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T. Ryan Gregory 🇨🇦 @tryangregory.bsky.social · 28m

AI models that lie, cheat and plot murder: how dangerous are LLMs really?

Tests of large language models reveal that they can behave in deceptive and potentially harmful ways. What does this mean for the future?

www.nature.com

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Reposted by TRAstonDrs

European Food Safety Authority @efsa.europa.eu · 5h

📣 Just published | 4th joint monthly report on #WestNileVirus with @ecdc.europa.eu

➡️ Belgium reports its first WNV outbreaks in wild birds – a new EU country affected
➡️ 989 human cases & 63 deaths across 13 countries
➡️ 127 equid & 217 bird outbreaks across 9 countries

More 👉 link.europa.eu/fNP38x

High Magnification Microscopy of Malaria Infected Mosquito.

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TRAstonDrs @castltrastondrs.bsky.social · 4h

Love is not just a confrontation with the absurdity of the world;
it is a refusal to be broken by it.
It is one of the ways we can each of us be stronger
than our rocks.
#AlbertCamus on
love and the absurd…
My little peaceful corner of life

Between shadow and light, where the world moves.

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TRAstonDrs @castltrastondrs.bsky.social · 5h

#Medsky🧪 #microsky #immunosky #publichealth #Pathophysiology, #etiology, Progression & Complications of #Diverticulitis & Acute Diverticulitis . A Review & Risk factors

JAMA @jama.com · 6h

Diverticulitis results in approximately 200 000 hospitalizations annually in the US, with an estimated health care expenditure of more than $6.3 billion annually. This Review summarizes the pathogenesis, diagnosis, and treatment of diverticulitis.

ja.ma/4q0P9pC

Diagram titled: "Figure 1. Pathophysiology, Progression, and Complications of Acute Diverticulitis", contrasting uncomplicated and complicated diverticulitis with labelled anatomical drawings and related clinical information.

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TRAstonDrs @castltrastondrs.bsky.social · 10h

a more comprehensive understanding of which patients are most likely to benefit from the combination of #mitazalimab & #mFOLFIRINOX

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TRAstonDrs @castltrastondrs.bsky.social · 10h

Clearance of ctDNA was able to predict radiological response with high accuracy (76.7%). Conversely, molecular progression was also significantly associated with worse OS .
The OPTIMIZE-1 biomarker analysis provides

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TRAstonDrs @castltrastondrs.bsky.social · 10h

Analysis of ctDNA, which is genetic material from tumor cells found in 🩸 , revealed additional prognostic biomarkers
- The study showed that 72% of patients achieved clearance of KRAS ctDNA during treatment. This molecular response was strongly associated with longer overall survival.

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TRAstonDrs @castltrastondrs.bsky.social · 10h

Patients who experienced a clinical response to treatment showed evidence of immune activation within their tumors. This included increases in myeloid & T cells, which contributed to the antitumor response

ascopubs.org/doi/10.1200/...

Biomarkers associated with outcomes from OPTIMIZE-1: CD40 agonist mitazalimab with mFOLFIRINOX in patients with untreated metastatic pancreatic cancer.

2624Background: Metastatic pancreatic ductal adenocarcinoma (mPDAC) has a 5-year overall survival (OS) rate of less than 5% and remains a leading cause of cancer related mortality. Mitazalimab, a huma...

ascopubs.org

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TRAstonDrs @castltrastondrs.bsky.social · 10h

www.sciencedirect.com/science/arti...
#Mitazalimab led to increased levels of activated immune cells, such as T cells, NK cells & myeloid cells, in the bloodstream. Higher levels of these activated immune cells correlated with better clinical outcomes.

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TRAstonDrs @castltrastondrs.bsky.social · 11h

This suggests that the tumor microenvironment may play a role in how patients respond to this combination therapy . Evidence that #mitazalimab's mechanism of action , activating the immune system was a significant factor in patient outcomes. Several findings point to this conclusion

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TRAstonDrs @castltrastondrs.bsky.social · 11h

The study found a specific gene signature linked to fibrosis in the tumor tissue at the start of treatment. Patients with higher baseline expression of this fibrosis-related gene signature had better overall survival (OS).

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TRAstonDrs @castltrastondrs.bsky.social · 11h

for untreated metastatic pancreatic cancer patients receiving #mitazalimab plus #mFOLFIRINOX: a tumor-intrinsic fibrosis gene signature, #mitazalimab-induced immune activation, and circulating tumor DNA (ctDNA) clearance.

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TRAstonDrs @castltrastondrs.bsky.social · 11h

@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Analysis of the OPTIMIZE-1 trial identified 3🔑 types of biomarkers associated with improved outcomes

storage.mfn.se/862d1c43-27d...

