RyanLab_TCD
@ryanlab.bsky.social
Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
January 12, 2026 at 9:28 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
📢Last weeks #immunometabolism report @biomednews.bsky.social hasn't come online so I'm highlighting this preprint from my selection:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit
January 4, 2026 at 9:41 AM
📢Last weeks #immunometabolism report @biomednews.bsky.social hasn't come online so I'm highlighting this preprint from my selection:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Activated T cells degrade extracellular proteins to enhance effector functions
biomed.news/bims-imicid/...
Interesting paper:
Activated T cells degrade extracellular proteins to enhance effector functions
December 28, 2025 at 3:16 PM
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Activated T cells degrade extracellular proteins to enhance effector functions
biomed.news/bims-imicid/...
Interesting paper:
Activated T cells degrade extracellular proteins to enhance effector functions
Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35
pubmed.ncbi.nlm.nih.gov/41446167/
pubmed.ncbi.nlm.nih.gov/41446167/
December 28, 2025 at 12:21 AM
Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35
pubmed.ncbi.nlm.nih.gov/41446167/
pubmed.ncbi.nlm.nih.gov/41446167/
🎄Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️
biomed.news/bims-imicid/...
A great Christmas selection inside!
I) Gut microbiota promotes immune tolerance at the maternal-fetal interface
biomed.news/bims-imicid/...
A great Christmas selection inside!
I) Gut microbiota promotes immune tolerance at the maternal-fetal interface
December 23, 2025 at 1:00 PM
🎄Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️
biomed.news/bims-imicid/...
A great Christmas selection inside!
I) Gut microbiota promotes immune tolerance at the maternal-fetal interface
biomed.news/bims-imicid/...
A great Christmas selection inside!
I) Gut microbiota promotes immune tolerance at the maternal-fetal interface
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
Interesting findings:
I) Dynamic changes in mitochondria support phenotypic flexibility of microglia
II) Mitochondria are absent from microglial processes performing surveillance
biomed.news/bims-imicid/...
Interesting findings:
I) Dynamic changes in mitochondria support phenotypic flexibility of microglia
II) Mitochondria are absent from microglial processes performing surveillance
December 14, 2025 at 12:09 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
Interesting findings:
I) Dynamic changes in mitochondria support phenotypic flexibility of microglia
II) Mitochondria are absent from microglial processes performing surveillance
biomed.news/bims-imicid/...
Interesting findings:
I) Dynamic changes in mitochondria support phenotypic flexibility of microglia
II) Mitochondria are absent from microglial processes performing surveillance
I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer.
Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile.
Thank you very much!
Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile.
Thank you very much!
December 11, 2025 at 11:05 PM
I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer.
Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile.
Thank you very much!
Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile.
Thank you very much!
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
biomed.news/bims-imicid/...
Interesting finding:
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
December 7, 2025 at 2:07 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
biomed.news/bims-imicid/...
Interesting finding:
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
A huge collection inside!
Interesting finding:
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
biomed.news/bims-imicid/...
A huge collection inside!
Interesting finding:
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
December 5, 2025 at 5:35 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
A huge collection inside!
Interesting finding:
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
biomed.news/bims-imicid/...
A huge collection inside!
Interesting finding:
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
November 23, 2025 at 1:05 PM
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
biomed.news/bims-imicid/...
Interesting finding:
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
November 10, 2025 at 9:23 AM
Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
biomed.news/bims-imicid/...
Interesting finding:
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis #mitochondria
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
November 6, 2025 at 5:02 PM
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis #mitochondria
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
biomed.news/bims-imicid/...
Interesting finding:
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
November 3, 2025 at 4:27 PM
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
biomed.news/bims-imicid/...
Interesting finding:
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
📢 last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
biomed.news/bims-imicid/...
Interesting finding:
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
October 28, 2025 at 9:41 AM
📢 last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
biomed.news/bims-imicid/...
Interesting finding:
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
October 20, 2025 at 12:27 PM
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Many highlights inside!
incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
biomed.news/bims-imicid/...
Many highlights inside!
incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
October 12, 2025 at 12:11 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Many highlights inside!
incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
biomed.news/bims-imicid/...
Many highlights inside!
incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion
biomed.news/bims-imicid/...
Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion
October 5, 2025 at 9:22 AM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion
biomed.news/bims-imicid/...
Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion
Recently @natureportfolio.nature.com had an article about Bluesky being a better platform for sharing science than X. It hasn't been my experience to date. Same post yesterday had more engagement on X and LinkedIN. Wondering if it's domain specific? What are others experience?
September 29, 2025 at 8:20 AM
Recently @natureportfolio.nature.com had an article about Bluesky being a better platform for sharing science than X. It hasn't been my experience to date. Same post yesterday had more engagement on X and LinkedIN. Wondering if it's domain specific? What are others experience?
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
September 28, 2025 at 8:42 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
New cohort of @tcddublin.bsky.social Assitant Professors at our induction😀☘️
September 17, 2025 at 10:10 AM
New cohort of @tcddublin.bsky.social Assitant Professors at our induction😀☘️
🔉Last weeks #immunometabolism discoveries @biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Highlight:
Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila
biomed.news/bims-imicid/...
Highlight:
Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila
September 15, 2025 at 11:54 AM
🔉Last weeks #immunometabolism discoveries @biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Highlight:
Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila
biomed.news/bims-imicid/...
Highlight:
Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlight:
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlight:
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
September 10, 2025 at 7:50 AM
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlight:
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlight:
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
📢Last 2 weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlights:
Species-specific serine metabolism differentially controls natural killer cell functions
nature.com/articles/s42...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlights:
Species-specific serine metabolism differentially controls natural killer cell functions
nature.com/articles/s42...
August 27, 2025 at 10:48 PM
📢Last 2 weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlights:
Species-specific serine metabolism differentially controls natural killer cell functions
nature.com/articles/s42...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlights:
Species-specific serine metabolism differentially controls natural killer cell functions
nature.com/articles/s42...
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
August 11, 2025 at 11:34 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...