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Reposted by Journal of Experimental Medicine

Lucie Van Emmenis @lucie-jexpmed.bsky.social · 28m

And if you needed any more convincing about the importance of #Tregs, check out this #Viewpoint written by Shimon for @jem.org's 125th anniversary about the role of Tregs in immunological self-tolerance and autoimmunity 👉 rupress.org/jem/article/...

Taking regulatory T cells into medicine | Journal of Experimental Medicine | Rockefeller University Press

Shimon Sakaguchi recounts the work that lead to the identification of regulatory T cells.

rupress.org

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Reposted by Journal of Experimental Medicine

Lucie Van Emmenis @lucie-jexpmed.bsky.social · 28m

In light of Monday’s #Nobel Prize in Physiology or Medicine announcement, for #JEMLegacy let’s look back at one of Shimon Sakaguchi’s early @jem.org papers from 1985! rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 3h

Lioba Koerner, Xiaoming Li, Eveline Silnov, Lucie Laurien, and Manolis Pasparakis @unicologne.bsky.social reveal that a functional interplay of S161 and S166 phosphorylation events regulates RIPK1-dependent #CellDeath and #inflammation. rupress.org/jem/article/...

Journal of Experimental Medicine @jem.org · 3h

Tao Han, Chenchen Ruan, Jiahuai Han, Yingying Zhang et al. elucidate a mechanism of RIPK1 kinase–dependent function in TNF signaling and its role in cecal pathology and mouse mortality. rupress.org/jem/article/...

#InnateImmunity #Inflammation

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Journal of Experimental Medicine @jem.org · 3h

Virus imprinting matters: OC43-primed S2 antibodies show neutralizing potential and broad activity across five beta-#coronavirus subgenera, while #SARSCoV2-primed S2 antibodies remain narrow to sarbecoviruses and are largely non-neutralizing. From Changrob et al. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 4h

Idorn, Paludan et al. @au.dk characterize a mouse strain harboring a mutation found in a herpes simplex encephalitis patient. Defective IFN-driven antiviral responses led to hyperactivation of #inflammation, contributing to disease development. rupress.org/jem/article/...

@civia-aarhus.bsky.social

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Journal of Experimental Medicine @jem.org · 1d

Volodymyr Stetsenko, Daniel P. Gail, Stephen M. Carpenter et al. propose that the identification of TCRs, antigen specificities, and effector functions linked to CD4+ T cell recognition of M. #tuberculosis-infected macrophages will inform #TB vaccine design. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 1d

ICYMI: a special collection spotlighting recent, cutting-edge research on the mechanistic aspects of innate immune signaling upon #infection, in #autoimmunity, and in #neurodegeneration.

rupress.org/jem/collecti...

#InnateImmunity

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Journal of Experimental Medicine @jem.org · 2d

Han et al. reveal that RIPK1 S161 autophosphorylation promotes further autophosphorylation and can substitute for RIPK1 kinase activity in TNF-induced #necroptosis-mediated cecal damage and mouse death. rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

Journal of Experimental Medicine @jem.org · 2d

Xu et al. show that the cGAS-TREX1 axis forms a critical negative feedback loop in MSI-H/dMMR tumors. Trex1 loss amplifies tumor-intrinsic cGAS–STING signaling & activates CD8+ T cell–mediated antitumor immunity, highlighting TREX1 inhibition’s therapeutic potential

Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity

This study demonstrates that the cGAS-TREX1 axis forms a critical negative feedback loop, enabling immune evasion in MSI-H/dMMR tumors. They revealed that

rupress.org

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Journal of Experimental Medicine @jem.org · 2d

✍️ 💻 Our latest #CME activity @mskcme.bsky.social is now available! 👉 mskcc.cloud-cme.com/course/cours...

📄: “Multi-omics uncovers transcriptional programs of gut-resident memory CD4⁺ T cells in Crohn’s disease (Arase et al. doi.org/10.1084/jem....)

