Waggoner Lab
@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
IL-12-armored CAR T cells target TREM2+ tumor-associated macrophages to reprogram the tumor microenvuronment and drive tumor regression without systemic toxicity
@cp-cancercell.bsky.social @idoamitlab.bsky.social @florianingelfinger.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @idoamitlab.bsky.social @florianingelfinger.bsky.social
www.cell.com/cancer-cell/...
January 23, 2026 at 6:08 PM
IL-12-armored CAR T cells target TREM2+ tumor-associated macrophages to reprogram the tumor microenvuronment and drive tumor regression without systemic toxicity
@cp-cancercell.bsky.social @idoamitlab.bsky.social @florianingelfinger.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @idoamitlab.bsky.social @florianingelfinger.bsky.social
www.cell.com/cancer-cell/...
Targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity
@miriammerad.bsky.social
@brownlab1.bsky.social
@cp-cancercell.bsky.social
cell.com/cancer-cell/...
@miriammerad.bsky.social
@brownlab1.bsky.social
@cp-cancercell.bsky.social
cell.com/cancer-cell/...
January 23, 2026 at 5:58 PM
Targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity
@miriammerad.bsky.social
@brownlab1.bsky.social
@cp-cancercell.bsky.social
cell.com/cancer-cell/...
@miriammerad.bsky.social
@brownlab1.bsky.social
@cp-cancercell.bsky.social
cell.com/cancer-cell/...
Diffuse midline glioma tumor cells communicate with microglia through IGSF11-VISTA signaling, a tragetable pathway to promote tumor control
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...
January 23, 2026 at 5:50 PM
Diffuse midline glioma tumor cells communicate with microglia through IGSF11-VISTA signaling, a tragetable pathway to promote tumor control
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...
IFNγ regulates melanoma-associated lymphatic vessels, linking their metabolic and functional states to immune surveillance and metastasis
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @thelundlab.bsky.social @nyulangone.bsky.social
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @thelundlab.bsky.social @nyulangone.bsky.social
January 23, 2026 at 5:40 PM
IFNγ regulates melanoma-associated lymphatic vessels, linking their metabolic and functional states to immune surveillance and metastasis
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @thelundlab.bsky.social @nyulangone.bsky.social
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @thelundlab.bsky.social @nyulangone.bsky.social
Reduced plasma levels of CRTAM, LY9, CD6, and ICAM3 differentiate 'elite' from 'viremic' controllers of HIV, and elevations in these makers predict loss of controller status years in advance
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
January 23, 2026 at 5:16 PM
Reduced plasma levels of CRTAM, LY9, CD6, and ICAM3 differentiate 'elite' from 'viremic' controllers of HIV, and elevations in these makers predict loss of controller status years in advance
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
Can H5N1 avian influenza in dairy cattle be contained in the US? @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 23, 2026 at 5:02 PM
Can H5N1 avian influenza in dairy cattle be contained in the US? @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Waggoner Lab
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
www.nature.com
January 23, 2026 at 4:03 AM
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Damage assessment: Which of Donald Trump’s changes are likely to last—and which will fade? @science.org
www.science.org/content/arti...
www.science.org/content/arti...
Which of Trump’s upheavals in U.S. science are likely to stick?
A future president could reverse many changes, but greater White House control of science agencies may be here to stay
www.science.org
January 23, 2026 at 4:01 AM
Damage assessment: Which of Donald Trump’s changes are likely to last—and which will fade? @science.org
www.science.org/content/arti...
www.science.org/content/arti...
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 4:00 AM
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Oligodendrocyte progenitor cell differentiation is constitutive across brain regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 3:58 AM
Oligodendrocyte progenitor cell differentiation is constitutive across brain regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Platelet-derived structures in blood vessel walls increase inflammation and bleeding risk @science.org @nieswandtlab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 3:57 AM
Platelet-derived structures in blood vessel walls increase inflammation and bleeding risk @science.org @nieswandtlab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Repairing trust in science requires a more inclusive understanding of innovation @science.org @shobitap.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Repairing trust in science requires a more inclusive understanding of innovation
These are extraordinarily challenging times for university researchers across the United States. After decades of government largess based on the idea that a large and well-financed research ecosystem...
www.science.org
January 23, 2026 at 3:55 AM
Repairing trust in science requires a more inclusive understanding of innovation @science.org @shobitap.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 3:53 AM
Talking back: An unprecedented assault has forced the U.S. scientific community to rethink its advocacy tactics @science.org
www.science.org/content/arti...
www.science.org/content/arti...
