Waggoner Lab
@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
Reposted by Waggoner Lab
Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease | Science Advances www.science.org/doi/10.1126/...
Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease
Intermittent fasting enhances cognition in Alzheimer’s disease via gut microbial indole-3-propionic acid activating neuronal PXR.
www.science.org
November 29, 2025 at 2:23 AM
Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease | Science Advances www.science.org/doi/10.1126/...
Theory @cp-immunity.bsky.social
Quantifying the waning of humoral immunity
www.cell.com/immunity/ful...
Quantifying the waning of humoral immunity
www.cell.com/immunity/ful...
November 29, 2025 at 2:29 AM
Theory @cp-immunity.bsky.social
Quantifying the waning of humoral immunity
www.cell.com/immunity/ful...
Quantifying the waning of humoral immunity
www.cell.com/immunity/ful...
Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
November 29, 2025 at 2:25 AM
Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis @cellcellpress.bsky.social @stjuderesearch.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
November 29, 2025 at 2:23 AM
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis @cellcellpress.bsky.social @stjuderesearch.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 29, 2025 at 2:21 AM
Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 29, 2025 at 2:17 AM
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Review @science.org
Targeted protein degradation in the transmembrane and extracellular space
www.science.org/doi/10.1126/...
Targeted protein degradation in the transmembrane and extracellular space
www.science.org/doi/10.1126/...
November 29, 2025 at 2:15 AM
Review @science.org
Targeted protein degradation in the transmembrane and extracellular space
www.science.org/doi/10.1126/...
Targeted protein degradation in the transmembrane and extracellular space
www.science.org/doi/10.1126/...
Innate lymphoid cells mitigate graft-versus-host disease (GVHD) by inducing T-cell senescence via IL-9
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Old but gold: ILC-induced T-cell senescence prevents GVHD
In this issue of Blood,Tufa et al1 demonstrate that innate lymphoid cells (ILCs) mitigate graft-versus-host disease (GVHD) by inducing T-cell senescence vi
ashpublications.org
November 29, 2025 at 2:10 AM
Innate lymphoid cells mitigate graft-versus-host disease (GVHD) by inducing T-cell senescence via IL-9
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Happy to share an update to a 2018 preprint from @labwaggoner.bsky.social and our collaborators! Added Mb1-Cre models and mechanistic insights into Ddx3x regulation of B cell development @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Find Ddx3x is required in B cells in females
www.biorxiv.org/content/10.1...
Find Ddx3x is required in B cells in females
November 29, 2025 at 2:06 AM
Happy to share an update to a 2018 preprint from @labwaggoner.bsky.social and our collaborators! Added Mb1-Cre models and mechanistic insights into Ddx3x regulation of B cell development @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Find Ddx3x is required in B cells in females
www.biorxiv.org/content/10.1...
Find Ddx3x is required in B cells in females
Broad-spectrum antiviral brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 29, 2025 at 1:48 AM
Broad-spectrum antiviral brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Mechanical confinement induces ferroptosis through mitochondrial dysfunction @natcomms.nature.com www.nature.com/articles/s41...
November 29, 2025 at 1:45 AM
Mechanical confinement induces ferroptosis through mitochondrial dysfunction @natcomms.nature.com www.nature.com/articles/s41...
Review @natrevneuro.nature.com
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...
November 29, 2025 at 1:43 AM
Review @natrevneuro.nature.com
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...
