Journal of Clinical Investigation
@jci.org
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
A new theory helps explain blood clots complications in COVID-19
G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
November 25, 2025 at 5:15 PM
A new theory helps explain blood clots complications in COVID-19
G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
The strategic use of multiple models clarifies a longstanding controversy in pulmonary fibrosis
Dean Sheppard & team establish fibroblast proliferation as an important driver (and potential target) in pulmonary fibrosis: www.jci.org/articles/vie...
Dean Sheppard & team establish fibroblast proliferation as an important driver (and potential target) in pulmonary fibrosis: www.jci.org/articles/vie...
November 25, 2025 at 2:02 PM
The strategic use of multiple models clarifies a longstanding controversy in pulmonary fibrosis
Dean Sheppard & team establish fibroblast proliferation as an important driver (and potential target) in pulmonary fibrosis: www.jci.org/articles/vie...
Dean Sheppard & team establish fibroblast proliferation as an important driver (and potential target) in pulmonary fibrosis: www.jci.org/articles/vie...
Time to think about the flu
@shaonsengupta.bsky.social show disruptions in daily light cycles after infection worsen influenza outcomes, but timed meals can restore protection—highlighting how circadian rhythms shape immune defense.
www.jci.org/articles/vie...
@shaonsengupta.bsky.social show disruptions in daily light cycles after infection worsen influenza outcomes, but timed meals can restore protection—highlighting how circadian rhythms shape immune defense.
www.jci.org/articles/vie...
November 24, 2025 at 5:15 PM
Time to think about the flu
@shaonsengupta.bsky.social show disruptions in daily light cycles after infection worsen influenza outcomes, but timed meals can restore protection—highlighting how circadian rhythms shape immune defense.
www.jci.org/articles/vie...
@shaonsengupta.bsky.social show disruptions in daily light cycles after infection worsen influenza outcomes, but timed meals can restore protection—highlighting how circadian rhythms shape immune defense.
www.jci.org/articles/vie...
What drives pathogenic B-cell activation in autoimmunity & certain cancers?
@bgewurz.bsky.social & team show stimulation of B cells with pathogenic triggers strongly induces BCAT1, which localized to lysosomal membranes to support metabolic needs: www.jci.org/articles/vie...
@bgewurz.bsky.social & team show stimulation of B cells with pathogenic triggers strongly induces BCAT1, which localized to lysosomal membranes to support metabolic needs: www.jci.org/articles/vie...
November 24, 2025 at 2:02 PM
What drives pathogenic B-cell activation in autoimmunity & certain cancers?
@bgewurz.bsky.social & team show stimulation of B cells with pathogenic triggers strongly induces BCAT1, which localized to lysosomal membranes to support metabolic needs: www.jci.org/articles/vie...
@bgewurz.bsky.social & team show stimulation of B cells with pathogenic triggers strongly induces BCAT1, which localized to lysosomal membranes to support metabolic needs: www.jci.org/articles/vie...
From earlier this week: This issue’s cover features work by Fassihi et al. and Nakazawa et al. on the C-terminal deletion of transcription factor TFIIH-p52 subunit as a cause of xeroderma pigmentosum.
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 23, 2025 at 2:00 PM
From earlier this week: This issue’s cover features work by Fassihi et al. and Nakazawa et al. on the C-terminal deletion of transcription factor TFIIH-p52 subunit as a cause of xeroderma pigmentosum.
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
ICYMI: A strategy to overcome tumor cell resistance to PARP inhibitors—regardless of BRCA1 status
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
November 22, 2025 at 2:01 PM
ICYMI: A strategy to overcome tumor cell resistance to PARP inhibitors—regardless of BRCA1 status
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fungal vaccines: so needed, so feasible, and yet so far off: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
November 21, 2025 at 5:15 PM
Fungal vaccines: so needed, so feasible, and yet so far off: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
GSK3β guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensitivity: www.jci.org/articles/vie...
Justin W. Leung & David Gius comment on Heba S. Allam et al.: www.jci.org/articles/vie...
Justin W. Leung & David Gius comment on Heba S. Allam et al.: www.jci.org/articles/vie...
November 21, 2025 at 2:03 PM
GSK3β guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensitivity: www.jci.org/articles/vie...
Justin W. Leung & David Gius comment on Heba S. Allam et al.: www.jci.org/articles/vie...
