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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 1d

Could IGF-1R recruitment to chromatin regulatory regions be important in #ProstateCancer?

A brilliant team based @ndsurgicalsci.bsky.social share exciting new findings in Cancer Medicine.

Grab a ☕ and read: doi.org/10.1002/cam4...

Scientific Paper Published in Cancer Medicine, titled: Detection of Genome-Wide IGF-1R Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers. Written by Mills et al.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 7d

🎦 Watch Dr Bunmi Olajide in collaboration with @nasgp.bsky.social for practical guidance on prostate cancer detection, PSA testing & tackling health inequalities.

➡️ View here bit.ly/46a5WyZ

Woman sitting on sofa watching a webinar on her phone.

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Reposted by Prostate Cancer UK Professionals

Newcastle University Centre for Cancer @nucancer.bsky.social · 8d

💙 1 in 8 UK men will develop prostate cancer — but the risk is twice as high for men of African ancestry.

Yet, research in this group is still limited. That needs to change.

#MensHealth #ProstateCancer

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 8d

Could imaging, genetic and biomarker tests improve early #ProstateCancer detection?

A team led by Prof Prabhakar Rajan @qmbci.bsky.social explore different detection strategies in their latest publication in @bjuijournal.bsky.social.

Grab a ☕ and read: doi.org/10.1002/bco2...

Scientific Review Paper Published in BJUI Compass, titled: Emerging tools for the early detection of prostate cancer. Written by Haider et al.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 11d

🎦 On-demand webinar: Dr Bunmi Olajide with @NASGP on early detection of prostate cancer — risk assessment, PSA testing & health inequalities.

➡️Watch here: bit.ly/46a5WyZ

An individual is sitting at a kitchen counter watching a webinar on a tablet and holding a yellow mug. The kitchen has wooden shelves stocked with various kitchenware.

Reposted by Prostate Cancer UK Professionals

Society for Endocrinology @socendocrinology.bsky.social · 13d

Don't miss this: Claire Fletcher, part of the Hormone Dependent Cancer founding group, shares why this upcoming event is a must-attend for anyone working in the field. PLUS: abstract deadline extension to 1/10 bit.ly/4fqWdqL

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 15d

Can specific gene mutations drive CDK7 inhibitor resistance in #ProstateCancer?

A brilliant team led by @simak.bsky.social @imperialcollegeldn.bsky.social share exciting new findings in @embojournal.org.

Grab a ☕ and read: doi.org/10.1038/s443...

Scientific Paper Published in The EMBO Journal, titled: Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells. Written by Lai et al.

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Reposted by Prostate Cancer UK Professionals

Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 15d

🤝Our mentoring scheme brings #ProstateCancer researchers from different institutions together.

🚀To help navigate challenges & build successful careers - delivering maximum impact for men.

💪Together, we're building a stronger, more connected, research community.
prostatecanceruk.org/research/for...

It's an excellent scheme for establishing connections in your research areas, and it creates opportunities for potential future collaborations. James Thetford, Mentee. University of Surrey.

I am enthusiastic about providing help to ensure researchers succeed and thrive. Professor Jason Carroll, Mentor. University of Cambridge.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 15d

🤝Our mentoring scheme brings #ProstateCancer researchers from different institutions together.

🚀To help navigate challenges & build successful careers - delivering maximum impact for men.

💪Together, we're building a stronger, more connected, research community.
prostatecanceruk.org/research/for...

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 15d

Exciting🌟From Ideas to Innovation🌟Updates!

👩‍🔬Sessions chaired by Prostate Cancer UK Career Acceleration Fellows.
🎤30 brilliant researchers sharing Research Snapshots.
🚀All #ProstateCancer researchers welcome.
🗓️Check the webpage for agenda & registration.
👇
prostatecanceruk.org/research/for...

I'm looking forward to meeting like-minded researchers and hearing about all the exciting advances in prostate cancer research. Dr Sarah Gosling, Prostate Cancer UK Fellow.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 16d

🎦 Watch on-demand: Dr Bunmi Olajide & @NASGP.bsky.social present a focused session on early detection of prostate cancer in the UK.

Tailored for primary care, the webinar covers:
🔷Risk assessment
🔷PSA testing
🔷Tackling health inequalities

➡️View here bit.ly/46a5WyZ

Person sitting on a couch working on a Lenovo laptop.

Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 19d

The September edition of Research News is here! Find out more about:

💊 Exciting Research Findings.
🤝 Researcher Mentoring Scheme.
🏆 A Researcher Achievement.
💻 Upcoming New Seminar Series.
💰 Funding Opportunities.

📖 Read it here: prostatecanceruk.org/research/for...

