Lorenz Adlung Lab
@adlunglab.com
Data-driven & knowledge-based. Rooted in Hamburg, Germany.
Adipose and/or Systems Biology + Inflammation.
Account handled by π @LorenzAdlung.com
www.adlunglab.com
Adipose and/or Systems Biology + Inflammation.
Account handled by π @LorenzAdlung.com
www.adlunglab.com
Nice one: Adipocyte extracellular vesicles (EVs) fine-tune brain leptin signaling via miRNAs, driving energy balance. Engineered EVs delivering leptin-sensitizing miR-148a-3p (targeting SOCS3) reversed obesity in mice. From Wang et al.:
doi.org/10.1016/j.cm... 🧪
in @cp-cellmetabolism.bsky.social
doi.org/10.1016/j.cm... 🧪
in @cp-cellmetabolism.bsky.social
November 25, 2025 at 6:53 AM
Nice one: Adipocyte extracellular vesicles (EVs) fine-tune brain leptin signaling via miRNAs, driving energy balance. Engineered EVs delivering leptin-sensitizing miR-148a-3p (targeting SOCS3) reversed obesity in mice. From Wang et al.:
doi.org/10.1016/j.cm... 🧪
in @cp-cellmetabolism.bsky.social
doi.org/10.1016/j.cm... 🧪
in @cp-cellmetabolism.bsky.social
Our good friend @christophthaiss.bsky.social from @arcinstitute.org argues in the current @cp-immunity.bsky.social Voices that cytokine sensing by the brain may be key to decoding age-related decline, borrowing the concept of interoception from Erwin Schrödinger:
www.sciencedirect.co... 🧪
www.sciencedirect.co... 🧪
Aging and immunity
Time marches endlessly on … but what does that mean for the immune system? Here, investigators discuss how aging impacts the immune response and how i…
www.sciencedirect.com
November 24, 2025 at 7:05 AM
Our good friend @christophthaiss.bsky.social from @arcinstitute.org argues in the current @cp-immunity.bsky.social Voices that cytokine sensing by the brain may be key to decoding age-related decline, borrowing the concept of interoception from Erwin Schrödinger:
www.sciencedirect.co... 🧪
www.sciencedirect.co... 🧪
Shi et al. screened 707 drugs on gut-derived communities and found that nutrient competition plays a key role in how drugs reshape microbiomes. Great resource from Kerwyn Casey Huang and colleagues in @cp-cell.bsky.social
doi.org/10.1016/j.ce... 🧪
doi.org/10.1016/j.ce... 🧪
Nutrient competition predicts gut microbiome restructuring under drug perturbations
Human gut bacteria are routinely exposed to stresses, and community-level responses are difficult to predict. To interrogate these effects, we screene…
doi.org
November 20, 2025 at 6:48 AM
Shi et al. screened 707 drugs on gut-derived communities and found that nutrient competition plays a key role in how drugs reshape microbiomes. Great resource from Kerwyn Casey Huang and colleagues in @cp-cell.bsky.social
doi.org/10.1016/j.ce... 🧪
doi.org/10.1016/j.ce... 🧪
From single cells to whole organs. Leading edge article in @cp-cell.bsky.social explores “mesoscale modules” as key building blocks of tissue function. Conceptual network motifs for multicellular dynamics. A nice mind model for tackling complexity in biology: doi.org/10.1016/j.ce... 🧪
Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function
Recent studies at molecular and genomic scales have enriched our understanding of life’s most fundamental building block: the cell. However, bridging …
doi.org
November 19, 2025 at 7:27 AM
From single cells to whole organs. Leading edge article in @cp-cell.bsky.social explores “mesoscale modules” as key building blocks of tissue function. Conceptual network motifs for multicellular dynamics. A nice mind model for tackling complexity in biology: doi.org/10.1016/j.ce... 🧪
Our collaboration partners from Hamburg and Kiel published in @cp-cellreports.bsky.social a resource on how probiotics shape gut microbiomes in very-low-birth-weight infants at risk for late-onset sepsis.
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November 18, 2025 at 9:00 AM
Our collaboration partners from Hamburg and Kiel published in @cp-cellreports.bsky.social a resource on how probiotics shape gut microbiomes in very-low-birth-weight infants at risk for late-onset sepsis.
