Jamie Hackett
@jamiehackett.bsky.social
Developmental (epi)genomics group at EMBL Rome
Non-genetic inheritance. Epigenetic editing. ERC investigator 🇮🇹🇬🇧🇮🇪
Non-genetic inheritance. Epigenetic editing. ERC investigator 🇮🇹🇬🇧🇮🇪
Novel compact CRISPR systems unlock easier delivery and more applications... epigenome editing anyone 👀
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
Iterative engineering of a compact Cas9 ortholog for in vivo gene editing via single AAV delivery
The development of compact and efficient CRISPR-Cas systems is crucial for biomedical and therapeutic genome editing, particularly in vivo applications based on viral delivery. Here, we performed a co...
www.biorxiv.org
January 13, 2026 at 2:45 PM
Novel compact CRISPR systems unlock easier delivery and more applications... epigenome editing anyone 👀
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
www.biorxiv.org
January 5, 2026 at 12:51 PM
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
Reposted by Jamie Hackett
New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
September 30, 2025 at 6:55 AM
New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
Reposted by Jamie Hackett
📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Endogenous variability in transcription factor concentrations shapes their genome-wide occupancy
The control of transcription factor (TF) concentrations is crucial for the precise regulation of gene expression and cell fate decisions during development. Yet, TF concentrations can display substant...
www.biorxiv.org
September 26, 2025 at 8:12 AM
📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal
imageimagePaternal environmental exposures have been linked with modulation of phenotype and
disease risk in offspring via largely unclear mechanisms. This study employs in vitro
fertilization and sin...
www.embopress.org
September 27, 2025 at 7:28 AM
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Reposted by Jamie Hackett
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
www.biorxiv.org
September 18, 2025 at 9:55 AM
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
🤩🤩 it’s been a while
May 21, 2025 at 10:25 PM
🤩🤩 it’s been a while
Awhh, my lab are absolute legends!
May 19, 2025 at 11:38 AM
Awhh, my lab are absolute legends!
We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training.
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
May 15, 2025 at 7:38 AM
We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training.
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
Reposted by Jamie Hackett
Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome?
Funding call with deadline 15 June, decisions in July.
www.embl.org/about/info/s...
Funding call with deadline 15 June, decisions in July.
www.embl.org/about/info/s...
March 19, 2025 at 5:31 PM
Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome?
Funding call with deadline 15 June, decisions in July.
www.embl.org/about/info/s...
Funding call with deadline 15 June, decisions in July.
www.embl.org/about/info/s...
Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
Group Leader - Molecular Mechanisms of Environmental Adaptation
We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...
embl.wd103.myworkdayjobs.com
February 11, 2025 at 9:03 PM
Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
December 30, 2024 at 12:27 PM
Reposted by Jamie Hackett
As an "EIPOD" interdisciplinary postdoc in @jamiehackett.bsky.social and our lab, @denbobalab.bsky.social found that "Paternal microbiome perturbations impact offspring fitness" (2024): antibiotic treatment of male mice led to low birth weight & higher mortality in offspring
www.nature.com/artic...
www.nature.com/artic...
Paternal microbiome perturbations impact offspring fitness
Nature - Disturbances in the gut microbiota of male mice manifest as fitness defects in their offspring by affecting plancenta function, revealing a paternal gut–germline axis.
www.nature.com
December 19, 2024 at 2:00 PM
As an "EIPOD" interdisciplinary postdoc in @jamiehackett.bsky.social and our lab, @denbobalab.bsky.social found that "Paternal microbiome perturbations impact offspring fitness" (2024): antibiotic treatment of male mice led to low birth weight & higher mortality in offspring
www.nature.com/artic...
www.nature.com/artic...
