RyanLab_TCD
@ryanlab.bsky.social
Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪
Pinned
RyanLab_TCD
@ryanlab.bsky.social
· Nov 20
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 13, 2026 at 4:25 PM
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
January 12, 2026 at 9:28 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
Reposted by RyanLab_TCD
Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
January 11, 2026 at 6:37 AM
Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
Reposted by RyanLab_TCD
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates
Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger
academic.oup.com
January 11, 2026 at 3:58 PM
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
Reposted by RyanLab_TCD
How do cells assess mtDNA quality?
Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection.
We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae.
Great collaboration with the Schmoller Lab.
journals.plos.org/plosgenetics...
🧬⚡
Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection.
We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae.
Great collaboration with the Schmoller Lab.
journals.plos.org/plosgenetics...
🧬⚡
Local mitochondrial physiology defined by mtDNA quality guides purifying selection
Author summary Mitochondria are essential organelles in our cells that convert nutrients into usable cellular energy. They contain their own DNA, and mutations in this DNA can compromise mitochondrial...
journals.plos.org
January 10, 2026 at 4:00 PM
How do cells assess mtDNA quality?
Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection.
We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae.
Great collaboration with the Schmoller Lab.
journals.plos.org/plosgenetics...
🧬⚡
Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection.
We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae.
Great collaboration with the Schmoller Lab.
journals.plos.org/plosgenetics...
🧬⚡
'Infection-triggered disease onset carried a significantly higher risk of liver involvement than spontaneous or other disease triggers.'
Liver Involvement in POLG Disease—a Multicentre Cohort Study of 202 Patients onlinelibrary.wiley.com/doi/10.1002/...
Liver Involvement in POLG Disease—a Multicentre Cohort Study of 202 Patients onlinelibrary.wiley.com/doi/10.1002/...
Liver Involvement in POLG Disease—a Multicentre Cohort Study of 202 Patients
Liver involvement in POLG disease is common and associated with high morbidity and mortality. Detailed, large-scale, systematic studies of liver involvement are lacking. This study aims to describe t...
onlinelibrary.wiley.com
January 7, 2026 at 11:46 AM
'Infection-triggered disease onset carried a significantly higher risk of liver involvement than spontaneous or other disease triggers.'
Liver Involvement in POLG Disease—a Multicentre Cohort Study of 202 Patients onlinelibrary.wiley.com/doi/10.1002/...
Liver Involvement in POLG Disease—a Multicentre Cohort Study of 202 Patients onlinelibrary.wiley.com/doi/10.1002/...
Reposted by RyanLab_TCD
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
January 6, 2026 at 12:30 PM
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Reposted by RyanLab_TCD
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons
Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...
doi.org
January 5, 2026 at 5:50 PM
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Reposted by RyanLab_TCD
Congrats to Jan whose new paper on persulfide measurement is is out now in Nature Comms
January 6, 2026 at 9:55 AM
Congrats to Jan whose new paper on persulfide measurement is is out now in Nature Comms
Reposted by RyanLab_TCD
Review @natrevdrugdiscov.nature.com
Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications
www.nature.com/articles/s41...
Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications
www.nature.com/articles/s41...
January 5, 2026 at 9:27 PM
Review @natrevdrugdiscov.nature.com
Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications
www.nature.com/articles/s41...
Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications
www.nature.com/articles/s41...
Widely Targeted Metabolomics and Machine Learning Identify Succinate as a Key Metabolite in Sepsis-Associated Encephalopathy: iScience www.cell.com/iscience/ful...
Widely Targeted Metabolomics and Machine Learning Identify Succinate as a Key Metabolite in Sepsis-Associated Encephalopathy
Sepsis-associated encephalopathy (SAE) is a common and serious complication of sepsis
that leads to acute brain dysfunction and long-term cognitive impairment. We used
widely targeted LC–MS/MS plasma ...
www.cell.com
January 4, 2026 at 1:54 PM
Widely Targeted Metabolomics and Machine Learning Identify Succinate as a Key Metabolite in Sepsis-Associated Encephalopathy: iScience www.cell.com/iscience/ful...
The selection has arrived - biomed.news/bims-imicid/... #immunometabolism
January 4, 2026 at 12:19 PM
The selection has arrived - biomed.news/bims-imicid/... #immunometabolism
Reposted by RyanLab_TCD
Lupus nephritis is a type of immune-mediated glomerulonephritis and a serious complication of systemic lupus erythematosus that can affect up to 60% of patients with this condition.
