Journal of Clinical Investigation
@jci.org
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
Is LNK loss the missing link for treating Fanconi anemia?
Wei Tong & team show deleting the adaptor protein LNK boosts the ability of blood stem cells to regenerate with less DNA damage in mice, offering the potential for treatments in Fanconi Anemia: doi.org/10.1172/JCI1...
Wei Tong & team show deleting the adaptor protein LNK boosts the ability of blood stem cells to regenerate with less DNA damage in mice, offering the potential for treatments in Fanconi Anemia: doi.org/10.1172/JCI1...
January 12, 2026 at 5:15 PM
Is LNK loss the missing link for treating Fanconi anemia?
Wei Tong & team show deleting the adaptor protein LNK boosts the ability of blood stem cells to regenerate with less DNA damage in mice, offering the potential for treatments in Fanconi Anemia: doi.org/10.1172/JCI1...
Wei Tong & team show deleting the adaptor protein LNK boosts the ability of blood stem cells to regenerate with less DNA damage in mice, offering the potential for treatments in Fanconi Anemia: doi.org/10.1172/JCI1...
This study has broad implications across multiple neurological conditions
Jian Hu & team use mouse models to show peroxisomes license myelin debris degradation in myeloid cells, which enables debris clearance and remyelination after myelin damage: www.jci.org/articles/vie...
Jian Hu & team use mouse models to show peroxisomes license myelin debris degradation in myeloid cells, which enables debris clearance and remyelination after myelin damage: www.jci.org/articles/vie...
January 12, 2026 at 2:03 PM
This study has broad implications across multiple neurological conditions
Jian Hu & team use mouse models to show peroxisomes license myelin debris degradation in myeloid cells, which enables debris clearance and remyelination after myelin damage: www.jci.org/articles/vie...
Jian Hu & team use mouse models to show peroxisomes license myelin debris degradation in myeloid cells, which enables debris clearance and remyelination after myelin damage: www.jci.org/articles/vie...
ICYMI: The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI197141
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI197141
January 11, 2026 at 2:01 PM
ICYMI: The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI197141
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI197141
Shared earlier this week: Isn’t it ironic? Functional iron deficiency at the core of Parkinson's disease pathobiology
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
January 10, 2026 at 2:00 PM
Shared earlier this week: Isn’t it ironic? Functional iron deficiency at the core of Parkinson's disease pathobiology
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
Merlin’s Disappearing Act: NF2 loss conjures pancreatic cancer survival in the hostile tumor microenvironment: doi.org/10.1172/JCI2...
Sofia Ferreira & Laura D. Attardi comment on Yi Xu et al.: doi.org/10.1172/JCI1...
Sofia Ferreira & Laura D. Attardi comment on Yi Xu et al.: doi.org/10.1172/JCI1...
January 9, 2026 at 5:15 PM
Merlin’s Disappearing Act: NF2 loss conjures pancreatic cancer survival in the hostile tumor microenvironment: doi.org/10.1172/JCI2...
Sofia Ferreira & Laura D. Attardi comment on Yi Xu et al.: doi.org/10.1172/JCI1...
Sofia Ferreira & Laura D. Attardi comment on Yi Xu et al.: doi.org/10.1172/JCI1...
Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal: doi.org/10.1172/JCI2...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
January 9, 2026 at 2:02 PM
Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal: doi.org/10.1172/JCI2...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
Stephen P. Persaud @persaudsquad.bsky.social & John F. DiPersio provides a Commentary on Preksha Bhagchandani et al.: doi.org/10.1172/JCI1...
Introducing a gene mutation that induces pancreatic tumor evolution and therapeutic resistance with environmental stress.
Pei Wang & team show NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under nutrient deprivation: doi.org/10.1172/JCI1...
Pei Wang & team show NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under nutrient deprivation: doi.org/10.1172/JCI1...
January 8, 2026 at 5:15 PM
Introducing a gene mutation that induces pancreatic tumor evolution and therapeutic resistance with environmental stress.
Pei Wang & team show NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under nutrient deprivation: doi.org/10.1172/JCI1...
Pei Wang & team show NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under nutrient deprivation: doi.org/10.1172/JCI1...
