Journal of Clinical Investigation
@jci.org
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
ICYMI: The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI197141
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI197141
January 11, 2026 at 2:01 PM
ICYMI: The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI197141
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI197141
Shared earlier this week: Isn’t it ironic? Functional iron deficiency at the core of Parkinson's disease pathobiology
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
January 10, 2026 at 2:00 PM
Shared earlier this week: Isn’t it ironic? Functional iron deficiency at the core of Parkinson's disease pathobiology
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
Merlin’s Disappearing Act: NF2 loss conjures pancreatic cancer survival in the hostile tumor microenvironment: doi.org/10.1172/JCI2...
Sofia Ferreira & Laura D. Attardi comment on Yi Xu et al.: doi.org/10.1172/JCI1...
Sofia Ferreira & Laura D. Attardi comment on Yi Xu et al.: doi.org/10.1172/JCI1...
January 9, 2026 at 5:15 PM
Merlin’s Disappearing Act: NF2 loss conjures pancreatic cancer survival in the hostile tumor microenvironment: doi.org/10.1172/JCI2...
Sofia Ferreira & Laura D. Attardi comment on Yi Xu et al.: doi.org/10.1172/JCI1...
Sofia Ferreira & Laura D. Attardi comment on Yi Xu et al.: doi.org/10.1172/JCI1...
Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal: doi.org/10.1172/JCI2...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
January 9, 2026 at 2:02 PM
Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal: doi.org/10.1172/JCI2...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
Introducing a gene mutation that induces pancreatic tumor evolution and therapeutic resistance with environmental stress.
Pei Wang & team show NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under nutrient deprivation: doi.org/10.1172/JCI1...
Pei Wang & team show NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under nutrient deprivation: doi.org/10.1172/JCI1...
January 8, 2026 at 5:15 PM
Introducing a gene mutation that induces pancreatic tumor evolution and therapeutic resistance with environmental stress.
Pei Wang & team show NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under nutrient deprivation: doi.org/10.1172/JCI1...
Pei Wang & team show NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under nutrient deprivation: doi.org/10.1172/JCI1...
Clonal hematopoiesis of indeterminate potential (CHIP) is common in older individuals, but its connection with aortic valve stenosis was unclear.
Wesley T. Abplanalp & team now show CHIP activates procalcific pathways in macrophages and promotes AVS: www.jci.org/articles/vie...
Wesley T. Abplanalp & team now show CHIP activates procalcific pathways in macrophages and promotes AVS: www.jci.org/articles/vie...
January 8, 2026 at 2:01 PM
Clonal hematopoiesis of indeterminate potential (CHIP) is common in older individuals, but its connection with aortic valve stenosis was unclear.
Wesley T. Abplanalp & team now show CHIP activates procalcific pathways in macrophages and promotes AVS: www.jci.org/articles/vie...
Wesley T. Abplanalp & team now show CHIP activates procalcific pathways in macrophages and promotes AVS: www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
During caloric restriction, protein synthesis in the liver slows
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
January 7, 2026 at 6:38 PM
During caloric restriction, protein synthesis in the liver slows
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
Reposted by Journal of Clinical Investigation
Lung transplant recipients predisposed to impaired complement regulation have worse CLAD-free survival
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
January 7, 2026 at 2:30 PM
Lung transplant recipients predisposed to impaired complement regulation have worse CLAD-free survival
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
Review: Cardiovascular complications of pregnancy
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
January 6, 2026 at 5:15 PM
Review: Cardiovascular complications of pregnancy
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Can we help fat cells get in shape in diabetes?
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
January 6, 2026 at 2:03 PM
Can we help fat cells get in shape in diabetes?
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
Reposted by Journal of Clinical Investigation
The gut<->brain axis impact on health and disease is far more important than anticipated, as reflected by GLP-1 effects, modulating the immune system, direct neural circuits, the microbiome, and more. A stellar new, open-access review
www.jci.org/articles/vie...
www.jci.org/articles/vie...
January 5, 2026 at 4:12 PM
The gut<->brain axis impact on health and disease is far more important than anticipated, as reflected by GLP-1 effects, modulating the immune system, direct neural circuits, the microbiome, and more. A stellar new, open-access review
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Challenging dogma: Functional iron deficiency could, ironically, be at the core of Parkinson's disease
jci.org/articles/vie...
jci.org/articles/vie...
January 5, 2026 at 4:21 PM
Challenging dogma: Functional iron deficiency could, ironically, be at the core of Parkinson's disease
jci.org/articles/vie...
jci.org/articles/vie...
The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
January 5, 2026 at 2:02 PM
The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
Reposted by Journal of Clinical Investigation
JCI - Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels www.jci.org/articles/vie... in collaboration with Jeremy Rich @unclineberger.bsky.social
JCI -
Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels
www.jci.org
January 3, 2026 at 2:21 AM
JCI - Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels www.jci.org/articles/vie... in collaboration with Jeremy Rich @unclineberger.bsky.social
Reposted by Journal of Clinical Investigation
A new review @jclinicalinvest illustrates the critical nature of gut-brain communication in human disease and the potential to target gut-brain pathways for therapeutic benefit www.jci.org/articles/vie...
January 3, 2026 at 11:22 AM
A new review @jclinicalinvest illustrates the critical nature of gut-brain communication in human disease and the potential to target gut-brain pathways for therapeutic benefit www.jci.org/articles/vie...
From earlier this week:
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI197583
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI197583
January 4, 2026 at 2:00 PM
From earlier this week:
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI197583
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI197583
Isn’t it ironic? Functional iron deficiency at the core of Parkinsons disease pathobiology
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
January 3, 2026 at 2:02 PM
Isn’t it ironic? Functional iron deficiency at the core of Parkinsons disease pathobiology
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
Curing autoimmune diabetes in mice!