mRNA engineering of allogeneic mesenchymal stem cells enables coordinated delivery of T cell engagers and immunotherapeutic cues @natbiomedeng.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2025 at 1:40 AM
mRNA engineering of allogeneic mesenchymal stem cells enables coordinated delivery of T cell engagers and immunotherapeutic cues @natbiomedeng.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A distinct, microenvironment-driven route of neoantigen formation that fuels sustained autoreactivity in diabetes
www.nature.com/articles/s41... @natcomms.nature.com @washumedicine.bsky.social
www.nature.com/articles/s41... @natcomms.nature.com @washumedicine.bsky.social
November 29, 2025 at 1:37 AM
A distinct, microenvironment-driven route of neoantigen formation that fuels sustained autoreactivity in diabetes
www.nature.com/articles/s41... @natcomms.nature.com @washumedicine.bsky.social
www.nature.com/articles/s41... @natcomms.nature.com @washumedicine.bsky.social
Prolonged T cell dyshomeostasis driven by dysregulated homeostatic cytokine signals (inc IL7 & IL15) following acute SARS-CoV-2 infection @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2025 at 1:24 AM
Prolonged T cell dyshomeostasis driven by dysregulated homeostatic cytokine signals (inc IL7 & IL15) following acute SARS-CoV-2 infection @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2025 at 1:20 AM
Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2025 at 1:17 AM
Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Review @natrevneph.nature.com
Natural killer cells in kidney immune surveillance, injury and fibrosis
www.nature.com/articles/s41...
Natural killer cells in kidney immune surveillance, injury and fibrosis
www.nature.com/articles/s41...
Natural killer cells in kidney immune surveillance, injury and fibrosis - Nature Reviews Nephrology
This Review discusses the latest advances in natural killer cell biology, including insights into population heterogeneity, and examines the roles of these innate lymphocytes in kidney health and dise...
www.nature.com
November 29, 2025 at 1:11 AM
Review @natrevneph.nature.com
Natural killer cells in kidney immune surveillance, injury and fibrosis
www.nature.com/articles/s41...
Natural killer cells in kidney immune surveillance, injury and fibrosis
www.nature.com/articles/s41...
Historical and current spatiotemporal patterns of wild and vaccine-derived poliovirus spread @natmicrobiol.nature.com @imperialcollegeldn.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2025 at 1:07 AM
Historical and current spatiotemporal patterns of wild and vaccine-derived poliovirus spread @natmicrobiol.nature.com @imperialcollegeldn.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Tumor-specific bioorthogonal synthesis of proteolysis-targeting chimeras and nanoparticles boosts T cell activity @natbiomedeng.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2025 at 1:05 AM
Tumor-specific bioorthogonal synthesis of proteolysis-targeting chimeras and nanoparticles boosts T cell activity @natbiomedeng.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations @nataging.nature.com @ox.ac.uk
www.nature.com/articles/s43...
www.nature.com/articles/s43...
November 29, 2025 at 1:03 AM
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations @nataging.nature.com @ox.ac.uk
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Epigenetic drift is induced by dysregulation of iron metabolism in intestinal stem cells, leading to accumulating gene hypermethylation that propagates through crypt fission with aging
@leibnizfli.bsky.social @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
@leibnizfli.bsky.social @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
November 29, 2025 at 12:59 AM
Epigenetic drift is induced by dysregulation of iron metabolism in intestinal stem cells, leading to accumulating gene hypermethylation that propagates through crypt fission with aging
@leibnizfli.bsky.social @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
@leibnizfli.bsky.social @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Targeting of HIF2-driven cachexia in kidney cancer @naturemedicine.bsky.social @abu-remaileh.bsky.social
@danafarber.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...
@danafarber.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...
November 29, 2025 at 12:48 AM
Targeting of HIF2-driven cachexia in kidney cancer @naturemedicine.bsky.social @abu-remaileh.bsky.social
@danafarber.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...
@danafarber.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...
Cellular reprogramming and efficacy of neoadjuvant nab-paclitaxel and pembrolizumab in hormone receptor-positive breast cancer
@natcomms.nature.com @stolaney1.bsky.social @danafarber.bsky.social @vanallenlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@natcomms.nature.com @stolaney1.bsky.social @danafarber.bsky.social @vanallenlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2025 at 12:45 AM
Cellular reprogramming and efficacy of neoadjuvant nab-paclitaxel and pembrolizumab in hormone receptor-positive breast cancer
@natcomms.nature.com @stolaney1.bsky.social @danafarber.bsky.social @vanallenlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@natcomms.nature.com @stolaney1.bsky.social @danafarber.bsky.social @vanallenlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane @natcomms.nature.com @bgewurz.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2025 at 12:31 AM
CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane @natcomms.nature.com @bgewurz.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...