...

Cryo-EM identifies F-ENA of Bacillus thuringiensis as a widespread family of endospore appendages across Firmicutes - Nature Communications

B. thuringiensis spores contain uncharacterized protein filaments that extend from the surface of the exosporium. Here, the authors show that these filaments feature conserved β-barrel neck domains an...

www.nature.com

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Reposted

Adrià Sogues @adriasogues.bsky.social · Jul 30

Happy to see the final version out! Cryo-EM structure of the PS2 S-layer in Corynebacterium 🔬! We show it provides mechanical support to the cell wall and assembles at the poles in coordination with PG. It can also be used for covalent surface display.

www.pnas.org/doi/10.1073/...

#microsky

Cryo-EM structure and polar assembly of the PS2 S-layer of Corynebacterium glutamicum | PNAS

The polar-growing Corynebacteriales have a complex cell envelope architecture characterized by the presence of a specialized outer membrane compose...

www.pnas.org

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mikesleutel.bsky.social @mikesleutel.bsky.social · May 20

In our latest preprint we used cryoEM to solve the structure of A-ENA fibers and show that they are stabilized by 10 isopeptide bonds per monomer. A-ENA couples the spore to the cry-toxins, and in doing so increases the virulence of Bacillus thuringiensis: www.researchsquare.com/article/rs-6...

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