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Marco Lolaico

@mlolaico.bsky.social

75 followers 43 following 51 posts

Building nanoscale materials with DNA @ RUC, DK | Writing about AI-based protein design, DNA nanotech, molecular programming and more @ https://plentyofroom.beehiiv.com/

plentyofroom.beehiiv.com

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Marco Lolaico @mlolaico.bsky.social · Sep 5

Such a cool work! And turning a weakness of DNA origami into a strength is super smart 😁🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Sep 4

Can you use DNA traps to fight tumors?

This new work uses DNA origami nanostructures to capture TGF𝛽1, a cytokine involved in tumor growth and immune suppression. The system reduces tumor size and increases survival in mice! 🧪🖥️🧬

Read the whole breakdown here 👉 tinyurl.com/ytz7e7fr

DNA Trash Cans: Outsmarting Tumor Signals with Origami Tech!

DNA origami creates innovative "tumor traps" that capture cancer-signaling molecules, offering a groundbreaking approach to targeting and neutralizing uncontrolled cellular growth.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Aug 29

Cool work! Plastics from DNA? Funny idea 😎🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 28

400 million tonnes of plastic are produced each year, with tons of environmental problems.

Can DNA-based plastic be the solution? Super cool work! 🧪🖥️🧬

PS read and subscribe here 👉 plentyofroom.beehiiv.com/p/dna-plasti...

DNA Plastics: Recyclable, Biodegradable Revolution!

DNA and sugar chains create biodegradable, recyclable plastics, offering an innovative solution to global plastic pollution through groundbreaking molecular engineering.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Aug 8

Protein emulation with a silly name? Yes please 😎🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Aug 8

Emus and protein science?
Proteins are dynamic, but it's hard to study their transitions 🧪🖥️🧬

BioEmu uses machine learning to emulate protein dynamics with high precision and speed!

It complements simulations: first test with BioEmu, then continue with MD.

Read and subscribe tinyurl.com/enf5apzc

AI-Powered Protein Dynamics: Decoding Hidden Molecular Movements!

AI-powered protein dynamics: Machine learning decodes hidden molecular movements, revealing complex protein behavior through innovative computational techniques.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Jul 27

Don't miss this cool work! 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 25

New issue is here 🎉

Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable".

But today a new method creates binders using the power of computational methods! 🧪🖥️🧬

Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...

AI-Designed Protein Targeting: Taming Disordered Protein Chaos!

AI-powered computational design unlocks disordered protein targets, transforming our understanding of flexible molecular structures and potential therapeutic approaches.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Jul 21

Great work! 😎🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 20

Do you want to save your data in DNA? Well, now is coming closer!

This amazing work from University of Washington and Microsoft explore how to use CRISPR-Cas9 to access data in DNA databases. Cool! 🧪🧬🖥️

Read the whole breakdown here 👉 plentyofroom.beehiiv.com/p/crispr-bas...

CRISPR-Based Data Storage: DNA Search Engine Revolution!

CRISPR-Cas9 breakthrough: Innovative DNA data storage and retrieval method uses genetic engineering to transform digital information archiving.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Jul 13

The perfect article for your Sunday 😎🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 10

Bacteria turning plastic into drugs? Oh yeah!

Sometimes bacteria aren't enough to solve problems. What about merging biocompatible chemistry and bacteria to turn plastic bottles into paracetamol? 🧪🖥️🧬

Want to get more like this? Just subscribe! 👉 plentyofroom.beehiiv.com/p/synbio-bre...
#chemistry

Synbio Breakthrough: Turning Plastic Bottles into Life-Saving Drugs!

Synthetic biology transforms plastic waste into life-saving drugs, showcasing innovative chemistry that turns environmental challenges into medical breakthroughs.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Jul 6

Don't miss this amazing work! 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jul 3

Finding new drugs is hard. Even more for macrocycles, the molecules that could be the new best thing in medicine!

🧪Enter RFpeptides, a machine learning pipeline for macrocycle binders! Great work from @uwproteindesign.bsky.social
Want more like this? 👉 tinyurl.com/2da2k8dy
#biotech #ML #AI 🧬🖥️

AI Macrocycle Design: Revolutionizing Drug Discovery with Machine Learning!

