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Ivan Zanoni @lozanzi.bsky.social · 1d

#LiveForever! Chen, Mao &co show @science.org that not all #cGAS are equals & that naked mole-rats one bears a 4 amino acid mutation which enhances DNA repair & when transferred in aged mice dampens frailty, hair graying, inflammatory & senescence markers! www.science.org/doi/10.1126/...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

www.science.org

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Reposted by Ivan Zanoni

Lorenz Adlung Lab @adlunglab.com · 1d

Late to the party, but: Host-oxidized phospholipids (oxPLs) form during infection & epigenetically silence IL-10 via AKT→EZH2→H3K27me3, driving lethal inflammation. Blocking oxPLs boosts IL-10 + survival. Kudos, @lozanzi.bsky.social; out in @cp-immunity.bsky.social:
doi.org/10.1016/j.im... 🧪

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…

doi.org

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Ivan Zanoni @lozanzi.bsky.social · 2d

Exciting #science as always @raflynn5.bsky.social &friends 👇👇👇 Thrilled to be part of this 🤗

Ryan Flynn @raflynn5.bsky.social · 3d

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

www.biorxiv.org

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Ivan Zanoni @lozanzi.bsky.social · 6d

#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟‍♂️ controls macrophage metabolism & gut inflammation. Low 🧟‍♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟‍♂️ drives glycolysis & intestinal inflammation 🔥 !!

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation

de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms macrophage energy metabolism in a concentration-dependent fashion, promoting either anti- or pro-inflammatory immun...

www.cell.com

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Ivan Zanoni @lozanzi.bsky.social · 7d

#Microbiota #FriendOrFoe? Our own @bostonchildrens.bsky.social Chatila, Benamar &co show @cp-immunity.bsky.social that #gut microbiota drives Notch3+ Tregs which migrate to brain & interacts with microglia becoming Th17 cells, subvert CNS resident neuropetide-responsive Tregs, supporting MS/EAE!

Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis

Benamar et al. demonstrate that Notch3+ Treg cells are increased in multiple sclerosis and in EAE. They are induced in the gut by microbiota and translocate to the CNS to degenerate into pathogenic Th...

www.cell.com

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Ivan Zanoni @lozanzi.bsky.social · 7d

Nicolas, one talk after the other non-stop… ahahah.. it was great seeing and talking to you in Lausanne! Already looking forward to the next time 😉

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Reposted by Ivan Zanoni

Adriana Forero @adforu.bsky.social · 8d

We are currently in the process of recruiting a technician. 🥼🐭🔬

If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!

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Ivan Zanoni @lozanzi.bsky.social · 9d

What a fantastic day to start the Immunobiology of #PRRs Symposium in beautiful Lausanne! Much looking forward to being part of an amazing line up of speakers, & to presenting a brand new story on a 100-year old protein whose function remains poorly understood! 😉

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Ivan Zanoni @lozanzi.bsky.social · 13d

#WeekendRead! #MicrobiotaPower! Jang, Jung &co show @natmetabolism.nature.com that dietary fibre protects against dietary fructose-driven insulin resistance & liver steatosis via promoting fructose utilization by small intestine microbiota & favoring anti-oxidant responses in the liver!

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis - Nature Metabolism

The dietary fibre inulin is shown to promote fructose catabolism by the small intestinal microbiome, thereby mitigating fructose-induced hepatic lipogenesis and steatosis.

bit.ly

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Ivan Zanoni @lozanzi.bsky.social · 14d

What a fantastic day spent @ Brown University talking about all things inflammation & innate immunity! Thanks Sanghyun Lee for hosting me, and to all faculties, postdocs & students for exciting discussions!

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Reposted by Ivan Zanoni

Régis Joulia @regisjoulia.bsky.social · 16d

🚨 We are #recruiting! 🚨My lab is looking for a highly motivated Research Technician to join us for the next 3 years.

👉 Apply via the link www.imperial.ac.uk/jobs/search-... or feel free to reach out for more information!

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Ivan Zanoni @lozanzi.bsky.social · 20d

#WeekendRead! #MicrobiotaPower! Wang, Lin &co reveal @immunity-cp.bsky.social that a #GutSkinAxis that drives skin inflammation in psoriatic prone mice & patients caused by indole-producing gut bugs that increase host I3S driving AHR-dependent skin Th17 activation! www.cell.com/immunity/abs...

Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells

Wang et al. demonstrate that gut rather than skin microbiota promote skin inflammation in a spontaneous psoriasis mouse model by fueling the production of the metabolite indoxyl sulfate (I3S). I3S amp...

www.cell.com

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Reposted by Ivan Zanoni

Jonathan Kagan @jkagan1.bsky.social · 21d

Original report on the regulators of TLR4 endocytosis and its importance in TRIF-IFN signaling.
@lozanzi.bsky.social @harvardmed.bsky.social @harvardmicro.bsky.social
www.cell.com/fulltext/S00...

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

The pattern recognition receptor CD14 not only delivers bacterial lipopolysaccharide to TLR4 on the plasma membrane of dendritic cells but also regulates TLR4 endocytosis and trafficking to the endoso...

www.cell.com

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Reposted by Ivan Zanoni

Jonathan Kagan @jkagan1.bsky.social · 21d

This work derives from prior studies on the structure-function relationship between Bacteroides LPS and TLR4 endocytosis and signaling.
www.sciencedirect.com/science/arti...

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria

Microbe-induced receptor trafficking has emerged as an essential means to promote innate immune signal transduction. Upon detection of bacterial lipop…

www.sciencedirect.com

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Ivan Zanoni @lozanzi.bsky.social · 22d

Fascinating discussion about cell death by several leaders in the field. If we get to understand cell death better, can we #LiveForever 😉?!👇👉 doi.org/10.1038/s41594-025-01646-x

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Ivan Zanoni @lozanzi.bsky.social · 23d

You are on 🔥 today! I see you everywhere 😉

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Reposted by Ivan Zanoni

Ada Weinstock @aweinstock.bsky.social · 23d

Thank you @jem.org for the invite to participate in this Viewpoint alongside such inspiring scientists 🤩🤩

Journal of Experimental Medicine @jem.org · 23d

In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher. rupress.org/jem/article/...
@quinascience.bsky.social @aweinstock.bsky.social @osterhoutlab.bsky.social
#WomeninSTEM

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Reposted by Ivan Zanoni

Ada Weinstock @aweinstock.bsky.social · 23d

So happy to see the final version of our paper out today @jclinical-invest.bsky.social 🤗

Journal of Clinical Investigation @jci.org · 23d

How diet influences atherosclerosis in obesity…

@aweinstock.bsky.social & team show short-term caloric restriction resolves atherosclerosis inflammation in obese mice, but weight regain accelerates its adverse effects: buff.ly/ieqwQ3O

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Reposted by Ivan Zanoni

Journal of Clinical Investigation @jci.org · 23d

How diet influences atherosclerosis in obesity…

@aweinstock.bsky.social & team show short-term caloric restriction resolves atherosclerosis inflammation in obese mice, but weight regain accelerates its adverse effects: buff.ly/ieqwQ3O

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Ivan Zanoni @lozanzi.bsky.social · 23d

Thanks for sharing!! 🤗

Reposted by Ivan Zanoni

Annemarthe Van der Veen @annemarthe.bsky.social · 23d

An amazing resource written by the great Ivan Zanoni and Daniel Boehmer! 👏🏻

Ivan Zanoni @lozanzi.bsky.social · Aug 21

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

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Ivan Zanoni @lozanzi.bsky.social · 25d

#InterferonPower! Li, Park &co show @cp-immunity.bsky.social that IL-15 negatively regulates CD103 expression on CD8 T cells allowing formation of effector T cells & that engagement of CD103 on CD8 T cells by E-cadherin+ dendritic cells is necessary to drive memory formation via type I IFNs & IL-12

Integrin CD103 expression in naive CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function

Integrin CD103 mediates memory T cell tissue residency by binding E-cadherin-expressing epithelial cells, but why CD103 is also expressed on circulating naive CD8+ T cells has been unclear. Li et al. ...

www.cell.com

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Ivan Zanoni @lozanzi.bsky.social · 27d

#WeekendRead #InterferonPower! Hegde, @miriammerad.bsky.social &co show @nature.com that #tumor-derived factors drive NRF2 activation in bone marrow myeloid progenitors, dampening IFN-I/-III responses & favoring emergence of immunosuppressive monocyte-derived macrophages!

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature

An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...

www.nature.com

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Ivan Zanoni @lozanzi.bsky.social · 28d

Thanks for sharing Thiago!! 😌

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Ivan Zanoni @lozanzi.bsky.social · 29d

Thanks Kat!! 😊