The American Society for Clinical Investigation
@the-asci.org
The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry.
https://the-asci.org
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https://the-asci.org
Take action for federal funding of research:
https://www.fundresearch.org/
Join us for ASCI Scientific Session on January 28th, 1-2PM EST:
Dr. Jay K. Kolls discussing: CD4+ T cell and Lung Immunity: lessons from HIV and primary immunodeficiencies
Register: buff.ly/i1VP2pL
Dr. Jay K. Kolls discussing: CD4+ T cell and Lung Immunity: lessons from HIV and primary immunodeficiencies
Register: buff.ly/i1VP2pL
January 14, 2026 at 6:38 PM
Join us for ASCI Scientific Session on January 28th, 1-2PM EST:
Dr. Jay K. Kolls discussing: CD4+ T cell and Lung Immunity: lessons from HIV and primary immunodeficiencies
Register: buff.ly/i1VP2pL
Dr. Jay K. Kolls discussing: CD4+ T cell and Lung Immunity: lessons from HIV and primary immunodeficiencies
Register: buff.ly/i1VP2pL
Reposted by The American Society for Clinical Investigation
From RIME to reason
In this Research Letter by Hal M. Hoffman @ferhatay.bsky.social & team, scRNA-seq analysis before & after treatment of recurrent infectious mucocutaneous eruption (RIME) reveals dysregulation of TNF/IFN signaling & classical monocytes: doi.org/10.1172/jci....
In this Research Letter by Hal M. Hoffman @ferhatay.bsky.social & team, scRNA-seq analysis before & after treatment of recurrent infectious mucocutaneous eruption (RIME) reveals dysregulation of TNF/IFN signaling & classical monocytes: doi.org/10.1172/jci....
January 14, 2026 at 2:02 PM
From RIME to reason
In this Research Letter by Hal M. Hoffman @ferhatay.bsky.social & team, scRNA-seq analysis before & after treatment of recurrent infectious mucocutaneous eruption (RIME) reveals dysregulation of TNF/IFN signaling & classical monocytes: doi.org/10.1172/jci....
In this Research Letter by Hal M. Hoffman @ferhatay.bsky.social & team, scRNA-seq analysis before & after treatment of recurrent infectious mucocutaneous eruption (RIME) reveals dysregulation of TNF/IFN signaling & classical monocytes: doi.org/10.1172/jci....
ASCI member Fabio Cominelli 🙌
This study challenges the concept that colon cancer is a strictly nontransmissible disease
Fabio Cominelli & team report on a missense mutation in Muc2 that promotes gut microbiome and metabolome-dependent colitis-associated tumorigenesis in mice: doi.org/10.1172/JCI1...
Fabio Cominelli & team report on a missense mutation in Muc2 that promotes gut microbiome and metabolome-dependent colitis-associated tumorigenesis in mice: doi.org/10.1172/JCI1...
January 14, 2026 at 2:16 PM
ASCI member Fabio Cominelli 🙌
Individuals with autoimmune disease on immunosuppressants often have suboptimal responses to COVID-19 vaccines.
Here, ASCI member Judith A. James & team perform a randomized trial, reporting additional COVID-19 vaccination is effective & safe: insight.jci.org/articles/vie...
Here, ASCI member Judith A. James & team perform a randomized trial, reporting additional COVID-19 vaccination is effective & safe: insight.jci.org/articles/vie...
January 12, 2026 at 6:01 PM
Individuals with autoimmune disease on immunosuppressants often have suboptimal responses to COVID-19 vaccines.
Here, ASCI member Judith A. James & team perform a randomized trial, reporting additional COVID-19 vaccination is effective & safe: insight.jci.org/articles/vie...
Here, ASCI member Judith A. James & team perform a randomized trial, reporting additional COVID-19 vaccination is effective & safe: insight.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Celebrating a decade of JCI Insight — reflections from a former Editor in Chief
Kathleen L. Collins looks back on a transformative chapter as a testament to the power of collaboration: doi.org/10.1172/jci....
Kathleen L. Collins looks back on a transformative chapter as a testament to the power of collaboration: doi.org/10.1172/jci....
January 12, 2026 at 2:03 PM
Celebrating a decade of JCI Insight — reflections from a former Editor in Chief
Kathleen L. Collins looks back on a transformative chapter as a testament to the power of collaboration: doi.org/10.1172/jci....
Kathleen L. Collins looks back on a transformative chapter as a testament to the power of collaboration: doi.org/10.1172/jci....
From ASCI member John F. DiPersio!
Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal: doi.org/10.1172/JCI2...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
January 9, 2026 at 2:31 PM
From ASCI member John F. DiPersio!
Reposted by The American Society for Clinical Investigation
Congratulations to Dr. Amin Nassar, named a recipient of an Emerging-Generation Award by @the-asci.org. E-Gen Awards recognize post-MD, pre–faculty appointment physician-scientists who are meaningfully engaged in immersive research.
January 8, 2026 at 10:28 PM
Congratulations to Dr. Amin Nassar, named a recipient of an Emerging-Generation Award by @the-asci.org. E-Gen Awards recognize post-MD, pre–faculty appointment physician-scientists who are meaningfully engaged in immersive research.
