JCI insight
@insight.jci.org
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
Dysregulated calcium signaling contributes to Alzheimer’s, but the molecular details are unresolved.
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
November 25, 2025 at 2:02 PM
Dysregulated calcium signaling contributes to Alzheimer’s, but the molecular details are unresolved.
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Reposted by JCI insight
Nguyen et al. identified a novel ROS-Ca2+ overload-mTORC1 cytopathic mechanism that underlies impaired autophagy and proposed various protective strategies to correct or relieve pathogenic alteration in β-cell lipotoxicity. 🧪
#PancSky
insight.jci.org/articles/vie...
#PancSky
insight.jci.org/articles/vie...
November 24, 2025 at 10:39 AM
Nguyen et al. identified a novel ROS-Ca2+ overload-mTORC1 cytopathic mechanism that underlies impaired autophagy and proposed various protective strategies to correct or relieve pathogenic alteration in β-cell lipotoxicity. 🧪
#PancSky
insight.jci.org/articles/vie...
#PancSky
insight.jci.org/articles/vie...
Reposted by JCI insight
Very excited to share the latest work from our lab in @insight.jci.org, highlighting a role for the #septin #cytoskeleton in protecting against "leaky gut", by recruiting non-muscle myosin II and stabilizing the tight junction.
Credit to @dominikrobak.bsky.social for the stunning cover image!
Credit to @dominikrobak.bsky.social for the stunning cover image!
This issue’s Cover: @ebrahim-lab.bsky.social @dominikrobak.bsky.social& team report on the septin cytoskeleton at apical junctions of intestinal epithelial cells, whereby it maintains barrier integrity & protects from inflammation: insight.jci.org/articles/vie...
November 24, 2025 at 6:01 PM
Very excited to share the latest work from our lab in @insight.jci.org, highlighting a role for the #septin #cytoskeleton in protecting against "leaky gut", by recruiting non-muscle myosin II and stabilizing the tight junction.
Credit to @dominikrobak.bsky.social for the stunning cover image!
Credit to @dominikrobak.bsky.social for the stunning cover image!
This issue’s Cover: @ebrahim-lab.bsky.social @dominikrobak.bsky.social& team report on the septin cytoskeleton at apical junctions of intestinal epithelial cells, whereby it maintains barrier integrity & protects from inflammation: insight.jci.org/articles/vie...
November 24, 2025 at 5:06 PM
This issue’s Cover: @ebrahim-lab.bsky.social @dominikrobak.bsky.social& team report on the septin cytoskeleton at apical junctions of intestinal epithelial cells, whereby it maintains barrier integrity & protects from inflammation: insight.jci.org/articles/vie...
Shared previously: In antibody-mediated glomerulonephritis, excessive neutrophilic inflammation contributes to kidney damage.
Partha S. Biswas & team find neutrophils upregulate Glut1 in murine AGN and Glut1-inhibitor treatment in mice ameliorates renal pathology.
insight.jci.org/articles/vie...
Partha S. Biswas & team find neutrophils upregulate Glut1 in murine AGN and Glut1-inhibitor treatment in mice ameliorates renal pathology.
insight.jci.org/articles/vie...
November 23, 2025 at 2:00 PM
Shared previously: In antibody-mediated glomerulonephritis, excessive neutrophilic inflammation contributes to kidney damage.
Partha S. Biswas & team find neutrophils upregulate Glut1 in murine AGN and Glut1-inhibitor treatment in mice ameliorates renal pathology.
insight.jci.org/articles/vie...
Partha S. Biswas & team find neutrophils upregulate Glut1 in murine AGN and Glut1-inhibitor treatment in mice ameliorates renal pathology.
insight.jci.org/articles/vie...
ICYMI: Predicting outcomes at an early stage of severe COVID-19…
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
November 22, 2025 at 2:00 PM
ICYMI: Predicting outcomes at an early stage of severe COVID-19…
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
Reposted by JCI insight
Our new paper that reveals immune-stromal crosstalk in synovium of juveniles idiopathic arthritis by spatial transcriptomics and newly developed computational tool is out in @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
JCI Insight -
Spatial transcriptomics reveals immune–stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis
insight.jci.org
November 22, 2025 at 4:28 AM
Our new paper that reveals immune-stromal crosstalk in synovium of juveniles idiopathic arthritis by spatial transcriptomics and newly developed computational tool is out in @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Should antiplatelet agents be given alongside lipid-lowering therapies after artery stent procedure?