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Really cool work from the lab of Joshua D. Rabinowitz @princeton.edu: Spatial mapping of metabolites across mouse liver and small intestine. Interesting that stem cells in the crypt taste other lipids than mature enterocytes at the tip of the vilus (Fig. 2)
🔗 www.nature.com/artic... 🧪
🔗 www.nature.com/artic... 🧪
Spatial metabolic gradients in the liver and small intestine
Nature - Mapping of spatial metabolic gradients in the mouse liver and intestine identifies fructose-induced focal derangements in liver metabolism.
www.nature.com
November 17, 2025 at 7:45 AM
Really cool work from the lab of Joshua D. Rabinowitz @princeton.edu: Spatial mapping of metabolites across mouse liver and small intestine. Interesting that stem cells in the crypt taste other lipids than mature enterocytes at the tip of the vilus (Fig. 2)
🔗 www.nature.com/artic... 🧪
🔗 www.nature.com/artic... 🧪
We care a lot about time. Now one of my best science friends, Melania Barile, et al. introduce TemporalVAE, a deep generative model that maps scRNA-seq data onto developmental time! It works with zero-shot & identifies time-sensitive genes @natcellbio.nature.com
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TemporalVAE: atlas-assisted temporal mapping of time-series single-cell transcriptomes during embryogenesis
Nature Cell Biology - Liu et al. present TemporalVAE, a method for integrating single-cell time course data. The model proposes a workflow to determine the biological timing of samples and its...
doi.org
November 16, 2025 at 8:08 AM
We care a lot about time. Now one of my best science friends, Melania Barile, et al. introduce TemporalVAE, a deep generative model that maps scRNA-seq data onto developmental time! It works with zero-shot & identifies time-sensitive genes @natcellbio.nature.com
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Single-cell multiomics reveals a nestin-negative mesenchymal stem-like subpopulation driving malignant peripheral nerve sheath tumors; distinct from nestin-positive cells and tied to clinical severity. ZEB1 & ALDH1A1 emerge as therapeutic targets.
www.science.org/doi/... 🧪
www.science.org/doi/... 🧪
Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy
Single-cell omics reveals nestin-negative mesenchymal neural crest stem-like cells and key regulators for MPNST malignancy.
www.science.org
November 15, 2025 at 8:19 AM
Single-cell multiomics reveals a nestin-negative mesenchymal stem-like subpopulation driving malignant peripheral nerve sheath tumors; distinct from nestin-positive cells and tied to clinical severity. ZEB1 & ALDH1A1 emerge as therapeutic targets.
www.science.org/doi/... 🧪
www.science.org/doi/... 🧪
Mitochondrial dysfunction in myeloid cells drives autoimmunity via maladaptive states like exhaustion and senescence. E.g., in lupus, VDAC1-mediated mtDNA release activates cGAS-STING, fueling chronic IFN signaling, write Kwong & Kaplan in @cp-trendsimmuno.bsky.social
doi.org/10.1016/j.it... 🧪
doi.org/10.1016/j.it... 🧪
Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases
Autoimmune diseases arise from genetic and environmental factors that disrupt immune tolerance. Recent studies highlight the role of myeloid cell immu…
doi.org
November 14, 2025 at 7:57 AM
Mitochondrial dysfunction in myeloid cells drives autoimmunity via maladaptive states like exhaustion and senescence. E.g., in lupus, VDAC1-mediated mtDNA release activates cGAS-STING, fueling chronic IFN signaling, write Kwong & Kaplan in @cp-trendsimmuno.bsky.social
doi.org/10.1016/j.it... 🧪
doi.org/10.1016/j.it... 🧪
MASLD & sarcopenia are linked by more than age: visceral fat & insulin resistance drive both, liver and muscle disease. E.g., Zheng et al. highlight how low muscle-to-visceral fat ratio predicts advanced fibrosis. @natrevendo.nature.com doi.org/10.1038/s415... 🧪
Sarcopenia and MASLD: novel insights and the future
Nature Reviews Endocrinology - There is growing recognition of the metabolic links between metabolic dysfunction-associated steatotic liver disease (MASLD) and sarcopenia and the need to take these...
