JCI insight
@insight.jci.org
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
Marking 10-years of JCI Insight, this Anniversary Collection brings together reflections from editors across the journal’s tenure, looking back—and ahead: insight.jci.org/collections/...
January 14, 2026 at 5:15 PM
Marking 10-years of JCI Insight, this Anniversary Collection brings together reflections from editors across the journal’s tenure, looking back—and ahead: insight.jci.org/collections/...
From RIME to reason
In this Research Letter by Hal M. Hoffman @ferhatay.bsky.social & team, scRNA-seq analysis before & after treatment of recurrent infectious mucocutaneous eruption (RIME) reveals dysregulation of TNF/IFN signaling & classical monocytes: doi.org/10.1172/jci....
In this Research Letter by Hal M. Hoffman @ferhatay.bsky.social & team, scRNA-seq analysis before & after treatment of recurrent infectious mucocutaneous eruption (RIME) reveals dysregulation of TNF/IFN signaling & classical monocytes: doi.org/10.1172/jci....
January 14, 2026 at 2:02 PM
From RIME to reason
In this Research Letter by Hal M. Hoffman @ferhatay.bsky.social & team, scRNA-seq analysis before & after treatment of recurrent infectious mucocutaneous eruption (RIME) reveals dysregulation of TNF/IFN signaling & classical monocytes: doi.org/10.1172/jci....
In this Research Letter by Hal M. Hoffman @ferhatay.bsky.social & team, scRNA-seq analysis before & after treatment of recurrent infectious mucocutaneous eruption (RIME) reveals dysregulation of TNF/IFN signaling & classical monocytes: doi.org/10.1172/jci....
Offering a high-resolution spatial atlas of pediatric arthritis:
@juninamo.bsky.social & team profiles nearly 400,000 cells across 9 patients with juvenile idiopathic arthritis, revealing disease-specific immune–stromal interactions within the synovium: doi.org/10.1172/jci....
@juninamo.bsky.social & team profiles nearly 400,000 cells across 9 patients with juvenile idiopathic arthritis, revealing disease-specific immune–stromal interactions within the synovium: doi.org/10.1172/jci....
January 13, 2026 at 2:03 PM
Offering a high-resolution spatial atlas of pediatric arthritis:
@juninamo.bsky.social & team profiles nearly 400,000 cells across 9 patients with juvenile idiopathic arthritis, revealing disease-specific immune–stromal interactions within the synovium: doi.org/10.1172/jci....
@juninamo.bsky.social & team profiles nearly 400,000 cells across 9 patients with juvenile idiopathic arthritis, revealing disease-specific immune–stromal interactions within the synovium: doi.org/10.1172/jci....
Celebrating a decade of JCI Insight — reflections from a former Editor in Chief
Kathleen L. Collins looks back on a transformative chapter as a testament to the power of collaboration: doi.org/10.1172/jci....
Kathleen L. Collins looks back on a transformative chapter as a testament to the power of collaboration: doi.org/10.1172/jci....
January 12, 2026 at 2:03 PM
Celebrating a decade of JCI Insight — reflections from a former Editor in Chief
Kathleen L. Collins looks back on a transformative chapter as a testament to the power of collaboration: doi.org/10.1172/jci....
Kathleen L. Collins looks back on a transformative chapter as a testament to the power of collaboration: doi.org/10.1172/jci....
Acute rheumatic fever is an autoinflammatory disease
@njmoreland.bsky.social, @rhcmcg.bsky.social report widespread antibody heterogeneity, yet identify a protein expressed in cardiac muscle as an immunodominant autoantigen: doi.org/10.1172/jci....
@njmoreland.bsky.social, @rhcmcg.bsky.social report widespread antibody heterogeneity, yet identify a protein expressed in cardiac muscle as an immunodominant autoantigen: doi.org/10.1172/jci....
January 11, 2026 at 2:01 PM
Acute rheumatic fever is an autoinflammatory disease
@njmoreland.bsky.social, @rhcmcg.bsky.social report widespread antibody heterogeneity, yet identify a protein expressed in cardiac muscle as an immunodominant autoantigen: doi.org/10.1172/jci....
@njmoreland.bsky.social, @rhcmcg.bsky.social report widespread antibody heterogeneity, yet identify a protein expressed in cardiac muscle as an immunodominant autoantigen: doi.org/10.1172/jci....
