Lightnews — Scholar-powered news

www.MitoWorld.org @mitoworld.bsky.social · 25d

The core information resources on the site include a directory of leading mitochondrial researchers, academic institutions, clinical centers. We invite inquiries, and we are always looking for collaborators and supporters.

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www.MitoWorld.org @mitoworld.bsky.social · 25d

§ MitoNews. We post articles from outside sources and feature mitochondria newsfeeds from PubMed, Nature Portfolio, PRNewswire and Google on our homepage.

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www.MitoWorld.org @mitoworld.bsky.social · 25d

§ “Beyond the Disease”. In partnership with the United Mitochondrial Disease Foundation (www.UMDF.org), we compile a monthly set of papers to be published in their newsletter.

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www.MitoWorld.org @mitoworld.bsky.social · 25d

§ MitoCast. We conduct video interviews and accumulate information from leading researchers and clinicians.

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www.MitoWorld.org @mitoworld.bsky.social · 25d

§ MitoBlog. We post on the latest research papers, profile mitochondrial researchers and clinicians, portray mitochondria labs globally, and report on major conferences.

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www.MitoWorld.org @mitoworld.bsky.social · 25d

Guided by a senior scientific advisory board and several mitochondrial medicine clinicians, MitoWorld’s mostly volunteer team produces the following media.

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www.MitoWorld.org @mitoworld.bsky.social · 25d

#MitoWorld is committed to raising public, professional and patient community awareness globally about mitochondria science, diseases, dysfunction and health. As a central resource, MitoWorld strives to share advances in mitochondrial research and clinical practice.

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www.MitoWorld.org @mitoworld.bsky.social · 25d

MitoWorld Supports Mitochondrial Disease Week

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www.MitoWorld.org @mitoworld.bsky.social · Aug 18

Leigh Syndrome Research Retreat and Workshop of
the Cure Mito Foundation is accepting proposals from researchers and medical professionals interested in participating in a 2-day in-person retreat and workshop to advance research and treatment strategies for Leigh syndrome. lnkd.in/e62nYUHm

Home

Leigh syndrome (sometimes called Leigh’s disease) is a rare and severe neurometabolic disorder and a type of primary mitochondrial disease.

www.CureMito.org

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www.MitoWorld.org @mitoworld.bsky.social · Jun 23

The first-ever conference dedicated entirely to mitochondrial DNA just wrapped up in Nashville!

From mutation mechanisms to repair strategies and cutting-edge editing techniques, it was a landmark event.

See the full recap 👇

mitoworld.org/mechanisms-o...

Mechanisms of Mitochondrial DNA Mutation and Repair - MitoWorld

If our website is MitoWorld, the Mechanisms of Mitochondrial DNA Mutation and Repair conference was the introductory gathering of what could be called “mtDNA World.” The organizers, Patrick Chinnery (...

mitoworld.org

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www.MitoWorld.org @mitoworld.bsky.social · May 26

A must-read for anyone in mitochondria research!

Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!

View our summary mitoworld.org/special-issu...

Special Issue: Cell Biology of Mitochondria - MitoWorld

The special issue of Journal of Cell Science (JCS) on the “Cell Biology of Mitochondria” looks to be one of the most comprehensive open series of papers, opinions, perspectives, interviews, reviews an...

mitoworld.org

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www.MitoWorld.org @mitoworld.bsky.social · May 26

Scientific American has a new (open) article by Columbia’s Martin Picard, comparing mitochondria to microprocessors.

It follows landmark pieces from July 1957 (“Powerhouse of the Cell”) and Aug 1997 (Wallace on mtDNA in aging & disease).

Read our summary:
mitoworld.org/mitochondria...

Mitochondria Are More Than Powerhouses — They’re the Motherboard of the Cell - MitoWorld

Columbia University mitochondria researcher Martin Picard’s life changed in 2014 when he peered through a microscope in Douglas Wallace’s lab at the Children’s Hospital Philadelphia. He saw something ...

mitoworld.org

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www.MitoWorld.org @mitoworld.bsky.social · May 19

Identifying Mitochondrial Mutations - MitoWorld

Next-generation sequencing has become the method of choice diagnosing diseases and risks, but the size difference between the nuclear and mitochondrial genomes complicates its value for mitochondrial ...

mitoworld.org

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www.MitoWorld.org @mitoworld.bsky.social · May 19

Has unlocking the genetic secrets behind mitochondrial diseases just got easier?

