Waggoner Lab
@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
Germinal center responses can recover from transient loss of T cell help, but the sustained reduction in TFH cells impairs recall responses @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @babrahaminst.bsky.social @linterman.bsky.social
www.science.org/doi/10.1126/... @babrahaminst.bsky.social @linterman.bsky.social
January 23, 2026 at 11:17 PM
Germinal center responses can recover from transient loss of T cell help, but the sustained reduction in TFH cells impairs recall responses @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @babrahaminst.bsky.social @linterman.bsky.social
www.science.org/doi/10.1126/... @babrahaminst.bsky.social @linterman.bsky.social
Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust mite throughout sexual maturation @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @lloydlab.bsky.social @sejalsaglani.bsky.social @imperialcollegeldn.bsky.social
www.science.org/doi/10.1126/... @lloydlab.bsky.social @sejalsaglani.bsky.social @imperialcollegeldn.bsky.social
January 23, 2026 at 11:12 PM
Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust mite throughout sexual maturation @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @lloydlab.bsky.social @sejalsaglani.bsky.social @imperialcollegeldn.bsky.social
www.science.org/doi/10.1126/... @lloydlab.bsky.social @sejalsaglani.bsky.social @imperialcollegeldn.bsky.social
TDRD3 regulates immune tolerance via activating Klf2 gene to promote iTreg differentiation and function
www.science.org/doi/10.1126/...
@cityofhope.bsky.social
www.science.org/doi/10.1126/...
@cityofhope.bsky.social
January 23, 2026 at 11:10 PM
TDRD3 regulates immune tolerance via activating Klf2 gene to promote iTreg differentiation and function
www.science.org/doi/10.1126/...
@cityofhope.bsky.social
www.science.org/doi/10.1126/...
@cityofhope.bsky.social
Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice @ucberkeleyofficial.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 11:09 PM
Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice @ucberkeleyofficial.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
CD318 is up-regulated in activated CD8 T cells defining a regulatory subtype with therapeutic potential
www.science.org/doi/10.1126/...
@cityofhope.bsky.social
www.science.org/doi/10.1126/...
@cityofhope.bsky.social
January 23, 2026 at 11:07 PM
CD318 is up-regulated in activated CD8 T cells defining a regulatory subtype with therapeutic potential
www.science.org/doi/10.1126/...
@cityofhope.bsky.social
www.science.org/doi/10.1126/...
@cityofhope.bsky.social
RSV orchestrates cell death and IL-1β release via spatially distinct, linked death signaling axes for immune evasion and spread
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 11:05 PM
RSV orchestrates cell death and IL-1β release via spatially distinct, linked death signaling axes for immune evasion and spread
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Tissue-resident NK cells adapt dynamically to early HIV, revealing memory-like subsets that link viral control and dysfunction
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 11:04 PM
Tissue-resident NK cells adapt dynamically to early HIV, revealing memory-like subsets that link viral control and dysfunction
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A nanotherapy that reprograms immune and neural circuits halts bone metastasis, relieves cancer pain, and restores bone integrity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 11:01 PM
A nanotherapy that reprograms immune and neural circuits halts bone metastasis, relieves cancer pain, and restores bone integrity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Dexamethasone reprograms glioblastoma nicotinamide metabolism, sensitizing tumors to methionine restriction and enabling PET
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 11:00 PM
Dexamethasone reprograms glioblastoma nicotinamide metabolism, sensitizing tumors to methionine restriction and enabling PET
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural studies reveal how influenza virus switches between making new RNA genomes and exporting them from the host nucleus @ox.ac.uk
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 23, 2026 at 10:58 PM
Structural studies reveal how influenza virus switches between making new RNA genomes and exporting them from the host nucleus @ox.ac.uk
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TH2 to TH17 cell conversion via interleukin-4-STAT5 axis in mice
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
January 23, 2026 at 10:55 PM
The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TH2 to TH17 cell conversion via interleukin-4-STAT5 axis in mice
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Review @natrevclinonc.nature.com @stanforduniversity.bsky.social
The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer
www.nature.com/articles/s41...
The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer
www.nature.com/articles/s41...
January 23, 2026 at 10:53 PM
Review @natrevclinonc.nature.com @stanforduniversity.bsky.social
The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer
www.nature.com/articles/s41...
The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer
www.nature.com/articles/s41...
Review @natrevcancer.nature.com
Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy
www.nature.com/articles/s41...
Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy
www.nature.com/articles/s41...
January 23, 2026 at 10:51 PM
Review @natrevcancer.nature.com
Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy
www.nature.com/articles/s41...
Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy
www.nature.com/articles/s41...