CD40 agonist mitazalimab with mFOLFIRINOX in untreated metastatic pancreatic cancer: Biomarkers associated with outcomes from OPTIMIZE-1

Van Laethem et al. report that the combination of mFOLFIRINOX and mitazalimab has manageable safety and encouraging activity. Mitazalimab-induced immune activation and a fibrosis gene signature correlate with better outcomes. These results may inform future patient stratification strategies supporting a planned randomized confirmatory trial in mPDAC.

www.cell.com

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TRAstonDrs @castltrastondrs.bsky.social · 11h

Current standard of care regimens, such as gemcitabine + nab-paclitaxel & FOLFIRINOX, achieve objective response rates (ORRs) of 20%–40% & a median progression-free survival (PFS) of approximately 6 months.The recently approved NALIRIFOX regimen provides similar outcomes.

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TRAstonDrs @castltrastondrs.bsky.social · 11h

#Medsky🧪 #Oncosky #pharmsky #publichealth #Pancreaticductaladenocarcinoma is a highly aggressive malignancy with a dismal prognosis. It is projected to become 2nd leading cause of cancer-related deaths by 2030 . Metastatic PDAC (mPDAC) is particularly lethal, with a 5-year survival rate of only 3%.

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TRAstonDrs @castltrastondrs.bsky.social · 11h

These findings suggest that rehabilitation for severe LC patients should move beyond simple deconditioning theory and consider targeted, specific strategies.

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TRAstonDrs @castltrastondrs.bsky.social · 11h

@yalepress.bsky.social
news.yale.edu/2023/12/19/s...

www.nature.com/articles/s41...

www.jci.org/articles/vie...
@npr.org
www.npr.org/sections/hea...

pmc.ncbi.nlm.nih.gov/articles/PMC....

Study helps explain post-COVID exercise intolerance

Exercise intolerance is one symptom associated with long COVID. A new study helps explain its cause.

news.yale.edu

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TRAstonDrs @castltrastondrs.bsky.social · 11h

identified in muscle biopsies point to physiological damage that is distinct from simple deconditioning.
@nature.com
www.nature.com/articles/s41...

www.cdc.gov/long-covid/h...

www.genome.gov/genetics-glo...
@eurekalert.bsky.social
www.eurekalert.org/news-release...

Muscle abnormalities worsen after post-exertional malaise in long COVID - Nature Communications

In this longitudinal, case-controlled, cohort design study, authors show that post-exertional malaise is associated with severe exercise-induced myopathy, local and systemic metabolic disturbances and infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID.

www.nature.com

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TRAstonDrs @castltrastondrs.bsky.social · 11h

can lead to the formation of microclots, which may restrict blood flow & oxygen delivery to muscle tissue.
- some effects are due to inactivity during illness, the specific mitochondrial dysfunction & altered immune response

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TRAstonDrs @castltrastondrs.bsky.social · 11h

the energy-producing powerhouses within cells, which may explain the severe fatigue & muscle weakness.
- Evidences suggests that the immune system may develop an autoimmune response against muscle cells, causing inflammation & damage
- Widespread damage to the lining of blood vessels

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TRAstonDrs @castltrastondrs.bsky.social · 11h

-The lingering inflammatory state "cytokine storm" experienced during the initial infection can persist in severe LC , damaging muscle tissue over time.
- in some studies found Mitochondria dysfunction ,

pmc.ncbi.nlm.nih.gov/articles/PMC....

The Impact of Long COVID-19 on Muscle Health

COVID-19 negatively impacts several organs and systems weeks or months after initial diagnosis. Skeletal muscle can be affected, leading to fatigue, lower mobility, weakness, and poor physical perform...

pmc.ncbi.nlm.nih.gov

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TRAstonDrs @castltrastondrs.bsky.social · 11h

The cause of these persistent issues is still under investigation, but the study suggests several potential mechanisms.
www.frontiersin.org/journals/phy...

www.sciencedirect.com/science/arti...

www.cell.com/trends/endoc...

onlinelibrary.wiley.com/doi/full/10....

Frontiers | Long COVID-19 alters muscle architecture and muscle-tendon force transmission: a one-year longitudinal study

IntroductionThere are limited studies on the long-term effects of COVID-19 on skeletal muscle morphology and architecture. Therefore, this study aims to addr...

www.frontiersin.org

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TRAstonDrs @castltrastondrs.bsky.social · 12h

Lingering nerve and muscle damage .The findings are consistent with #polyneuromyopathy, a disorder affecting both nerves & muscles, which may explain the long-term muscle weakness, fatigue & nerve conduction experienced by some #neurocovid patients.

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TRAstonDrs @castltrastondrs.bsky.social · 12h

- High prevalence increased echogenicity (poorer muscle architecture) & higher chronaxie values (an indicator of neuromuscular excitability disorders) in the tibialis anterior muscle in some LC group

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TRAstonDrs @castltrastondrs.bsky.social · 12h

-The severe LC group had a higher muscle echogenicity in the tibialis anterior & gastrocnemius lateralis muscles for up to one year after the initial infection. High echogenicity often indicates poorer muscle quality due to an increased infiltration of fat & connective tissue.

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