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Journal of Clinical Investigation @jci.org · 2h

We thought the brain couldn’t use fatty acids or metabolize triglyceride-rich lipoproteins.

Stephen G. Young & team now provide convincing evidence for lipoprotein lipase-mediated intravascular triglyceride processing in the CNS:
www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 4h

Perturbation of the circadian clock in chronic diseases involving organ fibrosis

This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 7h

Resistance to endocrine therapy in HR+ early breast cancer remains a challenge

Clarissa Gerhauser & team identify epi-/genetic features associated with primary resistance to tamoxifen and aromatase inhibitors in HR+/HER2- breast cancer & develop predictors: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 1d

The reno-protective effects of SGLT2 inhibitors cannot be fully explained by their glucose-lowering actions.

Quaggin & team now show SGLT2 inhibition increases tissue levels of SAM, resulting in enhanced H3K27 trimethylation & repression of inflammatory genes: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 1d

Genetic and environmental factors converge in congenital craniofacial birth defects

Paul A. Trainor @aussiebiologist.bsky.social & team explore a mouse model of Treacher Collins syndrome, reporting on ROS & genomic instability involved in phenotype variability:
www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 2d

Gut complement system: a new frontier in microbiota-host communication and intestinal homeostasis

As part of JCI’s ongoing Review series on complement biology and therapeutics, Xianbin Tian et al. discuss the unique adaptations of intestinal complement: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 2d

Progress towards enhancing #cancer immunotherapies in the context of solid tumors!

William E. Carson III & team show BRD4 inhibition can reduce suppressive immune cells in murine cancer models: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 3d

ICYMI: This issue’s cover art represents the potential for improving pain relief by restoring #circadian rhythmicity.

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: jci.org/articles/vie...

Reposted by Journal of Clinical Investigation

TRAstonDrs @castltrastondrs.bsky.social · 6d

#Medsky🧪 #immunosky #publichealth This study found circadian rhythms & biopsychosocial characteristics significantly influence opioid use in patients with chronic low back pain (CLBP). Poor circadian rhythmicity is associated with worse pain outcomes & higher opioid use,

Journal of Clinical Investigation @jci.org · 7d

This issue’s cover art represents the potential for improving pain relief by restoring circadian rhythmicity

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: buff.ly/GR3SOAK

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Journal of Clinical Investigation @jci.org · 4d

From earlier this week: Another installment in JCI’s Review series on complement biology and therapeutics:

Carsten Krieg & Silvia Guglietta highlight the complement system in intestinal inflammation and cancer: www.jci.org/articles/vie...

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Reposted by Journal of Clinical Investigation

mariejeansson.bsky.social @mariejeansson.bsky.social · 23d

Super happy about our new publication! JCI - TIE2 activation by antibody-clustered endogenous angiopoietin-2 prevents capillary loss and fibrosis in experimental kidney disease www.jci.org/articles/vie...

JCI - TIE2 activation by antibody-clustered endogenous angiopoietin-2 prevents capillary loss and fibrosis in experimental kidney disease

www.jci.org

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Journal of Clinical Investigation @jci.org · 5d

Ruling In, Ruling Out: The Clinical Utility of Plasma Biomarkers in Alzheimer’s Diagnosis

This Viewpoint by Julie K Wisch & Beau M Ances frames first FDA-approved test for amyloid pathology in a historical context and highlights implications for practice: www.jci.org/articles/vie...

Journal of Clinical Investigation @jci.org · 5d

A die is cast: Autologous neutralizing antibody resistance shapes the HIV reservoir during uninterrupted ART: www.jci.org/articles/vie...

Nancie M. Archin comments on Natalie F. McMyn et al.: www.jci.org/articles/vie...

Journal of Clinical Investigation @jci.org · 5d

A major barrier to HIV cure is a population of T cells that harbors replication-competent proviruses

Here, Robert F. Siliciano & team report most viruses in the latent HIV-1 reservoir are resistant to autologous neutralizing antibodies: www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 5d

T cell engagers are effective in treating myeloma, but dosing schedules have not been defined.

In this research letter, Madhav V. Dhodapkar & team find in vivo CD4+ T cell fitness within 48 hours following TCE therapy correlates with outcomes: www.jci.org/articles/vie...

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Reposted by Journal of Clinical Investigation

Eric Topol @erictopol.bsky.social · 6d

The role of perturbation of our circadian clock plays in promoting the fibrosis (scarring) of organs
www.jci.org/articles/vie...

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Reposted by Journal of Clinical Investigation

Nikki Link @nikkilink.bsky.social · Jul 10

Nicole's collaborative paper accepted. Be on the lookout for the final version at the Journal of Clinical Investigation. www.jci.org/articles/vie...

JCI - Mutations in spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly

www.jci.org

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Reposted by Journal of Clinical Investigation

Matt Wortham @worthamlab.bsky.social · 6d

It's great to see the final version of our SIRT2 paper in JCI along with an astute commentary from trailblazers in beta cell regeneration—thanks for highlighting our work! @likatz.bsky.social @donaldscottmssm.bsky.social @jci.org @sanderlaberlin.bsky.social tinyurl.com/y6rx69x7 tinyurl.com/ydvv9u2s

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Journal of Clinical Investigation @jci.org · 6d

Another installment in JCI’s Review series on complement biology and therapeutics:

Carsten Krieg & Silvia Guglietta highlight the complement system in intestinal inflammation and cancer: buff.ly/DokQiAr

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Journal of Clinical Investigation @jci.org · 6d

Maybe you didn’t hear—this molecule is silencing oncogenes

Chad V. Pecot & team developed an inverted RNAi molecule that enhances dual silencing of KRAS and MYC in cancer models: buff.ly/xzjBnEL

Reposted by Journal of Clinical Investigation

Doriana Taccardi @dorianataccardi.bsky.social · 7d

Our new paper is out! @ghasemloulab.bsky.social

The cover art was created by @quanamadison.bsky.social
inspired by her own experiences with chronic pain. It all started with a chat at the back of a taxi while at @napainschool.bsky.social and ended up with a beautiful piece of art.

Journal of Clinical Investigation @jci.org · 7d

This issue’s cover art represents the potential for improving pain relief by restoring circadian rhythmicity

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: buff.ly/GR3SOAK

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Journal of Clinical Investigation @jci.org · 7d

Emerging roles for complement in lung transplantation

As part of JCI’s Review series on complement biology and therapeutics, Hrishikesh S. Kulkarni et al. explore complement activation and strategies for inhibition in the lung transplant process: buff.ly/UXQWFKq

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Journal of Clinical Investigation @jci.org · 7d

This issue’s cover art represents the potential for improving pain relief by restoring circadian rhythmicity

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: buff.ly/GR3SOAK

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Journal of Clinical Investigation @jci.org · 7d

As part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor Scott Friedman @hepascott.bsky.social

Prakash Ramachandran & colleagues consider fibrosis mechanisms as informed by omics approaches: buff.ly/B1PYpFt

Journal of Clinical Investigation @jci.org · 7d

SNW1 variants are associated microcephaly, but mechanism for reduced brain volume was unclear.

Ji et al. employ Drosophila and human cerebral organoid models, revealing how SNW1 mutations disrupt RNA splicing, alter neurodevelopmental genes, & reduce the NSC pool:
buff.ly/RGD6ufw

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