Reposted by Jamie Hackett
Strongly recommend DNAme researchers to take a look at this important study. Consistent with work from Schubeler lab: higher-order mut in DNAme reader proteins lead to only minor transcriptional changes. Reinforces the idea that DNAme does not establish heterochromatin through reader proteins
After a year of extra work and edits with @joncahn.bsky.social, I am overjoyed to share the final version of our work:
Characterization of DNA methylation reader proteins of Arabidopsis thaliana
Published in Genome Research @genomeresearch.bsky.social
genome.cshlp.org/content/earl...
Characterization of DNA methylation reader proteins of Arabidopsis thaliana
Published in Genome Research @genomeresearch.bsky.social
genome.cshlp.org/content/earl...
Characterization of DNA methylation reader proteins of Arabidopsis thaliana
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
December 9, 2024 at 8:28 AM
Strongly recommend DNAme researchers to take a look at this important study. Consistent with work from Schubeler lab: higher-order mut in DNAme reader proteins lead to only minor transcriptional changes. Reinforces the idea that DNAme does not establish heterochromatin through reader proteins
Reposted by Jamie Hackett
Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...
➡️Register now www.grc.org/histone-and-...
December 8, 2024 at 11:38 AM
Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...
➡️Register now www.grc.org/histone-and-...
Reposted by Jamie Hackett
Computational with a PhD in some quantiative science, and want to make the world a better place with AI in healthcare? Want to work with some of the most innovative AI groups in the life sciences? Want to work for Europe, across Cambridge and Heidelberg, living in the UK? Two more days to apply:
NEW: Postdoctoral Fellow with @ewanbirney
The project is based in the Birney Research group at @emblebi and working closely with Open Targets and @MoritzGerstung's group at DKFZ
The project is based in the Birney Research group at @emblebi and working closely with Open Targets and @MoritzGerstung's group at DKFZ
December 6, 2024 at 11:19 AM
Computational with a PhD in some quantiative science, and want to make the world a better place with AI in healthcare? Want to work with some of the most innovative AI groups in the life sciences? Want to work for Europe, across Cambridge and Heidelberg, living in the UK? Two more days to apply:
Reposted by Jamie Hackett
One of my illustrations made an appearance at the MPI #epigenetics conference! thanks to the boss @jamiehackett.bsky.social presenting the cool science we do in the lab 🔥
December 7, 2024 at 8:28 AM
One of my illustrations made an appearance at the MPI #epigenetics conference! thanks to the boss @jamiehackett.bsky.social presenting the cool science we do in the lab 🔥
Reposted by Jamie Hackett
Interested in an #interdisciplinary PhD on the #epigenetics of human disease (or know someone who is)? Come work with us through the 2025 MRC HGU PhD program. Excellent and friendly collegiate environment and a great city:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Please share 🙏 (1/2)
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Please share 🙏 (1/2)
MRC four-year International PhD programme: Human Genetics, Genomics and Disease
Applications now open.
institute-genetics-cancer.ed.ac.uk
December 3, 2024 at 4:35 PM
Interested in an #interdisciplinary PhD on the #epigenetics of human disease (or know someone who is)? Come work with us through the 2025 MRC HGU PhD program. Excellent and friendly collegiate environment and a great city:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Please share 🙏 (1/2)
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Please share 🙏 (1/2)
Reposted by Jamie Hackett
The good news: you only click on the "join" button once and then you following all the pack persists in the absence of the initiating stimulus. 😀
In all seriousness, a stellar group of folks to follow.
In all seriousness, a stellar group of folks to follow.
We've now filled one #Epigenetics, Chromatin and Gene regulation starter pack. Thanks for all the enthusiasm and support, if you'd like to be listed @raduzabet.bsky.social has been hard at work getting part II up and running:
go.bsky.app/SqLa3aw
go.bsky.app/SqLa3aw
December 2, 2024 at 12:27 PM
The good news: you only click on the "join" button once and then you following all the pack persists in the absence of the initiating stimulus. 😀
In all seriousness, a stellar group of folks to follow.
In all seriousness, a stellar group of folks to follow.
Reposted by Jamie Hackett
Protein-based inheritance could be the new frontier in understanding transgenerational epigenetic inheritance. Great preview from @odedrechavi.bsky.social and @ethanewe.bsky.social on a very interesting new paper from @wbderry.bsky.social lab.