Prepare for slingshot
Editor in Chief Oliver Eickelberg discusses our core mission, challenges, and trajectory, in recognition of JCI Insight’s 10-year anniversary. doi.org/10.1172/jci....
Editor in Chief Oliver Eickelberg discusses our core mission, challenges, and trajectory, in recognition of JCI Insight’s 10-year anniversary. doi.org/10.1172/jci....
January 10, 2026 at 5:15 PM
Prepare for slingshot
Editor in Chief Oliver Eickelberg discusses our core mission, challenges, and trajectory, in recognition of JCI Insight’s 10-year anniversary. doi.org/10.1172/jci....
Editor in Chief Oliver Eickelberg discusses our core mission, challenges, and trajectory, in recognition of JCI Insight’s 10-year anniversary. doi.org/10.1172/jci....
The native human glomerulus features a slit diaphragm resembling a densely interwoven fishnet
Here, Achilleas S. Frangakis & team resolve a specialized component of the kidney’s filtration barrier across the extracellular space at the nanometer scale: doi.org/10.1172/jci....
Here, Achilleas S. Frangakis & team resolve a specialized component of the kidney’s filtration barrier across the extracellular space at the nanometer scale: doi.org/10.1172/jci....
January 10, 2026 at 2:02 PM
The native human glomerulus features a slit diaphragm resembling a densely interwoven fishnet
Here, Achilleas S. Frangakis & team resolve a specialized component of the kidney’s filtration barrier across the extracellular space at the nanometer scale: doi.org/10.1172/jci....
Here, Achilleas S. Frangakis & team resolve a specialized component of the kidney’s filtration barrier across the extracellular space at the nanometer scale: doi.org/10.1172/jci....
When the JCI went rogue
Founding Editor Howard A. Rockman tells us about launching JCI Insight ten years ago: doi.org/10.1172/jci....
Founding Editor Howard A. Rockman tells us about launching JCI Insight ten years ago: doi.org/10.1172/jci....
January 9, 2026 at 8:30 PM
When the JCI went rogue
Founding Editor Howard A. Rockman tells us about launching JCI Insight ten years ago: doi.org/10.1172/jci....
Founding Editor Howard A. Rockman tells us about launching JCI Insight ten years ago: doi.org/10.1172/jci....
Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system
January 9, 2026 at 5:15 PM
Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system
Ready for a tour through vascular permeability
This issue’s cover features work by Sara González-Hernández et al. on the role of endothelial PROX1 (a lymphatic marker) in pathological disruption to the blood brain barrier: doi.org/10.1172/jci....
This issue’s cover features work by Sara González-Hernández et al. on the role of endothelial PROX1 (a lymphatic marker) in pathological disruption to the blood brain barrier: doi.org/10.1172/jci....
January 9, 2026 at 5:15 PM
Ready for a tour through vascular permeability
This issue’s cover features work by Sara González-Hernández et al. on the role of endothelial PROX1 (a lymphatic marker) in pathological disruption to the blood brain barrier: doi.org/10.1172/jci....
This issue’s cover features work by Sara González-Hernández et al. on the role of endothelial PROX1 (a lymphatic marker) in pathological disruption to the blood brain barrier: doi.org/10.1172/jci....
We need immunostimulatory agents for chronic infections & cancer (without toxicity)
Here, Takuya Yamamoto & team show SA-5, a novel oral TLR7 agonist, safely stimulates immune responses in young and aged macaques: doi.org/10.1172/jci....
Here, Takuya Yamamoto & team show SA-5, a novel oral TLR7 agonist, safely stimulates immune responses in young and aged macaques: doi.org/10.1172/jci....
January 8, 2026 at 2:03 PM
We need immunostimulatory agents for chronic infections & cancer (without toxicity)
Here, Takuya Yamamoto & team show SA-5, a novel oral TLR7 agonist, safely stimulates immune responses in young and aged macaques: doi.org/10.1172/jci....
Here, Takuya Yamamoto & team show SA-5, a novel oral TLR7 agonist, safely stimulates immune responses in young and aged macaques: doi.org/10.1172/jci....
Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19
January 7, 2026 at 2:56 PM
Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19
How does SARS-CoV2 affect cardiac conduction?