MitoPhen - is a database that brings together genotype-phenotype information and mitochondrial DNA variant levels to reveal rare mitochondrial diseases in patients not suspected of those disease

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Reposted by www.MitoWorld.org

Catalina Vasilescu, PhD @cvasilescu.bsky.social · May 18

Here it is, a new collection of papers related to #mitochondrialdisease! 📚

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social

ALDH4A1 functions as an active component of the MPC complex

Hsu et al, ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
https://pubmed.ncbi.nlm.nih.gov/40355545/

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www.MitoWorld.org @mitoworld.bsky.social · May 15

Could targeting mitochondria be the key to slowing aging?

We spoke to Dr Jennifer Trowbridge at The Jackson Laboratory who reveals that tweaking mitochondrial activity in blood stem cells may help prevent age-related diseases.

Read more below:

Treating Mitochondria to Slow Aging? - MitoWorld

The laboratory of Dr. Jennifer Trowbridge at The Jackson Laboratory published a paper that describes how a genetic mutation that alters the function of mitochondria may provide a target for slowing ag...

mitoworld.org

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www.MitoWorld.org @mitoworld.bsky.social · May 12

Can cancer hijack your immune system - #mitochondria first?

New research reveals a striking mechanism of immune evasion: cancer cells can transfer defective mitochondria into cytotoxic T cells, impairing their energy production and killing ability.

mitoworld.org/the-great-mi...

The Great Mitochondrial Replacement - MitoWorld

Cytotoxic T cells are vital for eliminating cancer cells and thus for restraining tumour growth. However, many types of cancer cell blunt this immune attack by issuing signals that somehow cripple the...

mitoworld.org

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www.MitoWorld.org @mitoworld.bsky.social · Mar 10

New research from Dr Craig Thompson reveals that mitochondria do more than generate energy - they form specialized subpopulations under stress, playing a key role in cancer cell survival.

Will this discovery could reshape our understanding of metabolism and disease treatment?

MitoCast: Craig Thompson

YouTube video by MitochondriaWorld™

www.youtube.com

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www.MitoWorld.org @mitoworld.bsky.social · Feb 17

Thanks for sharing!

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Reposted by www.MitoWorld.org

Catalina Vasilescu, PhD @cvasilescu.bsky.social · Feb 16

#mitochondrialdisease research from last week!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social @mitowomen.bsky.social

Mitofusin 2 displays fusion-independent roles in proteostasis surveillance

Mitofusin 2 displays fusion-independent roles in proteostasis surveillance

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www.MitoWorld.org @mitoworld.bsky.social · Feb 12

Thank you, Catalina!

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www.MitoWorld.org @mitoworld.bsky.social · Feb 12

We want to follow everyone working with #mitochondria!

Leave a like if you think we should follow you, or tag your colleagues and workmates in the comments below!

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www.MitoWorld.org @mitoworld.bsky.social · Feb 9

We've partnered with UMDF!

To kick off our collaboration, we're pleased to announce the launch of "BeyondTheDisease".

Each month, we will recap the latest mitochondrial research and news, along with analyzing how it could impact mitochondrial disease research.

mitoworld.org/mitomedia/be...

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www.MitoWorld.org @mitoworld.bsky.social · Jan 28

Research teams led by Martin Picard at Columbia University and Ryan Mills at the University of Michigan have found that mtDNA fragments - known as nuclear mitochondrial DNA segments (numts) - integrate into the nuclear genome at a high rate.

We interviewed Martin Picard to learn more about Numts:

Mitochondrial DNA Fragments (Numts) Insert Into Our Genome Sometimes With Serious Results - MitoWorld

The article “Jumping ‘Numts’ from Mitochondria Can Be Fast and Deadly” by Martin Picard, published online in Scientific American on January 3, 2025, sheds new light on a significant biological phenome...

mitoworld.org

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Reposted by www.MitoWorld.org

Catalina Vasilescu, PhD @cvasilescu.bsky.social · Jan 26

Start your week fresh with this outstanding collection of #mitochondrialdisease papers from last week!

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitowomen.bsky.social @mitoworld.bsky.social

Hypoxia as medicine

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