the-asci.org
The American Society for Clinical Investigation
@the-asci.org
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The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry. https://the-asci.org Take action for federal funding of research: https://www.fundresearch.org/
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The American Society for Clinical Investigation @the-asci.org · 2d
Update: The Early-Career Award (YPSA/E-Gen) deadline has been extended to October 21
the-asci.org
The American Society for Clinical Investigation @the-asci.org · Aug 22
ASCI Early-Career Award Nominations are open: Emerging-Generation + Young Physician-Scientist Awards

High-level recognition on this critical career path! Awardees access @JointMeeting, networking, and career-development opportunities.

Deadline: Oct. 15

More at: jci.me/ecawa
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 15h
We thought the brain couldn’t use fatty acids or metabolize triglyceride-rich lipoproteins.

ASCI member Stephen G. Young & team now provide convincing evidence for lipoprotein lipase-mediated intravascular triglyceride processing in the CNS: www.jci.org/articles/vie...
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The American Society for Clinical Investigation @the-asci.org · 1d
ASCI member Quaggin & team now show SGLT2 inhibition increases tissue levels of SAM, resulting in enhanced H3K27 trimethylation & repression of inflammatory genes:
www.jci.org/articles/vie...
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The American Society for Clinical Investigation @the-asci.org · 1d
How might air pollution contribute to insulin resistance?

ASCI member Sanjay Rajagopalan & team demonstrate exposure to PM2.5 air pollution in mice leads to mitochondrial dysfunction in brown fat & metabolic dysfunction through epigenetic regulation: insight.jci.org/articles/vie...
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The American Society for Clinical Investigation @the-asci.org · 2d
Progress towards enhancing #cancer immunotherapies in the context of solid tumors!

ASCI member William E. Carson III & team show BRD4 inhibition can reduce suppressive immune cells in murine cancer models: www.jci.org/articles/vie...
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 2d
Update: The Early-Career Award (YPSA/E-Gen) deadline has been extended to October 21
the-asci.org
The American Society for Clinical Investigation @the-asci.org · Aug 22
ASCI Early-Career Award Nominations are open: Emerging-Generation + Young Physician-Scientist Awards

High-level recognition on this critical career path! Awardees access @JointMeeting, networking, and career-development opportunities.

Deadline: Oct. 15

More at: jci.me/ecawa
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 5d
A major barrier to HIV cure is a population of T cells that harbors replication-competent proviruses

Here, ASCI member Robert F. Siliciano & team report most viruses in the latent HIV-1 reservoir are resistant to autologous neutralizing antibodies: www.jci.org/articles/vie...
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The American Society for Clinical Investigation @the-asci.org · 5d
T cell engagers are effective in treating myeloma, but dosing schedules have not been defined.

In this research letter, ASCI member Madhav V. Dhodapkar & team find in vivo CD4+ T cell fitness within 48 hours following TCE therapy correlates with outcomes: www.jci.org/articles/vie...
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The American Society for Clinical Investigation @the-asci.org · 6d
Maybe you didn’t hear—this molecule is silencing oncogenes

ASCI member Chad V. Pecot & team developed an inverted RNAi molecule that enhances dual silencing of KRAS and MYC in cancer models: buff.ly/xzjBnEL
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The American Society for Clinical Investigation @the-asci.org · 6d
On a FOX hunt in severe autoimmunity

ASCI member Jonathan S. Maltzman & team explore the functional interactions among FOXP family members in regulatory T cells, revealing loss of Foxp1 & Foxp4 in Tregs from mice causes systemic inflammation and premature lethality: buff.ly/4kzMQe0
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The American Society for Clinical Investigation @the-asci.org · 7d
Emerging roles for complement in lung transplantation

As part of JCI’s Review series on complement biology and therapeutics, ASCI member Hrishikesh S. Kulkarni et al. explore complement activation and strategies for inhibition in the lung transplant process: buff.ly/UXQWFKq
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 8d
ATTN: Medical School Deans! The ASCI PSSF Fellowship Nominations are open.

Our immersive, mentored, gap-year opportunity is for MD-only medical students.

MS Dean’s nomination deadline: 10/13/25
Final application deadline: 1/6/26
Contact: [email protected]

Details: buff.ly/O4zWRl1
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 12d
Irregular heartbeat is a common complication after surgery.