A Tribute to Stuart A. Kornfeld (1932–2025) by Richard Steet and Richard D. Cummings: doi.org/10.1172/JCI2...
January 8, 2026 at 2:30 PM
A Tribute to Stuart A. Kornfeld (1932–2025) by Richard Steet and Richard D. Cummings: doi.org/10.1172/JCI2...
During caloric restriction, protein synthesis in the liver slows
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
January 7, 2026 at 6:38 PM
During caloric restriction, protein synthesis in the liver slows
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
Lung transplant recipients predisposed to impaired complement regulation have worse CLAD-free survival
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
January 7, 2026 at 2:30 PM
Lung transplant recipients predisposed to impaired complement regulation have worse CLAD-free survival
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Review: Cardiovascular complications of pregnancy
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
January 6, 2026 at 5:15 PM
Review: Cardiovascular complications of pregnancy
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Reposted by The American Society for Clinical Investigation
Can we help fat cells get in shape in diabetes?
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
January 6, 2026 at 2:03 PM
Can we help fat cells get in shape in diabetes?
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
Reposted by The American Society for Clinical Investigation
The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
January 5, 2026 at 2:02 PM
The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
The enduring flame: our legacy of resilience, a time of unprecedented potential, and igniting the future of discovery: doi.org/10.1172/JCI1...
ASCI Presidential Address by Anna Greka
ASCI Presidential Address by Anna Greka
January 5, 2026 at 2:30 PM
The enduring flame: our legacy of resilience, a time of unprecedented potential, and igniting the future of discovery: doi.org/10.1172/JCI1...
ASCI Presidential Address by Anna Greka
ASCI Presidential Address by Anna Greka
Reposted by The American Society for Clinical Investigation
cGAS/STING-mediated γδ T cell recruitment drives radioresistance: implications for improving radioimmunotherapy outcomes: doi.org/10.1172/JCI2...
Brooke C. Braman & David R. Raleigh comment on Yue Deng et al. doi.org/10.1172/JCI1...
Brooke C. Braman & David R. Raleigh comment on Yue Deng et al. doi.org/10.1172/JCI1...
December 26, 2025 at 2:01 PM
cGAS/STING-mediated γδ T cell recruitment drives radioresistance: implications for improving radioimmunotherapy outcomes: doi.org/10.1172/JCI2...
Brooke C. Braman & David R. Raleigh comment on Yue Deng et al. doi.org/10.1172/JCI1...
Brooke C. Braman & David R. Raleigh comment on Yue Deng et al. doi.org/10.1172/JCI1...
In this first in a series of Perspectives videos highlighting the connection between patients and physician-scientists, Dr. David Weinstock, an expert in the field of hematopoietic stem cell transplantation, and Samantha Watson, two-time cancer survivor, share their stories: buff.ly/9CDPFYt
December 23, 2025 at 5:12 PM
In this first in a series of Perspectives videos highlighting the connection between patients and physician-scientists, Dr. David Weinstock, an expert in the field of hematopoietic stem cell transplantation, and Samantha Watson, two-time cancer survivor, share their stories: buff.ly/9CDPFYt
A promising therapeutic in cardiac disease
ASCI member Howard A. Rockman & team identify a small molecule β1AR allosteric modulator that suppresses exercise-induced ventricular tachycardia in a murine model of catecholaminergic polymorphic ventricular tachycardia: doi.org/10.1172/JCI1...
ASCI member Howard A. Rockman & team identify a small molecule β1AR allosteric modulator that suppresses exercise-induced ventricular tachycardia in a murine model of catecholaminergic polymorphic ventricular tachycardia: doi.org/10.1172/JCI1...
December 22, 2025 at 2:30 PM
A promising therapeutic in cardiac disease
ASCI member Howard A. Rockman & team identify a small molecule β1AR allosteric modulator that suppresses exercise-induced ventricular tachycardia in a murine model of catecholaminergic polymorphic ventricular tachycardia: doi.org/10.1172/JCI1...
ASCI member Howard A. Rockman & team identify a small molecule β1AR allosteric modulator that suppresses exercise-induced ventricular tachycardia in a murine model of catecholaminergic polymorphic ventricular tachycardia: doi.org/10.1172/JCI1...
Providing a conceptual framework for targeting mitochondrial metabolism in immunotherapy & transplantation
ASCI member Pavan Reddy & team show the mitochondrial complex II component SDHA as a key switch in CD4 & CD8 T cell metabolism, function & differentiation: doi.org/10.1172/JCI1...
ASCI member Pavan Reddy & team show the mitochondrial complex II component SDHA as a key switch in CD4 & CD8 T cell metabolism, function & differentiation: doi.org/10.1172/JCI1...
December 19, 2025 at 5:07 PM
Providing a conceptual framework for targeting mitochondrial metabolism in immunotherapy & transplantation
ASCI member Pavan Reddy & team show the mitochondrial complex II component SDHA as a key switch in CD4 & CD8 T cell metabolism, function & differentiation: doi.org/10.1172/JCI1...
