Journal of Experimental Medicine
@jem.org
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
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The 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward 👉 rupress.org/jem/collecti...
Transient inhibition of type I interferon enhances CD8⁺ T cell stemness and #vaccine protection. From Benjamin Broomfield @benjbroom.bsky.social, Joanna Groom @groomlab.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 9, 2026 at 3:15 PM
Transient inhibition of type I interferon enhances CD8⁺ T cell stemness and #vaccine protection. From Benjamin Broomfield @benjbroom.bsky.social, Joanna Groom @groomlab.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design. From Kevin Groen, Benjamin Hale (@benhale.bsky.social) and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Autoimmunity
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Autoimmunity
January 8, 2026 at 3:15 PM
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design. From Kevin Groen, Benjamin Hale (@benhale.bsky.social) and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Autoimmunity
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Autoimmunity
Reposted by Journal of Experimental Medicine
Happy New Year from all of us @jem.org. For this month’s #JEMLegacy we are going back to the 90s with this report on lymphotoxin’s role in chronic inflammation
tinyurl.com/2ua2cezw
tinyurl.com/2ua2cezw
January 7, 2026 at 5:27 PM
Happy New Year from all of us @jem.org. For this month’s #JEMLegacy we are going back to the 90s with this report on lymphotoxin’s role in chronic inflammation
tinyurl.com/2ua2cezw
tinyurl.com/2ua2cezw
Sirimuvva Tadepalli, Derek Clements, Juliana Idoyaga @idoyagalab.bsky.social and colleagues reveal that CD301b⁺ monocyte-derived dendritic cells mediate resistance to #radiotherapy 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 7, 2026 at 3:15 PM
Sirimuvva Tadepalli, Derek Clements, Juliana Idoyaga @idoyagalab.bsky.social and colleagues reveal that CD301b⁺ monocyte-derived dendritic cells mediate resistance to #radiotherapy 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...
#InfectiousDisease
#InfectiousDisease
January 7, 2026 at 2:30 PM
In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...
#InfectiousDisease
#InfectiousDisease
Reposted by Journal of Experimental Medicine
Congrats to Jirka and Dominik @imgprague.bsky.social It was a privilege to help a bit together with other labs from the Faculty of Science @sciencecharles.bsky.social Charles University @sciencecharles.bsky.social.
Březina et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...
#Tolerance #Autoimmunity
#Tolerance #Autoimmunity
January 7, 2026 at 7:16 AM
Congrats to Jirka and Dominik @imgprague.bsky.social It was a privilege to help a bit together with other labs from the Faculty of Science @sciencecharles.bsky.social Charles University @sciencecharles.bsky.social.
Březina et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...
#Tolerance #Autoimmunity
#Tolerance #Autoimmunity
January 6, 2026 at 8:30 PM
Březina et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...
#Tolerance #Autoimmunity
#Tolerance #Autoimmunity
Review: The cribriform plate is a skull region where olfactory nerves link the nasal cavity and brain. Laaker, Fabry et al. review evidence that this interface also acts as a gateway between the CNS and the peripheral immune system, with relevance to neuropathologies. rupress.org/jem/article/...htt
January 6, 2026 at 6:30 PM
Review: The cribriform plate is a skull region where olfactory nerves link the nasal cavity and brain. Laaker, Fabry et al. review evidence that this interface also acts as a gateway between the CNS and the peripheral immune system, with relevance to neuropathologies. rupress.org/jem/article/...htt
Lettera et al. @dimiccolab.bsky.social show that human #hematopoiesis across #aging is characterized by stable #StemCell numbers and reduced erythroid/lymphoid output. rupress.org/jem/article/...
#TechnicalAdvances #Resources #StemCells
#TechnicalAdvances #Resources #StemCells
January 6, 2026 at 6:01 PM
Lettera et al. @dimiccolab.bsky.social show that human #hematopoiesis across #aging is characterized by stable #StemCell numbers and reduced erythroid/lymphoid output. rupress.org/jem/article/...
#TechnicalAdvances #Resources #StemCells
#TechnicalAdvances #Resources #StemCells
RORγt eTACs mediate oral #tolerance and Treg induction. From Im-Hong Sun, Anita Qualls, Han Yin, James Gardner @gardnerlabucsf.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 6, 2026 at 3:15 PM
RORγt eTACs mediate oral #tolerance and Treg induction. From Im-Hong Sun, Anita Qualls, Han Yin, James Gardner @gardnerlabucsf.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Cunzhen Li, Zhen Xiong, Deyuan Kong et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/...