"Leaving sticky notes for the children" - Here's a new "Dispatch" @ethanewe.bsky.social and I wrote in @currentbiology.bsky.social
about the cool story by Matt and @wbderry.bsky.social on heritable amyloids! (published in @naturecellbiology.bsky.social)
www.sciencedirect.com/science/arti...
about the cool story by Matt and @wbderry.bsky.social on heritable amyloids! (published in @naturecellbiology.bsky.social)
www.sciencedirect.com/science/arti...
Inheritance: Leaving sticky notes for the children
It is currently unknown to what degree parents’ life history can affect the next generation and how such information might be transmitted. A new study…
www.sciencedirect.com
December 2, 2024 at 4:42 PM
Protein-based inheritance could be the new frontier in understanding transgenerational epigenetic inheritance. Great preview from @odedrechavi.bsky.social and @ethanewe.bsky.social on a very interesting new paper from @wbderry.bsky.social lab.
We are beginning to understand how the full repertoire of inheritable units can affect phenotypic variability
Beyond the main player - DNA sequence - transmitted chromatin, RNA, metabolites and proteins all play their role…
Beyond the main player - DNA sequence - transmitted chromatin, RNA, metabolites and proteins all play their role…
"Leaving sticky notes for the children" - Here's a new "Dispatch" @ethanewe.bsky.social and I wrote in @currentbiology.bsky.social
about the cool story by Matt and @wbderry.bsky.social on heritable amyloids! (published in @naturecellbiology.bsky.social)
www.sciencedirect.com/science/arti...
about the cool story by Matt and @wbderry.bsky.social on heritable amyloids! (published in @naturecellbiology.bsky.social)
www.sciencedirect.com/science/arti...
Inheritance: Leaving sticky notes for the children
It is currently unknown to what degree parents’ life history can affect the next generation and how such information might be transmitted. A new study…
www.sciencedirect.com
December 2, 2024 at 7:58 PM
We are beginning to understand how the full repertoire of inheritable units can affect phenotypic variability
Beyond the main player - DNA sequence - transmitted chromatin, RNA, metabolites and proteins all play their role…
Beyond the main player - DNA sequence - transmitted chromatin, RNA, metabolites and proteins all play their role…
Reposted by Jamie Hackett
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Redirecting
doi.org
December 2, 2024 at 4:44 PM
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Reposted by Jamie Hackett
Please check out this upcoming Gordon Conference (GRC) on Developmental Biology - March 2025
Very diverse and relevant topics! and Gordon Research Seminar (GRS) accompanying it as well ! (speaker list in commentts)
www.grc.org/developmenta...
Very diverse and relevant topics! and Gordon Research Seminar (GRS) accompanying it as well ! (speaker list in commentts)
www.grc.org/developmenta...
2025 Developmental Biology Conference GRC
The 2025 Gordon Research Conference on Developmental Biology will be held in Pomona, California. Apply today to reserve your spot.
www.grc.org
December 2, 2024 at 4:24 AM
Please check out this upcoming Gordon Conference (GRC) on Developmental Biology - March 2025
Very diverse and relevant topics! and Gordon Research Seminar (GRS) accompanying it as well ! (speaker list in commentts)
www.grc.org/developmenta...
Very diverse and relevant topics! and Gordon Research Seminar (GRS) accompanying it as well ! (speaker list in commentts)
www.grc.org/developmenta...
Reposted by Jamie Hackett
Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
December 1, 2024 at 12:30 PM
Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
Postdoc positions in epigenetics!
We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms
Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️
See👇or contact me for other options. Pls RS
We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms
Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️
See👇or contact me for other options. Pls RS
December 2, 2024 at 11:32 AM
Postdoc positions in epigenetics!
We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms
Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️
See👇or contact me for other options. Pls RS
We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms
Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️
See👇or contact me for other options. Pls RS