Adlung Lab
@adlunglab.com
Data-driven & knowledge-based. Rooted in Hamburg, Germany.
Adipose and/or Systems Biology + Inflammation.
Account handled by π @LorenzAdlung.com
www.adlunglab.com
Adipose and/or Systems Biology + Inflammation.
Account handled by π @LorenzAdlung.com
www.adlunglab.com
🧵 Super interesting: Zorn, Collet & Farooqi et al. @cam.ac.uk studied nearly 8,000 people with severe early onset obesity and found that MC4R deficiency causes obesity but unexpectedly protects against cardiovascular disease. How is this possible?
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January 12, 2026 at 7:11 AM
🧵 Super interesting: Zorn, Collet & Farooqi et al. @cam.ac.uk studied nearly 8,000 people with severe early onset obesity and found that MC4R deficiency causes obesity but unexpectedly protects against cardiovascular disease. How is this possible?
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Sunday read: Van Hul and Cani from UC Louvain reflect on 20 years of gut microbiome research. Despite linking gut bacteria to obesity, diabetes, cardiovascular disease, and more, clinical translation isn't there, yet. Why? ⤵️
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January 11, 2026 at 12:45 PM
Sunday read: Van Hul and Cani from UC Louvain reflect on 20 years of gut microbiome research. Despite linking gut bacteria to obesity, diabetes, cardiovascular disease, and more, clinical translation isn't there, yet. Why? ⤵️
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Choudhary & Li discuss how HIV escapes lenacapavir, the first capsid inhibitor dosed every 6 months. Pennetzdorfer et al. reveal three resistance pathways emerge during treatment failure. What are the consequences of these resistance mechanisms? ⬇️
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January 10, 2026 at 12:24 PM
Choudhary & Li discuss how HIV escapes lenacapavir, the first capsid inhibitor dosed every 6 months. Pennetzdorfer et al. reveal three resistance pathways emerge during treatment failure. What are the consequences of these resistance mechanisms? ⬇️
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Guo et al. identify OCR369, a cis-regulatory element that specifically controls RORγt expression in gut antigen-presenting cells but not in T cells. Why does this matter? ⬇️
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January 9, 2026 at 11:58 AM
Guo et al. identify OCR369, a cis-regulatory element that specifically controls RORγt expression in gut antigen-presenting cells but not in T cells. Why does this matter? ⬇️
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Wang et al. discover that adipocyte-derived extracellular vesicles (Ad-EVs) are key regulators of central leptin sensitivity. In obesity, the loss of leptin-sensitizing miRNAs in Ad-EVs contributes to leptin resistance and weight gain. But how does this work? ⬇️
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January 9, 2026 at 7:13 AM
Wang et al. discover that adipocyte-derived extracellular vesicles (Ad-EVs) are key regulators of central leptin sensitivity. In obesity, the loss of leptin-sensitizing miRNAs in Ad-EVs contributes to leptin resistance and weight gain. But how does this work? ⬇️
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👀 The German Research Foundation (DFG) now officially allows the (limited) use of LLMs for reviewing DFG grants. Use of LLMs in grant writing is allowed since 2023. Will be interesting to see how this will change "evaluation practice" in real life...
Oha, die @dfg.de erlaubt jetzt innerhalb eines klar definierten Rahmens den Einsatz von KI zur Begutachtung von Anträgen: www.dfg.de/de/aktuelles...
Bin gespannt, wie sich das auf die Praxis auswirken wird. Ich werde meine Anträge in Zukunft sicher anders (selbst) schreiben... Was meint ihr? 🧪
Bin gespannt, wie sich das auf die Praxis auswirken wird. Ich werde meine Anträge in Zukunft sicher anders (selbst) schreiben... Was meint ihr? 🧪
Künstliche Intelligenz in der Begutachtung
www.dfg.de
January 8, 2026 at 2:14 PM
👀 The German Research Foundation (DFG) now officially allows the (limited) use of LLMs for reviewing DFG grants. Use of LLMs in grant writing is allowed since 2023. Will be interesting to see how this will change "evaluation practice" in real life...
