Maxim Greenberg
@maxvcg.bsky.social
Group leader at Institut Jacques Monod. When I say "epigenetics" what I really mean is "DNA methylation".
www.maximgreenberglab.com
www.maximgreenberglab.com
I wouldn't go that far, but good friends were in Paris and we celebrated T-day on Sunday. They made pecan pie, which I haven't eaten since moving to France. I had three pieces, and I can't stop thinking about it.
November 26, 2025 at 6:59 AM
I wouldn't go that far, but good friends were in Paris and we celebrated T-day on Sunday. They made pecan pie, which I haven't eaten since moving to France. I had three pieces, and I can't stop thinking about it.
Reposted by Maxim Greenberg
Scientists: have you been the target of an online harassment campaign, doxxing, or weaponized FOIA requests? I'd like to talk to you about steps you had to take to protect your digital security for an upcoming Nature story. (You can be anonymous if necessary.)
RTs appreciated.
RTs appreciated.
November 26, 2025 at 12:18 AM
Scientists: have you been the target of an online harassment campaign, doxxing, or weaponized FOIA requests? I'd like to talk to you about steps you had to take to protect your digital security for an upcoming Nature story. (You can be anonymous if necessary.)
RTs appreciated.
RTs appreciated.
Reposted by Maxim Greenberg
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!
link.springer.com/collections/...
link.springer.com/collections/...
Enhancer-promoter interactions
Genome Biology is calling for submissions to our Collection on enhancer-promoter interactions.
Enhancer–promoter interactions are central to the regulation ...
link.springer.com
November 25, 2025 at 10:55 AM
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!
link.springer.com/collections/...
link.springer.com/collections/...
Reposted by Maxim Greenberg
Congratulations to Celia Municio-Diaz in the lab for this new publication, showing that Cell Wall mechanosensors taken from distant yeast species can still function and detect forces in the foreign cell wall of fission yeast cells!
@ijmonod.bsky.social @cnrsbiologie.bsky.social
@ijmonod.bsky.social @cnrsbiologie.bsky.social
November 25, 2025 at 3:00 PM
Congratulations to Celia Municio-Diaz in the lab for this new publication, showing that Cell Wall mechanosensors taken from distant yeast species can still function and detect forces in the foreign cell wall of fission yeast cells!
@ijmonod.bsky.social @cnrsbiologie.bsky.social
@ijmonod.bsky.social @cnrsbiologie.bsky.social
In virtually every bit of scientific writing I've done, I have a sentence along the lines of "during early mammalian development" when discussing epigenetic reprogramming. Just realized I have to amend this to "eutherian" now... Thanks a lot @lab-turner.bsky.social @angeloniallegra.bsky.social ...
November 25, 2025 at 3:17 PM
In virtually every bit of scientific writing I've done, I have a sentence along the lines of "during early mammalian development" when discussing epigenetic reprogramming. Just realized I have to amend this to "eutherian" now... Thanks a lot @lab-turner.bsky.social @angeloniallegra.bsky.social ...
Reposted by Maxim Greenberg
i’m not crying you’re crying
xkcd: Fifteen Years
xkcd: Fifteen Years
Fifteen Years
xkcd.com
November 25, 2025 at 1:58 AM
i’m not crying you’re crying
xkcd: Fifteen Years
xkcd: Fifteen Years
Reposted by Maxim Greenberg
We seem to be in the golden age of centromere biology
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:41 PM
We seem to be in the golden age of centromere biology
Reposted by Maxim Greenberg
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Maxim Greenberg
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
November 23, 2025 at 1:51 AM
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
I asked AI if there’s a German word for being in awe of something that will destroy us
November 22, 2025 at 4:26 PM
I asked AI if there’s a German word for being in awe of something that will destroy us
Reposted by Maxim Greenberg
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Maxim Greenberg
« Far right to the rescue on Europe’s gene-editing revolution »
😳 whaaa???
Why can’t European socialist parties be more supportive of science?
www.politico.eu/article/far-...
😳 whaaa???
Why can’t European socialist parties be more supportive of science?
www.politico.eu/article/far-...
Far right to the rescue on Europe’s gene-editing revolution
Previously ignored, two far-right lawmakers could end an impasse on gene-edited plants.
www.politico.eu
November 20, 2025 at 12:50 PM
« Far right to the rescue on Europe’s gene-editing revolution »
😳 whaaa???
Why can’t European socialist parties be more supportive of science?
www.politico.eu/article/far-...
😳 whaaa???
Why can’t European socialist parties be more supportive of science?
www.politico.eu/article/far-...
Reposted by Maxim Greenberg
It’s hard to correctly estimate the level of fumigation that will be required to restore public trust and proper function in the CDC (and several other executive branches) after what has occurred over the past ten months (has it really only been ten months?!)
November 20, 2025 at 6:54 AM
It’s hard to correctly estimate the level of fumigation that will be required to restore public trust and proper function in the CDC (and several other executive branches) after what has occurred over the past ten months (has it really only been ten months?!)
Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics
November 19, 2025 at 9:48 AM
Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics
Reposted by Maxim Greenberg
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Et tu, @plosbiology.org ?
Research into brain–body communication is being reinvigorated as the field unites under the umbrella of #interoception. Our new #Editorial highlights four Perspectives that show the breadth of this emerging field #neurosky 🧪 🧵 ⬇️
plos.io/4r2SRzL
plos.io/4r2SRzL
November 17, 2025 at 2:52 PM
Et tu, @plosbiology.org ?
Reposted by Maxim Greenberg
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Cadherins modulate the self-organizing potential of pseudo-embryos
Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization.
Mayran et al. uncover that this competence depends on a cadherin switch regulated
by Snai1-driven E-cadhe...
www.cell.com
November 17, 2025 at 10:37 AM
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Reposted by Maxim Greenberg
It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation
November 14, 2025 at 7:09 PM
It’s been an immense pleasure to present and discuss our work on genome organization and genomic imprinting with the Canadian community at the CEEHRC Epigenetics meeting #CanEpi25 in beautiful Banff. Immensely grateful to the trainee committee for their kind invitation
Reposted by Maxim Greenberg
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
November 14, 2025 at 2:27 PM
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
It is shocking how bad the @washingtonpost.com editorial page has become in the last year. The thrust of this article (so you don't have to read it) is "yeah, Trump is corrupt, but so were presidents in the 1880s" and I quote "In short, we need to get a grip." www.washingtonpost.com/opinions/202...
Opinion | Shocked by Trump’s profiteering? Here’s some perspective.
There are periods in American history when graft was the rule, not the exception.
www.washingtonpost.com
November 14, 2025 at 7:43 AM
It is shocking how bad the @washingtonpost.com editorial page has become in the last year. The thrust of this article (so you don't have to read it) is "yeah, Trump is corrupt, but so were presidents in the 1880s" and I quote "In short, we need to get a grip." www.washingtonpost.com/opinions/202...
Vertebrate rna directed dna methylation!
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
November 13, 2025 at 11:56 AM
Vertebrate rna directed dna methylation!
Reposted by Maxim Greenberg
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
www.biorxiv.org
November 12, 2025 at 2:57 AM
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
Reposted by Maxim Greenberg
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
November 13, 2025 at 9:26 AM
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Reposted by Maxim Greenberg
New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡
Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.
Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.
November 11, 2025 at 7:00 PM
New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡
Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.
Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.