doi.org
November 13, 2025 at 6:25 AM
MASLD & sarcopenia are linked by more than age: visceral fat & insulin resistance drive both, liver and muscle disease. E.g., Zheng et al. highlight how low muscle-to-visceral fat ratio predicts advanced fibrosis. @natrevendo.nature.com doi.org/10.1038/s415... 🧪
Dural mast cells at the CSF–brain interface are gatekeepers of neuroinflammation; blocking or permitting immune cell entry in stroke and meningitis. Spotlight in @cp-trendsimmuno.bsky.social by our good friends from @aleksdelab.bsky.social
doi.org/10.1016/j.it... 🧪
doi.org/10.1016/j.it... 🧪
Keep your neutrophils close, but your mast cells closer
Immune activity at the cerebrospinal fluid (CSF)–dura–brain interface regulates key functions of brain physiology. In two back-to-back papers, Mamulad…
doi.org
November 12, 2025 at 10:28 AM
Dural mast cells at the CSF–brain interface are gatekeepers of neuroinflammation; blocking or permitting immune cell entry in stroke and meningitis. Spotlight in @cp-trendsimmuno.bsky.social by our good friends from @aleksdelab.bsky.social
doi.org/10.1016/j.it... 🧪
doi.org/10.1016/j.it... 🧪
Aging remodels tissue-resident macrophages; e.g., pro-inflammatory(!), lipid-associated macrophages expand in aged muscle, reflecting altered repair and inflammatory states. Terekhova et al. review human human immune aging in @cp-immunity.bsky.social
doi.org/10.1016/j.im... 🧪
doi.org/10.1016/j.im... 🧪
Human immune aging
Aging is an essential aspect of human life, and studying its mechanisms is crucial for extending lifespan and improving quality of life. The immune sy…
doi.org
November 11, 2025 at 6:21 AM
Aging remodels tissue-resident macrophages; e.g., pro-inflammatory(!), lipid-associated macrophages expand in aged muscle, reflecting altered repair and inflammatory states. Terekhova et al. review human human immune aging in @cp-immunity.bsky.social
doi.org/10.1016/j.im... 🧪
doi.org/10.1016/j.im... 🧪
Was really great to host a workshop / "hackathon" for mathematical modelling of single-cell data in Hamburg, I think the pictures speak for themselves:
November 7, 2025 at 11:21 AM
Was really great to host a workshop / "hackathon" for mathematical modelling of single-cell data in Hamburg, I think the pictures speak for themselves:
"Healthy obese" in UK biobank. 266 genetic variants linked to body fat distribution & metabolic health.
8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪
8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities
Nature Medicine - Genotype-phenotype data from over 450,000 individuals was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower...
doi.org
October 17, 2025 at 12:24 PM
"Healthy obese" in UK biobank. 266 genetic variants linked to body fat distribution & metabolic health.
8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪
8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪
I‘m very happy that our recent publication was selected as Paper Of the Month by the dean’s office. Paid off that I insisted to submit an application even though we knew it’s gonna be a tough competition.
www.sciencedirect.com/science/arti... 🧪
www.sciencedirect.com/science/arti... 🧪
October 17, 2025 at 10:39 AM
I‘m very happy that our recent publication was selected as Paper Of the Month by the dean’s office. Paid off that I insisted to submit an application even though we knew it’s gonna be a tough competition.
www.sciencedirect.com/science/arti... 🧪
www.sciencedirect.com/science/arti... 🧪
Wow, @pascual-reguant.bsky.social, very impressive talk at #EMBLSpatialBiology! Presented preprint with @hoheyn.bsky.social: www.biorxiv.org/content/10.1...
You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪
You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪
Imaging-based multimodal profiling of single cells with STAMP - Nature Reviews Genetics
In this Tools of the Trade article, Kellie Wise and Anna Pascual-Reguant introduce STAMP (single-cell transcriptomics analysis and multimodal profiling), which harnesses imaging to measure RNA and/or ...
www.nature.com
October 17, 2025 at 9:21 AM
Wow, @pascual-reguant.bsky.social, very impressive talk at #EMBLSpatialBiology! Presented preprint with @hoheyn.bsky.social: www.biorxiv.org/content/10.1...
You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪
You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪
Very interesting talk by @orrlaboratory.bsky.social at #EMBLSpatialBiology. In preparation, I read their recent paper, and found some decent astrocyte signalling and proteinopathy in it 👇🏻👇🏻 www.sciencedirect.com/science/arti... 🧪
Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology
Alterations in transactivating response region DNA-binding protein 43 (TDP-43) are prevalent in amyotrophic lateral sclerosis (ALS), frontotemporal de…
www.sciencedirect.com
October 17, 2025 at 8:16 AM
Very interesting talk by @orrlaboratory.bsky.social at #EMBLSpatialBiology. In preparation, I read their recent paper, and found some decent astrocyte signalling and proteinopathy in it 👇🏻👇🏻 www.sciencedirect.com/science/arti... 🧪
Clostridium butyricum targets colorectal cancer via secD–GRP78. Suppression of IL-6 reactivates CD8⁺ T cells & boosts anti-PD-1. Validated in humanized mice and patient organoids in co-culture with tumor-infiltrating lymphocytes: doi.org/10.1016/j.cc... 🧪 @cp-cancercell.bsky.social
Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
Most colorectal cancer (CRC) patients do not respond to immune checkpoint blockade (ICB) therapy. Here, we identify Clostridium butyricum as a probiot…
doi.org
October 16, 2025 at 6:00 AM
Clostridium butyricum targets colorectal cancer via secD–GRP78. Suppression of IL-6 reactivates CD8⁺ T cells & boosts anti-PD-1. Validated in humanized mice and patient organoids in co-culture with tumor-infiltrating lymphocytes: doi.org/10.1016/j.cc... 🧪 @cp-cancercell.bsky.social
Awesome talk by @halloulab.bsky.social at #EMBLSpatialBiology. May the force be with you in biophysical phenotypes of spatial transcriptomics; out now in @natmethods.nature.com: www.nature.com/articles/s41... 🧪
A computational pipeline for spatial mechano-transcriptomics - Nature Methods
The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.