#Microbiome #IBD #Inflammation
#Microbiome #IBD #Inflammation
January 5, 2026 at 9:30 PM
Cunzhen Li, Zhen Xiong, Deyuan Kong et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/...
#Microbiome #IBD #Inflammation
#Microbiome #IBD #Inflammation
Bittar, Nussenzweig et al. @rockefeller.edu describe expanded clones of authentic CD4+ T cell carrying intact latent HIV-1 proviruses derived from people living with #HIV. Their transcriptome mirrors their primary cells of origin. rupress.org/jem/article/...
January 5, 2026 at 9:15 PM
Bittar, Nussenzweig et al. @rockefeller.edu describe expanded clones of authentic CD4+ T cell carrying intact latent HIV-1 proviruses derived from people living with #HIV. Their transcriptome mirrors their primary cells of origin. rupress.org/jem/article/...
Farré Díaz, Kabrani, Rajewsky et al. @mdc-berlin.bsky.social describe a broadly applicable system for sequential targeted mutagenesis using two recombinases sequentially activated from a single locus. rupress.org/jem/article/...
January 5, 2026 at 9:00 PM
Farré Díaz, Kabrani, Rajewsky et al. @mdc-berlin.bsky.social describe a broadly applicable system for sequential targeted mutagenesis using two recombinases sequentially activated from a single locus. rupress.org/jem/article/...
Jiuxing Feng, Baitong Wu, Yujiang Geno Shi et al. show that Tet2ΔMye exacerbates liver #fibrosis through stabilizing Ccl2/Ccl8 mRNAs in pro-inflammatory monocyte-derived #macrophages, creating a #chemokine-driven inflammatory loop. rupress.org/jem/article/...
#Inflammation
#Inflammation
January 5, 2026 at 8:45 PM
Jiuxing Feng, Baitong Wu, Yujiang Geno Shi et al. show that Tet2ΔMye exacerbates liver #fibrosis through stabilizing Ccl2/Ccl8 mRNAs in pro-inflammatory monocyte-derived #macrophages, creating a #chemokine-driven inflammatory loop. rupress.org/jem/article/...
#Inflammation
#Inflammation
#TcellEngagers (#TCEs) are engineered to redirect the body’s #Tcells toward disease. Their versatility, expanding target range, and growing clinical impact are redefining immune-based therapy. In a new review, Baeuerle et al. describe why they’re rising so quickly.: rupress.org/jem/article/...
January 5, 2026 at 8:30 PM
#TcellEngagers (#TCEs) are engineered to redirect the body’s #Tcells toward disease. Their versatility, expanding target range, and growing clinical impact are redefining immune-based therapy. In a new review, Baeuerle et al. describe why they’re rising so quickly.: rupress.org/jem/article/...
JEM’s January issue is here! rupress.org/jem/issue/22...
The cover is a light-sheet #microscopy image of a cleared, immunostained human skin biopsy depicting podoplanin-positive, αSMA-negative lymphatic vessels (yellow-red) & αSMA-positive blood vessels (blue). (Bauer et al. doi.org/10.1084/jem....)
The cover is a light-sheet #microscopy image of a cleared, immunostained human skin biopsy depicting podoplanin-positive, αSMA-negative lymphatic vessels (yellow-red) & αSMA-positive blood vessels (blue). (Bauer et al. doi.org/10.1084/jem....)
January 5, 2026 at 4:30 PM
JEM’s January issue is here! rupress.org/jem/issue/22...
The cover is a light-sheet #microscopy image of a cleared, immunostained human skin biopsy depicting podoplanin-positive, αSMA-negative lymphatic vessels (yellow-red) & αSMA-positive blood vessels (blue). (Bauer et al. doi.org/10.1084/jem....)
The cover is a light-sheet #microscopy image of a cleared, immunostained human skin biopsy depicting podoplanin-positive, αSMA-negative lymphatic vessels (yellow-red) & αSMA-positive blood vessels (blue). (Bauer et al. doi.org/10.1084/jem....)
Neonatal #microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon. By Åsa Johansson, George Birchenough @gobletcellguy.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 5, 2026 at 3:15 PM
Neonatal #microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon. By Åsa Johansson, George Birchenough @gobletcellguy.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Xu, Batista et al. @ragoninstitute.bsky.social found that FIP200, a complex molecule with multiple functions in and beyond the #autophagy pathway, regulates the proliferation of B cells after activation and prevents the accumulation of dysfunctional #mitochondria rupress.org/jem/article/...
