Journal of Experimental Medicine
@jem.org
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jem
🌐 rupress.org/jem
New report from Zhou et al. (rupress.org/jem/article/...) provides important new insights into the genotype–phenotype correlation and the molecular pathogenesis of essential #thrombocythemia. Insights by Skoda and Silvennoinen: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
November 25, 2025 at 8:15 PM
New report from Zhou et al. (rupress.org/jem/article/...) provides important new insights into the genotype–phenotype correlation and the molecular pathogenesis of essential #thrombocythemia. Insights by Skoda and Silvennoinen: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology
November 25, 2025 at 7:00 PM
Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology
Hanson Tam, Jason Cyster et al. identify GPR34 as a receptor required for cDC1 efferocytosis and cross-presentation and suggest a model where PLA1A catabolizes phosphatidylserine on apoptotic cells to generate GPR34 ligands. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
November 24, 2025 at 7:45 PM
Hanson Tam, Jason Cyster et al. identify GPR34 as a receptor required for cDC1 efferocytosis and cross-presentation and suggest a model where PLA1A catabolizes phosphatidylserine on apoptotic cells to generate GPR34 ligands. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
✍️ 💻 JEM's latest #CME activity @mskcme.bsky.social is now available! New content 📄: “Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis (Zhou et al. doi.org/10.1084/jem....
Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
November 24, 2025 at 3:15 PM
✍️ 💻 JEM's latest #CME activity @mskcme.bsky.social is now available! New content 📄: “Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis (Zhou et al. doi.org/10.1084/jem....
Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
November 21, 2025 at 8:15 PM
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
Reposted by Journal of Experimental Medicine
📢📢NEW PAPER📢📢
Sequencing has greatly accelerated the number of known human genetic immune disorders--we immunologists call them 'inborn errors of immunity'.
This review in @jem.org is our attempt to summarize all the described single gene defects affecting the IRF family of transcription factors.
Sequencing has greatly accelerated the number of known human genetic immune disorders--we immunologists call them 'inborn errors of immunity'.
This review in @jem.org is our attempt to summarize all the described single gene defects affecting the IRF family of transcription factors.
Stojcic et al. @turveylab.bsky.social review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
November 21, 2025 at 5:51 PM
📢📢NEW PAPER📢📢
Sequencing has greatly accelerated the number of known human genetic immune disorders--we immunologists call them 'inborn errors of immunity'.
This review in @jem.org is our attempt to summarize all the described single gene defects affecting the IRF family of transcription factors.
Sequencing has greatly accelerated the number of known human genetic immune disorders--we immunologists call them 'inborn errors of immunity'.
This review in @jem.org is our attempt to summarize all the described single gene defects affecting the IRF family of transcription factors.
Stojcic et al. @turveylab.bsky.social review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
November 21, 2025 at 5:45 PM
Stojcic et al. @turveylab.bsky.social review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
Panda et al. of the Colonna lab identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
November 21, 2025 at 5:01 PM
Panda et al. of the Colonna lab identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
ICYMI: Read the latest #neuroscience research in JEM! The collection highlights the latest discoveries in meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...
#SfN25
#SfN25
November 21, 2025 at 3:30 PM
ICYMI: Read the latest #neuroscience research in JEM! The collection highlights the latest discoveries in meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...
#SfN25
#SfN25
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
November 20, 2025 at 7:45 PM
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
AC/DC: Highway to Cell. Victor Bosteels (@victor-bosteels.bsky.social), William Stainier, and Caetano Reis e Sousa (@reisesousalab.bsky.social) @crick.ac.uk discuss work by Tam et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#InnateImmunity #DendriticCells
#InnateImmunity #DendriticCells
November 20, 2025 at 3:30 PM
AC/DC: Highway to Cell. Victor Bosteels (@victor-bosteels.bsky.social), William Stainier, and Caetano Reis e Sousa (@reisesousalab.bsky.social) @crick.ac.uk discuss work by Tam et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#InnateImmunity #DendriticCells
#InnateImmunity #DendriticCells
Esther Obeng leads a research group focused on myelodysplastic syndromes (MDS), investigating how normal hematopoietic #StemCells develop into cancerous cells, as well as developing targeted therapies for MDS patients. We spoke to Esther for our latest #PeopleAndIdeas: rupress.org/jem/article/...
November 19, 2025 at 8:15 PM
Esther Obeng leads a research group focused on myelodysplastic syndromes (MDS), investigating how normal hematopoietic #StemCells develop into cancerous cells, as well as developing targeted therapies for MDS patients. We spoke to Esther for our latest #PeopleAndIdeas: rupress.org/jem/article/...