In this research letter, ASCI member Xander H.T. Wehrens & team reveal a factor derived from atrial fibroblasts—MIF—necessary for atrial macrophage recruitment and post-operative AFib: buff.ly/PL8GnGT
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The American Society for Clinical Investigation @the-asci.org · 13d
An open letter to the NIH: Value and costs in publishing

Here we share our response to the NIH’s request for information on maximizing research funds by limiting allowable publishing costs: buff.ly/K6hbsA4

#AcademicPublishing #ScholarlyPublishing #OpenAccess
@scholarlykitchen.bsky.social
JCI - View
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the-asci.org
The American Society for Clinical Investigation @the-asci.org · 13d
Acute kidney injury increases the risk for long-term kidney dysfunction.

Here, ASCI member Chirag R. Parikh & team identify urine proteins in pathways of degenerative tubular cell injury, inflammation & fibrosis associated with long-term eGFR decline after hospitalization with AKI: buff.ly/6xqmTk5
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The American Society for Clinical Investigation @the-asci.org · 14d
Can we root out the seeds of metastasis?

ASCI member Huiping Liu & team identify a rare T cell subset that cluster circulating tumor cells to promote metastasis in breast cancer, then provide a proof-of-concept block using VLA-4 antibody in preclinical models: buff.ly/o5N4RMr
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 15d
Classical type 1 dendritic cells have roles in immunoregulation, but their involvement in organ transplant was unclear.

ASCI member Kory J. Lavine & team reveal cDC1s expand after costimulation blockade & are essential for long-term cardiac allograft acceptance in mice:
buff.ly/VECueEr
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The American Society for Clinical Investigation @the-asci.org · 16d
Can we drive anti-tumor immunity in advanced prostate and ovarian cancers?

ASCI member Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/SDFvlox
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the-asci.org
The American Society for Clinical Investigation @the-asci.org · 19d
Getting a grip on TSH-resistant hypothyroidism

ASCI member Peter Arvan & team reveal thyroidal expression of ER molecular chaperone GRP170 is required for efficient TSH-mediated thyroid hormone synthesis: buff.ly/fhwpCeK
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The American Society for Clinical Investigation @the-asci.org · 20d
Erythropoietic protoporphyria causes phototoxicity and can also involve the liver due to protoporphyrin IX accumulation in red blood cells.

ASCI member Mark D. Fleming & team find bitopertin reduces PPIX accumulation and mitigates liver disease in EPP models: buff.ly/9TuVOy3
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 21d
Somatic mutations are surprisingly widespread in most tissues, and some may protect against disease.

ASCI member @haozhulab.bsky.social & team now reveal TBX3 somatic mutations in the liver influence metabolic dysfunction-associated steatotic liver disease
(#MASLD): buff.ly/Ob2JxYY
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the-asci.org
The American Society for Clinical Investigation @the-asci.org · 22d
Could metformin reduce structural heart disease?

ASCI member Chinmay M. Trivedi & team find epigenetic changes in nuclear DNA aberrantly activate mitochondria, causing aortic valve stenosis, with improvement by metformin in mice:
buff.ly/rmQsCU0
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 22d
Current dogma posits IFN-γ and CD8+ T cells have anti-tumor roles.

Now, ASCI member Alexander Sasha Krupnick & team examine multiple lung adenocarcinoma models and discover IFN-γ derived from lung cancer cells can, in fact, promote tumor growth via CD8+ T cell chemokines: buff.ly/mEVwWHy
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the-asci.org
The American Society for Clinical Investigation @the-asci.org · 23d
A vaccine for Pseudomonas has eluded researchers for decades

ASCI member @nizet.bsky.social & team now provide a different vaccination approach, demonstrating an engineered nanoparticle vaccine protects mice against lethal pneumonia.

Full report: buff.ly/Ipwj7gT
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the-asci.org
The American Society for Clinical Investigation @the-asci.org · 23d
People with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares.

In this research letter, ASCI member Johann E. Gudjonsson & team show spesolimab treatment helps control the inflammation and prevent future flares.

buff.ly/cYw1WJG
the-asci.org
The American Society for Clinical Investigation @the-asci.org · 24d
Cancer can activate the coagulation system, but how do anticoagulants affect checkpoint therapy?

ASCI member Wolfram Ruf & team show coagulation signaling subverts the tumor-DNA immune response & anticoagulants with ICB synergistically reduce tumor growth in mice.

buff.ly/jyIQNvz