December 31, 2025 at 8:45 PM
Xu, Batista et al. @ragoninstitute.bsky.social found that FIP200, a complex molecule with multiple functions in and beyond the #autophagy pathway, regulates the proliferation of B cells after activation and prevents the accumulation of dysfunctional #mitochondria rupress.org/jem/article/...
Cayatte, Picant, Vétizou, & Vivier @ciml.bsky.social review current insights into human #NKcell heterogeneity and function, their roles in viral #infection, #autoimmunity, #neurodegeneration, and #transplantation, and the emerging therapeutic opportunities they offer. rupress.org/jem/article/...
December 31, 2025 at 2:30 PM
Cayatte, Picant, Vétizou, & Vivier @ciml.bsky.social review current insights into human #NKcell heterogeneity and function, their roles in viral #infection, #autoimmunity, #neurodegeneration, and #transplantation, and the emerging therapeutic opportunities they offer. rupress.org/jem/article/...
ICYMI: Read our special collection highlighting important JEM studies by Shimon Sakaguchi on regulatory T (Treg) cells. 👉 rupress.org/jem/collecti...
Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, this year's #NobelPrize winners in Physiology or Medicine!
Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, this year's #NobelPrize winners in Physiology or Medicine!
December 30, 2025 at 9:15 PM
ICYMI: Read our special collection highlighting important JEM studies by Shimon Sakaguchi on regulatory T (Treg) cells. 👉 rupress.org/jem/collecti...
Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, this year's #NobelPrize winners in Physiology or Medicine!
Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, this year's #NobelPrize winners in Physiology or Medicine!
New work from LeBlanc, Sobel, Constantinides (@mikerobe.bsky.social) et al. @scripps.edu demonstrates that transient depletion of riboflavin-synthesizing commensals in early life can adversely affect responses to subsequent infections. rupress.org/jem/article/...
#MucosalImmunology #Microbiome #MAIT
#MucosalImmunology #Microbiome #MAIT
December 30, 2025 at 4:15 PM
New work from LeBlanc, Sobel, Constantinides (@mikerobe.bsky.social) et al. @scripps.edu demonstrates that transient depletion of riboflavin-synthesizing commensals in early life can adversely affect responses to subsequent infections. rupress.org/jem/article/...
#MucosalImmunology #Microbiome #MAIT
#MucosalImmunology #Microbiome #MAIT
Gut dysbiosis from high-salt diet promotes #glioma via propionate-mediated TGF-β activation. From Chae Won Kim, Hyun-Jin Kim, Heung Kyu Lee, and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Microbiome
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Microbiome
December 30, 2025 at 3:15 PM
Gut dysbiosis from high-salt diet promotes #glioma via propionate-mediated TGF-β activation. From Chae Won Kim, Hyun-Jin Kim, Heung Kyu Lee, and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Microbiome
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Microbiome
In this perspective, Ryan Langlois @langloislab.bsky.social suggests that understanding fever’s role in shaping antiviral gene #evolution may illuminate blind spots in our comprehension of host–pathogen interactions and antiviral mechanisms. rupress.org/jem/article/...
#InfectiousDisease #Virology
#InfectiousDisease #Virology
December 29, 2025 at 7:29 PM
In this perspective, Ryan Langlois @langloislab.bsky.social suggests that understanding fever’s role in shaping antiviral gene #evolution may illuminate blind spots in our comprehension of host–pathogen interactions and antiviral mechanisms. rupress.org/jem/article/...
#InfectiousDisease #Virology
#InfectiousDisease #Virology
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal #fibrosis and homeostasis. From Ahmed Kabil, Michael Hughes, Kelly McNagny @kmcnagny.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
December 29, 2025 at 3:15 PM
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal #fibrosis and homeostasis. From Ahmed Kabil, Michael Hughes, Kelly McNagny @kmcnagny.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Recent study from Arai, Kawakami, Sakaguchi and colleagues shows that oral antigen exposure under co-stimulation blockade induces Treg cells to establish immune #tolerance. rupress.org/jem/article/...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
December 29, 2025 at 3:15 PM
Recent study from Arai, Kawakami, Sakaguchi and colleagues shows that oral antigen exposure under co-stimulation blockade induces Treg cells to establish immune #tolerance. rupress.org/jem/article/...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...
📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...