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Single-cell RNA sequencing (scRNA-seq) has transformed our ability to resolve cellular heterogeneity, but extracting meaningful signals remains challenging due to technical noise, batch effects, and the limitations of current feature selection methods. We present Entropy Sorting Feature Selection (ESFS), a modular, user-friendly framework that captures multivariate gene expression relationships without imputation or denoising via latent spaces. Across diverse datasets, ESFS improves interpretability and reveals biology missed by standard workflows: identifying coherent developmental programs in eight independent human embryo datasets without batch integration; resolving spatial gene expression in mouse colon obscured by conventional analyses; distinguishing shared and tumour-specific microenvironments in glioblastoma; and disambiguating spatial, temporal, and neurogenic programs in the developing mouse neural tube. By operating in gene expression space, ESFS produces interpretable, biologically meaningful outputs while reducing artefacts introduced by feature extraction. These results position ESFS as a powerful means to uncover relevant molecular signatures in noisy, high-dimensional transcriptomics data. ### Competing Interest Statement The authors have declared no competing interest. Cancer Research UK, CC001051 Medical Research Council, https://ror.org/03x94j517, CC001051 Wellcome Trust, CC001051 Wellcome Trust, 220379/D/20/Z European Molecular Biology Organization, 792-2021 UK Research and Innovation, EP/X031225/1

Il nuovo progetto GRNevo, finanziato con un grant FIS-3 Advanced da 1,9 milioni di euro, studierà come si formano i neuroni durante lo sviluppo in specie animali molto distanti tra loro: dal moscerino...

Pathway to Independence programme | Development | The Company of Biologists Development's Pathway to Independence programme Launched in 2022, Development’s Pathway Independence programm...

Vertebrates show a striking diversity of brain size and morphology. Mammals, in particular, have an especially large cerebral cortex, presenting with a characteristic six-layered structure that is bel...

On these pages we highlight the range of resources that we offer to early-career researchers.

The Editor-in-Chief (EIC) of Journal of Cell Science plays a key role in defining the overall vision of the journal, helping to decide on journal strategy, policy and priorities, and overseeing all co...

Benzinger et al. develop a chemo-optogenetic system for precise spatiotemporal control of morphogen production in vitro. Using light-controlled Sonic hedgehog expression, they recapitulate neural tube...

ABSTRACT. For post-docs pursuing an academic career, the transition to a group leader position can be a notoriously difficult one, not least because the availability of necessary support and training ...

Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.

The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attemp...

Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Zhang et al. identify a global temporal chromatin program that operates across the developing vertebrate nervous system to control neural cell diversity. This mechanism, which involves Nr6a1 and NFIA/...