The American Society for Clinical Investigation
@the-asci.org
The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry.
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How is fecal microbiota transplantation protective in recurrent C. difficile infection?
ASCI member William A. Petri Jr. & team report treatment promotes activation of cell proliferation pathways and type 2 responses within the colon: doi.org/10.1172/jci....
ASCI member William A. Petri Jr. & team report treatment promotes activation of cell proliferation pathways and type 2 responses within the colon: doi.org/10.1172/jci....
January 15, 2026 at 5:05 PM
How is fecal microbiota transplantation protective in recurrent C. difficile infection?
ASCI member William A. Petri Jr. & team report treatment promotes activation of cell proliferation pathways and type 2 responses within the colon: doi.org/10.1172/jci....
ASCI member William A. Petri Jr. & team report treatment promotes activation of cell proliferation pathways and type 2 responses within the colon: doi.org/10.1172/jci....
This Research Letter describes a new molecular basis for lipodystrophy syndromes
ASCI member Abhimanyu Garg & team report a recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis and hypoglycemia: doi.org/10.1172/JCI1...
ASCI member Abhimanyu Garg & team report a recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis and hypoglycemia: doi.org/10.1172/JCI1...
January 15, 2026 at 2:30 PM
This Research Letter describes a new molecular basis for lipodystrophy syndromes
ASCI member Abhimanyu Garg & team report a recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis and hypoglycemia: doi.org/10.1172/JCI1...
ASCI member Abhimanyu Garg & team report a recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis and hypoglycemia: doi.org/10.1172/JCI1...
Join us for ASCI Scientific Session on January 28th, 1-2PM EST:
Dr. Jay K. Kolls discussing: CD4+ T cell and Lung Immunity: lessons from HIV and primary immunodeficiencies
Register: buff.ly/i1VP2pL
Dr. Jay K. Kolls discussing: CD4+ T cell and Lung Immunity: lessons from HIV and primary immunodeficiencies
Register: buff.ly/i1VP2pL
January 14, 2026 at 6:38 PM
Join us for ASCI Scientific Session on January 28th, 1-2PM EST:
Dr. Jay K. Kolls discussing: CD4+ T cell and Lung Immunity: lessons from HIV and primary immunodeficiencies
Register: buff.ly/i1VP2pL
Dr. Jay K. Kolls discussing: CD4+ T cell and Lung Immunity: lessons from HIV and primary immunodeficiencies
Register: buff.ly/i1VP2pL
Individuals with autoimmune disease on immunosuppressants often have suboptimal responses to COVID-19 vaccines.
Here, ASCI member Judith A. James & team perform a randomized trial, reporting additional COVID-19 vaccination is effective & safe: insight.jci.org/articles/vie...
Here, ASCI member Judith A. James & team perform a randomized trial, reporting additional COVID-19 vaccination is effective & safe: insight.jci.org/articles/vie...
January 12, 2026 at 6:01 PM
Individuals with autoimmune disease on immunosuppressants often have suboptimal responses to COVID-19 vaccines.
Here, ASCI member Judith A. James & team perform a randomized trial, reporting additional COVID-19 vaccination is effective & safe: insight.jci.org/articles/vie...
Here, ASCI member Judith A. James & team perform a randomized trial, reporting additional COVID-19 vaccination is effective & safe: insight.jci.org/articles/vie...
A Tribute to Stuart A. Kornfeld (1932–2025) by Richard Steet and Richard D. Cummings: doi.org/10.1172/JCI2...
January 8, 2026 at 2:30 PM
A Tribute to Stuart A. Kornfeld (1932–2025) by Richard Steet and Richard D. Cummings: doi.org/10.1172/JCI2...
During caloric restriction, protein synthesis in the liver slows
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
January 7, 2026 at 6:38 PM
During caloric restriction, protein synthesis in the liver slows
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
ASCI member Marc K. Hellerstein & team now show nitric oxide is essential for this reduction, which occurs as a rapid transition event between weeks 4-5 in mice: doi.org/10.1172/JCI1...