AI-powered protein design creates macrocycles, leveraging machine learning to generate novel drug candidates and transform molecular engineering approaches.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Jun 29

Amazing work! 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jun 29

Nothing to read on Sunday? I got you covered!

What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪

Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML
#Ai

Computational Protein Design: Regenerative Medicine's Healing Future!

Computational protein design revolutionizes regenerative medicine, engineering innovative biomaterials and scaffolds to guide tissue regeneration like sci-fi healing techniques.

Marco Lolaico @mlolaico.bsky.social · Jun 6

Looking for some cool research? Don't miss this one then! 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Jun 5

30% of proteins and 50% of target drugs are membrane proteins. And yet, their production is still hard! A great article from @ucdavis.bsky.social merges cell-free systems, robotics and machine learning to improve this!
Subscribe to get more like this 🧪🧬🖥️ #biotech #machinelearning #robotics

Membrane Protein Synthesis: Robotics & ML Advancement!

Membrane protein production platform uses robotics and machine learning to revolutionize drug development, tackling challenges in synthesizing critical cellular proteins.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · May 30

Super cool work! 😎 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · May 29

Last week AI designed RNA, today it creates dynamic proteins! Small movements have a big impact in proteins, but it has been hard to replicate: until now! Great work from @ucsanfrancisco.bsky.social Subscribe to get more 👉 plentyofroom.beehiiv.com/p/ai-protein... 🧪🧬🖥️ #biotech #AI #deeplearning

AI Protein Switches: Designing Dynamic Multistate Molecular Machines!

AI-powered protein design creates dynamic, multistate protein switches that respond to mutations and ligands, increasing molecular engineering capabilities.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · May 25

🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · May 24

Searching for a weekend read? I got you! Is it possible to leverage AI to create functional RNAs? Well, from now yes! 🧪 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech

AI RNA Design: Generating Functional Molecules with Machine Learning!

AI RNA design: Advanced machine learning techniques create functional RNA molecules, from CRISPR guides to innovative toehold switches.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · May 23

Are you looking for something to read? Here you go! AI has shown potential for protein design (looking at you, Alphafold). But is it possible to leverage it to create functional RNA? Well, from now yes! 🧪🖥️🧬 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech

AI RNA Design: Generating Functional Molecules with Machine Learning!

AI RNA design: Advanced machine learning techniques create functional RNA molecules, from CRISPR guides to innovative toehold switches.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · May 18

Looking for some weekend reading? 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · May 17

Did you miss this week's issue? Don't worry, you're still in time 😎 Today's paper mixes DNA origami with high-resolution microscopy to create nanopatterned functional surfaces! 🧪 Subscribe to get more like this! 👉 plentyofroom.beehiiv.com/p/nanoscale-... #DNA #nanotech #lithograpy #printing

DNA Origami Meets Lithography: Nanoscale Dog Printing

DNA origami meets lithography: Nanoscale patterning breakthrough creates precise DNA nanocrystals with intricate designs, including a playful dog print at nanometer resolution.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · May 16

Amazing work bridging top-down and bottom-up nanofabrication! 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · May 15

Do you want to print microscale dogs with nanoscale features? Well, now you can! Today's paper mixes DNA origami with high-resolution microscopy to create nanopatterned functional surfaces! 🧪🖥️🧬 Subscribe to get more like this! 👉 plentyofroom.beehiiv.com #DNA #nanotech #lithograpy #printing

DNA Origami Meets Lithography: Nanoscale Dog Printing

DNA origami meets lithography: Nanoscale patterning breakthrough creates precise DNA nanocrystals with intricate designs, including a playful dog print at nanometer resolution.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · May 10

Thank you very much for your explanation! I'm not too much into spatial transcriptomics, so your input is great! And yeah, I have also seen very limited adoption, looking at the methods it looks also very complicated.

Marco Lolaico @mlolaico.bsky.social · May 10

Ahahah probably the right choice! I think it's a cool idea, definitely years away from any real use. What is your opinion?

Marco Lolaico @mlolaico.bsky.social · May 9

Should I get rid of my microscope? DNA microscopy lets you image your sample using only sequencing, now in 3D! 🧪 Super cool work from University of Chicago. Subscribe today! #DNA #biotech #imaging #microscopy
plentyofroom.beehiiv.com/p/dna-micros...

