Craig Kaplan
@triggerloop.bsky.social
Professor, Department of Biological Sciences, University of Pittsburgh. RNA polymerase II mechanism, classic films, #classiccountdown once in awhile
Reposted by Craig Kaplan
Here we go. Its ALL #NIHGrant applications. Dec 8 is the new deadline. And a one page prelim data update will be accepted for all May Council submissions. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 6:52 PM
Here we go. Its ALL #NIHGrant applications. Dec 8 is the new deadline. And a one page prelim data update will be accepted for all May Council submissions. grants.nih.gov/grants/guide...
Reposted by Craig Kaplan
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
November 24, 2025 at 6:57 PM
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
Reposted by Craig Kaplan
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
This seems like it could be a cool paper in the quote post trying to get at mechanism of super important surveillance kinase 1/
November 24, 2025 at 2:24 AM
This seems like it could be a cool paper in the quote post trying to get at mechanism of super important surveillance kinase 1/
Glorious Technicolor
November 23, 2025 at 7:03 PM
Glorious Technicolor
I sent for juice you give me poison >>>>>>>>>>>
November 23, 2025 at 4:28 AM
I sent for juice you give me poison >>>>>>>>>>>
Reposted by Craig Kaplan
Dream on, Sluggo
November 23, 2025 at 4:25 AM
Dream on, Sluggo
Reposted by Craig Kaplan
Stop supporting AI
November 22, 2025 at 11:05 PM
Stop supporting AI
Reposted by Craig Kaplan
I have been looking at Black Friday sales for a week but I do not actually need anything so instead I closed all those tabs and bought a Polaroid for a foster kid in Florida who uses photography to deal with big feelings. Perhaps you would like to do the same for one of the kids at the link below?
🧵 We are, in fact, doing the thing again for @onesimplewish.bsky.social. In 2024, the kind people of this community put the money cannon on blast to help grant $75K in wishes for children in foster care. Toys, tech, a suit for job interviews. Here we go again! 👇
www.onesimplewish.org/giving/megwa...
www.onesimplewish.org/giving/megwa...
November 22, 2025 at 9:48 PM
I have been looking at Black Friday sales for a week but I do not actually need anything so instead I closed all those tabs and bought a Polaroid for a foster kid in Florida who uses photography to deal with big feelings. Perhaps you would like to do the same for one of the kids at the link below?
Me logging on
November 22, 2025 at 3:19 PM
Me logging on
Reposted by Craig Kaplan
FYI: turning off "Smart features" also turns off spell check and the promotions and social tabs. And more.
In effect, a lot of traditional tools in gmail are switched off if you don't let them upload your contracts, love notes, and sad messages to your friends into their plagiarism machine.
In effect, a lot of traditional tools in gmail are switched off if you don't let them upload your contracts, love notes, and sad messages to your friends into their plagiarism machine.
If you use GMail, AI (Gemini) was turned on yesterday by default and now scans all of your content for machine learning. To turn off, go to Settings>General and scroll down. Uncheck the box for "Smart features."
There's other "Smart" add-ons as well, but that's the one that reads your content.
There's other "Smart" add-ons as well, but that's the one that reads your content.
November 20, 2025 at 10:05 PM
FYI: turning off "Smart features" also turns off spell check and the promotions and social tabs. And more.
In effect, a lot of traditional tools in gmail are switched off if you don't let them upload your contracts, love notes, and sad messages to your friends into their plagiarism machine.
In effect, a lot of traditional tools in gmail are switched off if you don't let them upload your contracts, love notes, and sad messages to your friends into their plagiarism machine.
Reposted by Craig Kaplan
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Craig Kaplan
The administration is building a legal pathway for ad hoc grant terminations:
"if the agency determines that the award no longer effectuates the program goals or agency priorities"
Converting multiyear grants to 'at whim' coin flips will undermine the stability & leadership of American science.
"if the agency determines that the award no longer effectuates the program goals or agency priorities"
Converting multiyear grants to 'at whim' coin flips will undermine the stability & leadership of American science.
Update on a significant development NIH grant terms.
On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.
But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.
1/
On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.
But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.
1/
HHS devises legal playbook for future grant terminations, internal memo shows
Exclusive: HHS devises a legal playbook for future research grant terminations, an internal memo shows.
www.statnews.com
November 20, 2025 at 4:06 PM
The administration is building a legal pathway for ad hoc grant terminations:
"if the agency determines that the award no longer effectuates the program goals or agency priorities"
Converting multiyear grants to 'at whim' coin flips will undermine the stability & leadership of American science.
"if the agency determines that the award no longer effectuates the program goals or agency priorities"
Converting multiyear grants to 'at whim' coin flips will undermine the stability & leadership of American science.