#NephSky
#NephSky
Lupus nephritis - Nature Reviews Disease Primers
Lupus nephritis is an autoimmune-mediated glomerulonephritis and a serious complication of systemic lupus erythematosus. In this Primer, Parodis and colleagues describe the epidemiology and pathophysiology of this disease, discuss current diagnosis and management, and highlight the effects on patient quality of life as well as future areas of research.
www.nature.com
January 4, 2026 at 11:45 AM
Lupus nephritis is a type of immune-mediated glomerulonephritis and a serious complication of systemic lupus erythematosus that can affect up to 60% of patients with this condition.
#NephSky
#NephSky
📢Last weeks #immunometabolism report @biomednews.bsky.social hasn't come online so I'm highlighting this preprint from my selection:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit
January 4, 2026 at 9:41 AM
📢Last weeks #immunometabolism report @biomednews.bsky.social hasn't come online so I'm highlighting this preprint from my selection:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit
Reposted by RyanLab_TCD
Pathogenic B cell responses to allergens are reprogrammed by blockade of IL-4 and IL-13 signaling @sciimmunology.bsky.social @kellybruton.bsky.social @mcmasteruniversity.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 3, 2026 at 2:26 AM
Pathogenic B cell responses to allergens are reprogrammed by blockade of IL-4 and IL-13 signaling @sciimmunology.bsky.social @kellybruton.bsky.social @mcmasteruniversity.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by RyanLab_TCD
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration www.nature.com/articles/s41...
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience
Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.
www.nature.com
January 2, 2026 at 3:24 PM
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration www.nature.com/articles/s41...
Reposted by RyanLab_TCD
☕Zhang et al. characterize the #mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner #mitochondria membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation.
👉https://rdcu.be/eXjMB
bit.ly/3YZ0PNj
👉https://rdcu.be/eXjMB
bit.ly/3YZ0PNj
MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains - Nature Cell Biology
Zhang et al. characterize the mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner mitochondrial membrane stress by inducing membrane subdomains promoting homeostat...
bit.ly
January 2, 2026 at 3:52 PM
☕Zhang et al. characterize the #mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner #mitochondria membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation.
👉https://rdcu.be/eXjMB
bit.ly/3YZ0PNj
👉https://rdcu.be/eXjMB
bit.ly/3YZ0PNj
Reposted by RyanLab_TCD
Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase: Cell Reports www.cell.com/cell-reports...
Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase
Colina-Tenorio et al. show that MICOS interacts with the Cox1 and Cox3 assembly modules
and facilitates respiratory complex IV biogenesis. By recruiting assembly factors
and the mitochondrial multifun...
www.cell.com
January 1, 2026 at 1:39 PM
Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase: Cell Reports www.cell.com/cell-reports...
Reposted by RyanLab_TCD
@biorxivpreprint.bsky.social Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade @mdanderson.bsky.social @jimallisonphd.bsky.social @pamsharmamdphd.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 31, 2025 at 3:57 PM
@biorxivpreprint.bsky.social Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade @mdanderson.bsky.social @jimallisonphd.bsky.social @pamsharmamdphd.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by RyanLab_TCD
Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
December 29, 2025 at 5:22 PM
Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Activated T cells degrade extracellular proteins to enhance effector functions
biomed.news/bims-imicid/...
Interesting paper:
Activated T cells degrade extracellular proteins to enhance effector functions
December 28, 2025 at 3:16 PM
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Activated T cells degrade extracellular proteins to enhance effector functions
biomed.news/bims-imicid/...
Interesting paper:
Activated T cells degrade extracellular proteins to enhance effector functions
Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35
pubmed.ncbi.nlm.nih.gov/41446167/
pubmed.ncbi.nlm.nih.gov/41446167/
December 28, 2025 at 12:21 AM
Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35
pubmed.ncbi.nlm.nih.gov/41446167/
pubmed.ncbi.nlm.nih.gov/41446167/
Reposted by RyanLab_TCD
Deletion of Ptpn2 in B cells promotes autoimmunity via TLR and JAK/STAT signaling @insight.jci.org @cuanschutz.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
December 24, 2025 at 5:31 AM
Deletion of Ptpn2 in B cells promotes autoimmunity via TLR and JAK/STAT signaling @insight.jci.org @cuanschutz.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Reposted by RyanLab_TCD
Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19 @insight.jci.org @hopkinsmedicine.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
December 24, 2025 at 5:30 AM
Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19 @insight.jci.org @hopkinsmedicine.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...