DNA Microscopy: Seeing by Sequencing Revolution!

DNA microscopy revolutionizes imaging: sequencing techniques create unprecedented 3D cellular visualization, transforming how we image biological samples.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · May 8

Are you wondering if AI will steal your job? I don't know about that, but it can create new enzymes! 🧪 Subscribe to get more like this in your inbox! #science #AI

AI Enzyme Design: Powering Molecular Catalysis with Cutting-Edge AI!

AI revolutionizes enzyme design, using machine learning to create innovative biological catalysts for complex reactions and molecular engineering breakthroughs.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · May 2

That's the spirit!

Marco Lolaico @mlolaico.bsky.social · May 2

Amazing work! Had to learn a lot to cover this 😂😅🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · May 1

New issue is here! 🎉🧪🧬🖥️ CRISPR delivery is a problem: ENVLPE solves it! Amazing work from @tum.de and @www.helmholtz-munich.de Read everything and subscribe at 👉 plentyofroom.beehiiv.com/p/crispr-del... #geneediting #biotech #CRISPR

CRISPR Delivery: ENVLPE Boosts Gene Editing Efficiency 4x!

CRISPR delivery breakthrough: ENVLPE platform revolutionizes gene editing with 4x improved efficiency, transforming cellular engineering and molecular medicine.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Apr 27

Looking for something to read today? Maybe you're also traveling to a conference? Here you go then 😎🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Apr 24

New issue is out! 🎉 What if we could increase rapid test's sensitivity by 100x, without increasing the cost? How? Using DNA origami! 🧪🧬🖥️ Great work from @lmumuenchen.bsky.social and @tum.de Subscribe at 👉 plentyofroom.beehiiv.com/p/dna-origam... #diagnostics #biotech #DNA #DNAorigami

DNA Origami Boosts Rapid Test Sensitivity: Diagnostics Breakthrough!

DNA origami revolutionizes rapid testing: nanotech boosts diagnostic sensitivity 125x, transforming point-of-care and home testing technology.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Apr 25

Great paper! And I did my best to summarise it as well 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Apr 24

New issue is out! 🎉 What if we could increase rapid test's sensitivity by 100x, without increasing the cost? How? Using DNA origami! 🧪🧬🖥️ Great work from @lmumuenchen.bsky.social and @tum.de Subscribe at 👉 plentyofroom.beehiiv.com/p/dna-origam... #diagnostics #biotech #DNA #DNAorigami

DNA Origami Boosts Rapid Test Sensitivity: Diagnostics Breakthrough!

DNA origami revolutionizes rapid testing: nanotech boosts diagnostic sensitivity 125x, transforming point-of-care and home testing technology.

plentyofroom.beehiiv.com

Marco Lolaico @mlolaico.bsky.social · Apr 22

Amazing science 🧪

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Apr 22

Are you looking for some "productive" procrastination? I have the solution: just head here and read how to improve delivery of RNA therapeutics! 😎🧬🖥️🧪 And don't forget to subscribe of course! #science #drugdelivery #drugs #RNA

AI-Designed RNA Delivery: Nature-Inspired Nanoparticles Target Immune Cells!

Cutting-edge nanomedicine breakthrough: lipid nanoparticles revolutionize RNA drug delivery, targeting immune cells in bone marrow and spleen with precision.

plentyofroom.beehiiv.com

Reposted by Marco Lolaico

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Apr 21

This will always be my favourite 🧪 #science #sciencehumor #humor

Marco Lolaico @mlolaico.bsky.social · Apr 17

Amazing work out of my "neighbours" at @dtu.dk 😎🧪🧬🖥️

Plenty of Room - Newsletter @plenty-of-room.bsky.social · Apr 17

New issue today! 🎉 I covered a great article out of @dtu.dk and @instadeep.bsky.social: can AI accelerate peptide discovery? 😎🧪🖥️🧬 The answer is yes, thanks to InstaNovo! Read everything and subscribe at 👉 plentyofroom.beehiiv.com/p/ai-protein... #AI #machinelearning #biotech #proteinscience

AI Protein Sequencing Breakthrough: Decoding Peptides Faster!

AI-powered protein sequencing: Instanovo uses advanced machine learning to decipher peptide structures, revolutionizing proteomics and biomedical research.

plentyofroom.beehiiv.com