Reposted by Craig Kaplan
This is revolting
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 2:53 AM
This is revolting
Reposted by Craig Kaplan
Shameful
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 2:52 AM
Shameful
Reposted by Craig Kaplan
Time to vote for our GSA officers!
Please repost
Please repost
☑️ GSA Board Elections are open—we're calling our members to make their voice heard!
Help shape the future of our Society by voting for the next Vice President, Treasurer, and three Directors. Cast your ballot by November 30, 2025: buff.ly/TAENAkq
Help shape the future of our Society by voting for the next Vice President, Treasurer, and three Directors. Cast your ballot by November 30, 2025: buff.ly/TAENAkq
November 19, 2025 at 7:52 PM
Time to vote for our GSA officers!
Please repost
Please repost
Reposted by Craig Kaplan
All data are available on Zenodo and we'd love to see what you can do with it! Cydney also made a nice notebook to run the predictive model (including DMS scan) in Colab!
Preprint: biorxiv.org/content/10.1...
Colab: colab.research.google.com/drive/1KNWvG...
Data: docs.google.com/forms/d/e/1F...
Preprint: biorxiv.org/content/10.1...
Colab: colab.research.google.com/drive/1KNWvG...
Data: docs.google.com/forms/d/e/1F...
Global Analysis of Aggregation Determinants in Small Protein Domains
Protein aggregation is an obstacle for engineering effective recombinant proteins for biotechnology and therapeutic applications. Predicting protein aggregation propensity remains challenging due to t...
biorxiv.org
November 19, 2025 at 9:16 PM
All data are available on Zenodo and we'd love to see what you can do with it! Cydney also made a nice notebook to run the predictive model (including DMS scan) in Colab!
Preprint: biorxiv.org/content/10.1...
Colab: colab.research.google.com/drive/1KNWvG...
Data: docs.google.com/forms/d/e/1F...
Preprint: biorxiv.org/content/10.1...
Colab: colab.research.google.com/drive/1KNWvG...
Data: docs.google.com/forms/d/e/1F...
Reposted by Craig Kaplan
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Come to OKC Will Rogers airport in the next 4 minutes if you want to hear Music Box Dancer (and go insane)
November 19, 2025 at 7:29 PM
Come to OKC Will Rogers airport in the next 4 minutes if you want to hear Music Box Dancer (and go insane)
This is a #TCMbanger and you can still see beautiful art deco building where Bacall’s apartment was set on walk up stairs to Coit Tower
#ComingUpOnTCM
DARK PASSAGE (1947) Humphrey Bogart. Lauren Bacall, Bruce Bennett, Agnes Moorehead
Dir.: Delmer Daves 1:00 PM PT
A man falsely convicted of his wife's murder escapes prison to search for the real killer.
1h 46m | Film Noir | TV-PG
#TCM #TCMParty
DARK PASSAGE (1947) Humphrey Bogart. Lauren Bacall, Bruce Bennett, Agnes Moorehead
Dir.: Delmer Daves 1:00 PM PT
A man falsely convicted of his wife's murder escapes prison to search for the real killer.
1h 46m | Film Noir | TV-PG
#TCM #TCMParty
November 17, 2025 at 8:39 PM
This is a #TCMbanger and you can still see beautiful art deco building where Bacall’s apartment was set on walk up stairs to Coit Tower
Reposted by Craig Kaplan
The Dan Ryan Expressway, by Wesley Willis
American, 1963-2003
1986
More info: https://www.artic.edu/artworks/204579
American, 1963-2003
1986
More info: https://www.artic.edu/artworks/204579
November 17, 2025 at 6:53 PM
The Dan Ryan Expressway, by Wesley Willis
American, 1963-2003
1986
More info: https://www.artic.edu/artworks/204579
American, 1963-2003
1986
More info: https://www.artic.edu/artworks/204579
Reposted by Craig Kaplan
@asbmb.bsky.social 2026 meeting abstract deadline is TODAY!
Submit your abstract by 11:59 p.m. EST. Share your research with thousands of researchers using biochemistry and molecular biology to transform our understanding of the world.
www.asbmb.org/annual-meeti...
Submit your abstract by 11:59 p.m. EST. Share your research with thousands of researchers using biochemistry and molecular biology to transform our understanding of the world.
www.asbmb.org/annual-meeti...
Abstracts
www.asbmb.org
November 17, 2025 at 4:54 PM
@asbmb.bsky.social 2026 meeting abstract deadline is TODAY!
Submit your abstract by 11:59 p.m. EST. Share your research with thousands of researchers using biochemistry and molecular biology to transform our understanding of the world.
www.asbmb.org/annual-meeti...
Submit your abstract by 11:59 p.m. EST. Share your research with thousands of researchers using biochemistry and molecular biology to transform our understanding of the world.
www.asbmb.org/annual-meeti...
What a cool finding
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 6:39 PM
What a cool finding
Reposted by Craig Kaplan
