Tommy Vierbuchen
@tvierbuchen.bsky.social
Assistant Professor, Developmental Biology, Center for Stem Cell Biology at Sloan Kettering. Building next generation stem cell models to study genetics of brain development.
https://www.mskcc.org/research/ski/labs/thomas-vierbuchen
https://www.mskcc.org/research/ski/labs/thomas-vierbuchen
Pinned
Tommy Vierbuchen
@tvierbuchen.bsky.social
· Aug 27
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
Reposted by Tommy Vierbuchen
Don't miss this episode!
Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.
Check it out: https://bit.ly/48dmghX
Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.
Check it out: https://bit.ly/48dmghX
November 26, 2025 at 1:01 AM
Don't miss this episode!
Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.
Check it out: https://bit.ly/48dmghX
Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.
Check it out: https://bit.ly/48dmghX
Reposted by Tommy Vierbuchen
Now live, and thanks to @erictopol.bsky.social for organising this!
Matthew Cobb (@matthewcobb2)
This was a terrific discussion with Eric about my new biography of Francis Crick.
substack.com
November 25, 2025 at 8:42 PM
Now live, and thanks to @erictopol.bsky.social for organising this!
Reposted by Tommy Vierbuchen
New work from our lab: a simple motif-based model can distinguish between distal cell type specific regulatory elements with extremely high accuracy - in all metazoans including plants.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Motif-based models accurately predict cell type-specific distal regulatory elements - Nature Communications
Decoding cell identity from DNA alone is a challenge. Here, the authors demonstrate that counting transcription factor motifs in regulatory DNA can forecast cell-type specificity outperforming deep-le...
www.nature.com
November 25, 2025 at 3:54 AM
New work from our lab: a simple motif-based model can distinguish between distal cell type specific regulatory elements with extremely high accuracy - in all metazoans including plants.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tommy Vierbuchen
Our next episode features Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social
Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠
Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠
November 24, 2025 at 11:34 PM
Our next episode features Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social
Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠
Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠
Reposted by Tommy Vierbuchen
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Tommy Vierbuchen
Unified Generation of Regionalized Neural Organoids from Single-Lumen Neuroepithelium https://www.biorxiv.org/content/10.1101/2025.11.18.689013v1
November 18, 2025 at 9:32 PM
Unified Generation of Regionalized Neural Organoids from Single-Lumen Neuroepithelium https://www.biorxiv.org/content/10.1101/2025.11.18.689013v1
Reposted by Tommy Vierbuchen
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 2:51 PM
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by Tommy Vierbuchen
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 13, 2025 at 4:00 PM
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Reposted by Tommy Vierbuchen
There’s a terrific review of CRICK in @science.org tonight, thanks to @adrianwoolfson.bsky.social. The PDF isn’t working right now; I’ll post a screenshot later. Here’s the paywalled html link:
Francis Crick’s life and legacy
A new biography offers a definitive account of the DNA decoder
www.science.org
November 13, 2025 at 8:13 PM
There’s a terrific review of CRICK in @science.org tonight, thanks to @adrianwoolfson.bsky.social. The PDF isn’t working right now; I’ll post a screenshot later. Here’s the paywalled html link:
Reposted by Tommy Vierbuchen
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
November 10, 2025 at 9:46 PM
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Reposted by Tommy Vierbuchen
Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds https://www.biorxiv.org/content/10.1101/2025.11.08.687374v1
November 10, 2025 at 3:30 AM
Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds https://www.biorxiv.org/content/10.1101/2025.11.08.687374v1
Reposted by Tommy Vierbuchen
In the most recent episode of the Epigenetics Podcast, we talked with Ryan Corces from @gladstoneinst.bsky.social about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease. #podacst #chromatin #epigenetics
Listen here: www.activemotif.com/podcasts-rya...
Listen here: www.activemotif.com/podcasts-rya...
October 20, 2025 at 7:01 AM
In the most recent episode of the Epigenetics Podcast, we talked with Ryan Corces from @gladstoneinst.bsky.social about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease. #podacst #chromatin #epigenetics
Listen here: www.activemotif.com/podcasts-rya...
