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Reposted by The EMBO Journal

Jörg Vogel @jorg-vogel-lab.bsky.social · 12h

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

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The EMBO Journal @embojournal.org · 23h

Can one target cancer-associated fibroblasts in the pancreatic tumor environment?
@peifferphd.bsky.social, Olivier Peulen et al @universitedeliege.bsky.social show inhibition of myoferlin can block TGFBR1 trafficking and impair ECM production and CAF contractility
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 1d

New method paper:
Bennie Lemmens et al @scilifelab.se describe 3D-SPARK, a super-resolution microscopy method that maps changes in DNA replication nanostructures in response to genetic perturbations or drugs, linking spatial cell biology with DNA synthesis dynamics
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 1d

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation
Svenja Jäger et al show that specific α-synuclein conformations promote the accumulation of highly seeding-competent fibril fragments/oligomeric species
www.embopress.org/doi/full/10....

The EMBO Journal @embojournal.org · 2d

See also the nice commentary by Middleton & Day
highlighting the new @embojournal.org article as well as three related reports!
www.embopress.org/doi/full/10....

RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal | The EMBO Journal

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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The EMBO Journal @embojournal.org · 2d

RNF114 and RNF166 exemplify a new E3 ligases family that recognizes #MARUbylation –hybrid ADP-ribose/ubiquitin modifications– and extends them with K11-linked polyubiquitin
@jnpruneda.bsky.social @michaelnadbio.bsky.social and colleagues
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 2d

#RefereedPreprint c/o @reviewcommons.org by Faccioli, Biasini et al:
Transient exposure of cryptic phosphorylation sites buried in protein cores during folding may represent novel regulatory mechanism linking co-translational modification to protein folding control
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 2d

How to scale cellular structures with overall cell size?
Kurt Schmoller, Marija Cvijovic and colleagues use genetics and live-cell imaging to define the origin of size control for the paradigmatic septin ring in budding yeast

www.embopress.org/doi/full/10....

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Reposted by The EMBO Journal

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 5d

Evidence for BLTP3A lipid transporter in the repair of lysosomes

📷 Michael G Hanna et al @yaleschoolofmed.bsky.social in @embojournal.org

➡️ bpod.org.uk/archive/2025...

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The EMBO Journal @embojournal.org · 8d

Featured in ISSUE 19:
Programmed cell revival for regeneration - including N&V & cover
Fusobacterium-CAF interactions in colorectal cancer
ncRNA roles in DRT defense-associated reverse transcriptase anti-phage system
PARP7 as degradation tag in proteotoxic stress
…
www.embopress.org/toc/14602075...

This cover highlights the article Programmed cell revival from imminent cell death enhances tissue repair and regeneration by Kollori Dhar, Kautilya Kumar Jena, Santosh Chauhan and colleagues. The cover image illustrates the concept of “programmed cell revival”, a genetically orchestrated process through which cells recover from near-death states. Symbolizing this transformation, a phoenix, long emblematic of renewal, rises from its dying form, echoing the cell's ability to resurrect from a death-like state triggered by lysosomotropic agents. Adjacent to this metaphor, microscopy images depict cells stained for mitochondria and calcium during both the death and revival phases, highlighting dramatic shifts in mitochondria dynamics and calcium flux. Together, the visual narrative captures the transition from cellular collapse to full regenerative awakening, emphasizing the study’s core message: cell death may not always be final, it can be reversed through an intrinsic revival code that also holds therapeutic promise for tissue regeneration.

Scientific illustration by Suhani Chauhan

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Reposted by The EMBO Journal

Rahul K @theresearch.bsky.social · 8d

For those who celebrate October as #NobelPrize announcements month @nobelprize.bsky.social 🎃🇸🇪🇳🇴

#NobelPrize2025 dates & time ⬇️
www.nobelprize.org/prizes/about...

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Reposted by The EMBO Journal

James Briscoe @jamesbriscoe.bsky.social · 8d

Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows

Read about the scientific visions of eight dev bio post-docs entering the academic job market

journals.biologists.com/dev/article/...