Clonal hematopoiesis of indeterminate potential (CHIP) is common in older individuals, but its connection with aortic valve stenosis was unclear.
Wesley T. Abplanalp & team now show CHIP activates procalcific pathways in macrophages and promotes AVS: www.jci.org/articles/vie...
Wesley T. Abplanalp & team now show CHIP activates procalcific pathways in macrophages and promotes AVS: www.jci.org/articles/vie...
January 8, 2026 at 2:01 PM
Clonal hematopoiesis of indeterminate potential (CHIP) is common in older individuals, but its connection with aortic valve stenosis was unclear.
Wesley T. Abplanalp & team now show CHIP activates procalcific pathways in macrophages and promotes AVS: www.jci.org/articles/vie...
Wesley T. Abplanalp & team now show CHIP activates procalcific pathways in macrophages and promotes AVS: www.jci.org/articles/vie...
Review: Cardiovascular complications of pregnancy
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
January 6, 2026 at 5:15 PM
Review: Cardiovascular complications of pregnancy
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Yijun Yang et al. explore pregnancy-related cardiovascular adaptations and complications, along with the mechanisms, animal models, and racial and ethnic disparities tied to these conditions: doi.org/10.1172/JCI1...
Can we help fat cells get in shape in diabetes?
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
January 6, 2026 at 2:03 PM
Can we help fat cells get in shape in diabetes?
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
Here, James C. Lo & team identify FAM20C as a key mediator of obesity-induced adipocyte dysfunction and inflammation, suggesting its inhibition as a potential therapy for type 2 diabetes: doi.org/10.1172/JCI1...
The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
January 5, 2026 at 2:02 PM
The role of suPAR and related proteins in kidney, heart diseases, and diabetes
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
In this Review, Jochen Reiser & team highlight the soluble form of the urokinase plasminogen activator and its related proteins beyond their prognostic value as markers of inflammation: doi.org/10.1172/JCI1...
From earlier this week:
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI197583
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI197583
January 4, 2026 at 2:00 PM
From earlier this week:
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI197583
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI197583
Isn’t it ironic? Functional iron deficiency at the core of Parkinsons disease pathobiology
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
January 3, 2026 at 2:02 PM
Isn’t it ironic? Functional iron deficiency at the core of Parkinsons disease pathobiology
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
This Viewpoint by Ian Peikon & Nancy C. Andrews calls for a rethink of iron’s position in PD pathology and treatment: doi.org/10.1172/JCI2...
Behind the Scenes: Authors Preksha Bhagchandani, Stephan Ramos, and Seung K. Kim with their mouse models. Photo credit: Steve Fisch/Stanford Medicine/Seung Kim lab
January 2, 2026 at 7:30 PM
Behind the Scenes: Authors Preksha Bhagchandani, Stephan Ramos, and Seung K. Kim with their mouse models. Photo credit: Steve Fisch/Stanford Medicine/Seung Kim lab
Curing autoimmune diabetes in mice!
Seung K. Kim & team present a clinically translatable, low toxicity conditioning regimen in combination with hematopoietic cell and islet transplantation that reverses established type 1 diabetes in mice: www.jci.org/articles/vie...
Seung K. Kim & team present a clinically translatable, low toxicity conditioning regimen in combination with hematopoietic cell and islet transplantation that reverses established type 1 diabetes in mice: www.jci.org/articles/vie...
January 2, 2026 at 7:30 PM
Curing autoimmune diabetes in mice!
Seung K. Kim & team present a clinically translatable, low toxicity conditioning regimen in combination with hematopoietic cell and islet transplantation that reverses established type 1 diabetes in mice: www.jci.org/articles/vie...
Seung K. Kim & team present a clinically translatable, low toxicity conditioning regimen in combination with hematopoietic cell and islet transplantation that reverses established type 1 diabetes in mice: www.jci.org/articles/vie...
Behind the Scenes: First author Jessica Maung (right) and co-author Hadla Hariri (left) gearing up for some microscope magic!
January 2, 2026 at 5:05 PM
Behind the Scenes: First author Jessica Maung (right) and co-author Hadla Hariri (left) gearing up for some microscope magic!