Venetos, Stomberski & Stamler et al. show that the denitrosylase SCoR2 promotes fat storage and lipogenesis. In mice, deleting or drugging SCoR2 prevented diet-induced obesity and fatty liver disease (MASLD). How does SCoR2 control lipid metabolism? ⬇️
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January 8, 2026 at 12:34 PM
Venetos, Stomberski & Stamler et al. show that the denitrosylase SCoR2 promotes fat storage and lipogenesis. In mice, deleting or drugging SCoR2 prevented diet-induced obesity and fatty liver disease (MASLD). How does SCoR2 control lipid metabolism? ⬇️
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Wang et al. discover mitoxyperilysis, a new lytic cell death mechanism triggered when innate immune activation meets metabolic stress. It is independent of pyroptosis, necroptosis, and ferroptosis. What is the mechanism? ⬇️
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January 8, 2026 at 6:00 AM
Wang et al. discover mitoxyperilysis, a new lytic cell death mechanism triggered when innate immune activation meets metabolic stress. It is independent of pyroptosis, necroptosis, and ferroptosis. What is the mechanism? ⬇️
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Last year, I submitted a grant, and two days later, I saw this @nature.com paper from @lodhilab.bsky.social coming out, which nicely supports (but doesn't scoop) the core idea of my proposal. Let's hope the reviewers keep up with the current literature! 🤞🏻
www.nature.com/artic... 🧪
www.nature.com/artic... 🧪
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis
Nature - A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for...
www.nature.com
January 7, 2026 at 1:43 PM
Last year, I submitted a grant, and two days later, I saw this @nature.com paper from @lodhilab.bsky.social coming out, which nicely supports (but doesn't scoop) the core idea of my proposal. Let's hope the reviewers keep up with the current literature! 🤞🏻
www.nature.com/artic... 🧪
www.nature.com/artic... 🧪
Ashayeripanah et al. reveal IL-4 markedly boosts cDC1 yield from bone marrow progenitors when combined with Flt3L. These type 1 conventional dendritic cells are rare but powerful immune sentinels against cancer. How does this work? ⬇️ (👀 @reginedress.bsky.social)
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January 7, 2026 at 7:02 AM
Ashayeripanah et al. reveal IL-4 markedly boosts cDC1 yield from bone marrow progenitors when combined with Flt3L. These type 1 conventional dendritic cells are rare but powerful immune sentinels against cancer. How does this work? ⬇️ (👀 @reginedress.bsky.social)
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Boulton, Grund & Scheraga et al. discover that TRPV4, a mechanosensitive ion channel, acts as a brake on lung inflammation. In bacterial pneumonia, TRPV4 limits macrophage activation by directly binding to the NF-κB subunit p65. What is the molecular mechanism? ⬇️
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January 6, 2026 at 12:47 PM
Boulton, Grund & Scheraga et al. discover that TRPV4, a mechanosensitive ion channel, acts as a brake on lung inflammation. In bacterial pneumonia, TRPV4 limits macrophage activation by directly binding to the NF-κB subunit p65. What is the molecular mechanism? ⬇️
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Great piece from Gerald Schweiger @tuwien.at
www.nature.com/artic... @nature.com
TL;DR: Cumulative costs spent on grant applications must not exceed available funding to prevent net drain of research resources. 🧪
How to prevent? ⤵️
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www.nature.com/artic... @nature.com
TL;DR: Cumulative costs spent on grant applications must not exceed available funding to prevent net drain of research resources. 🧪
How to prevent? ⤵️
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Point of no returns: researchers are crossing a threshold in the fight for funding
Nature - With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.
www.nature.com
January 6, 2026 at 6:49 AM
Great piece from Gerald Schweiger @tuwien.at
www.nature.com/artic... @nature.com
TL;DR: Cumulative costs spent on grant applications must not exceed available funding to prevent net drain of research resources. 🧪
How to prevent? ⤵️
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www.nature.com/artic... @nature.com
TL;DR: Cumulative costs spent on grant applications must not exceed available funding to prevent net drain of research resources. 🧪
How to prevent? ⤵️
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Two new @nature.com papers on HIV therapy point to immunological protection mediated by
stem-like CD8+ T cells and hint at therapeutic methods to boost their numbers.
N&V: www.nature.com/artic... @natimmunol.nature.com
Paper 1: doi.org/10.1038/s415...
Paper 2: doi.org/10.1038/s415...
stem-like CD8+ T cells and hint at therapeutic methods to boost their numbers.
