Craig Kaplan
@triggerloop.bsky.social
Professor, Department of Biological Sciences, University of Pittsburgh. RNA polymerase II mechanism, classic films, #classiccountdown once in awhile
Reposted by Craig Kaplan
This seems to strongly suggest that the incoming president of UVA doctored his CV to the edge of outright dishonesty, and that the most recent changes came months before Jim Ryan was forced, as if they were made in anticipation in Ryan’s removal. augustafreepress.com/news/vanishi...
How UVA’s presidential search missed what took us an hour to find
Inside Higher Ed frames the controversy surrounding Scott C. Beardsley's appointment as the University of Virginia's president.
augustafreepress.com
January 11, 2026 at 8:02 PM
This seems to strongly suggest that the incoming president of UVA doctored his CV to the edge of outright dishonesty, and that the most recent changes came months before Jim Ryan was forced, as if they were made in anticipation in Ryan’s removal. augustafreepress.com/news/vanishi...
@sbarolo.bsky.social should I take kiddo to Kiera Knightly P&P (haven’t seen it)
January 11, 2026 at 7:12 PM
@sbarolo.bsky.social should I take kiddo to Kiera Knightly P&P (haven’t seen it)
RPJr SPECIFICALLY warned us about FREAKY ghosts
Shadyside. South Aiken Ave. Caller said that a ghost just felt him up. Caller wants to meet with PD to talk about options.
January 10, 2026 at 11:32 PM
RPJr SPECIFICALLY warned us about FREAKY ghosts
Reposted by Craig Kaplan
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Redirecting
doi.org
December 6, 2025 at 5:02 PM
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Reposted by Craig Kaplan
We lost an icon 10 years ago today. 🤍
@chrisdeville.bsky.social on Bowie’s final masterpiece: stereogum.com/2484243/blac...
@chrisdeville.bsky.social on Bowie’s final masterpiece: stereogum.com/2484243/blac...
January 10, 2026 at 7:45 PM
We lost an icon 10 years ago today. 🤍
@chrisdeville.bsky.social on Bowie’s final masterpiece: stereogum.com/2484243/blac...
@chrisdeville.bsky.social on Bowie’s final masterpiece: stereogum.com/2484243/blac...
It's time for another Casey Kasem American Top 40 flashback #AT40. This week, we travel back to January 8, 1972. Who will be #1?
Listen to Casey on SiriusXM 70s, and follow this 🧵 to find out.
Listen to Casey on SiriusXM 70s, and follow this 🧵 to find out.
January 10, 2026 at 6:08 PM
Reposted by Craig Kaplan
(2019)
THE OLYMPICS: OK Italy, we're giving you 2026, can you pull it off?
ITALY: Yes, we just have to build one arena, very easy, the easiest of any Olympics
(2026)
THE OLYMPICS: OK we're here! how is that one arena looking?
ITALY: (sitting at a cafe, reading a newspaper) mi scusi????
THE OLYMPICS: OK Italy, we're giving you 2026, can you pull it off?
ITALY: Yes, we just have to build one arena, very easy, the easiest of any Olympics
(2026)
THE OLYMPICS: OK we're here! how is that one arena looking?
ITALY: (sitting at a cafe, reading a newspaper) mi scusi????
You say "all the venues" but this is basically the only new venue they needed to build. Everything else was existing or temporary.
The Italians couldn't build one (1) arena on time, when they had about 7 years to plan.
The Italians couldn't build one (1) arena on time, when they had about 7 years to plan.
if you're surprised to learn that the Winter Olympics are just a month away, don't worry, you're not alone, the people building all the venues in Italy also appear to be surprised the Olympics are just a month away
January 10, 2026 at 4:07 PM
(2019)
THE OLYMPICS: OK Italy, we're giving you 2026, can you pull it off?
ITALY: Yes, we just have to build one arena, very easy, the easiest of any Olympics
(2026)
THE OLYMPICS: OK we're here! how is that one arena looking?
ITALY: (sitting at a cafe, reading a newspaper) mi scusi????