Perspective @natrevimmunol.nature.com @scripps.edu
Beyond suppression: the paradox of JAK inhibitors as amplifiers of cancer immunotherapy
www.nature.com/articles/s41...
Beyond suppression: the paradox of JAK inhibitors as amplifiers of cancer immunotherapy
www.nature.com/articles/s41...
January 23, 2026 at 10:48 PM
Perspective @natrevimmunol.nature.com @scripps.edu
Beyond suppression: the paradox of JAK inhibitors as amplifiers of cancer immunotherapy
www.nature.com/articles/s41...
Beyond suppression: the paradox of JAK inhibitors as amplifiers of cancer immunotherapy
www.nature.com/articles/s41...
A thymic organoid model providing a practical platform for studying thymic cellular interactions and thymopoiesis in vitro @natcomms.nature.com @inserm.fr
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 23, 2026 at 10:46 PM
A thymic organoid model providing a practical platform for studying thymic cellular interactions and thymopoiesis in vitro @natcomms.nature.com @inserm.fr
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
January 23, 2026 at 10:11 PM
CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
Activated CD38+ mast cells promote gastric cancer progression by suppressing CD8+ T cell cytotoxic activity through adenosine metabolism @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
January 23, 2026 at 10:09 PM
Activated CD38+ mast cells promote gastric cancer progression by suppressing CD8+ T cell cytotoxic activity through adenosine metabolism @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression
@cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
@cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
January 23, 2026 at 10:08 PM
Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression
@cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
@cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
IL-12-armored CAR T cells target TREM2+ tumor-associated macrophages to reprogram the tumor microenvuronment and drive tumor regression without systemic toxicity
@cp-cancercell.bsky.social @idoamitlab.bsky.social @florianingelfinger.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @idoamitlab.bsky.social @florianingelfinger.bsky.social
www.cell.com/cancer-cell/...
January 23, 2026 at 6:08 PM
IL-12-armored CAR T cells target TREM2+ tumor-associated macrophages to reprogram the tumor microenvuronment and drive tumor regression without systemic toxicity
@cp-cancercell.bsky.social @idoamitlab.bsky.social @florianingelfinger.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @idoamitlab.bsky.social @florianingelfinger.bsky.social
www.cell.com/cancer-cell/...
Targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity
@miriammerad.bsky.social
@brownlab1.bsky.social
@cp-cancercell.bsky.social
cell.com/cancer-cell/...
@miriammerad.bsky.social
@brownlab1.bsky.social
@cp-cancercell.bsky.social
cell.com/cancer-cell/...
January 23, 2026 at 5:58 PM
Targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity
@miriammerad.bsky.social
@brownlab1.bsky.social
@cp-cancercell.bsky.social
cell.com/cancer-cell/...
@miriammerad.bsky.social
@brownlab1.bsky.social
@cp-cancercell.bsky.social
cell.com/cancer-cell/...
Diffuse midline glioma tumor cells communicate with microglia through IGSF11-VISTA signaling, a tragetable pathway to promote tumor control
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...
January 23, 2026 at 5:50 PM
Diffuse midline glioma tumor cells communicate with microglia through IGSF11-VISTA signaling, a tragetable pathway to promote tumor control
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...
@cp-cancercell.bsky.social @radboudumc.bsky.social @rcollot.bsky.social
www.cell.com/cancer-cell/...
IFNγ regulates melanoma-associated lymphatic vessels, linking their metabolic and functional states to immune surveillance and metastasis
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @thelundlab.bsky.social @nyulangone.bsky.social
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @thelundlab.bsky.social @nyulangone.bsky.social
January 23, 2026 at 5:40 PM
IFNγ regulates melanoma-associated lymphatic vessels, linking their metabolic and functional states to immune surveillance and metastasis
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @thelundlab.bsky.social @nyulangone.bsky.social
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @thelundlab.bsky.social @nyulangone.bsky.social
Reduced plasma levels of CRTAM, LY9, CD6, and ICAM3 differentiate 'elite' from 'viremic' controllers of HIV, and elevations in these makers predict loss of controller status years in advance
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
January 23, 2026 at 5:16 PM
Reduced plasma levels of CRTAM, LY9, CD6, and ICAM3 differentiate 'elite' from 'viremic' controllers of HIV, and elevations in these makers predict loss of controller status years in advance
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
Can H5N1 avian influenza in dairy cattle be contained in the US? @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 23, 2026 at 5:02 PM
Can H5N1 avian influenza in dairy cattle be contained in the US? @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Waggoner Lab
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
www.nature.com
January 23, 2026 at 4:03 AM
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...