Journal of Experimental Medicine
@jem.org
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
π rupress.org/jem
π rupress.org/jem
Pinned
The 2025 ππ¦π΄π΅ π°π§ πππ highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward π rupress.org/jem/collecti...
ERAdP facilitates biogenesis of dense core vesicles in #Paneth cells to enhance intestinal defense, say Cunzhen Li, Zhen Xiong, Deyuan Kong, Yun Chen, Qiang Zhan, Zusen Fan (Institute of Biophysics, Chinese Academy of Sciences) and colleagues: rupress.org/jem/article/...
#InfectiousDisease #IBD
#InfectiousDisease #IBD
January 12, 2026 at 4:04 PM
ERAdP facilitates biogenesis of dense core vesicles in #Paneth cells to enhance intestinal defense, say Cunzhen Li, Zhen Xiong, Deyuan Kong, Yun Chen, Qiang Zhan, Zusen Fan (Institute of Biophysics, Chinese Academy of Sciences) and colleagues: rupress.org/jem/article/...
#InfectiousDisease #IBD
#InfectiousDisease #IBD
FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells, say Carlota FarrΓ© DΓaz, Eleni Kabrani, Klaus Rajewsky and colleagues @mdc-berlin.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology
#LymphocyteBiology
January 12, 2026 at 3:45 PM
FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells, say Carlota FarrΓ© DΓaz, Eleni Kabrani, Klaus Rajewsky and colleagues @mdc-berlin.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology
#LymphocyteBiology
Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes. From @hlpeks.bsky.social, @emmaschambers.bsky.social, @bcellsrosser.bsky.social, Ciurtin et al. π rupress.org/jem/article/...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 12, 2026 at 3:15 PM
Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes. From @hlpeks.bsky.social, @emmaschambers.bsky.social, @bcellsrosser.bsky.social, Ciurtin et al. π rupress.org/jem/article/...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Tet2 deficiencyβinduced expansion of monocyte-derived #macrophages promotes liver #fibrosis Jiuxing Feng, Baitong Wu, Yujiang Geno Shi and colleagues (Fudan University): rupress.org/jem/article/...
#Hematopoiesis #InnateImmunity #Inflammation
#Hematopoiesis #InnateImmunity #Inflammation
January 12, 2026 at 3:03 PM
Tet2 deficiencyβinduced expansion of monocyte-derived #macrophages promotes liver #fibrosis Jiuxing Feng, Baitong Wu, Yujiang Geno Shi and colleagues (Fudan University): rupress.org/jem/article/...
#Hematopoiesis #InnateImmunity #Inflammation
#Hematopoiesis #InnateImmunity #Inflammation
T cell engagers emerge as a compelling therapeutic modality. New review from Baeuerle, Grieshaber-Bouyer, Sauer, and Michaelson: rupress.org/jem/article/...
#CancerFocus #TumorImmunology #TcellEngagers
#CancerFocus #TumorImmunology #TcellEngagers
January 12, 2026 at 2:30 PM
T cell engagers emerge as a compelling therapeutic modality. New review from Baeuerle, Grieshaber-Bouyer, Sauer, and Michaelson: rupress.org/jem/article/...
#CancerFocus #TumorImmunology #TcellEngagers
#CancerFocus #TumorImmunology #TcellEngagers
Transient inhibition of type I interferon enhances CD8βΊ T cell stemness and #vaccine protection. From Benjamin Broomfield @benjbroom.bsky.social, Joanna Groom @groomlab.bsky.social and colleagues π rupress.org/jem/article/...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 9, 2026 at 3:15 PM
Transient inhibition of type I interferon enhances CD8βΊ T cell stemness and #vaccine protection. From Benjamin Broomfield @benjbroom.bsky.social, Joanna Groom @groomlab.bsky.social and colleagues π rupress.org/jem/article/...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design. From Kevin Groen, Benjamin Hale (@benhale.bsky.social) and colleagues π rupress.org/jem/article/...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Autoimmunity
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Autoimmunity
January 8, 2026 at 3:15 PM
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design. From Kevin Groen, Benjamin Hale (@benhale.bsky.social) and colleagues π rupress.org/jem/article/...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Autoimmunity
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
#Autoimmunity
Reposted by Journal of Experimental Medicine
Happy New Year from all of us @jem.org. For this monthβs #JEMLegacy we are going back to the 90s with this report on lymphotoxinβs role in chronic inflammation
tinyurl.com/2ua2cezw
tinyurl.com/2ua2cezw
January 7, 2026 at 5:27 PM
Happy New Year from all of us @jem.org. For this monthβs #JEMLegacy we are going back to the 90s with this report on lymphotoxinβs role in chronic inflammation
tinyurl.com/2ua2cezw
tinyurl.com/2ua2cezw
Sirimuvva Tadepalli, Derek Clements, Juliana Idoyaga @idoyagalab.bsky.social and colleagues reveal that CD301bβΊ monocyte-derived dendritic cells mediate resistance to #radiotherapy π rupress.org/jem/article/...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 7, 2026 at 3:15 PM
Sirimuvva Tadepalli, Derek Clements, Juliana Idoyaga @idoyagalab.bsky.social and colleagues reveal that CD301bβΊ monocyte-derived dendritic cells mediate resistance to #radiotherapy π rupress.org/jem/article/...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1βΊCXCL5βΊ #fibroblasts & SPP1βΊ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...