Listen here: www.activemotif.com/podcasts-rya...
Reposted by Tommy Vierbuchen
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 7, 2025 at 6:06 PM
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Reposted by Tommy Vierbuchen
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
ZMYND11 Restrains KMT2A to Enable a Neuronal Developmental Program
Mutations in the chromatin reader and tumor suppressor ZMYND11 are the cause of ZMYND11-related syndromic intellectual disability (ZRSID), a disorder characterized by symptoms such as language and mot...
www.biorxiv.org
November 4, 2025 at 11:37 PM
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
Reposted by Tommy Vierbuchen
Oocyte-like mouse cells made from stem cells even without the guiding signals from ovarian cells. Another step towards in vitro gametes.
www.cell.com/developmenta...
www.cell.com/developmenta...
In vitro oogenesis breaks free of the ovary
In this issue of Developmental Cell, Nosaka et al. differentiate mouse pluripotent
stem cells to large germinal vesicle-stage oocyte-like cells in the absence of ovarian
somatic cells. Their paradigm ...
www.cell.com
November 3, 2025 at 7:54 PM
Oocyte-like mouse cells made from stem cells even without the guiding signals from ovarian cells. Another step towards in vitro gametes.
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Tommy Vierbuchen
tepid take: a lotttttt of job postings for bio-AI researchers, not enough job postings for generating-the-extremely-necessary-data-for-bio-AI researchers
October 2, 2025 at 2:16 PM
tepid take: a lotttttt of job postings for bio-AI researchers, not enough job postings for generating-the-extremely-necessary-data-for-bio-AI researchers
Reposted by Tommy Vierbuchen
The Kim Lab (sskimlab.org) at UC Irvine is recruiting motivated grad students interested in uncovering how transcriptional regulators direct cell fates. We accept students through the CMB (cmb.uci.edu) and MCSB (ccbs.uci.edu/education/mcsb/) PhD programs. Please share with prospective grad students!
Kim Lab at UC Irvine
Visit the post for more.
sskimlab.org
October 30, 2025 at 3:37 PM
The Kim Lab (sskimlab.org) at UC Irvine is recruiting motivated grad students interested in uncovering how transcriptional regulators direct cell fates. We accept students through the CMB (cmb.uci.edu) and MCSB (ccbs.uci.edu/education/mcsb/) PhD programs. Please share with prospective grad students!
Reposted by Tommy Vierbuchen
Post-translational Tuning of Human Cortical Progenitor Neuronal Output https://www.biorxiv.org/content/10.1101/2025.10.27.684791v1
October 28, 2025 at 12:31 AM
Post-translational Tuning of Human Cortical Progenitor Neuronal Output https://www.biorxiv.org/content/10.1101/2025.10.27.684791v1
Reposted by Tommy Vierbuchen
Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
October 27, 2025 at 10:31 PM
Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
Reposted by Tommy Vierbuchen
Pervasive context-dependent effects in the genetic architecture of complex and quantitative traits revealed by a powerful multiparent mapping population in yeast https://www.biorxiv.org/content/10.1101/2025.10.27.683165v1
October 27, 2025 at 11:33 PM
Pervasive context-dependent effects in the genetic architecture of complex and quantitative traits revealed by a powerful multiparent mapping population in yeast https://www.biorxiv.org/content/10.1101/2025.10.27.683165v1
Reposted by Tommy Vierbuchen
For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease.
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
October 27, 2025 at 11:51 AM
For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease.
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
Reposted by Tommy Vierbuchen
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
October 24, 2025 at 4:31 PM
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
Reposted by Tommy Vierbuchen
What a cool paper. Also note that this very careful analysis does not support the majority of synonymous variants being non-neutral in yeast
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 6:30 PM
What a cool paper. Also note that this very careful analysis does not support the majority of synonymous variants being non-neutral in yeast
Reposted by Tommy Vierbuchen
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