Journal of Experimental Medicine @jem.org · 2d

William Branchett, Anne O’Garra et al. @crick.ac.uk suggest that early type I IFN signaling during M. #tuberculosis infection favors #neutrophil accumulation and limits CD4+ T cell infiltration into developing lesions. rupress.org/jem/article/...

#TB

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Journal of Experimental Medicine @jem.org · 2d

Lioba Koerner, Xiaoming Li, Eveline Silnov, Lucie Laurien, and Manolis Pasparakis @unicologne.bsky.social show that RIPK1 autophosphorylation at S161 is crucial for regulating cell death and #inflammation. rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

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Journal of Experimental Medicine @jem.org · 2d

CD2 and its ligands are involved in development and activation of #MAITcells, say Kaiwen Zhu, Yan Lu, André Veillette et al. @ircm.bsky.social rupress.org/jem/article/...

#InnateImmunity #LymphocyteBiology

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Journal of Experimental Medicine @jem.org · 3d

The STING pathway drives non-inflammatory #neurodegeneration in NGLY1 deficiency, say Kun Yang, Nan Yan and colleagues (UT Southwestern Medical Center): rupress.org/jem/article/...

From our Pattern Recognition Receptors & Beyond #InnateImmunity collection: rupress.org/jem/collecti...

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Journal of Experimental Medicine @jem.org · 3d

Congratulations to JEM advisory editor Shimon Sakaguchi, along with Mary Brunkow and Fred Ramsdell, on winning the 2025 #Nobel Prize in Physiology or Medicine for their groundbreaking discoveries on peripheral immune tolerance

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Journal of Experimental Medicine @jem.org · 3d

Our October issue is here! rupress.org/jem/issue/22...
The cover image shows the lung of a mouse infected with M. #tuberculosis stained for #neutrophils (orange) normal lung parenchyma (blue), collagen (white) and CD4 T cells (green). See @bengern.bsky.social et al. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · 3d

Wouters, Meyts et al. @kuleuvenuniversity.bsky.social show that next to biallelic deleterious mutations in ADA2, monoallelic dominant negative missense variants in ADA2 can also underlie ADA2 deficiency. rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

Journal of Experimental Medicine @jem.org · 6d

Zhu, Xu, Caspi et al. show that Vγ6 γδ T cells sense commensals via TLR2 to fuel IL-17A-mediated barrier defense at the ocular surface. rupress.org/jem/article/...

From our Pattern Recognition Receptors & Beyond #InnateImmunity collection: rupress.org/jem/collecti...

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Journal of Experimental Medicine @jem.org · 6d

New findings from Qing Chang, Jian-Fu Chen et al. @usc.edu show lymphatic vessels are present in the skull periosteum but absent in bone marrow, with channel and bone marrow heterogeneity varying by skull region and age. rupress.org/jem/article/...

#HumanDiseaseGenetics

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Journal of Experimental Medicine @jem.org · 6d

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action by Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social et al: rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

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Journal of Experimental Medicine @jem.org · 7d

What’s a Journal-Based #CME activity? ✍️ 💻 A full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME activity in collaboration with @mskcme.bsky.social is NOW available 👉 mskcc.cloud-cme.com/course/cours...

Journal of Experimental Medicine @jem.org · 7d

@lbernaleau.bsky.social et al @rebsamenlab.bsky.social identify ER-resident CCDC134 as an essential regulator of TLR responses that binds & stabilizes the TLR chaperone Gp96 rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

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Reposted by Journal of Experimental Medicine

Zhijuan Qiu @zhijuanjexpmed.bsky.social · 7d

This #JEMLegacy tweet highlights two papers from 1965 by Drs. Phil Gold and Samuel O. Freedman @mcgill.ca on the discovery of the Carcinoembryonic Antigen (CEA), the basis for the widely used CEA blood test.
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rupress.org/jem/article/...

#cancer #biomarker #CEA

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Journal of Experimental Medicine @jem.org · 7d

Eri Ishikawa, Sho Yamasaki et al. reveal a selective role for protein kinase D in invariant natural killer T (iNKT) cell development. rupress.org/jem/article/...

#LymphocyteBiology

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