The EMBO Journal
@embojournal.org
Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org
Fast-fair-transparent / Open Access / Open Science
Fast-fair-transparent / Open Access / Open Science
ROS generated in Arabidopsis roots recruit the beneficial rhizobacterium Pseudomonas anguilliseptica to promote plant growth and enhance pathogen resistance
Yan Liang, Bin Ma and coworkers
link.springer.com/article/10.1...
Yan Liang, Bin Ma and coworkers
link.springer.com/article/10.1...
January 13, 2026 at 7:55 AM
ROS generated in Arabidopsis roots recruit the beneficial rhizobacterium Pseudomonas anguilliseptica to promote plant growth and enhance pathogen resistance
Yan Liang, Bin Ma and coworkers
link.springer.com/article/10.1...
Yan Liang, Bin Ma and coworkers
link.springer.com/article/10.1...
Ordering of cell cycle events by regulated proteolysis is not just for eukaryotes:
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
January 12, 2026 at 2:19 PM
Ordering of cell cycle events by regulated proteolysis is not just for eukaryotes:
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
Wenli Jiang et al show that turnover of the neuronal scaffold protein ARMS is regulated by autophagy, via a non-canonical ARMS interaction specifically with the Atg8-family GABARAP
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 12, 2026 at 10:38 AM
Wenli Jiang et al show that turnover of the neuronal scaffold protein ARMS is regulated by autophagy, via a non-canonical ARMS interaction specifically with the Atg8-family GABARAP
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Diversity in mechanisms for epigenetic specification of vertebrate centromeres:
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
January 12, 2026 at 8:21 AM
Diversity in mechanisms for epigenetic specification of vertebrate centromeres:
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
January 9, 2026 at 9:06 AM
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
Revisiting giant virus-host dynamics in brown algae: Susana Coelho and colleagues @mpi-bio-fml.bsky.social review old stories and new perspectives
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 8, 2026 at 2:17 PM
Revisiting giant virus-host dynamics in brown algae: Susana Coelho and colleagues @mpi-bio-fml.bsky.social review old stories and new perspectives
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis
Celia Baroux and collaborators
link.springer.com/article/10.1...
Celia Baroux and collaborators
link.springer.com/article/10.1...
January 8, 2026 at 9:05 AM
Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis
Celia Baroux and collaborators
link.springer.com/article/10.1...
Celia Baroux and collaborators
link.springer.com/article/10.1...
Highlights in our first 2026 issue:
NLRP6 can sense you bacteria
Immunemap data sharing in intravital imaging
…
ADP-ribosylation as protein degradation mark
Damage sensing in PINK1-Parkin–mediated mitophagy
Perspective: innate immunity in tumor immunosurveillance
…
link.springer.com/journal/4431...
NLRP6 can sense you bacteria
Immunemap data sharing in intravital imaging
…
ADP-ribosylation as protein degradation mark
Damage sensing in PINK1-Parkin–mediated mitophagy
Perspective: innate immunity in tumor immunosurveillance
…
link.springer.com/journal/4431...
January 7, 2026 at 12:50 PM
Highlights in our first 2026 issue:
NLRP6 can sense you bacteria
Immunemap data sharing in intravital imaging
…
ADP-ribosylation as protein degradation mark
Damage sensing in PINK1-Parkin–mediated mitophagy
Perspective: innate immunity in tumor immunosurveillance
…
link.springer.com/journal/4431...
NLRP6 can sense you bacteria
Immunemap data sharing in intravital imaging
…
ADP-ribosylation as protein degradation mark
Damage sensing in PINK1-Parkin–mediated mitophagy
Perspective: innate immunity in tumor immunosurveillance
…
link.springer.com/journal/4431...
Final issue 24/25!
Comment: Measuring mitochondrial membrane potential
Highlights: Tau/TDP-43 double-trouble; immunoactive complement C3 fragment
Review: antifungal immunity signaling
…
Cover: liver capture of bacteria by CRP; Chen et al
link.springer.com/journal/4431...
Comment: Measuring mitochondrial membrane potential
Highlights: Tau/TDP-43 double-trouble; immunoactive complement C3 fragment
Review: antifungal immunity signaling
…
Cover: liver capture of bacteria by CRP; Chen et al
link.springer.com/journal/4431...
December 15, 2025 at 9:44 AM
Final issue 24/25!
Comment: Measuring mitochondrial membrane potential
Highlights: Tau/TDP-43 double-trouble; immunoactive complement C3 fragment
Review: antifungal immunity signaling
…
Cover: liver capture of bacteria by CRP; Chen et al
link.springer.com/journal/4431...
Comment: Measuring mitochondrial membrane potential
Highlights: Tau/TDP-43 double-trouble; immunoactive complement C3 fragment
Review: antifungal immunity signaling
…
Cover: liver capture of bacteria by CRP; Chen et al
link.springer.com/journal/4431...
The m6A reader IGF2BP3 cooperates with YBX2 to regulate histone-to-protamine replacement during mouse spermiogenesis
Mei Wang and coworkers
link.springer.com/article/10.1...
Mei Wang and coworkers
link.springer.com/article/10.1...
December 10, 2025 at 7:59 AM
The m6A reader IGF2BP3 cooperates with YBX2 to regulate histone-to-protamine replacement during mouse spermiogenesis
Mei Wang and coworkers
link.springer.com/article/10.1...
Mei Wang and coworkers
link.springer.com/article/10.1...
ERAD without N-glycosylation?
Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans
link.springer.com/article/10.1...
Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans
link.springer.com/article/10.1...
December 5, 2025 at 1:53 PM
ERAD without N-glycosylation?
Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans
link.springer.com/article/10.1...
Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans
link.springer.com/article/10.1...
In ISSUE 23
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
December 4, 2025 at 7:43 AM
In ISSUE 23
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
Lysosomal localization impacts their function in neurons:
Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination
www.embopress.org/doi/full/10....
Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination
www.embopress.org/doi/full/10....
December 2, 2025 at 2:17 PM
Lysosomal localization impacts their function in neurons:
Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination
www.embopress.org/doi/full/10....
Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination
www.embopress.org/doi/full/10....
Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles
By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating
www.embopress.org/doi/full/10....
By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating
www.embopress.org/doi/full/10....
December 2, 2025 at 10:47 AM
Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles
By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating
www.embopress.org/doi/full/10....
By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating
www.embopress.org/doi/full/10....
ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
December 2, 2025 at 9:20 AM
ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
December 1, 2025 at 3:21 PM
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
Mono-ADP-ribosylation as a degradation mark?
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
December 1, 2025 at 3:20 PM
Mono-ADP-ribosylation as a degradation mark?
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 28, 2025 at 4:10 PM
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
November 28, 2025 at 11:42 AM
MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
Weekend reading:
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
November 28, 2025 at 11:40 AM
Weekend reading:
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development:
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
November 28, 2025 at 7:28 AM
New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development:
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
November 27, 2025 at 10:56 AM
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
November 27, 2025 at 9:12 AM
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 21, 2025 at 12:59 PM
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
November 21, 2025 at 7:32 AM
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....