Christian Frezza
@frezzalab.bsky.social
I post papers on #cancermetabolism and #mitochondrialbiology. I also post about academia, metal music, and mindfulness.
https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-christian-frezza/
https://orcid.org/0000-0002-3293-7397
https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-christian-frezza/
https://orcid.org/0000-0002-3293-7397
Pinned
Christian Frezza
@frezzalab.bsky.social
· Nov 13
The mindful scientist
A more mindful approach to science can help scientists to handle negative and positive emotions better.
network.febs.org
This is an old post, but I would like to propose it again as I am new here.
This is a topic I am very passionate about. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic.
The mindful scientist network.febs.org/posts/the-mi... #FEBSnet
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports www.embopress.org/doi/full/10....
Congratulations to Suzan Ber and Alessandro Esposito and the rest of the team for this very cool piece of work!
Congratulations to Suzan Ber and Alessandro Esposito and the rest of the team for this very cool piece of work!
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports
imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer
cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling,
uncovering a vuln...
www.embopress.org
November 23, 2025 at 7:04 AM
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports www.embopress.org/doi/full/10....
Congratulations to Suzan Ber and Alessandro Esposito and the rest of the team for this very cool piece of work!
Congratulations to Suzan Ber and Alessandro Esposito and the rest of the team for this very cool piece of work!
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
November 23, 2025 at 6:51 AM
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
great work Dylan, Eloise, and the rest of the team!
November 20, 2025 at 6:13 PM
great work Dylan, Eloise, and the rest of the team!
Reposted by Christian Frezza
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 4:09 PM
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia: Cell www.cell.com/cell/fulltex...
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
Reduced levels of the essential metabolite heme are a common feature of acute myeloid
leukemia, and consequently, leukemic cells are highly sensitive to inhibition of de
novo heme synthesis. Blockade ...
www.cell.com
November 20, 2025 at 3:29 PM
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia: Cell www.cell.com/cell/fulltex...
Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....
Measuring mitochondrial membrane potential | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
November 19, 2025 at 5:43 PM
Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....
Reposted by Christian Frezza
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
www.nature.com/articles/s42...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency - Nature Metabolism
In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycer...
www.nature.com
November 16, 2025 at 7:21 AM
www.nature.com/articles/s42...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
November 16, 2025 at 7:04 AM
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
A whole-brain single-cell atlas of circadian neural activity in mice | Science www.science.org/doi/10.1126/...
A whole-brain single-cell atlas of circadian neural activity in mice
The mammalian brain comprises numerous anatomical regions with distinct functions despite their extensive connectivity. However, how spontaneous neural activity is coordinated across regions over the ...
www.science.org
November 13, 2025 at 7:07 PM
A whole-brain single-cell atlas of circadian neural activity in mice | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
www.science.org
November 13, 2025 at 7:05 PM
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation: Cell Host & Microbe www.cell.com/cell-host-mi...
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation
de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms
macrophage energy metabolism in a concentration-dependent fashion, promoting either
anti- or pro-inflammatory immun...
www.cell.com
November 13, 2025 at 3:47 PM
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation: Cell Host & Microbe www.cell.com/cell-host-mi...
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature
Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...
www.nature.com
November 12, 2025 at 6:02 PM
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Reposted by Christian Frezza
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
November 9, 2025 at 9:24 AM
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
November 9, 2025 at 6:28 AM
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
Great work from @rjdlab.bsky.social !!
Great work from @rjdlab.bsky.social !!
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 7, 2025 at 7:35 AM
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
Great work from @rjdlab.bsky.social !!
Great work from @rjdlab.bsky.social !!
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of
mitochondrial ribosomes in response to metabolic state. This structural “gear-switching”
mechanism fine-tunes mitoch...
www.cell.com
November 6, 2025 at 6:37 PM
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of
mitochondrial ribosomes in response to metabolic state. This structural “gear-switching”
mechanism fine-tunes mitoch...
www.cell.com
November 6, 2025 at 4:57 PM
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
As a mindfulness advocate, it is important to stress that meditation can have downsides if approached carelessly. It’s crucial to prepare and practice moderation. If meditation causes distress, that’s okay! Adjust your approach to your mindfulness journey.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
November 6, 2025 at 10:42 AM
As a mindfulness advocate, it is important to stress that meditation can have downsides if approached carelessly. It’s crucial to prepare and practice moderation. If meditation causes distress, that’s okay! Adjust your approach to your mindfulness journey.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
www.nature.com
November 5, 2025 at 5:04 PM
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Lymph node environment drives FSP1 targetability in metastasizing melanoma