Seung K. Kim & team present a clinically translatable, low toxicity conditioning regimen in combination with hematopoietic cell and islet transplantation that reverses established type 1 diabetes in mice: www.jci.org/articles/vie...
Seung K. Kim & team present a clinically translatable, low toxicity conditioning regimen in combination with hematopoietic cell and islet transplantation that reverses established type 1 diabetes in mice: www.jci.org/articles/vie...
January 2, 2026 at 7:30 PM
Curing autoimmune diabetes in mice!
Seung K. Kim & team present a clinically translatable, low toxicity conditioning regimen in combination with hematopoietic cell and islet transplantation that reverses established type 1 diabetes in mice: www.jci.org/articles/vie...
Seung K. Kim & team present a clinically translatable, low toxicity conditioning regimen in combination with hematopoietic cell and islet transplantation that reverses established type 1 diabetes in mice: www.jci.org/articles/vie...
This issue’s Cover features work by Maung et al. on laminin A gene mutations in patients with familial partial lipodystrophy 2 and their association with suppressed lipid metabolism and mitochondrial pathways, as well as increased inflammation. www.jci.org/articles/vie...
January 2, 2026 at 5:05 PM
This issue’s Cover features work by Maung et al. on laminin A gene mutations in patients with familial partial lipodystrophy 2 and their association with suppressed lipid metabolism and mitochondrial pathways, as well as increased inflammation. www.jci.org/articles/vie...
New approach spotlight ✨
Domenico Mavilio & team characterize intrahepatic and circulating NK cells in patients with metastatic colon cancer, identifying a cell population with an antitumor signature and revealing IL-1R8 and CXCR4 as potential targets: doi.org/10.1172/JCI1...
Domenico Mavilio & team characterize intrahepatic and circulating NK cells in patients with metastatic colon cancer, identifying a cell population with an antitumor signature and revealing IL-1R8 and CXCR4 as potential targets: doi.org/10.1172/JCI1...
January 2, 2026 at 2:02 PM
New approach spotlight ✨
Domenico Mavilio & team characterize intrahepatic and circulating NK cells in patients with metastatic colon cancer, identifying a cell population with an antitumor signature and revealing IL-1R8 and CXCR4 as potential targets: doi.org/10.1172/JCI1...
Domenico Mavilio & team characterize intrahepatic and circulating NK cells in patients with metastatic colon cancer, identifying a cell population with an antitumor signature and revealing IL-1R8 and CXCR4 as potential targets: doi.org/10.1172/JCI1...
Reposted by Journal of Clinical Investigation
New in The Journal of Clinical Investigation from @ucsfohns.bsky.social's Drs. Jennifer Grandis & Daniel Johnson: "Patient-Derived Xenograft Models of Fanconi Anemia-Associated Head & Neck Cancer Identify Personalized Therapeutic Strategies."
JCI - Patient-Derived Xenograft Models of Fanconi Anemia-Associated Head and Neck Cancer Identify Personalized Therapeutic Strategies
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December 30, 2025 at 9:46 PM
New in The Journal of Clinical Investigation from @ucsfohns.bsky.social's Drs. Jennifer Grandis & Daniel Johnson: "Patient-Derived Xenograft Models of Fanconi Anemia-Associated Head & Neck Cancer Identify Personalized Therapeutic Strategies."
Tumor virus–induced lineage survival circuit drives Merkel cell carcinogenesis: doi.org/10.1172/JCI2...
Masahiro Shuda provides a Commentary on Lingling Miao et al.: doi.org/10.1172/JCI1...
Masahiro Shuda provides a Commentary on Lingling Miao et al.: doi.org/10.1172/JCI1...
January 1, 2026 at 5:15 PM
Tumor virus–induced lineage survival circuit drives Merkel cell carcinogenesis: doi.org/10.1172/JCI2...
Masahiro Shuda provides a Commentary on Lingling Miao et al.: doi.org/10.1172/JCI1...
Masahiro Shuda provides a Commentary on Lingling Miao et al.: doi.org/10.1172/JCI1...
Looking back on 2025 with a year of JCI covers
Music by Bensound; License code: OPYBHJ1Y0XH0EWQO; Artist: Theatre Of Delays; Song: Prism
Music by Bensound; License code: OPYBHJ1Y0XH0EWQO; Artist: Theatre Of Delays; Song: Prism
January 1, 2026 at 2:02 PM
Looking back on 2025 with a year of JCI covers
Music by Bensound; License code: OPYBHJ1Y0XH0EWQO; Artist: Theatre Of Delays; Song: Prism
Music by Bensound; License code: OPYBHJ1Y0XH0EWQO; Artist: Theatre Of Delays; Song: Prism
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI1...
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI1...
December 31, 2025 at 5:15 PM
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI1...
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI1...
Count down: Our top 5 most-accessed manuscripts of 2025!
#1:Estimation of prevalence of autoimmune diseases in the United States using electronic health record data: doi.org/10.1172/JCI1...
#1:Estimation of prevalence of autoimmune diseases in the United States using electronic health record data: doi.org/10.1172/JCI1...
December 31, 2025 at 2:02 PM
Count down: Our top 5 most-accessed manuscripts of 2025!
#1:Estimation of prevalence of autoimmune diseases in the United States using electronic health record data: doi.org/10.1172/JCI1...
#1:Estimation of prevalence of autoimmune diseases in the United States using electronic health record data: doi.org/10.1172/JCI1...