Brian O'Rourke & team show long-lasting cardiac arrhythmias are linked to innate immune activation and oxidative stress in the absence of direct cardiac viral infection, in an animal model of COVID-19: doi.org/10.1172/jci....
Brian O'Rourke & team show long-lasting cardiac arrhythmias are linked to innate immune activation and oxidative stress in the absence of direct cardiac viral infection, in an animal model of COVID-19: doi.org/10.1172/jci....
January 7, 2026 at 2:02 PM
How does SARS-CoV2 affect cardiac conduction?
Brian O'Rourke & team show long-lasting cardiac arrhythmias are linked to innate immune activation and oxidative stress in the absence of direct cardiac viral infection, in an animal model of COVID-19: doi.org/10.1172/jci....
Brian O'Rourke & team show long-lasting cardiac arrhythmias are linked to innate immune activation and oxidative stress in the absence of direct cardiac viral infection, in an animal model of COVID-19: doi.org/10.1172/jci....
How does NVP-BHG712 protect against pulmonary fibrosis in mice?
Mohit Kapoor & team identify EphB4 receptor as a crucial mediator of PF that regulates genes involved in ECM organization, ER cargo concentration & protein trafficking in fibroblasts: doi.org/10.1172/jci....
Mohit Kapoor & team identify EphB4 receptor as a crucial mediator of PF that regulates genes involved in ECM organization, ER cargo concentration & protein trafficking in fibroblasts: doi.org/10.1172/jci....
January 6, 2026 at 2:02 PM
How does NVP-BHG712 protect against pulmonary fibrosis in mice?
Mohit Kapoor & team identify EphB4 receptor as a crucial mediator of PF that regulates genes involved in ECM organization, ER cargo concentration & protein trafficking in fibroblasts: doi.org/10.1172/jci....
Mohit Kapoor & team identify EphB4 receptor as a crucial mediator of PF that regulates genes involved in ECM organization, ER cargo concentration & protein trafficking in fibroblasts: doi.org/10.1172/jci....
A rebrand for proteasome inhibition in solid tumors
In this Research Letter, Larrain et al. investigate the potential of hepatic artery infusion pump delivery of carfilzomib, to continuously direct a large dose to the tumor with least hepatic toxicity: doi.org/10.1172/jci....
In this Research Letter, Larrain et al. investigate the potential of hepatic artery infusion pump delivery of carfilzomib, to continuously direct a large dose to the tumor with least hepatic toxicity: doi.org/10.1172/jci....
January 5, 2026 at 2:02 PM
A rebrand for proteasome inhibition in solid tumors
In this Research Letter, Larrain et al. investigate the potential of hepatic artery infusion pump delivery of carfilzomib, to continuously direct a large dose to the tumor with least hepatic toxicity: doi.org/10.1172/jci....
In this Research Letter, Larrain et al. investigate the potential of hepatic artery infusion pump delivery of carfilzomib, to continuously direct a large dose to the tumor with least hepatic toxicity: doi.org/10.1172/jci....
Celebrating 10 years of JCI Insight!
The video highlights selected covers through the years
—
Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays
The video highlights selected covers through the years
—
Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays
January 4, 2026 at 2:00 PM
Celebrating 10 years of JCI Insight!
The video highlights selected covers through the years
—
Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays
The video highlights selected covers through the years
—
Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays
Worth revisiting from 2025: Epigenetic scarring after chronic infection or cancer can lock immune cells into a dysfunctional state.
Here, @hazemghoneim.bsky.social & team develop an in vitro model of terminal CD8+ T cell dysfunction that better mimics in vivo exhaustion: doi.org/10.1172/jci....
Here, @hazemghoneim.bsky.social & team develop an in vitro model of terminal CD8+ T cell dysfunction that better mimics in vivo exhaustion: doi.org/10.1172/jci....
January 3, 2026 at 2:02 PM
Worth revisiting from 2025: Epigenetic scarring after chronic infection or cancer can lock immune cells into a dysfunctional state.
Here, @hazemghoneim.bsky.social & team develop an in vitro model of terminal CD8+ T cell dysfunction that better mimics in vivo exhaustion: doi.org/10.1172/jci....
Here, @hazemghoneim.bsky.social & team develop an in vitro model of terminal CD8+ T cell dysfunction that better mimics in vivo exhaustion: doi.org/10.1172/jci....