ASCI member Pavan Reddy & team show the mitochondrial complex II component SDHA as a key switch in CD4 & CD8 T cell metabolism, function & differentiation: doi.org/10.1172/JCI1...
Reposted by The American Society for Clinical Investigation
A widely held hypothesis posits that ER stress drives cell death in thyroid disease
Here, Peter Arvan & team generate thyroglobulin KO mice, finding stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress: doi.org/10.1172/JCI1...
Here, Peter Arvan & team generate thyroglobulin KO mice, finding stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress: doi.org/10.1172/JCI1...
December 18, 2025 at 2:06 PM
A widely held hypothesis posits that ER stress drives cell death in thyroid disease
Here, Peter Arvan & team generate thyroglobulin KO mice, finding stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress: doi.org/10.1172/JCI1...
Here, Peter Arvan & team generate thyroglobulin KO mice, finding stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress: doi.org/10.1172/JCI1...
Reposted by The American Society for Clinical Investigation
An activate-to-eliminate approach in HIV
Joel N. Blankson & team report on a strategy to selectively eliminate antigen-specific HIV infected CD4+ T cells by stimulation with cognate peptides and incubation with antiproliferative drugs: doi.org/10.1172/JCI1...
Joel N. Blankson & team report on a strategy to selectively eliminate antigen-specific HIV infected CD4+ T cells by stimulation with cognate peptides and incubation with antiproliferative drugs: doi.org/10.1172/JCI1...
December 17, 2025 at 2:03 PM
An activate-to-eliminate approach in HIV
Joel N. Blankson & team report on a strategy to selectively eliminate antigen-specific HIV infected CD4+ T cells by stimulation with cognate peptides and incubation with antiproliferative drugs: doi.org/10.1172/JCI1...
Joel N. Blankson & team report on a strategy to selectively eliminate antigen-specific HIV infected CD4+ T cells by stimulation with cognate peptides and incubation with antiproliferative drugs: doi.org/10.1172/JCI1...
Merkel cell polyomavirus can cause cancer, but how cells adopt a neuroendocrine state was unclear
ASCI member Isaac Brownell & team find a unique interaction between the integrated virus and the host’s circuitry for neuroendocrine TFs in Markel cell carcinoma: doi.org/10.1172/JCI1...
ASCI member Isaac Brownell & team find a unique interaction between the integrated virus and the host’s circuitry for neuroendocrine TFs in Markel cell carcinoma: doi.org/10.1172/JCI1...
December 16, 2025 at 5:06 PM
Merkel cell polyomavirus can cause cancer, but how cells adopt a neuroendocrine state was unclear
ASCI member Isaac Brownell & team find a unique interaction between the integrated virus and the host’s circuitry for neuroendocrine TFs in Markel cell carcinoma: doi.org/10.1172/JCI1...
ASCI member Isaac Brownell & team find a unique interaction between the integrated virus and the host’s circuitry for neuroendocrine TFs in Markel cell carcinoma: doi.org/10.1172/JCI1...
A new platform for advanced prostate cancer
ASCI member Steven P. Balk & team find AKT activation mitigates efficacy of AR targeted therapy in TMPRSS2:ERG fusion prostate cancer, suggesting combination therapy targeting AR and AKT in those with T:E fusion PCa: doi.org/10.1172/JCI1...
ASCI member Steven P. Balk & team find AKT activation mitigates efficacy of AR targeted therapy in TMPRSS2:ERG fusion prostate cancer, suggesting combination therapy targeting AR and AKT in those with T:E fusion PCa: doi.org/10.1172/JCI1...
December 15, 2025 at 2:30 PM
A new platform for advanced prostate cancer
ASCI member Steven P. Balk & team find AKT activation mitigates efficacy of AR targeted therapy in TMPRSS2:ERG fusion prostate cancer, suggesting combination therapy targeting AR and AKT in those with T:E fusion PCa: doi.org/10.1172/JCI1...
ASCI member Steven P. Balk & team find AKT activation mitigates efficacy of AR targeted therapy in TMPRSS2:ERG fusion prostate cancer, suggesting combination therapy targeting AR and AKT in those with T:E fusion PCa: doi.org/10.1172/JCI1...
Could TRPV4 blockers benefit patients with pancreatic cancer?
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
December 12, 2025 at 5:05 PM
Could TRPV4 blockers benefit patients with pancreatic cancer?
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
Reposted by The American Society for Clinical Investigation
Author Dr. Seth Zoth tells us about their discovery: A protective and heterosubtypic antibody lineage targeting the influenza A virus neuraminidase active site: doi.org/10.1172/JCI1...
December 11, 2025 at 5:16 PM
Author Dr. Seth Zoth tells us about their discovery: A protective and heterosubtypic antibody lineage targeting the influenza A virus neuraminidase active site: doi.org/10.1172/JCI1...
Reposted by The American Society for Clinical Investigation
You're only as old as your organs
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
December 11, 2025 at 2:02 PM
You're only as old as your organs
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.