Lung transplant recipients predisposed to impaired complement regulation have worse CLAD-free survival
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
January 7, 2026 at 2:30 PM
Lung transplant recipients predisposed to impaired complement regulation have worse CLAD-free survival
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
ASCI member Hrishikesh S. Kulkarni & team reveal this phenotype is associated with intragraft B-cell activation and donor-specific antibodies in mice: www.jci.org/articles/vie...
The enduring flame: our legacy of resilience, a time of unprecedented potential, and igniting the future of discovery: doi.org/10.1172/JCI1...
ASCI Presidential Address by Anna Greka
ASCI Presidential Address by Anna Greka
January 5, 2026 at 2:30 PM
The enduring flame: our legacy of resilience, a time of unprecedented potential, and igniting the future of discovery: doi.org/10.1172/JCI1...
ASCI Presidential Address by Anna Greka
ASCI Presidential Address by Anna Greka
In this first in a series of Perspectives videos highlighting the connection between patients and physician-scientists, Dr. David Weinstock, an expert in the field of hematopoietic stem cell transplantation, and Samantha Watson, two-time cancer survivor, share their stories: buff.ly/9CDPFYt
December 23, 2025 at 5:12 PM
In this first in a series of Perspectives videos highlighting the connection between patients and physician-scientists, Dr. David Weinstock, an expert in the field of hematopoietic stem cell transplantation, and Samantha Watson, two-time cancer survivor, share their stories: buff.ly/9CDPFYt
A promising therapeutic in cardiac disease
ASCI member Howard A. Rockman & team identify a small molecule β1AR allosteric modulator that suppresses exercise-induced ventricular tachycardia in a murine model of catecholaminergic polymorphic ventricular tachycardia: doi.org/10.1172/JCI1...
ASCI member Howard A. Rockman & team identify a small molecule β1AR allosteric modulator that suppresses exercise-induced ventricular tachycardia in a murine model of catecholaminergic polymorphic ventricular tachycardia: doi.org/10.1172/JCI1...
December 22, 2025 at 2:30 PM
A promising therapeutic in cardiac disease
ASCI member Howard A. Rockman & team identify a small molecule β1AR allosteric modulator that suppresses exercise-induced ventricular tachycardia in a murine model of catecholaminergic polymorphic ventricular tachycardia: doi.org/10.1172/JCI1...
ASCI member Howard A. Rockman & team identify a small molecule β1AR allosteric modulator that suppresses exercise-induced ventricular tachycardia in a murine model of catecholaminergic polymorphic ventricular tachycardia: doi.org/10.1172/JCI1...
Providing a conceptual framework for targeting mitochondrial metabolism in immunotherapy & transplantation
ASCI member Pavan Reddy & team show the mitochondrial complex II component SDHA as a key switch in CD4 & CD8 T cell metabolism, function & differentiation: doi.org/10.1172/JCI1...
ASCI member Pavan Reddy & team show the mitochondrial complex II component SDHA as a key switch in CD4 & CD8 T cell metabolism, function & differentiation: doi.org/10.1172/JCI1...
December 19, 2025 at 5:07 PM
Providing a conceptual framework for targeting mitochondrial metabolism in immunotherapy & transplantation
ASCI member Pavan Reddy & team show the mitochondrial complex II component SDHA as a key switch in CD4 & CD8 T cell metabolism, function & differentiation: doi.org/10.1172/JCI1...
ASCI member Pavan Reddy & team show the mitochondrial complex II component SDHA as a key switch in CD4 & CD8 T cell metabolism, function & differentiation: doi.org/10.1172/JCI1...
Merkel cell polyomavirus can cause cancer, but how cells adopt a neuroendocrine state was unclear
ASCI member Isaac Brownell & team find a unique interaction between the integrated virus and the host’s circuitry for neuroendocrine TFs in Markel cell carcinoma: doi.org/10.1172/JCI1...
ASCI member Isaac Brownell & team find a unique interaction between the integrated virus and the host’s circuitry for neuroendocrine TFs in Markel cell carcinoma: doi.org/10.1172/JCI1...
December 16, 2025 at 5:06 PM
Merkel cell polyomavirus can cause cancer, but how cells adopt a neuroendocrine state was unclear
ASCI member Isaac Brownell & team find a unique interaction between the integrated virus and the host’s circuitry for neuroendocrine TFs in Markel cell carcinoma: doi.org/10.1172/JCI1...