www.nature.com
October 15, 2025 at 1:58 PM
Awesome talk by @halloulab.bsky.social at #EMBLSpatialBiology. May the force be with you in biophysical phenotypes of spatial transcriptomics; out now in @natmethods.nature.com: www.nature.com/articles/s41... 🧪
Stunning, what @sabrinalewis.bsky.social just showed at #EMBLSpatialBiology! LeGO depicts cell populations in lung metastases in 3D: www.researchsquare.com/article/rs-6... 🧪 Soon out in npj Imaging @natureportfolio.nature.com
LeGO-3D: 3D imaging of lung metastases and vascularisation using light sheet fluorescence microscopy
Cancer metastasis involves a complex cascade of events, where cancer cells migrate from their site of origin to secondary sites via the lymphatic and circulatory system. During this process, some canc...
www.researchsquare.com
October 15, 2025 at 12:33 PM
Stunning, what @sabrinalewis.bsky.social just showed at #EMBLSpatialBiology! LeGO depicts cell populations in lung metastases in 3D: www.researchsquare.com/article/rs-6... 🧪 Soon out in npj Imaging @natureportfolio.nature.com
🧬 miR-10a liposomes rewire macrophage mitochondrial metabolism (↑OXPHOS), boost H3 acetylation, inducing epigenetic M1→M2 shift. Liposome injection leads to shrinkage of plaques in ApoE−/− mice. Fei Fang et al. in @natcomms.nature.com: doi.org/10.1038/s414... 🧪
Reprogramming mitochondrial metabolism and epigenetics of macrophages via miR-10a liposomes for atherosclerosis therapy
Nature Communications - This study shows that restoring mitochondrial respiration in atherosclerotic macrophages reopens their chromatin, enabling phenotype reprogramming. Using targeted liposomes...
doi.org
October 15, 2025 at 10:27 AM
🧬 miR-10a liposomes rewire macrophage mitochondrial metabolism (↑OXPHOS), boost H3 acetylation, inducing epigenetic M1→M2 shift. Liposome injection leads to shrinkage of plaques in ApoE−/− mice. Fei Fang et al. in @natcomms.nature.com: doi.org/10.1038/s414... 🧪
Really cool talk (even though confidential) by @pathologop.bsky.social at #EMBLSpatialBiology!
So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol:
journals.plos.org/ploscompbiol... 🧪
So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol:
journals.plos.org/ploscompbiol... 🧪
The tumour histopathology “glossary” for AI developers
The applications of artificial intelligence (AI) and deep learning (DL) are leading to significant advances in cancer research, particularly in analysing histopathology images for prognostic and treat...
journals.plos.org
October 15, 2025 at 9:29 AM
Really cool talk (even though confidential) by @pathologop.bsky.social at #EMBLSpatialBiology!
So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol:
journals.plos.org/ploscompbiol... 🧪
So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol:
journals.plos.org/ploscompbiol... 🧪
Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology!
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer - Nature Genetics
This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.
www.nature.com
October 15, 2025 at 7:28 AM
Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology!
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Ressource of chronic sinus inflammation shows that M2-like macrophages attract eosinophils, mast and tuft (!) cells amplifying Th2 response. Airway stem cells drive tissue remodeling; effects are reduced by dupilumab. @cp-immunity.bsky.social by Guanrui Liao et al. doi.org/10.1016/j.im... 🧪
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal cavity affecting millions worldwide. Its complex pathophysiolog…
doi.org
October 15, 2025 at 7:27 AM
Ressource of chronic sinus inflammation shows that M2-like macrophages attract eosinophils, mast and tuft (!) cells amplifying Th2 response. Airway stem cells drive tissue remodeling; effects are reduced by dupilumab. @cp-immunity.bsky.social by Guanrui Liao et al. doi.org/10.1016/j.im... 🧪