@vinitiwari1.bsky.social & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 19, 2025 at 4:15 PM
@vinitiwari1.bsky.social & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Final day at #SfN25! If you're in San Diego, stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
November 19, 2025 at 4:15 PM
Final day at #SfN25! If you're in San Diego, stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
New findings from Bauer, Halin et al. @ethz.ch reveal key differences between human and murine dermal afferent #lymphatics and provide a deeper understanding of human lymphatic-related (patho)physiological processes: rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity #inflammation
#CardiovascularBiology #InnateImmunity #inflammation
November 18, 2025 at 7:45 PM
New findings from Bauer, Halin et al. @ethz.ch reveal key differences between human and murine dermal afferent #lymphatics and provide a deeper understanding of human lymphatic-related (patho)physiological processes: rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity #inflammation
#CardiovascularBiology #InnateImmunity #inflammation
In this review, Lennol, @maudgratuze.bsky.social et al. assess all the available evidence regarding how two crucial elements are intertwined in #Alzheimers disease pathophysiology: tau and apoE. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 18, 2025 at 4:15 PM
In this review, Lennol, @maudgratuze.bsky.social et al. assess all the available evidence regarding how two crucial elements are intertwined in #Alzheimers disease pathophysiology: tau and apoE. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Attending #SfN25 in San Diego? Stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
November 18, 2025 at 3:45 PM
Attending #SfN25 in San Diego? Stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote #thrombocytosis. Radek Skoda and Olli Silvennoinen (@bcmhouston.bsky.social) highlight new work from the Bo Huang group (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
November 18, 2025 at 3:45 PM
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote #thrombocytosis. Radek Skoda and Olli Silvennoinen (@bcmhouston.bsky.social) highlight new work from the Bo Huang group (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Papadopoulos, Kipnis et al. present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 17, 2025 at 4:15 PM
Papadopoulos, Kipnis et al. present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Attending #SfN25 in San Diego? Visit @rupress.org booth #3719 to chat about the journal and pick up our #Neuroscience Collection magazine 📚 as well as an exclusive pouch! 🎁 We look forward to meeting you! 💬 💡
November 17, 2025 at 3:00 PM
Attending #SfN25 in San Diego? Visit @rupress.org booth #3719 to chat about the journal and pick up our #Neuroscience Collection magazine 📚 as well as an exclusive pouch! 🎁 We look forward to meeting you! 💬 💡
Reposted by Journal of Experimental Medicine
Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.
Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
November 13, 2025 at 9:18 PM
Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.
Reposted by Journal of Experimental Medicine
The Other Vessels: Subsets of lymphatic vessel lining & valve cells in the skin revealed by single-cell RNA sequencing & 3D imaging
📷 Aline Bauer et al, @ethz.ch in @jem.org
➡️ bpod.org.uk/archive/2025...
📷 Aline Bauer et al, @ethz.ch in @jem.org
➡️ bpod.org.uk/archive/2025...
November 15, 2025 at 11:57 AM
The Other Vessels: Subsets of lymphatic vessel lining & valve cells in the skin revealed by single-cell RNA sequencing & 3D imaging
📷 Aline Bauer et al, @ethz.ch in @jem.org
➡️ bpod.org.uk/archive/2025...
📷 Aline Bauer et al, @ethz.ch in @jem.org
➡️ bpod.org.uk/archive/2025...
Reposted by Journal of Experimental Medicine
We are so excited to announce that our latest paper is out in @jem.org
By combining single-cell RNA sequencing and 3D imaging, we reveal striking structural and molecular differences between human and mouse dermal lymphatic vasculature, opening up new perspectives on #Lymphatics and #HumanBiology
By combining single-cell RNA sequencing and 3D imaging, we reveal striking structural and molecular differences between human and mouse dermal lymphatic vasculature, opening up new perspectives on #Lymphatics and #HumanBiology
Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin | Journal of Experimental Medicine | Rockefeller University Press
This study reveals how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–bas
rupress.org
November 15, 2025 at 10:07 PM
We are so excited to announce that our latest paper is out in @jem.org
By combining single-cell RNA sequencing and 3D imaging, we reveal striking structural and molecular differences between human and mouse dermal lymphatic vasculature, opening up new perspectives on #Lymphatics and #HumanBiology
By combining single-cell RNA sequencing and 3D imaging, we reveal striking structural and molecular differences between human and mouse dermal lymphatic vasculature, opening up new perspectives on #Lymphatics and #HumanBiology
Reposted by Journal of Experimental Medicine
Check out our new study in @jem.org on #Lymphatics using #SingleCell and #3DImaging in human skin, revealing new features of the lymphatic vascular system in #HumanBiology!
Transcriptomics- and 3D imaging-based characterization of the lymphatic vasculature in human skin. New study from Aline Bauer, Cornelia Halin and colleagues @ethz.ch: rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity #inflammation #Lymphatics
#CardiovascularBiology #InnateImmunity #inflammation #Lymphatics
November 15, 2025 at 10:25 PM
Check out our new study in @jem.org on #Lymphatics using #SingleCell and #3DImaging in human skin, revealing new features of the lymphatic vascular system in #HumanBiology!
Reposted by Journal of Experimental Medicine
It was a great pleasure to be a part of this new study from @halinlab.bsky.social focusing on the #Lymphatics in human skin!
Transcriptomics- and 3D imaging-based characterization of the lymphatic vasculature in human skin. New study from Aline Bauer, Cornelia Halin and colleagues @ethz.ch: rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity #inflammation #Lymphatics
#CardiovascularBiology #InnateImmunity #inflammation #Lymphatics
November 16, 2025 at 12:14 AM
It was a great pleasure to be a part of this new study from @halinlab.bsky.social focusing on the #Lymphatics in human skin!