THE OLYMPICS: OK Italy, we're giving you 2026, can you pull it off?
ITALY: Yes, we just have to build one arena, very easy, the easiest of any Olympics
(2026)
THE OLYMPICS: OK we're here! how is that one arena looking?
ITALY: (sitting at a cafe, reading a newspaper) mi scusi????
Reposted by Craig Kaplan
Labathon week skill-building report: tetrad dissection (lots!), long read genome assembly, DNA copy number analysis, pinning, bulk segregant mapping, FACS ploidy estimation, mating type testing, AI for coding, lit review, learning about weird stuff like mating type switching and tetraploid meiosis
January 9, 2026 at 10:37 PM
Labathon week skill-building report: tetrad dissection (lots!), long read genome assembly, DNA copy number analysis, pinning, bulk segregant mapping, FACS ploidy estimation, mating type testing, AI for coding, lit review, learning about weird stuff like mating type switching and tetraploid meiosis
Try incognito mode in different browsers to get SciENcv to work. Also I have noticed major increase in eRA commons problems with different web browsers
Same. That was the only way I could get the stupid sciencv to work as well.
January 9, 2026 at 10:48 PM
Try incognito mode in different browsers to get SciENcv to work. Also I have noticed major increase in eRA commons problems with different web browsers
Reposted by Craig Kaplan
Big new piece: @alexreisner.bsky.social presents the most compelling evidence yet that generative AI directly stores and reproduces training material—it does not "learn," not really. This could have substantial legal consequences for the tech industry.
AI’s Memorization Crisis
Large language models don’t “learn”—they copy. And that could change everything for the tech industry.
www.theatlantic.com
January 9, 2026 at 10:40 PM
Big new piece: @alexreisner.bsky.social presents the most compelling evidence yet that generative AI directly stores and reproduces training material—it does not "learn," not really. This could have substantial legal consequences for the tech industry.
Reposted by Craig Kaplan
@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...
Deep contrastive learning enables genome-wide virtual screening
Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...
www.science.org
January 9, 2026 at 6:55 PM
@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...
Reposted by Craig Kaplan
The @zeitlingerlab.bsky.social is pleased to announce @sergio-gma91.bsky.social’s preprint “High-resolution binding data of TFIID and cofactors show promoter-specific differences in vivo” (www.biorxiv.org/content/10.6...).
TLDR; TFIID behaves differently depending on promoter type. More below:
TLDR; TFIID behaves differently depending on promoter type. More below:
High-resolution binding data of TFIID and cofactors show promoter-specific differences in vivo
TFIID is instrumental in recognizing promoter sequences and initiating transcription, yet a cohesive understanding of how this complex interacts with and functions at different promoter types in vivo ...
www.biorxiv.org
January 9, 2026 at 6:30 PM
The @zeitlingerlab.bsky.social is pleased to announce @sergio-gma91.bsky.social’s preprint “High-resolution binding data of TFIID and cofactors show promoter-specific differences in vivo” (www.biorxiv.org/content/10.6...).
TLDR; TFIID behaves differently depending on promoter type. More below:
TLDR; TFIID behaves differently depending on promoter type. More below:
Reposted by Craig Kaplan
Our eLetter github.com/caseywdunn/s... responding to a recent Science paper was just posted. The paper found more genes with consistent support for sponge-sister than ctenophore-sister. We found several technical issues that, when corrected, reverse the conclusions and recover ctenophore-sister.
January 9, 2026 at 11:44 AM
Our eLetter github.com/caseywdunn/s... responding to a recent Science paper was just posted. The paper found more genes with consistent support for sponge-sister than ctenophore-sister. We found several technical issues that, when corrected, reverse the conclusions and recover ctenophore-sister.
Reposted by Craig Kaplan
Reposted by Craig Kaplan
In other words, rather than accept a union, the current owners closed a newspaper that’s almost as old as the US.
The Post Gazette was killed today because the Blocks, after fighting the longest strike in US history at 1,133 days, were irrevocably told by the Supreme Court today that they lost. So they're closing a newspaper that first published in 1786 because they're mad.
triblive.com/business/pit...
triblive.com/business/pit...
