The EMBO Journal
@embojournal.org
Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org
Fast-fair-transparent / Open Access / Open Science
Fast-fair-transparent / Open Access / Open Science
Pinned
Issue 22:
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Reposted by The EMBO Journal
✨ Happy to share that our work is now published in @embojournal.org ! ✨
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of maternal-to-zygotic transition in teleosts | The EMBO Journal
imageimagePost-translational regulation during the maternal-to-zygotic transition (MZT) remains
largely unexplored. Using an optimized CRISPR-RfxCas13d screening strategy, this study
identifies Bckdk ...
www.embopress.org
November 20, 2025 at 3:14 PM
✨ Happy to share that our work is now published in @embojournal.org ! ✨
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal
The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...
link.springer.com
November 20, 2025 at 3:17 PM
Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
Reposted by The EMBO Journal
Early registration and abstract deadlines are 15 December for @fusionconf.bsky.social "Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference". @embojournal.org Senior Editor Daniel Klimmeck is looking forward to this meeting in Malta!
For info & registration: bit.ly/43AaInH
For info & registration: bit.ly/43AaInH
Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference | Fusion Conferences
Biennial international 2026 Mitochondria and Cell Fate Transitions Conference in Malta. Register now to apply for short talk and poster opportunities.
bit.ly
November 21, 2025 at 11:35 AM
Early registration and abstract deadlines are 15 December for @fusionconf.bsky.social "Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference". @embojournal.org Senior Editor Daniel Klimmeck is looking forward to this meeting in Malta!
For info & registration: bit.ly/43AaInH
For info & registration: bit.ly/43AaInH
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 21, 2025 at 12:59 PM
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
November 21, 2025 at 7:32 AM
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy?
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
November 20, 2025 at 7:01 PM
Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy?
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Now published in peer-reviewed version:
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
November 20, 2025 at 6:57 PM
Now published in peer-reviewed version:
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Christoph Ringli and collaborators identify a new regulator of the Arabidopsis extensin-mediated cell wall integrity sensing: phosphatase PP2C12 inhibiting receptor kinase FERONIA
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 20, 2025 at 1:57 PM
Christoph Ringli and collaborators identify a new regulator of the Arabidopsis extensin-mediated cell wall integrity sensing: phosphatase PP2C12 inhibiting receptor kinase FERONIA
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cytosolic receptors and signaling in antifungal immunity
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
November 20, 2025 at 1:56 PM
Cytosolic receptors and signaling in antifungal immunity
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Chromatin recruitment and cohesion establishment of human Sororin requires not just SMC3 acetylation, but also S-phase PARylation of the Sororin-binding microprotein RSMC
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
November 20, 2025 at 7:41 AM
Chromatin recruitment and cohesion establishment of human Sororin requires not just SMC3 acetylation, but also S-phase PARylation of the Sororin-binding microprotein RSMC
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
November 19, 2025 at 3:20 PM
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
We are pleased to once again partner with @fusionconf.bsky.social for the 2026 conference season! Looking forward to "Fibroblast Growth Factor Signalling in Development, Health & Disease Conference" in March when @embomolmed.org editor Lise Roth will attend.
Registration until 5 Feb: bit.ly/49nSmKj
Registration until 5 Feb: bit.ly/49nSmKj
Fibroblast Growth Factor Signalling in Development, Health & Disease Conference | Fusion Conferences
Receptor Tyrosine Kinases (RTKs) are cell-surface receptors that, upon ligand binding, regulate cell-to-cell communication during embryonic development and in adult life. Among RTKs, the twenty-two Fi...
bit.ly
November 19, 2025 at 10:43 AM
We are pleased to once again partner with @fusionconf.bsky.social for the 2026 conference season! Looking forward to "Fibroblast Growth Factor Signalling in Development, Health & Disease Conference" in March when @embomolmed.org editor Lise Roth will attend.
Registration until 5 Feb: bit.ly/49nSmKj
Registration until 5 Feb: bit.ly/49nSmKj
Reposted by The EMBO Journal
Our new paper is officially published today in
@embojournal.org !
We show that protein phosphorylation plays a key regulatory role during early embryogenesis.
An amazing collaboration with
@crisprscan.bsky.social
🔗 www.embopress.org/doi/full/10....