Justin W. Leung & David Gius comment on Heba S. Allam et al.: www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Ilucidating the critical interplay between environmental timing cues and endogenous #CircadianRhythms for #Influenza outcomes www.jci.org/articles/vie... @sengupta_shaon #ImmuneResponse #Chronobiology #CircadianMedicine #TranslationalScience
JCI -
Effect of external cues on clock-driven protection from influenza A infection
www.jci.org
November 20, 2025 at 9:49 PM
Ilucidating the critical interplay between environmental timing cues and endogenous #CircadianRhythms for #Influenza outcomes www.jci.org/articles/vie... @sengupta_shaon #ImmuneResponse #Chronobiology #CircadianMedicine #TranslationalScience
Currently there are no anti-fungal vaccines
Here, Bruce S. Klein & team identify a major antigen expressed in a family of fungal infectious diseases common in North America—and it stimulates potent immunity in mice and humans: www.jci.org/articles/vie...
Here, Bruce S. Klein & team identify a major antigen expressed in a family of fungal infectious diseases common in North America—and it stimulates potent immunity in mice and humans: www.jci.org/articles/vie...
November 20, 2025 at 5:15 PM
Currently there are no anti-fungal vaccines
Here, Bruce S. Klein & team identify a major antigen expressed in a family of fungal infectious diseases common in North America—and it stimulates potent immunity in mice and humans: www.jci.org/articles/vie...
Here, Bruce S. Klein & team identify a major antigen expressed in a family of fungal infectious diseases common in North America—and it stimulates potent immunity in mice and humans: www.jci.org/articles/vie...
Can in vitro–induced regulatory T cells promote lung recovery?
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
November 20, 2025 at 2:02 PM
Can in vitro–induced regulatory T cells promote lung recovery?
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Hello Beta Cell folks, here's my final work as a postdoc with Michigan Medicine! Beta cell ERAD impairment affects proinsulin proteostasis not just by blocking degradation, but also by triggering stress that shuts down new synthesis. Happy reading!
New insights into islet ER stress responses, proinsulin biosynthesis, ERAD and ERD1 using β-cell-specific Hrd1-KO mice & rodent (and human islet) β-cells treated acutely with HRD1 inhibitor. jci.org/articles/vie...
@jci.org
@jci.org
November 19, 2025 at 1:35 AM
Hello Beta Cell folks, here's my final work as a postdoc with Michigan Medicine! Beta cell ERAD impairment affects proinsulin proteostasis not just by blocking degradation, but also by triggering stress that shuts down new synthesis. Happy reading!
Genetic and environmental influences in autism: Guiding the future of tailored early detection and intervention
A Viewpoint by Alexandra L. Bey et al.: www.jci.org/articles/vie...
A Viewpoint by Alexandra L. Bey et al.: www.jci.org/articles/vie...
November 19, 2025 at 5:15 PM
Genetic and environmental influences in autism: Guiding the future of tailored early detection and intervention
A Viewpoint by Alexandra L. Bey et al.: www.jci.org/articles/vie...
A Viewpoint by Alexandra L. Bey et al.: www.jci.org/articles/vie...
A strategy to overcome tumor cell resistance to PARP inhibitors—regardless of BRCA1 status
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
November 19, 2025 at 2:03 PM
A strategy to overcome tumor cell resistance to PARP inhibitors—regardless of BRCA1 status
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
New insights into islet ER stress responses, proinsulin biosynthesis, ERAD and ERD1 using β-cell-specific Hrd1-KO mice & rodent (and human islet) β-cells treated acutely with HRD1 inhibitor. jci.org/articles/vie...
@jci.org
@jci.org
November 18, 2025 at 7:39 PM
New insights into islet ER stress responses, proinsulin biosynthesis, ERAD and ERD1 using β-cell-specific Hrd1-KO mice & rodent (and human islet) β-cells treated acutely with HRD1 inhibitor. jci.org/articles/vie...
@jci.org
@jci.org
Reposted by Journal of Clinical Investigation
Also, quick additional post to highlight this fantastic work on novel genetic mutations in the ARHGAP19 gene that cause Charcot-Marie-Tooth (CMT) Disease, now published in @jci.org .
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy
www.jci.org
November 18, 2025 at 8:23 PM
Also, quick additional post to highlight this fantastic work on novel genetic mutations in the ARHGAP19 gene that cause Charcot-Marie-Tooth (CMT) Disease, now published in @jci.org .