N&V: www.nature.com/artic... @natimmunol.nature.com
Paper 1: doi.org/10.1038/s415...
Paper 2: doi.org/10.1038/s415...
Stemness for HIV control
Nature Immunology - Stemness for HIV control
www.nature.com
January 5, 2026 at 1:33 PM
Two new @nature.com papers on HIV therapy point to immunological protection mediated by
stem-like CD8+ T cells and hint at therapeutic methods to boost their numbers.
N&V: www.nature.com/artic... @natimmunol.nature.com
Paper 1: doi.org/10.1038/s415...
Paper 2: doi.org/10.1038/s415...
stem-like CD8+ T cells and hint at therapeutic methods to boost their numbers.
N&V: www.nature.com/artic... @natimmunol.nature.com
Paper 1: doi.org/10.1038/s415...
Paper 2: doi.org/10.1038/s415...
Our good friend and next-door colleague, Nikolai, just published his discovery, that mice restrict protein intake after illness, even at the cost of survival. Three amino acids (glutamine, lysine, threonine) drive this aversion. How is "too much protein" sensed by the body? ⬇️
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January 5, 2026 at 1:00 PM
Our good friend and next-door colleague, Nikolai, just published his discovery, that mice restrict protein intake after illness, even at the cost of survival. Three amino acids (glutamine, lysine, threonine) drive this aversion. How is "too much protein" sensed by the body? ⬇️
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Jin, Cenier & Schirmer et al. reveal that bacteria in the mouth are not restrained to the oral cavity. E.g., in liver disease, Veillonella and Streptococcus translocate to the gut where they produce a collagenase that worsens gut barrier damage. How? ⬇️
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January 5, 2026 at 9:01 AM
Jin, Cenier & Schirmer et al. reveal that bacteria in the mouth are not restrained to the oral cavity. E.g., in liver disease, Veillonella and Streptococcus translocate to the gut where they produce a collagenase that worsens gut barrier damage. How? ⬇️
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Weekend 🧵
Li & Sokol et al. screen 85 gut microbiota metabolites and discover indole-3-propionic acid (IPA) boosts mitochondrial respiration in CD4+ T cells while suppressing glycolysis.
How does this work? ⬇️
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Li & Sokol et al. screen 85 gut microbiota metabolites and discover indole-3-propionic acid (IPA) boosts mitochondrial respiration in CD4+ T cells while suppressing glycolysis.
How does this work? ⬇️
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January 4, 2026 at 8:10 AM
Weekend 🧵
Li & Sokol et al. screen 85 gut microbiota metabolites and discover indole-3-propionic acid (IPA) boosts mitochondrial respiration in CD4+ T cells while suppressing glycolysis.
How does this work? ⬇️
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Li & Sokol et al. screen 85 gut microbiota metabolites and discover indole-3-propionic acid (IPA) boosts mitochondrial respiration in CD4+ T cells while suppressing glycolysis.
How does this work? ⬇️
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van Rijn & Lopes et al. develop a live imaging platform for studying Salmonella attacks on human gut organoids. Immature intestinal cells are highly permissive to invasion, but what happens when they mature? ⬇️
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January 3, 2026 at 8:45 AM
van Rijn & Lopes et al. develop a live imaging platform for studying Salmonella attacks on human gut organoids. Immature intestinal cells are highly permissive to invasion, but what happens when they mature? ⬇️
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Casanueva Reimon, Gouveia & Steculorum et al. reveal early-life fat odors alone can prime obesity in offspring. Feeding dams bacon-scented chow (same calories as normal diet) was enough to reprogram metabolic responses. But how? ⬇️
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January 2, 2026 at 9:56 AM
Casanueva Reimon, Gouveia & Steculorum et al. reveal early-life fat odors alone can prime obesity in offspring. Feeding dams bacon-scented chow (same calories as normal diet) was enough to reprogram metabolic responses. But how? ⬇️
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🎆 Mukherjee et al. show hepatocyte mitochondrial NAD⁺ content limits liver regeneration. The transporter SLC25A51 controls this pool. Its overexpressing boosts regeneration as effectively as systemic NAD⁺ supplements. @pennmedicine.bsky.social @natmetabolism.nature.com doi.org/10.1038/s422... 🧪
Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration
Nature Metabolism - Modulating mitochondrial NAD+ levels by changing the expression of the mitochondrial NAD+ transporter, SLC25A51, Mukherjee et al. demonstrate that mitochondrial, rather than...
