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mspielmann.bsky.social
@mspielmann.bsky.social
260 followers 230 following 5 posts
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molgen.mpg.de
🧬 Only one month until the 2nd meeting on early embryogenesis & epigenetics. #Embryo2026

Barbara Treutlein (@ethz.ch) will speak about her work reconstructing human brain development with organoids and single-cell technologies!

More information: www.molgen.mpg.de/embryo2026
January 13, 2026 at 2:13 PM
Reposted
moorejille.bsky.social
Our paper on the newest version of the Registry of candidate cis-Regulatory Elements (cCREs) is out 🧬

Huge thanks to the many collaborators, experimentalists, analysts and software developers who made this work possible — truly a team effort!

A "meme-torial" of the science is coming soon 👀
An expanded registry of candidate cis-regulatory elements - Nature
The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types...
www.nature.com
January 7, 2026 at 6:47 PM
Reposted
axelvisel.bsky.social
Now out: The new ENCODE registry of candidate cis-regulatory elements (🐭/👶)

Major consortium effort, led by @moorejille.bsky.social - stay tuned for her "meme-torial"

www.nature.com/articles/s41...

@berkeleylab.lbl.gov @biosci.lbl.gov
AI slop depiction of regulatory landscapes, in a style that would give Caspar David Friedrich a cluster headache. Colorful cones erupt from the fog and launch rockets (presumably transcription factors) toward a suspiciously three-stranded DNA helix of unclear left- or right-handedness. Lone, brooding figures stare into the chromatin mist waiting for meaning to emerge, while Romantic ruins and cosmic arcs hint vaguely at long-range regulation, peak calling, and other things that ChatGPT definitely did not understand right.
January 7, 2026 at 9:45 PM
Reposted
erikloomis.bsky.social
Meanwhile, in countries that still do scientific research and medicine.....

www.bbc.com/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
January 4, 2026 at 1:31 PM
Reposted
mydennis.bsky.social
Excited to share our final accepted version of the CiFi method out today: www.nature.com/articles/s41...
December 8, 2025 at 5:54 PM
Reposted
uwgenome.bsky.social
Mapping single-cell diploid chromatin fiber architectures using DAF-seq
www.nature.com/articles/s41...
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology
Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.
www.nature.com
December 4, 2025 at 1:14 AM
Reposted
varianteffect.bsky.social
If you are planning to attend the Mutational Scanning Symposium (and companion workshops!) we recommend that you register as soon as possible to secure your spot!
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow
November 24, 2025 at 2:31 PM
Reposted
odedrechavi.bsky.social
"We thank the reviewers for their helpful suggestions"
November 23, 2025 at 11:19 AM
Reposted
molgen.mpg.de
IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...
November 18, 2025 at 4:05 PM
Reposted
jamesbriscoe.bsky.social
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader

Closing date 27th November

www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Reposted
molgen.mpg.de
📢 Speaker showcase for our 2nd Meeting #Embryo2026 🧬Vincent Pasque @pasquelab.bsky.social from @kuleuvenuniversity.bsky.social will speak about his work on modelling early human embryogenesis with naïve pluripotent stem cells.
More information👇
www.molgen.mpg.de/embryo2026
November 14, 2025 at 2:59 PM
Reposted
molgen.mpg.de
We were very happy to welcome this amazing group of early-career researchers as part of the @Falling Walls Science Summit in Berlin! Special thanks to @annaamonaco.bsky.social (Mundlos Lab) and @matthewkraushar.bsky.social for hosting the group and providing an in-depth tour of their labs!
November 11, 2025 at 10:07 AM
Reposted
fueyoraquel.bsky.social
Thrilled to start my Group Leader adventure with these and other great scientists!
November 6, 2025 at 8:11 PM
Reposted
molgen.mpg.de
We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Three new research groups joining the MPIMG
www.molgen.mpg.de
November 6, 2025 at 4:00 PM
Reposted
molgen.mpg.de
🧬📢 We look forward to welcoming Jacob Hanna from the Weizmann Institute of Science as part of our speaker lineup for the #Embryo2026 meeting!

More information 👇
www.molgen.mpg.de/embryo2026
November 5, 2025 at 12:31 PM
Reposted
natrevgenet.nature.com
New online! Redefining cellular reprogramming with advanced genomic technologies
Redefining cellular reprogramming with advanced genomic technologies
Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.
www.nature.com
October 17, 2025 at 1:59 PM
Reposted
varianteffect.bsky.social
🗓️Abstract Deadline Extended
to December 1st, 2025!
#VariantEffect26
ℹ️https://www.mss2026.org
November 3, 2025 at 2:30 PM
Reposted
molgen.mpg.de
The IMPRS-BAC call is open until January! Interested in applying to the graduate school? Here are ten tips for a successfull application! ⬇

Check out our projects and apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...

#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
October 28, 2025 at 10:51 AM
Reposted
natrevgenet.nature.com
ICYMI: New online! Redefining cellular reprogramming with advanced genomic technologies
Redefining cellular reprogramming with advanced genomic technologies
Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.
www.nature.com
October 24, 2025 at 2:00 PM
Reposted
molgen.mpg.de
📢🧬 Next in the speaker line-up for #Embryo2026 is @eileen-furlong.bsky.social from @embl.org who will present her research on

"Genome regulation during embryogenesis: Going loopy about enhancer regulation"

Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute
SharePic for the contribution of Eileen Furlong from EMBL for the 2nd Meeting on Early embryogenesis & epigenetics organized by the Max Planck Institute for Molecular Genetics in Berlin with support by the Weizmann Institute for Science. The SharePic features the portrait of Eileen and the title of her contritbution "Genome regulation during embryogenesis: Going loopy about enhancer regulation".
October 24, 2025 at 11:13 AM
Reposted
mattjones.bsky.social
Delighted to share our new study in @natcellbio.nature.com showing that the unique epigenetic landscape of ecDNA can enable the oncogenic enhancer activation of transposable elements! This was a great collaboration with @katerinakraft.bsky.social and @sedonamurphy.bsky.social. tinyurl.com/mwfbu4w4
Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
tinyurl.com
October 21, 2025 at 2:43 PM
Reposted
molgen.mpg.de
📢Speaker showcase for our 2nd Meeting #Embryo2026 🧬

@jamesbriscoe.bsky.social from @crick.ac.uk will speak on

The Dynamics of Neural Tube Formation

More information on www.molgen.mpg.de/embryo2026
October 17, 2025 at 8:22 AM
Reposted
natrevgenet.nature.com
Our featured article: Structural variants in the 3D genome as drivers of disease - Review by Varun K. A. Sreenivasan, Verónica Yumiceba & Malte Spielmann go.nature.com/4oiPdPQ
Free to read here: rdcu.be/eu0KR
Structural variants in the 3D genome as drivers of disease
Nature Reviews Genetics - Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical...
rdcu.be
October 15, 2025 at 11:54 AM
Reposted
natrevgenet.nature.com
Our November 2025 issue is now live: go.nature.com/4hlXnVx
Topics include: the impact of structural variation on the 3D genome in disease; single-cell DNA sequencing of somatic mutations; the role of transcription compartments in gene regulation; synonymous mutations and their consequences
October 15, 2025 at 11:54 AM
Reposted
jshendure.bsky.social
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
October 14, 2025 at 6:45 PM