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labwaggoner.bsky.social
Waggoner Lab
@labwaggoner.bsky.social
3.6K followers 2.3K following 5.7K posts
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 14h
@biorxivpreprint.bsky.social Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design
www.biorxiv.org/content/10.1... @upenn.edu @caltech.edu @bjorkman-lab.bsky.social Hahn Shaw Labs
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 14h
@biorxivpreprint.bsky.social Impaired IFNγ responsiveness of lung monocyte-derived cells limits immunity to Mycobacterium tuberculosis @ucsfhealth.bsky.social
www.biorxiv.org/content/10.1...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 14h
@biorxivpreprint.bsky.social Methionine metabolism shapes immune response against Mycobacterium tuberculosis
www.biorxiv.org/content/10.1...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 14h
@biorxivpreprint.bsky.social Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis @ufmedicine.bsky.social
www.biorxiv.org/content/10.1...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 14h
@biorxivpreprint.bsky.social Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8+ T cell-macrophage interactions
@stanforduniversity.bsky.social @niaidnews.bsky.social @txbiomed.bsky.social
www.biorxiv.org/content/10.1...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 15h
@biorxivpreprint.bsky.social UBA1 Mutations Drive RIPK1-Mediated Cell Death and Monocyte Dysfunction in VEXAS Syndrome @terrierben.bsky.social
www.biorxiv.org/content/10.1...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 22h
ROR2-specific CAR T cells are effective against hematologic and solid tumors and well tolerated in mice @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 22h
Review @moltherapy.bsky.social Innate Immune Cells in Chimeric Antigen Receptor Therapy
www.cell.com/molecular-th...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 22h
Review @MolTherapy Cancer Viroimmunotherapy Platforms Based on Varicella-Zoster Virus and Cytomegalovirus @mayoclinic.org
www.cell.com/molecular-th...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 22h
Patterns of secondary variants, influenced by cohort, phenotype, and primary-variant ascertainment, alter phenotypic outcomes in individuals with disease-associated primary variant @cellcellpress.bsky.social @girirajan.bsky.social @pennstateuniv.bsky.social
www.cell.com/cell/fulltex...
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 22h
Trex1 loss amplifies tumor-intrinsic cGAS–STING signaling and activates CD8+ T cell–mediated antitumor immunity @jem.org
rupress.org/jem/article-...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Sonelokimab, an IL-17A/IL-17F-inhibiting nanobody for active psoriatic arthritis: a randomized, placebo-controlled phase 2 trial @naturemedicine.bsky.social @uofglasgow.bsky.social
www.nature.com/articles/s41...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Folding-mediated secretion of pure bispecific antibodies @natbiotech.nature.com
www.nature.com/articles/s41...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Rheumatoid arthritis synovial fibroblasts modulate T cell activation @insight.jci.org @mskcancercenter.bsky.social
insight.jci.org/articles/vie...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
CRISPR/Cas-mediated activation of genes associated with inherited retinal dystrophies in human cells for diagnostic purposes @insight.jci.org
insight.jci.org/articles/vie...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
IL-17-producing γδ T cells in the tumor microenvironment promote radioresistance in mice @jci.org
www.jci.org/articles/vie...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Preprint: Aberrant Host mRNA Partitioning in Ebola Virus Condensates Driven by RNA Folding Perpetuates Species-Dependent IFN Response @lji.org
papers.ssrn.com/sol3/papers....
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Preprint: Multi-Modal Spatial Mapping of Cellular Senescence in Human Chronic Wounds from Aged Skin
papers.ssrn.com/sol3/papers.... @mayoclinic.org
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Preprint: NFATC2 mediates mechanical memory that primes cells for confined migration @ahcells.bsky.social @nusingapore.bsky.social
papers.ssrn.com/sol3/papers....
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Preprint: The Autoantibodyome Neuroimmune Signature of Neurodegeneration
papers.ssrn.com/sol3/papers....
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies @natcomms.nature.com
www.nature.com/articles/s41...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging @nataging.nature.com @bengurionuni.bsky.social
www.nature.com/articles/s43...
CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging - Nature Aging
Elyahu and colleagues describe the reciprocal interplay between senescent cells (SCs) and a helper T cell population that accumulates during aging. They show that selective depletion of this T cell population increases SC accumulation, accelerates frailty and limits lifespan in mice.
www.nature.com
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Large-scale generation of iNK and CAR-iNK cells from CD34+ hematopoietic stem and progenitor cells for adoptive immunotherapy @natbiomedeng.nature.com
www.nature.com/articles/s41...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire @natimmunol.nature.com @umasschan.bsky.social
www.nature.com/articles/s41...
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labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 23h
IFNγ-producing PD-1+ T cells are a potential key immune cell population mediating increased cardiovascular risk in patients with cancer receiving immune checkpoint inhibitor therapy @lunduniversity.bsky.social
www.nature.com/articles/s44...
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