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Microcephaly, epilepsy & diabetes syndrome (MEDS) is a rare disease
@evirgilio.bsky.social et al. now identify biallelic variants in the TMEM167A gene as a third cause of #MEDS & show TMEM167A is involved in protein trafficking in pancreatic beta-cells: www.jci.org/articles/vie...
@evirgilio.bsky.social et al. now identify biallelic variants in the TMEM167A gene as a third cause of #MEDS & show TMEM167A is involved in protein trafficking in pancreatic beta-cells: www.jci.org/articles/vie...
November 18, 2025 at 5:15 PM
Microcephaly, epilepsy & diabetes syndrome (MEDS) is a rare disease
@evirgilio.bsky.social et al. now identify biallelic variants in the TMEM167A gene as a third cause of #MEDS & show TMEM167A is involved in protein trafficking in pancreatic beta-cells: www.jci.org/articles/vie...
@evirgilio.bsky.social et al. now identify biallelic variants in the TMEM167A gene as a third cause of #MEDS & show TMEM167A is involved in protein trafficking in pancreatic beta-cells: www.jci.org/articles/vie...
A potential marker for pancreatic cancer tumor formation…
Thomas Mandel Clausen & team discover antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and a key enzyme involved with its synthesis is elevated in the early stages of PDAC development: buff.ly/CNCz0iW
Thomas Mandel Clausen & team discover antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and a key enzyme involved with its synthesis is elevated in the early stages of PDAC development: buff.ly/CNCz0iW
November 18, 2025 at 2:03 PM
A potential marker for pancreatic cancer tumor formation…
Thomas Mandel Clausen & team discover antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and a key enzyme involved with its synthesis is elevated in the early stages of PDAC development: buff.ly/CNCz0iW
Thomas Mandel Clausen & team discover antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and a key enzyme involved with its synthesis is elevated in the early stages of PDAC development: buff.ly/CNCz0iW
Expanding the landscape of nucleotide excision repair disorders: from discovery to therapy: www.jci.org/articles/vie...
Arjan F. Theil & Jan H.J. Hoeijmakers discuss two articles by Tomoo Ogi & team: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Arjan F. Theil & Jan H.J. Hoeijmakers discuss two articles by Tomoo Ogi & team: www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 17, 2025 at 7:30 PM
Expanding the landscape of nucleotide excision repair disorders: from discovery to therapy: www.jci.org/articles/vie...
Arjan F. Theil & Jan H.J. Hoeijmakers discuss two articles by Tomoo Ogi & team: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Arjan F. Theil & Jan H.J. Hoeijmakers discuss two articles by Tomoo Ogi & team: www.jci.org/articles/vie...
www.jci.org/articles/vie...
This issue’s cover features work by Fassihi et al. and Nakazawa et al. on the C-terminal deletion of transcription factor TFIIH-p52 subunit as a cause of xeroderma pigmentosum.
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 17, 2025 at 5:15 PM
This issue’s cover features work by Fassihi et al. and Nakazawa et al. on the C-terminal deletion of transcription factor TFIIH-p52 subunit as a cause of xeroderma pigmentosum.
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Dr. Matlawska-Wasowska, was published in the @jci.org for her study, “T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges.” Learn more: www.jci.org/articles/vie...
November 14, 2025 at 9:01 PM
Dr. Matlawska-Wasowska, was published in the @jci.org for her study, “T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges.” Learn more: www.jci.org/articles/vie...
ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
November 16, 2025 at 2:00 PM
ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
ICYMI: Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms: www.jci.org/articles/vie...
Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms: www.jci.org/articles/vie...
November 15, 2025 at 2:00 PM
ICYMI: Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms: www.jci.org/articles/vie...
Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms: www.jci.org/articles/vie...
S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
November 14, 2025 at 7:30 PM
S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
GAB2 couples genetic drivers and signaling networks in acute myeloid leukemia: www.jci.org/articles/vie...
Amanda Luvisotto & Lu Wang provide a Commentary on Michael H. Kramer et al.: www.jci.org/articles/vie...
Amanda Luvisotto & Lu Wang provide a Commentary on Michael H. Kramer et al.: www.jci.org/articles/vie...
November 14, 2025 at 5:15 PM
GAB2 couples genetic drivers and signaling networks in acute myeloid leukemia: www.jci.org/articles/vie...
Amanda Luvisotto & Lu Wang provide a Commentary on Michael H. Kramer et al.: www.jci.org/articles/vie...
Amanda Luvisotto & Lu Wang provide a Commentary on Michael H. Kramer et al.: www.jci.org/articles/vie...