Pathway to Independence: a forecast for the future of developmental biology

ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

journals.biologists.com

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The EMBO Journal @embojournal.org · 9d

#PIWI proteins orchestrate assembly and disassembly of the piRNA biogenesis machinery, by promoting formation of electron-dense intermitochondrial cement (IMC) in murine spermatocytes
Deqiang Ding and coworkers
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 9d

NFATc1 drives Orai3 transcription and proteolysis by harnessing epigenome differences in the MARCH8 promoter
Rajender Motiani and colleagues
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 9d

Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides
Axel Mogk, Marta Carroni et al
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 9d

Embryonic signatures of intergenerational epigenetic inheritance across paternal environment & genetic background
@jamiehackett.bsky.social et al @embl.org see transcriptome changes in offspring after fertilisation by fathers exposed to gut dysbiosis or western diet
www.embopress.org/doi/full/10....

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Reposted by The EMBO Journal

Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 15d

Can specific gene mutations drive CDK7 inhibitor resistance in #ProstateCancer?

A brilliant team led by @simak.bsky.social @imperialcollegeldn.bsky.social share exciting new findings in @embojournal.org.

Grab a ☕ and read: doi.org/10.1038/s443...

Scientific Paper Published in The EMBO Journal, titled: Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells. Written by Lai et al.

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The EMBO Journal @embojournal.org · 17d

Are you attenting the @embo.org workshop on SUMOylation this week?
So is our editor @hvodermaier.bsky.social - make sure to meet him and discuss your work with him
#EMBOsumoylation

Hartmut Vodermaier @hvodermaier.bsky.social · 17d

On the train to Montpellier for the #EMBOsumoylation conference - looking forward to the 2nd recurrence of this #EMBOevents workshop and to the latest research in the SUMO field!
meetings.embo.org/event/25-sum...

SUMOylation: From discovery to translation

Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …

meetings.embo.org

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The EMBO Journal @embojournal.org · 17d

Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage
DDR sensor ATR protects against nuclear envelope rupture via formin phosphorylation inducing F-actin formation
Christos Kamaras et al @grosselab.bsky.social
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 17d

Aging increases both #telomeric DNA damage and #Alzheimer’s disease risk. Fabrizio d'Adda di Fagagna and coworkers now find that these processes are linked, with Aβ42 oligomers triggering ROS-mediated telomeric damage that in turn increases neurotoxicity
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 20d

Commensal gut bacteria employ de-chelatase HmuS to harvest iron from heme
Martin Lawrence, Jennifer DuBois and colleagues
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 20d

New Aurora A kinase role in maintaining proper nuclear shape organization at mitotic exit:
NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes
Sachin Kotak @spindlebehavior.bsky.social et al
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 21d

Decoding #immunometabolism with next-generation tools:
Ping-Chih Ho and colleagues review key challenges in exploring metabolic regulation of dendritic cells and T-cells, highlighting emerging methods and strategies for overcoming them
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 22d

Insights into how –and why– #polyubiquitin chain architecture on collided #ribosomes is maintained:
Toshifumi Inada, Yoshitaka Matsuo et al find that distinct roles of yeast deubiquitinases Ubp2 and Ubp3 are essential for maintaining persistent #RQC activity
www.embopress.org/doi/full/10....

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The EMBO Journal @embojournal.org · 24d

In ISSUE 18:
Actin sequestration & polymerization by synaptic vesicle condensates
Brucella survival inside macrophages thanks to chimeric lipid transport system
Neuronal tau uptake via LRP1 and LRRK2
Cover by @drawimpacts.bsky.social for Daisuke Kohno and colleagues
www.embopress.org/toc/14602075...

This cover highlights the article FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons by Daisuke Kohno and colleagues. The cover illustrates FTO as a hungry lord commanding his messenger KIF1A with m6A-marked scrolls to hasten the cargo of AgRP and NPY. This metaphor highlights the study’s finding that FTO promotes KIF1A-mediated trafficking of dense-core vesicles containing AgRP and NPY, thereby promoting hunger and driving obesity.

Image concept by the authors, scientific illustration by @drawimpacts.bsky.social

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