#InfectiousDisease
#InfectiousDisease
January 7, 2026 at 2:30 PM
In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1βΊCXCL5βΊ #fibroblasts & SPP1βΊ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...
#InfectiousDisease
#InfectiousDisease
Reposted by Journal of Experimental Medicine
Congrats to Jirka and Dominik @imgprague.bsky.social It was a privilege to help a bit together with other labs from the Faculty of Science @sciencecharles.bsky.social Charles University @sciencecharles.bsky.social.
BΕezina et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...
#Tolerance #Autoimmunity
#Tolerance #Autoimmunity
January 7, 2026 at 7:16 AM
Congrats to Jirka and Dominik @imgprague.bsky.social It was a privilege to help a bit together with other labs from the Faculty of Science @sciencecharles.bsky.social Charles University @sciencecharles.bsky.social.
BΕezina et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...
#Tolerance #Autoimmunity
#Tolerance #Autoimmunity
January 6, 2026 at 8:30 PM
BΕezina et al. @czechacademy.bsky.social show that #Claudin 1 enables thymic type 1 #DendriticCells to localize in close proximity to medullary thymic epithelial cells, supporting the maturation & tolerogenic function of type 1 dendritic cells rupress.org/jem/article/...
#Tolerance #Autoimmunity
#Tolerance #Autoimmunity
Review: The cribriform plate is a skull region where olfactory nerves link the nasal cavity and brain. Laaker, Fabry et al. review evidence that this interface also acts as a gateway between the CNS and the peripheral immune system, with relevance to neuropathologies. rupress.org/jem/article/...htt
January 6, 2026 at 6:30 PM
Review: The cribriform plate is a skull region where olfactory nerves link the nasal cavity and brain. Laaker, Fabry et al. review evidence that this interface also acts as a gateway between the CNS and the peripheral immune system, with relevance to neuropathologies. rupress.org/jem/article/...htt
Lettera et al. @dimiccolab.bsky.social show that human #hematopoiesis across #aging is characterized by stable #StemCell numbers and reduced erythroid/lymphoid output. rupress.org/jem/article/...
#TechnicalAdvances #Resources #StemCells
#TechnicalAdvances #Resources #StemCells
January 6, 2026 at 6:01 PM
Lettera et al. @dimiccolab.bsky.social show that human #hematopoiesis across #aging is characterized by stable #StemCell numbers and reduced erythroid/lymphoid output. rupress.org/jem/article/...
#TechnicalAdvances #Resources #StemCells
#TechnicalAdvances #Resources #StemCells
RORΞ³t eTACs mediate oral #tolerance and Treg induction. From Im-Hong Sun, Anita Qualls, Han Yin, James Gardner @gardnerlabucsf.bsky.social and colleagues π rupress.org/jem/article/...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 6, 2026 at 3:15 PM
RORΞ³t eTACs mediate oral #tolerance and Treg induction. From Im-Hong Sun, Anita Qualls, Han Yin, James Gardner @gardnerlabucsf.bsky.social and colleagues π rupress.org/jem/article/...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Cunzhen Li, Zhen Xiong, Deyuan Kong et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/...
#Microbiome #IBD #Inflammation
#Microbiome #IBD #Inflammation
January 5, 2026 at 9:30 PM
Cunzhen Li, Zhen Xiong, Deyuan Kong et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/...
#Microbiome #IBD #Inflammation
#Microbiome #IBD #Inflammation
Bittar, Nussenzweig et al. @rockefeller.edu describe expanded clones of authentic CD4+ T cell carrying intact latent HIV-1 proviruses derived from people living with #HIV. Their transcriptome mirrors their primary cells of origin. rupress.org/jem/article/...
January 5, 2026 at 9:15 PM
Bittar, Nussenzweig et al. @rockefeller.edu describe expanded clones of authentic CD4+ T cell carrying intact latent HIV-1 proviruses derived from people living with #HIV. Their transcriptome mirrors their primary cells of origin. rupress.org/jem/article/...
FarrΓ© DΓaz, Kabrani, Rajewsky et al. @mdc-berlin.bsky.social describe a broadly applicable system for sequential targeted mutagenesis using two recombinases sequentially activated from a single locus. rupress.org/jem/article/...
January 5, 2026 at 9:00 PM
FarrΓ© DΓaz, Kabrani, Rajewsky et al. @mdc-berlin.bsky.social describe a broadly applicable system for sequential targeted mutagenesis using two recombinases sequentially activated from a single locus. rupress.org/jem/article/...