Animal studies clarify how vaccines protect, but limited human correlates complicate interpretation
Kate Bridges et al. now show cross-species blood transcriptional correlates of BCG-mediated protection include innate & adaptive immune processes: doi.org/10.1172/jci....
Kate Bridges et al. now show cross-species blood transcriptional correlates of BCG-mediated protection include innate & adaptive immune processes: doi.org/10.1172/jci....
January 2, 2026 at 2:01 PM
Animal studies clarify how vaccines protect, but limited human correlates complicate interpretation
Kate Bridges et al. now show cross-species blood transcriptional correlates of BCG-mediated protection include innate & adaptive immune processes: doi.org/10.1172/jci....
Kate Bridges et al. now show cross-species blood transcriptional correlates of BCG-mediated protection include innate & adaptive immune processes: doi.org/10.1172/jci....
Celebrating 10 years of JCI Insight!
The video highlights selected covers through the years
—
Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays
The video highlights selected covers through the years
—
Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays
January 1, 2026 at 2:02 PM
Celebrating 10 years of JCI Insight!
The video highlights selected covers through the years
—
Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays
The video highlights selected covers through the years
—
Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays
Count down: Our top 5 most-accessed manuscripts of 2025!
#1: Human Pegivirus alters immune and transcriptomic profiles in brain and blood of Parkinson's Disease patients: insight.jci.org/articles/vie...
@igorkoralnik.bsky.social @nmneurology.bsky.social
#1: Human Pegivirus alters immune and transcriptomic profiles in brain and blood of Parkinson's Disease patients: insight.jci.org/articles/vie...
@igorkoralnik.bsky.social @nmneurology.bsky.social
December 31, 2025 at 2:02 PM
Count down: Our top 5 most-accessed manuscripts of 2025!
#1: Human Pegivirus alters immune and transcriptomic profiles in brain and blood of Parkinson's Disease patients: insight.jci.org/articles/vie...
@igorkoralnik.bsky.social @nmneurology.bsky.social
#1: Human Pegivirus alters immune and transcriptomic profiles in brain and blood of Parkinson's Disease patients: insight.jci.org/articles/vie...
@igorkoralnik.bsky.social @nmneurology.bsky.social
Count down: Our top 5 most-accessed manuscripts of 2025!
#2: Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice: doi.org/10.1172/jci....
#2: Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice: doi.org/10.1172/jci....
December 30, 2025 at 2:02 PM
Count down: Our top 5 most-accessed manuscripts of 2025!
#2: Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice: doi.org/10.1172/jci....
#2: Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice: doi.org/10.1172/jci....
Count down: Our top 5 most-accessed manuscripts of 2025!
#3: NAD+ prevents chronic kidney disease by activating renal tubular metabolism: doi.org/10.1172/jci....
#3: NAD+ prevents chronic kidney disease by activating renal tubular metabolism: doi.org/10.1172/jci....
December 29, 2025 at 2:02 PM
Count down: Our top 5 most-accessed manuscripts of 2025!
#3: NAD+ prevents chronic kidney disease by activating renal tubular metabolism: doi.org/10.1172/jci....
#3: NAD+ prevents chronic kidney disease by activating renal tubular metabolism: doi.org/10.1172/jci....
AAV-mediated base editing restores cochlear gap junction in GJB2 dominant-negative mutation-associated syndromic hearing loss model
December 28, 2025 at 2:01 PM
AAV-mediated base editing restores cochlear gap junction in GJB2 dominant-negative mutation-associated syndromic hearing loss model
Count down: Our top 5 most-accessed manuscripts of 2025!
#4: AAV-mediated base editing restores cochlear gap-junction with a GJB2 dominant-negative mutation causing syndromic #hearing loss: doi.org/10.1172/jci....
#4: AAV-mediated base editing restores cochlear gap-junction with a GJB2 dominant-negative mutation causing syndromic #hearing loss: doi.org/10.1172/jci....
December 28, 2025 at 2:01 PM
Count down: Our top 5 most-accessed manuscripts of 2025!
#4: AAV-mediated base editing restores cochlear gap-junction with a GJB2 dominant-negative mutation causing syndromic #hearing loss: doi.org/10.1172/jci....
#4: AAV-mediated base editing restores cochlear gap-junction with a GJB2 dominant-negative mutation causing syndromic #hearing loss: doi.org/10.1172/jci....