Professor Gerhardt Attard holding a pipette.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 21d

👇A great opportunity to work on exciting new #ProstateCancer research in the brilliant @bevanlab.bsky.social

bevanlab.bsky.social @bevanlab.bsky.social · 23d

👋Postdoctoral opportunity! If you are a prostate cancer afficionado (or potential one) and like the thought of working as part of a multidisciplinary team at Imperial, in collaboration with great scientists in Europe and US, please check it out, and apply via this link
www.jobs.ac.uk/job/DOM665/p...

Post-Doctoral Research Associate at Imperial College London

Looking for a new job opportunity in academia? Check out this job opening for a Post-Doctoral Research Associate on jobs.ac.uk!

www.jobs.ac.uk

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 22d

🔊 Don’t miss Dr Bunmi Olajide on @nasgp.bsky.social! Key prostate cancer updates for primary care in one podcast.

➡️ Listen now bit.ly/3VGEBOC

Person using earphones and looking thoughtfully at a computer screen in an office setting.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 22d

Could faster MRI scans allow more men to receive timely #ProstateCancer diagnoses?

Research published in @jama.com led by @veerukasi.bsky.social, Dr Alex Ng & Dr Aqua Asif at @ucl.ac.uk compares the efficacy of shortened versus standard-length scans.

Grab a ☕ & read: doi.org/10.1001/jama...

Scientific Paper Published in The Journal of the American Medical Association, titled: Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis: The PRIME Diagnostic Clinical Trial. Written by Ng et al.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 24d

🎧 Tune in to our new @nasgp.bsky.social podcast with Dr Bunmi!

Everything primary care needs to know on prostate cancer:
🔵 Epidemiology & risk factors
🔵 Health inequalities
🔵 NICE NG12 & PSA thresholds
🔵 mpMRI, DRE & the TRANSFORM trial

➡️ Listen on Spotify: bit.ly/4maj9ME

Early detection of prostate cancer in primary care

NASGP · Episode

bit.ly

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 26d

How confident are you in spotting & managing prostate cancer early?

In our latest podcast with @nasgp.bsky.social & Dr Bunmi, we cover:

🔷UK epidemiology & risk factors
🔷PSA thresholds, mpMRI & DRE
🔷Health inequalities & TRANSFORM

➡️ A must-hear for primary care: bit.ly/3VGEBOC

Person wearing earphones sits at a desk with books and a computer, appearing thoughtful.

Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 28d

Can microbial communities be linked to specific cancer types, including #ProstateCancer?

A team @UeaMedical.bsky.social including Career Acceleration Fellow @AbrahamGihawi.bsky.social use @GenomicsEngland.bsky.social data to examine these links.

Grab a ☕ and read: buff.ly/HRJA9oc

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 29d

[8/8] 📖 If you would like to learn more about why this research is so important for men with advanced #ProstateCancer, you can read more about the project in our latest News & Views article: prostatecanceruk.org/about-us/new...

Prostate Cancer UK man icon holding a pipette

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 29d

[7/8] Impact:

🖊️ Tools that analyse tumour transcriptomes can pinpoint which men with advanced #ProstateCancer are likely to benefit from chemotherapy.

💙 This helps men avoid unnecessary chemotherapy and its associated side effects, ultimately enhancing their quality of life.

A man with a happy expression, smiling and enjoying time with his friends.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 29d

[6/8] Next, the team identified:

✅ In men with advanced #ProstateCancer, PTEN inactivity is associated with shorter survival on hormone therapy but predicts a greater survival benefit from docetaxel compared to PTEN-active tumours.

Graph showing that men with tumours exhibiting PTEN loss are more likely to benefit from combined chemotherapy and hormone therapy treatment.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 29d

[5/8] First, the study revealed:

✅ The Decipher signature is prognostic and helps identify men with advanced #ProstateCancer who are most likely to benefit from docetaxel.

Graph showing that men with high Decipher scores benefit from combining docetaxel chemotherapy with standard hormone therapy, whereas those with low scores do not.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 29d

[4/8] 🧬 The team analysed transcriptomes from 1,523 biopsies of men previously enrolled in the STAMPEDE trial using the Decipher signature and a signature that assesses PTEN activity, to evaluate their effectiveness in guiding treatment stratification.

Schematic illustrating the workflow for processing biopsies from men, including central H&E review, tumour macrodissection, microarray hybridization, and quality control analysis.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 29d

[3/8] 💊 Yet, while docetaxel extends survival for some men, responses vary, and clinicians have limited tools to predict who will benefit.

💡The team explored whether transcriptome analysis tools could identify men likely to benefit from docetaxel, with a particular focus on the Decipher signature.

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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 29d

[2/8] The STAMPEDE trial, led by @prof-nick-james.bsky.social and funded by @cancerresearchuk.org, showed that combining docetaxel chemotherapy with standard hormone therapy significantly improves outcomes for men with advanced #ProstateCancer.

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