Jiuxing Feng, Baitong Wu, Yujiang Geno Shi et al. show that Tet2ΞMye exacerbates liver #fibrosis through stabilizing Ccl2/Ccl8 mRNAs in pro-inflammatory monocyte-derived #macrophages, creating a #chemokine-driven inflammatory loop. rupress.org/jem/article/...
#Inflammation
#Inflammation
January 5, 2026 at 8:45 PM
Jiuxing Feng, Baitong Wu, Yujiang Geno Shi et al. show that Tet2ΞMye exacerbates liver #fibrosis through stabilizing Ccl2/Ccl8 mRNAs in pro-inflammatory monocyte-derived #macrophages, creating a #chemokine-driven inflammatory loop. rupress.org/jem/article/...
#Inflammation
#Inflammation
#TcellEngagers (#TCEs) are engineered to redirect the bodyβs #Tcells toward disease. Their versatility, expanding target range, and growing clinical impact are redefining immune-based therapy. In a new review, Baeuerle et al. describe why theyβre rising so quickly.: rupress.org/jem/article/...
January 5, 2026 at 8:30 PM
#TcellEngagers (#TCEs) are engineered to redirect the bodyβs #Tcells toward disease. Their versatility, expanding target range, and growing clinical impact are redefining immune-based therapy. In a new review, Baeuerle et al. describe why theyβre rising so quickly.: rupress.org/jem/article/...
JEMβs January issue is here! rupress.org/jem/issue/22...
The cover is a light-sheet #microscopy image of a cleared, immunostained human skin biopsy depicting podoplanin-positive, Ξ±SMA-negative lymphatic vessels (yellow-red) & Ξ±SMA-positive blood vessels (blue). (Bauer et al. doi.org/10.1084/jem....)
The cover is a light-sheet #microscopy image of a cleared, immunostained human skin biopsy depicting podoplanin-positive, Ξ±SMA-negative lymphatic vessels (yellow-red) & Ξ±SMA-positive blood vessels (blue). (Bauer et al. doi.org/10.1084/jem....)
January 5, 2026 at 4:30 PM
JEMβs January issue is here! rupress.org/jem/issue/22...
The cover is a light-sheet #microscopy image of a cleared, immunostained human skin biopsy depicting podoplanin-positive, Ξ±SMA-negative lymphatic vessels (yellow-red) & Ξ±SMA-positive blood vessels (blue). (Bauer et al. doi.org/10.1084/jem....)
The cover is a light-sheet #microscopy image of a cleared, immunostained human skin biopsy depicting podoplanin-positive, Ξ±SMA-negative lymphatic vessels (yellow-red) & Ξ±SMA-positive blood vessels (blue). (Bauer et al. doi.org/10.1084/jem....)
Neonatal #microbiota colonization primes maturation of goblet cellβmediated protection in the pre-weaning colon. By Γ
sa Johansson, George Birchenough @gobletcellguy.bsky.social and colleagues π rupress.org/jem/article/...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 5, 2026 at 3:15 PM
Neonatal #microbiota colonization primes maturation of goblet cellβmediated protection in the pre-weaning colon. By Γ
sa Johansson, George Birchenough @gobletcellguy.bsky.social and colleagues π rupress.org/jem/article/...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
π Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Xu, Batista et al. @ragoninstitute.bsky.social found that FIP200, a complex molecule with multiple functions in and beyond the #autophagy pathway, regulates the proliferation of B cells after activation and prevents the accumulation of dysfunctional #mitochondria rupress.org/jem/article/...
December 31, 2025 at 8:45 PM
Xu, Batista et al. @ragoninstitute.bsky.social found that FIP200, a complex molecule with multiple functions in and beyond the #autophagy pathway, regulates the proliferation of B cells after activation and prevents the accumulation of dysfunctional #mitochondria rupress.org/jem/article/...
Cayatte, Picant, VΓ©tizou, & Vivier @ciml.bsky.social review current insights into human #NKcell heterogeneity and function, their roles in viral #infection, #autoimmunity, #neurodegeneration, and #transplantation, and the emerging therapeutic opportunities they offer. rupress.org/jem/article/...
December 31, 2025 at 2:30 PM
Cayatte, Picant, VΓ©tizou, & Vivier @ciml.bsky.social review current insights into human #NKcell heterogeneity and function, their roles in viral #infection, #autoimmunity, #neurodegeneration, and #transplantation, and the emerging therapeutic opportunities they offer. rupress.org/jem/article/...
ICYMI: Read our special collection highlighting important JEM studies by Shimon Sakaguchi on regulatory T (Treg) cells. π rupress.org/jem/collecti...
Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, this year's #NobelPrize winners in Physiology or Medicine!
Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, this year's #NobelPrize winners in Physiology or Medicine!
December 30, 2025 at 9:15 PM
ICYMI: Read our special collection highlighting important JEM studies by Shimon Sakaguchi on regulatory T (Treg) cells. π rupress.org/jem/collecti...
Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, this year's #NobelPrize winners in Physiology or Medicine!
Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, this year's #NobelPrize winners in Physiology or Medicine!