doi.org
January 1, 2026 at 6:46 AM
🎆 Mukherjee et al. show hepatocyte mitochondrial NAD⁺ content limits liver regeneration. The transporter SLC25A51 controls this pool. Its overexpressing boosts regeneration as effectively as systemic NAD⁺ supplements. @pennmedicine.bsky.social @natmetabolism.nature.com doi.org/10.1038/s422... 🧪
🐋🧬 Firsanov, Zacher & Gorbunova et al. reveal why bowhead whales live 200+ years: enhanced DNA repair via CIRBP, no extra tumor suppressors! Whale cells have fewer mutations and CIRBP overexpression extended lifespan in Drosophila. 🪰 @nature.com
doi.org/10.1038/s415... 🧪
doi.org/10.1038/s415... 🧪
Evidence for improved DNA repair in the long-lived bowhead whale
Nature - Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.
doi.org
December 31, 2025 at 7:48 AM
🐋🧬 Firsanov, Zacher & Gorbunova et al. reveal why bowhead whales live 200+ years: enhanced DNA repair via CIRBP, no extra tumor suppressors! Whale cells have fewer mutations and CIRBP overexpression extended lifespan in Drosophila. 🪰 @nature.com
doi.org/10.1038/s415... 🧪
doi.org/10.1038/s415... 🧪
TL;DR: Reviewers cited in the second round of revisions are more likely to accept a manuscript, but less so if they request being cited themselves…
Are peer reviewers influenced by their work being cited?
Coercive citations
Reviewer citation requests can turn peer review into a transaction rather than an objective critique of the article.
buff.ly
December 30, 2025 at 8:53 AM
TL;DR: Reviewers cited in the second round of revisions are more likely to accept a manuscript, but less so if they request being cited themselves…
Lu, Zhang et al. develop PBSP to track PTM-specific protein secretion. They identify 818 itaconated secreted proteins in macrophages and show itaconation of FYN at Cys239 enhances kinase activity. @natcomms.nature.com
doi.org/10.1038/s414... 🧪
doi.org/10.1038/s414... 🧪
Spatiotemporal profiling of modification-specific proteome secretion uncovers an itaconation-activated tyrosine kinase
Nature Communications - Macrophages secrete diverse signaling proteins critical for intercellular communication and immune responses, processes tightly regulated by post-translational modifications...
doi.org
December 30, 2025 at 6:21 AM
Lu, Zhang et al. develop PBSP to track PTM-specific protein secretion. They identify 818 itaconated secreted proteins in macrophages and show itaconation of FYN at Cys239 enhances kinase activity. @natcomms.nature.com
doi.org/10.1038/s414... 🧪
doi.org/10.1038/s414... 🧪
Fernandez et al. use scRNA-seq + live-cell imaging to show quiescence and senescence exist on a continuum after chemotherapy, and not discrete states. They identify distinct "senotypes" and two paths to arrest. Key finding? ⬇️
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December 29, 2025 at 1:10 PM
Fernandez et al. use scRNA-seq + live-cell imaging to show quiescence and senescence exist on a continuum after chemotherapy, and not discrete states. They identify distinct "senotypes" and two paths to arrest. Key finding? ⬇️
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I discussed this with med school students in class during December. Turns out most concern on their side comes from bias. Privacy issues could be addressed by running local models on their laptops.
AI software is increasingly involved in reviewing papers, provoking interest and unease
go.nature.com/4qbaDj8
go.nature.com/4qbaDj8
AI is transforming peer review — and many scientists are worried
Artificial intelligence software is increasingly involved in reviewing papers, provoking interest and unease.
go.nature.com
December 28, 2025 at 5:05 PM
I discussed this with med school students in class during December. Turns out most concern on their side comes from bias. Privacy issues could be addressed by running local models on their laptops.
Wonderful holiday read: Khanmohammadi, Mirzaalikhan & Baratchi from Melbourne review how mechanical forces shape macrophage biology in @cellchembiol.bsky.social
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December 28, 2025 at 8:28 AM
Wonderful holiday read: Khanmohammadi, Mirzaalikhan & Baratchi from Melbourne review how mechanical forces shape macrophage biology in @cellchembiol.bsky.social
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