.
@embojournal.org !
We show that protein phosphorylation plays a key regulatory role during early embryogenesis.
An amazing collaboration with
@crisprscan.bsky.social
🔗 www.embopress.org/doi/full/10....
.
CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of maternal-to-zygotic transition in teleosts | The EMBO Journal
imageimagePost-translational regulation during the maternal-to-zygotic transition (MZT) remains
largely unexplored. Using an optimized CRISPR-RfxCas13d screening strategy, this study
identifies Bckdk ...
www.embopress.org
November 18, 2025 at 3:10 PM
Our new paper is officially published today in
@embojournal.org !
We show that protein phosphorylation plays a key regulatory role during early embryogenesis.
An amazing collaboration with
@crisprscan.bsky.social
🔗 www.embopress.org/doi/full/10....
.
@embojournal.org !
We show that protein phosphorylation plays a key regulatory role during early embryogenesis.
An amazing collaboration with
@crisprscan.bsky.social
🔗 www.embopress.org/doi/full/10....
.
Reposted by The EMBO Journal
NEW #research: A new @embojournal.org paper from
@bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky
🔗 Read more: bit.ly/4i6Hdjl
@bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky
🔗 Read more: bit.ly/4i6Hdjl
Decoding early development
Stowers Associate Investigator Ariel Bazzini, Ph.D., discusses a collaboration that uncovered a new mechanism guiding the earliest steps of life.
bit.ly
November 18, 2025 at 6:45 PM
NEW #research: A new @embojournal.org paper from
@bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky
🔗 Read more: bit.ly/4i6Hdjl
@bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky
🔗 Read more: bit.ly/4i6Hdjl
Starting today: @events.embl.org #EESNucleus
Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!
Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!
As my conference year draws to a close: still one last highlight coming up #EESNucleus on home turf @events.embl.org!
November 18, 2025 at 11:41 AM
Starting today: @events.embl.org #EESNucleus
Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!
Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
November 18, 2025 at 11:22 AM
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
November 17, 2025 at 2:28 PM
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
How can gut microbes modulate host lifespan?
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
November 17, 2025 at 1:22 PM
How can gut microbes modulate host lifespan?
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
Deadlines are approaching for @keystonesymposia.bsky.social #Ubiquitin Family Biology & Disease, this February in Banff! See scholarship, abstract and discount reg dates: keysym.us/KSUbiquitin26 #KSUbiquitin26
Your chance to meet our editor @hvodermaier.bsky.social & discuss your work with him!
Your chance to meet our editor @hvodermaier.bsky.social & discuss your work with him!
The Ubiquitin Family in Biology and Disease | Keystone Symposia
Join us at the Keystone Symposia on The Ubiquitin Family in Biology and Disease, February 2026, in Banff, with field leaders!
keysym.us
November 17, 2025 at 12:18 PM
Deadlines are approaching for @keystonesymposia.bsky.social #Ubiquitin Family Biology & Disease, this February in Banff! See scholarship, abstract and discount reg dates: keysym.us/KSUbiquitin26 #KSUbiquitin26
Your chance to meet our editor @hvodermaier.bsky.social & discuss your work with him!
Your chance to meet our editor @hvodermaier.bsky.social & discuss your work with him!
Issue 22:
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
November 17, 2025 at 9:48 AM
Issue 22:
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Reposted by The EMBO Journal
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:35 AM
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Reposted by The EMBO Journal
Re-upping this with a Bluetorial in a shameless act of self-promotion. 1/n
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 15, 2025 at 8:15 AM
Re-upping this with a Bluetorial in a shameless act of self-promotion. 1/n
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:02 AM
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
November 13, 2025 at 11:54 AM
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
#CIBseminars
Responsible Science Publishing & Open Science
Hartmut Vodermaier, @embojournal.org
📅November 19
⏰12pm
Responsible Science Publishing & Open Science
Hartmut Vodermaier, @embojournal.org
📅November 19
⏰12pm
November 12, 2025 at 10:01 AM
#CIBseminars
Responsible Science Publishing & Open Science
Hartmut Vodermaier, @embojournal.org
📅November 19
⏰12pm
Responsible Science Publishing & Open Science
Hartmut Vodermaier, @embojournal.org
📅November 19
⏰12pm