Laskou et al. find platelets hinder inflammation resolution in atherosclerotic plaques after lipid-lowering treatment in insulin-resistant mice: insight.jci.org/articles/vie...
Laskou et al. find platelets hinder inflammation resolution in atherosclerotic plaques after lipid-lowering treatment in insulin-resistant mice: insight.jci.org/articles/vie...
November 21, 2025 at 2:03 PM
Should antiplatelet agents be given alongside lipid-lowering therapies after artery stent procedure?
Laskou et al. find platelets hinder inflammation resolution in atherosclerotic plaques after lipid-lowering treatment in insulin-resistant mice: insight.jci.org/articles/vie...
Laskou et al. find platelets hinder inflammation resolution in atherosclerotic plaques after lipid-lowering treatment in insulin-resistant mice: insight.jci.org/articles/vie...
Vaccine responses in PLWH with incomplete immune recovery
Robert Thimme & team report low CD4 counts limit vaccine-induced virus-specific CD8 T cell immunity in HIV-infected immunological non-responders & highlight boosters for enhancing responses: insight.jci.org/articles/vie...
Robert Thimme & team report low CD4 counts limit vaccine-induced virus-specific CD8 T cell immunity in HIV-infected immunological non-responders & highlight boosters for enhancing responses: insight.jci.org/articles/vie...
November 20, 2025 at 2:03 PM
Vaccine responses in PLWH with incomplete immune recovery
Robert Thimme & team report low CD4 counts limit vaccine-induced virus-specific CD8 T cell immunity in HIV-infected immunological non-responders & highlight boosters for enhancing responses: insight.jci.org/articles/vie...
Robert Thimme & team report low CD4 counts limit vaccine-induced virus-specific CD8 T cell immunity in HIV-infected immunological non-responders & highlight boosters for enhancing responses: insight.jci.org/articles/vie...
Is one vaccine platform superior to another?
Here, Pablo Penaloza-MacMaster @pemac.bsky.social & team performed a side-by-side comparison of adenovirus, mRNA, and protein vaccines in mice, revealing vaccine performance is shaped by context: insight.jci.org/articles/vie...
Here, Pablo Penaloza-MacMaster @pemac.bsky.social & team performed a side-by-side comparison of adenovirus, mRNA, and protein vaccines in mice, revealing vaccine performance is shaped by context: insight.jci.org/articles/vie...
November 19, 2025 at 2:03 PM
Is one vaccine platform superior to another?
Here, Pablo Penaloza-MacMaster @pemac.bsky.social & team performed a side-by-side comparison of adenovirus, mRNA, and protein vaccines in mice, revealing vaccine performance is shaped by context: insight.jci.org/articles/vie...
Here, Pablo Penaloza-MacMaster @pemac.bsky.social & team performed a side-by-side comparison of adenovirus, mRNA, and protein vaccines in mice, revealing vaccine performance is shaped by context: insight.jci.org/articles/vie...
In antibody-mediated glomerulonephritis, excessive neutrophilic inflammation contributes to kidney damage.
Partha S. Biswas & team find neutrophils upregulate Glut1 in murine AGN and Glut1-inhibitor treatment in mice ameliorates renal pathology: insight.jci.org/articles/vie...
Partha S. Biswas & team find neutrophils upregulate Glut1 in murine AGN and Glut1-inhibitor treatment in mice ameliorates renal pathology: insight.jci.org/articles/vie...
November 18, 2025 at 2:02 PM
In antibody-mediated glomerulonephritis, excessive neutrophilic inflammation contributes to kidney damage.
Partha S. Biswas & team find neutrophils upregulate Glut1 in murine AGN and Glut1-inhibitor treatment in mice ameliorates renal pathology: insight.jci.org/articles/vie...
Partha S. Biswas & team find neutrophils upregulate Glut1 in murine AGN and Glut1-inhibitor treatment in mice ameliorates renal pathology: insight.jci.org/articles/vie...