ASCI member Isaac Brownell & team find a unique interaction between the integrated virus and the host’s circuitry for neuroendocrine TFs in Markel cell carcinoma: doi.org/10.1172/JCI1...
A new platform for advanced prostate cancer
ASCI member Steven P. Balk & team find AKT activation mitigates efficacy of AR targeted therapy in TMPRSS2:ERG fusion prostate cancer, suggesting combination therapy targeting AR and AKT in those with T:E fusion PCa: doi.org/10.1172/JCI1...
ASCI member Steven P. Balk & team find AKT activation mitigates efficacy of AR targeted therapy in TMPRSS2:ERG fusion prostate cancer, suggesting combination therapy targeting AR and AKT in those with T:E fusion PCa: doi.org/10.1172/JCI1...
December 15, 2025 at 2:30 PM
A new platform for advanced prostate cancer
ASCI member Steven P. Balk & team find AKT activation mitigates efficacy of AR targeted therapy in TMPRSS2:ERG fusion prostate cancer, suggesting combination therapy targeting AR and AKT in those with T:E fusion PCa: doi.org/10.1172/JCI1...
ASCI member Steven P. Balk & team find AKT activation mitigates efficacy of AR targeted therapy in TMPRSS2:ERG fusion prostate cancer, suggesting combination therapy targeting AR and AKT in those with T:E fusion PCa: doi.org/10.1172/JCI1...
Could TRPV4 blockers benefit patients with pancreatic cancer?
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
December 12, 2025 at 5:05 PM
Could TRPV4 blockers benefit patients with pancreatic cancer?
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
The mechanistic basis of chronic liver disease is still only partially understood.
ASCI member Harmeet Malhi & team discover ER-stress mediated S100A11 upregulation drives progression of fatty liver disease, revealing a new target for future treatments: doi.org/10.1172/JCI1...
ASCI member Harmeet Malhi & team discover ER-stress mediated S100A11 upregulation drives progression of fatty liver disease, revealing a new target for future treatments: doi.org/10.1172/JCI1...
December 10, 2025 at 6:38 PM
The mechanistic basis of chronic liver disease is still only partially understood.
ASCI member Harmeet Malhi & team discover ER-stress mediated S100A11 upregulation drives progression of fatty liver disease, revealing a new target for future treatments: doi.org/10.1172/JCI1...
ASCI member Harmeet Malhi & team discover ER-stress mediated S100A11 upregulation drives progression of fatty liver disease, revealing a new target for future treatments: doi.org/10.1172/JCI1...
A ten-year analysis of #HIV-1 reservoir cells in two elite controllers
ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....
ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....
December 10, 2025 at 5:05 PM
A ten-year analysis of #HIV-1 reservoir cells in two elite controllers
ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....
ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....
Claudin-2 deficiency reveals a corticomedullary calcium gradient driving kidney stone formation: doi.org/10.1172/JCI2...
ASCI member Benjamin D. Humphreys @humphreyslab.bsky.social provides an Editor’s Note on Christine V. Behm et al. doi.org/10.1172/JCI1...
ASCI member Benjamin D. Humphreys @humphreyslab.bsky.social provides an Editor’s Note on Christine V. Behm et al. doi.org/10.1172/JCI1...
December 4, 2025 at 6:38 PM
Claudin-2 deficiency reveals a corticomedullary calcium gradient driving kidney stone formation: doi.org/10.1172/JCI2...
ASCI member Benjamin D. Humphreys @humphreyslab.bsky.social provides an Editor’s Note on Christine V. Behm et al. doi.org/10.1172/JCI1...
ASCI member Benjamin D. Humphreys @humphreyslab.bsky.social provides an Editor’s Note on Christine V. Behm et al. doi.org/10.1172/JCI1...
Let’s GIV a NOD(2) to gut homeostasis
Here, ASCI member Pradipta Ghosh & team find a critical interaction between GIV and NOD2 in gut macrophages, revealing their importance in maintaining gut health and preventing inflammatory bowel diseases: doi.org/10.1172/JCI1...
Here, ASCI member Pradipta Ghosh & team find a critical interaction between GIV and NOD2 in gut macrophages, revealing their importance in maintaining gut health and preventing inflammatory bowel diseases: doi.org/10.1172/JCI1...
