Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct localization, turnover, and phenotypes. Septal adipose ...

A small-molecule heme oxygenase inhibitor disrupts perivascular macrophage–mediated suppression of T cell responses in preclinical models of cancer.

Obesity is associated with chronic, low-grade inflammation in metabolic tissues such as liver, adipose tissue and skeletal muscle implicating insulin …

Nature Metabolism - Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here,...

PPARγ downregulation in colonic CD8+ T cells from people with HIV (PWH) on antiretroviral therapy (ART) disrupts lipid metabolism and promotes contact-dependent epithelial apoptosis, leading to intestinal barrier dysfunction. Pharmacological activation of PPARγ restores metabolic fitness and reduces epithelial damage, revealing a potential therapeutic target for mucosal repair in PWH.

Nature Metabolism - The authors provide a comprehensive characterization of how glutamine uptake and utilization regulate macrophage function in atherosclerosis.

With thousands of papers being published everyday, it can be a task working out which matter. Here are some tips to help you decide.

Nature - Delphi-2M forecasts a person’s future health, covering more than 1,000 diseases, provides insights into co-morbidity dynamics and generates synthetic data for the training of AI...

To determine whether HIV persistence arises from the natural dynamics of memory (m)CD4+ T cells, we compare clonal dynamics of HIV proviruses and mCD4…

Nature Medicine - Using data from six population-scale cohorts involving more than 10 million individuals, a large language model-based aging signature is shown to outperform traditional aging...

A significant complication of Crohn’s disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the…

Nature Immunology - Mitochondrial electron transport chain activity provides ATP, generates superoxide, regulates apoptosis and provides the biosynthetic building blocks for growing cells. Here...

Dumont et al. reveal that although heat generated by shivering muscles and by the heart increases based on the degree of cold exposure, heat-producing mechanisms present in adipose tissues like brown and white fat respond in an all-or-nothing fashion. In brown fat, the heat produced likely reflects its thermogenic capacity.

npj Systems Biology and Applications - Dynamical systems theory as an organizing principle for single-cell biology

Nature - Bluesky posts about science garner more likes and reposts than similar ones on X.

Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.

With age and disease, skeletal muscle is progressively lost and replaced by fibrotic scar and intramuscular adipose tissue (IMAT). While strongly corr…