Predicting outcomes at an early stage of severe COVID-19…
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
November 17, 2025 at 2:02 PM
Predicting outcomes at an early stage of severe COVID-19…
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
ICYMI: In RA, fibroblast-like synoviocytes promote inflammation, but no medications target these cells.
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice:
insight.jci.org/articles/vie...
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice:
insight.jci.org/articles/vie...
November 16, 2025 at 2:02 PM
ICYMI: In RA, fibroblast-like synoviocytes promote inflammation, but no medications target these cells.
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice:
insight.jci.org/articles/vie...
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice:
insight.jci.org/articles/vie...
Previously shared: Podocyte injury and loss are key events in the progression of chronic kidney disease.
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases: insight.jci.org/articles/vie...
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases: insight.jci.org/articles/vie...
November 15, 2025 at 2:00 PM
Previously shared: Podocyte injury and loss are key events in the progression of chronic kidney disease.
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases: insight.jci.org/articles/vie...
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases: insight.jci.org/articles/vie...
Reposted by JCI insight
Excited to present our recent work on myosin as a molecular target for genetic muscle diseases! Kudos to all authors, especially Elise, Fanny and @myofinlab.bsky.social @ucph.bsky.social
JCI Insight -
Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy
insight.jci.org
November 13, 2025 at 10:18 AM
Excited to present our recent work on myosin as a molecular target for genetic muscle diseases! Kudos to all authors, especially Elise, Fanny and @myofinlab.bsky.social @ucph.bsky.social
Reposted by JCI insight
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
November 13, 2025 at 5:08 PM
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
In RA, fibroblast-like synoviocytes promote inflammation, but no medications target these cells.
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice: insight.jci.org/articles/vie...
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice: insight.jci.org/articles/vie...
November 12, 2025 at 2:03 PM
In RA, fibroblast-like synoviocytes promote inflammation, but no medications target these cells.
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice: insight.jci.org/articles/vie...
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice: insight.jci.org/articles/vie...
A high percentage of neonatal seizures resist treatment
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
November 11, 2025 at 2:03 PM
A high percentage of neonatal seizures resist treatment
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Podocyte injury and loss are key events in the progression of chronic kidney disease.
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases.
insight.jci.org/articles/vie...
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases.
insight.jci.org/articles/vie...
November 10, 2025 at 5:15 PM
Podocyte injury and loss are key events in the progression of chronic kidney disease.
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases.
insight.jci.org/articles/vie...
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases.
insight.jci.org/articles/vie...
Previously shared: Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
November 9, 2025 at 2:01 PM
Previously shared: Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
From earlier this week: Wiedemann Steiner syndrome is a rare genetic disorder.
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction: insight.jci.org/articles/vie...
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction: insight.jci.org/articles/vie...
November 8, 2025 at 2:01 PM
From earlier this week: Wiedemann Steiner syndrome is a rare genetic disorder.
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction: insight.jci.org/articles/vie...
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction: insight.jci.org/articles/vie...
Cell-free DNA methylomics identify tissue injury patterns in pediatric ARDS
In this Research Letter, Nadir Yehya & team assessed 24 children with ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls: insight.jci.org/articles/vie...
In this Research Letter, Nadir Yehya & team assessed 24 children with ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls: insight.jci.org/articles/vie...
November 7, 2025 at 2:04 PM
Cell-free DNA methylomics identify tissue injury patterns in pediatric ARDS
In this Research Letter, Nadir Yehya & team assessed 24 children with ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls: insight.jci.org/articles/vie...
In this Research Letter, Nadir Yehya & team assessed 24 children with ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls: insight.jci.org/articles/vie...
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
November 6, 2025 at 2:03 PM
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Reposted by JCI insight
Congrats to #LaitilaJenni & colleagues for their new @JCI_insight paper: Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy. #Myoblue tinyurl.com/yyuthutn
JCI Insight -
Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy
tinyurl.com
November 4, 2025 at 5:32 PM
Congrats to #LaitilaJenni & colleagues for their new @JCI_insight paper: Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy. #Myoblue tinyurl.com/yyuthutn
Recently, a rare pediatric case revealed a role for Site1-protease in development and lipid metabolism.
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
November 5, 2025 at 2:03 PM
Recently, a rare pediatric case revealed a role for Site1-protease in development and lipid metabolism.
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...