December 2, 2025 at 6:38 PM
Let’s GIV a NOD(2) to gut homeostasis
Here, ASCI member Pradipta Ghosh & team find a critical interaction between GIV and NOD2 in gut macrophages, revealing their importance in maintaining gut health and preventing inflammatory bowel diseases: doi.org/10.1172/JCI1...
Here, ASCI member Pradipta Ghosh & team find a critical interaction between GIV and NOD2 in gut macrophages, revealing their importance in maintaining gut health and preventing inflammatory bowel diseases: doi.org/10.1172/JCI1...
In people with HIV, the risk for cardiovascular events remains despite statin therapy.
Here, ASCI member Steven K. Grinspoon & team analyze REPIEVE trial data & find the protein ANGPTL3, which affects LDL processing beyond typical lipid problems: www.jci.org/articles/vie...
Here, ASCI member Steven K. Grinspoon & team analyze REPIEVE trial data & find the protein ANGPTL3, which affects LDL processing beyond typical lipid problems: www.jci.org/articles/vie...
December 1, 2025 at 2:30 PM
In people with HIV, the risk for cardiovascular events remains despite statin therapy.
Here, ASCI member Steven K. Grinspoon & team analyze REPIEVE trial data & find the protein ANGPTL3, which affects LDL processing beyond typical lipid problems: www.jci.org/articles/vie...
Here, ASCI member Steven K. Grinspoon & team analyze REPIEVE trial data & find the protein ANGPTL3, which affects LDL processing beyond typical lipid problems: www.jci.org/articles/vie...
Reduced heparan sulfate levels in cerebrospinal fluid reflect brain neuron correction in Sanfilippo B mice
ASCI member Patricia I. Dickson @pattidickson.bsky.social & team report on a biomarker in spinal fluid that reflects brain disease in a rare genetic disorder:
www.jci.org/articles/vie...
ASCI member Patricia I. Dickson @pattidickson.bsky.social & team report on a biomarker in spinal fluid that reflects brain disease in a rare genetic disorder:
www.jci.org/articles/vie...
November 28, 2025 at 6:38 PM
Reduced heparan sulfate levels in cerebrospinal fluid reflect brain neuron correction in Sanfilippo B mice
ASCI member Patricia I. Dickson @pattidickson.bsky.social & team report on a biomarker in spinal fluid that reflects brain disease in a rare genetic disorder:
www.jci.org/articles/vie...
ASCI member Patricia I. Dickson @pattidickson.bsky.social & team report on a biomarker in spinal fluid that reflects brain disease in a rare genetic disorder:
www.jci.org/articles/vie...
A new way to approach genotype-specific therapy
ASCI member Bjorn C. Knollmann & team present a two-step high-throughput approach for drug repurposing, identifying evacetrapib as a potential treatment for the channelopathy Long QT Syndrome (#LQTS): insight.jci.org/articles/vie...
ASCI member Bjorn C. Knollmann & team present a two-step high-throughput approach for drug repurposing, identifying evacetrapib as a potential treatment for the channelopathy Long QT Syndrome (#LQTS): insight.jci.org/articles/vie...
November 27, 2025 at 5:05 PM
A new way to approach genotype-specific therapy
ASCI member Bjorn C. Knollmann & team present a two-step high-throughput approach for drug repurposing, identifying evacetrapib as a potential treatment for the channelopathy Long QT Syndrome (#LQTS): insight.jci.org/articles/vie...
ASCI member Bjorn C. Knollmann & team present a two-step high-throughput approach for drug repurposing, identifying evacetrapib as a potential treatment for the channelopathy Long QT Syndrome (#LQTS): insight.jci.org/articles/vie...
A promising therapeutic approach for glioblastoma
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
November 14, 2025 at 5:05 PM
A promising therapeutic approach for glioblastoma
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
New insights into lipid redistribution!
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
November 14, 2025 at 12:16 AM
New insights into lipid redistribution!
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
A Research Letter by ASCI member Joshua T. Schiffer & team:
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
November 13, 2025 at 8:30 PM
A Research Letter by ASCI member Joshua T. Schiffer & team:
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
November 13, 2025 at 5:08 PM
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...