January 23, 2026 at 3:53 AM
Talking back: An unprecedented assault has forced the U.S. scientific community to rethink its advocacy tactics @science.org
www.science.org/content/arti...
www.science.org/content/arti...
Pressure on the pipeline: The Trump administration’s agenda is likely to reshape the scientific workforce
@science.org
www.science.org/content/arti...
@science.org
www.science.org/content/arti...
January 23, 2026 at 3:51 AM
Pressure on the pipeline: The Trump administration’s agenda is likely to reshape the scientific workforce
@science.org
www.science.org/content/arti...
@science.org
www.science.org/content/arti...
@biorxivpreprint.bsky.social IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis @cardiffuni.bsky.social www.biorxiv.org/content/10.1...
January 23, 2026 at 3:46 AM
@biorxivpreprint.bsky.social IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis @cardiffuni.bsky.social www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social Myeloid CD209 impairs T-cell activation by inducing ICAM-2-ERM-dependent cortical stiffening
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 23, 2026 at 3:44 AM
@biorxivpreprint.bsky.social Myeloid CD209 impairs T-cell activation by inducing ICAM-2-ERM-dependent cortical stiffening
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social New NK Cell Expansion Technology for the Development of Cellular Immunotherapies
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 23, 2026 at 3:42 AM
@biorxivpreprint.bsky.social New NK Cell Expansion Technology for the Development of Cellular Immunotherapies
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Identification of Lupus Immune Complex-Driven Pathogenic Pro-inflammatory Monocytes and Macrophages in Systemic Lupus Erythematosus @yalepress.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 23, 2026 at 3:35 AM
@biorxivpreprint.bsky.social Identification of Lupus Immune Complex-Driven Pathogenic Pro-inflammatory Monocytes and Macrophages in Systemic Lupus Erythematosus @yalepress.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
@cincychildrens.bsky.social @medrxivpreprint.bsky.social
A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
A collaboration with my colleagues Leah Kottyan & Matt Weirauch
www.medrxiv.org/content/10.6...
A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
A collaboration with my colleagues Leah Kottyan & Matt Weirauch
www.medrxiv.org/content/10.6...
January 23, 2026 at 3:29 AM
@cincychildrens.bsky.social @medrxivpreprint.bsky.social
A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
A collaboration with my colleagues Leah Kottyan & Matt Weirauch
www.medrxiv.org/content/10.6...
A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
A collaboration with my colleagues Leah Kottyan & Matt Weirauch
www.medrxiv.org/content/10.6...
Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation @natcomms.nature.com @crick.ac.uk
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 3:10 AM
Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation @natcomms.nature.com @crick.ac.uk
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting age-related LINE-1 activation alleviates cardiac aging @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Targeting age-related LINE-1 activation alleviates cardiac aging - Nature Aging
LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genet...
www.nature.com
January 23, 2026 at 3:07 AM
Targeting age-related LINE-1 activation alleviates cardiac aging @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina @natcomms.nature.com @cedarssinai.bsky.social @guerinchildrens.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 3:03 AM
Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina @natcomms.nature.com @cedarssinai.bsky.social @guerinchildrens.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants @natgenet.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 2:59 AM
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants @natgenet.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Review @natrevcardiol.nature.com
Molecular damage associated with ageing drives inflammation in cardiovascular disease
www.nature.com/articles/s41...
Molecular damage associated with ageing drives inflammation in cardiovascular disease
www.nature.com/articles/s41...
January 23, 2026 at 2:53 AM
Review @natrevcardiol.nature.com
Molecular damage associated with ageing drives inflammation in cardiovascular disease
www.nature.com/articles/s41...
Molecular damage associated with ageing drives inflammation in cardiovascular disease
www.nature.com/articles/s41...