Pittsburgh Post-Gazette announces closure
The owners of Pittsburgh Post-Gazette announced on Wednesday that the newspaper will “cease operations” on May 3. “Over the past 20 years, Block Communications has lost more than $35...
triblive.com
January 7, 2026 at 7:25 PM
In other words, rather than accept a union, the current owners closed a newspaper that’s almost as old as the US.
Reposted by Craig Kaplan
#Yeast #Genetics Meeting abstract submission and registration sites are open! Abstracts due March 5!
community.alliancegenome.org/t/yeast-gene...
community.alliancegenome.org/t/yeast-gene...
Yeast Genetics Meeting abstract submission and registration sites are open!
Abstract submission and registration for the 2026 Yeast Genetics Meeting are now open! Present at this premier meeting for students, postdoctoral scholars, research staff, principal investigators, and...
community.alliancegenome.org
January 7, 2026 at 4:11 PM
#Yeast #Genetics Meeting abstract submission and registration sites are open! Abstracts due March 5!
community.alliancegenome.org/t/yeast-gene...
community.alliancegenome.org/t/yeast-gene...
Reposted by Craig Kaplan
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
www.biorxiv.org
January 5, 2026 at 12:51 PM
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
SciENcv was a good tool and no problems when I used I since they rolled it out but I have no heard from multiple people that it has just been broken. Please get your biosketches done ASAP
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
January 7, 2026 at 1:09 AM
SciENcv was a good tool and no problems when I used I since they rolled it out but I have no heard from multiple people that it has just been broken. Please get your biosketches done ASAP
Reposted by Craig Kaplan
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
January 6, 2026 at 11:29 PM
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
Look at this crazy thing!
We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)
January 6, 2026 at 4:47 PM
Look at this crazy thing!
Reposted by Craig Kaplan
If I could rip the defensive talking mechanism out of the brains of every writer I have ever worked with I would, and install this operating chip instead ⬇️⬇️⬇️
There's an old tweet of yours that I used to revisit often - about how platforms like Twitter train us to try to build perfect fortresses of statements that preemptively address any interpretation, but that inevitably fails, so why not just say what you mean to people who want to understand
January 6, 2026 at 2:10 PM
If I could rip the defensive talking mechanism out of the brains of every writer I have ever worked with I would, and install this operating chip instead ⬇️⬇️⬇️
These are very very bad people
Kennedys antivaxx lawyer is already telegraphing their next move.
January 6, 2026 at 12:40 AM
These are very very bad people
Reposted by Craig Kaplan
RFK Jr. just changed to the childhood vaccine schedule and is now recommending fewer shots for kids. Doctors and experts already told me all these changes are confusing physicians and parents, and risk making kids less safe talkingpointsmemo.com/news/parents...
Parents and Doctors Are Left in the Dark Amid Trump Admin’s Murky Childhood Vaccine Guidelines
Dr. Jessica Weisz, a pediatrician in D.C., has seen more and more...
talkingpointsmemo.com
January 5, 2026 at 8:05 PM
RFK Jr. just changed to the childhood vaccine schedule and is now recommending fewer shots for kids. Doctors and experts already told me all these changes are confusing physicians and parents, and risk making kids less safe talkingpointsmemo.com/news/parents...
Reposted by Craig Kaplan
BREAKING: Federal health officials on Monday announced dramatic revisions to the slate of vaccines recommended for American children, reducing the number of diseases prevented by routine shots to 11 from 17.
www.nytimes.com/2026/01/05/h...
www.nytimes.com/2026/01/05/h...
Kennedy Scales Back the Number of Vaccines Recommended for Children
www.nytimes.com
January 5, 2026 at 7:01 PM
BREAKING: Federal health officials on Monday announced dramatic revisions to the slate of vaccines recommended for American children, reducing the number of diseases prevented by routine shots to 11 from 17.
www.nytimes.com/2026/01/05/h...
www.nytimes.com/2026/01/05/h...