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JCI insight @insight.jci.org · 9h

How are the collecting ducts of the kidney formed and maintained?

This issue’s cover features work by Karen I. López-Cayuqueo & team on the role of transcription factor TFAP2A in the architecture of the adult—but not embryonic—renal collecting duct: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 1d

How might air pollution contribute to insulin resistance?

Sanjay Rajagopalan & team demonstrate exposure to PM2.5 air pollution in mice leads to mitochondrial dysfunction in brown fat & metabolic dysfunction through epigenetic regulation: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 2d

NF1 is frequently mutated in glioblastoma, yet therapies targeting this alteration often fall short.

Harish N. Vasudevan & team now show NF1 mutant glioblastomas exhibit prognostic signatures with distinct sensitivity to MEK inhibition: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 3d

ICYMI: Proof-of-concept: A vaccination strategy to prevent coxsackie virus B3–induced development of pancreatic cancer

Pandey et al. vaccinate mice against the common enterovirus CVB3, decreasing infected cells & dramatically reducing abnormal pancreatic areas: insight.jci.org/articles/vie...

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JCI insight @insight.jci.org · 4d

Previously shared: A technical advance in the field of organ transplantation!

@tobias-b-huber.bsky.social & team develop a metabolite-enhanced perfusion solution that improves kidney transplant viability, testing it across various species, including humans: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 5d

How can we study the effects of radiation on immune cells in #cancer?

Using innovative human pancreatic tumor models, @science-wallet.bsky.social and team reveal photon and particle radiotherapy induce signals—grouped as modules—that attract immune cells: insight.jci.org/articles/vie...

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Reposted by JCI insight

American Physician Scientists Association @a-p-s-a.bsky.social · 6d

🚨 New publication! 🚨In this perspective published in
@insight.jci.org, previous APSA Presidents and Executive Committee members highlight key APSA milestones in strengthening the physician-scientist community, including 20 years of the joint ASCI/AAP/APSA annual meeting!

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JCI insight @insight.jci.org · 6d

On a FOX hunt in severe autoimmunity

Jonathan S. Maltzman & team explore the functional interactions among FOXP family members in regulatory T cells, revealing loss of Foxp1 & Foxp4 in Tregs from mice causes systemic inflammation and premature lethality: buff.ly/4kzMQe0

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JCI insight @insight.jci.org · 7d

Behind the Scenes: the Khader lab takes a summer outing!

JCI insight @insight.jci.org · 7d

This case series highlights risk factors for infection by a non-tuberculous mycobacterium.

Ananya Gupta @drabhi.bsky.social et al. link GATA2 mutation in the context of immune dysfunction to enhanced susceptibility to M. heamophilum infection in humans: buff.ly/pPIhSlx

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JCI insight @insight.jci.org · 8d

This research article is climbing to the top with views!

Stimulation of skeletal stem cells in the growth plate promotes linear bone growth by Dana Trompet et al.

buff.ly/bvEZnpb

JCI Insight - Stimulation of skeletal stem cells in the growth plate promotes linear bone growth

Research ArticleBone biologyStem cells Open Access | 10.1172/jci.insight.165226

insight.jci.org

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JCI insight @insight.jci.org · 8d

Proof-of-concept: A vaccination strategy to prevent coxsackie virus B3–induced development of pancreatic cancer

Pandey et al. vaccinate mice against the common enterovirus CVB3, decreasing infected cells & dramatically reducing abnormal pancreatic areas: buff.ly/EV0u2mK

JCI insight @insight.jci.org · 9d

A technical advance in the field of organ transplantation!

@tobias-b-huber.bsky.social & team develop a metabolite-enhanced perfusion solution that improves kidney transplant viability, testing it across various species, including humans:
buff.ly/FyKsRiE

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Reposted by JCI insight

Yijia Li @yijiali89.bsky.social · 25d

JCI Insight - Virologic characteristics of SARS-CoV-2 infection across evolving omicron subvariants insight.jci.org/articles/vie...

JCI Insight - Virologic characteristics of SARS-CoV-2 infection across evolving omicron subvariants

insight.jci.org

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JCI insight @insight.jci.org · 10d

Previously shared: GLP-2 analogs are used for short bowel syndrome.

Kudo et al. studied intestinal tissue from 5 patients throughout a year, finding GLP-2 analogs induce nutrient-absorbing and immune-suppressive cells while also enhancing microbiota diversity: buff.ly/hiG0IDk

JCI insight @insight.jci.org · 11d

ICYMI: 30 years ago, researchers identified polycystin proteins as involved with autosomal dominant polycystic kidney disease.

This issue’s cover features work by Ivana Y. Kuo & team @pkdfoundation.bsky.social on the polycystin complex and its critical role in urine concentration:
buff.ly/aTN2NxA

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JCI insight @insight.jci.org · 12d

Irregular heartbeat is a common complication after surgery.

In this research letter, Xander H.T. Wehrens & team reveal a factor derived from atrial fibroblasts—MIF—necessary for atrial macrophage recruitment and post-operative AFib: buff.ly/PL8GnGT

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Reposted by JCI insight

Journal of Clinical Investigation @jci.org · 13d

An open letter to the NIH: Value and costs in publishing

Here we share our response to the NIH’s request for information on maximizing research funds by limiting allowable publishing costs: buff.ly/K6hbsA4

#AcademicPublishing #ScholarlyPublishing #OpenAccess
@scholarlykitchen.bsky.social

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JCI insight @insight.jci.org · 13d

Acute kidney injury increases the risk for long-term kidney dysfunction

Wen et al. identify urine proteins in pathways of degenerative tubular cell injury, inflammation & fibrosis associated with long-term eGFR decline after hospitalization with AKI: buff.ly/6xqmTk5

JCI insight @insight.jci.org · 14d

GLP-2 analogs are used for short bowel syndrome.

Kudo et al. studied intestinal tissue from 5 patients throughout a year, finding GLP-2 analogs induce nutrient-absorbing and immune-suppressive cells while also enhancing microbiota diversity: buff.ly/hiG0IDk

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JCI insight @insight.jci.org · 15d

30 years ago, researchers identified polycystin proteins as involved with autosomal dominant polycystic kidney disease.

This issue’s cover features work by Ivana Y. Kuo & team @pkdfoundation.bsky.social on the polycystin complex and its critical role in urine concentration: buff.ly/aTN2NxA

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JCI insight @insight.jci.org · 15d

How well do blood tests reflect the pulmonary microenvironment in post-transplant lung injury?

@mattzinter.bsky.social & team evaluate paired lung and peripheral blood transcriptomes in patients with hematopoietic stem cell transplants.

Full report: buff.ly/IuYJxNr

JCI insight @insight.jci.org · 16d

No bones about it—cellular recycling increases bone formation

Melda Onal & team show mice with increased autophagy in osteoblast lineage cells have enhanced bone mass and strength.

buff.ly/4pcEoLd

JCI insight @insight.jci.org · 17d

ICYMI: A vaccine for Pseudomonas has eluded researchers for decades

@nizet.bsky.social & team now provide a different vaccination approach, demonstrating an engineered nanoparticle vaccine protects mice against lethal pneumonia.

Full report: buff.ly/QgqHe0M