Waggoner Lab
@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
Reposted by Waggoner Lab
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
www.nature.com
January 23, 2026 at 4:03 AM
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Damage assessment: Which of Donald Trump’s changes are likely to last—and which will fade? @science.org
www.science.org/content/arti...
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Which of Trump’s upheavals in U.S. science are likely to stick?
A future president could reverse many changes, but greater White House control of science agencies may be here to stay
www.science.org
January 23, 2026 at 4:01 AM
Damage assessment: Which of Donald Trump’s changes are likely to last—and which will fade? @science.org
www.science.org/content/arti...
www.science.org/content/arti...
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development @science.org
www.science.org/doi/10.1126/...
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January 23, 2026 at 4:00 AM
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development @science.org
www.science.org/doi/10.1126/...
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Oligodendrocyte progenitor cell differentiation is constitutive across brain regions @science.org
www.science.org/doi/10.1126/...
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January 23, 2026 at 3:58 AM
Oligodendrocyte progenitor cell differentiation is constitutive across brain regions @science.org
www.science.org/doi/10.1126/...
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Platelet-derived structures in blood vessel walls increase inflammation and bleeding risk @science.org @nieswandtlab.bsky.social
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January 23, 2026 at 3:57 AM
Platelet-derived structures in blood vessel walls increase inflammation and bleeding risk @science.org @nieswandtlab.bsky.social
www.science.org/doi/10.1126/...
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Repairing trust in science requires a more inclusive understanding of innovation @science.org @shobitap.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Repairing trust in science requires a more inclusive understanding of innovation
These are extraordinarily challenging times for university researchers across the United States. After decades of government largess based on the idea that a large and well-financed research ecosystem...
www.science.org
January 23, 2026 at 3:55 AM
Repairing trust in science requires a more inclusive understanding of innovation @science.org @shobitap.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 3:53 AM
Talking back: An unprecedented assault has forced the U.S. scientific community to rethink its advocacy tactics @science.org
www.science.org/content/arti...
www.science.org/content/arti...
January 23, 2026 at 3:53 AM
Talking back: An unprecedented assault has forced the U.S. scientific community to rethink its advocacy tactics @science.org
www.science.org/content/arti...
www.science.org/content/arti...
Pressure on the pipeline: The Trump administration’s agenda is likely to reshape the scientific workforce
@science.org
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@science.org
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January 23, 2026 at 3:51 AM
Pressure on the pipeline: The Trump administration’s agenda is likely to reshape the scientific workforce
@science.org
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@science.org
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@biorxivpreprint.bsky.social IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis @cardiffuni.bsky.social www.biorxiv.org/content/10.1...
January 23, 2026 at 3:46 AM
@biorxivpreprint.bsky.social IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis @cardiffuni.bsky.social www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social Myeloid CD209 impairs T-cell activation by inducing ICAM-2-ERM-dependent cortical stiffening
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 23, 2026 at 3:44 AM
@biorxivpreprint.bsky.social Myeloid CD209 impairs T-cell activation by inducing ICAM-2-ERM-dependent cortical stiffening
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social New NK Cell Expansion Technology for the Development of Cellular Immunotherapies
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 23, 2026 at 3:42 AM
@biorxivpreprint.bsky.social New NK Cell Expansion Technology for the Development of Cellular Immunotherapies
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Identification of Lupus Immune Complex-Driven Pathogenic Pro-inflammatory Monocytes and Macrophages in Systemic Lupus Erythematosus @yalepress.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 23, 2026 at 3:35 AM
@biorxivpreprint.bsky.social Identification of Lupus Immune Complex-Driven Pathogenic Pro-inflammatory Monocytes and Macrophages in Systemic Lupus Erythematosus @yalepress.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@cincychildrens.bsky.social @medrxivpreprint.bsky.social
A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
A collaboration with my colleagues Leah Kottyan & Matt Weirauch
www.medrxiv.org/content/10.6...
A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
A collaboration with my colleagues Leah Kottyan & Matt Weirauch
www.medrxiv.org/content/10.6...
January 23, 2026 at 3:29 AM
@cincychildrens.bsky.social @medrxivpreprint.bsky.social
A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
A collaboration with my colleagues Leah Kottyan & Matt Weirauch
www.medrxiv.org/content/10.6...
A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
A collaboration with my colleagues Leah Kottyan & Matt Weirauch
www.medrxiv.org/content/10.6...
Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation @natcomms.nature.com @crick.ac.uk
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 3:10 AM
Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation @natcomms.nature.com @crick.ac.uk
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting age-related LINE-1 activation alleviates cardiac aging @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Targeting age-related LINE-1 activation alleviates cardiac aging - Nature Aging
LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genet...
www.nature.com
January 23, 2026 at 3:07 AM
Targeting age-related LINE-1 activation alleviates cardiac aging @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina @natcomms.nature.com @cedarssinai.bsky.social @guerinchildrens.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 3:03 AM
Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina @natcomms.nature.com @cedarssinai.bsky.social @guerinchildrens.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants @natgenet.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 2:59 AM
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants @natgenet.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Review @natrevcardiol.nature.com
Molecular damage associated with ageing drives inflammation in cardiovascular disease
www.nature.com/articles/s41...
Molecular damage associated with ageing drives inflammation in cardiovascular disease
www.nature.com/articles/s41...
January 23, 2026 at 2:53 AM
Review @natrevcardiol.nature.com
Molecular damage associated with ageing drives inflammation in cardiovascular disease
www.nature.com/articles/s41...
Molecular damage associated with ageing drives inflammation in cardiovascular disease
www.nature.com/articles/s41...
Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 2:50 AM
Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung @natcomms.nature.com @niaidnews.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 2:48 AM
Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung @natcomms.nature.com @niaidnews.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 22, 2026 at 9:48 PM
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Innate lymphoid cells activated by the cytokine TL1A link colitis to emergency granulopoiesis and the recruitment of tumor-promoting neutrophils @cp-immunity.bsky.social @weillcornell.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
January 22, 2026 at 9:47 PM
Innate lymphoid cells activated by the cytokine TL1A link colitis to emergency granulopoiesis and the recruitment of tumor-promoting neutrophils @cp-immunity.bsky.social @weillcornell.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Review @cp-cellrepmed.bsky.social
Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions
www.cell.com/cell-reports...
Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions
www.cell.com/cell-reports...
January 22, 2026 at 9:43 PM
Review @cp-cellrepmed.bsky.social
Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions
www.cell.com/cell-reports...
Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions
www.cell.com/cell-reports...
Review @cp-cellrepmed.bsky.social
Pipe dream to pipeline: Journey of cancer vaccines and the road ahead
www.cell.com/cell-reports...
Pipe dream to pipeline: Journey of cancer vaccines and the road ahead
www.cell.com/cell-reports...
January 22, 2026 at 9:42 PM
Review @cp-cellrepmed.bsky.social
Pipe dream to pipeline: Journey of cancer vaccines and the road ahead
www.cell.com/cell-reports...
Pipe dream to pipeline: Journey of cancer vaccines and the road ahead
www.cell.com/cell-reports...