This issue’s Cover features work by Maung et al. on laminin A gene mutations in patients with familial partial lipodystrophy 2 and their association with suppressed lipid metabolism and mitochondrial pathways, as well as increased inflammation. www.jci.org/articles/vie...
January 2, 2026 at 5:05 PM
This issue’s Cover features work by Maung et al. on laminin A gene mutations in patients with familial partial lipodystrophy 2 and their association with suppressed lipid metabolism and mitochondrial pathways, as well as increased inflammation. www.jci.org/articles/vie...
New approach spotlight ✨
Domenico Mavilio & team characterize intrahepatic and circulating NK cells in patients with metastatic colon cancer, identifying a cell population with an antitumor signature and revealing IL-1R8 and CXCR4 as potential targets: doi.org/10.1172/JCI1...
Domenico Mavilio & team characterize intrahepatic and circulating NK cells in patients with metastatic colon cancer, identifying a cell population with an antitumor signature and revealing IL-1R8 and CXCR4 as potential targets: doi.org/10.1172/JCI1...
January 2, 2026 at 2:02 PM
New approach spotlight ✨
Domenico Mavilio & team characterize intrahepatic and circulating NK cells in patients with metastatic colon cancer, identifying a cell population with an antitumor signature and revealing IL-1R8 and CXCR4 as potential targets: doi.org/10.1172/JCI1...
Domenico Mavilio & team characterize intrahepatic and circulating NK cells in patients with metastatic colon cancer, identifying a cell population with an antitumor signature and revealing IL-1R8 and CXCR4 as potential targets: doi.org/10.1172/JCI1...
Tumor virus–induced lineage survival circuit drives Merkel cell carcinogenesis: doi.org/10.1172/JCI2...
Masahiro Shuda provides a Commentary on Lingling Miao et al.: doi.org/10.1172/JCI1...
Masahiro Shuda provides a Commentary on Lingling Miao et al.: doi.org/10.1172/JCI1...
January 1, 2026 at 5:15 PM
Tumor virus–induced lineage survival circuit drives Merkel cell carcinogenesis: doi.org/10.1172/JCI2...
Masahiro Shuda provides a Commentary on Lingling Miao et al.: doi.org/10.1172/JCI1...
Masahiro Shuda provides a Commentary on Lingling Miao et al.: doi.org/10.1172/JCI1...
Looking back on 2025 with a year of JCI covers
Music by Bensound; License code: OPYBHJ1Y0XH0EWQO; Artist: Theatre Of Delays; Song: Prism
Music by Bensound; License code: OPYBHJ1Y0XH0EWQO; Artist: Theatre Of Delays; Song: Prism
January 1, 2026 at 2:02 PM
Looking back on 2025 with a year of JCI covers
Music by Bensound; License code: OPYBHJ1Y0XH0EWQO; Artist: Theatre Of Delays; Song: Prism
Music by Bensound; License code: OPYBHJ1Y0XH0EWQO; Artist: Theatre Of Delays; Song: Prism
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI1...
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI1...
December 31, 2025 at 5:15 PM
n = 1,235,695‼️
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI1...
Here, Henry R. Kranzler & team analyze the genetics of chronic pain using GWAS and single-cell data, revealing variant enrichment in brain glutamatergic and DRG C-fiber neurons, informing translational research pathways: doi.org/10.1172/JCI1...
Count down: Our top 5 most-accessed manuscripts of 2025!
#1:Estimation of prevalence of autoimmune diseases in the United States using electronic health record data: doi.org/10.1172/JCI1...
#1:Estimation of prevalence of autoimmune diseases in the United States using electronic health record data: doi.org/10.1172/JCI1...
December 31, 2025 at 2:02 PM
Count down: Our top 5 most-accessed manuscripts of 2025!
#1:Estimation of prevalence of autoimmune diseases in the United States using electronic health record data: doi.org/10.1172/JCI1...
#1:Estimation of prevalence of autoimmune diseases in the United States using electronic health record data: doi.org/10.1172/JCI1...
Unwinding the mysteries of fibrosis
Wan-Li Ma & team show excessive collagen type VII mediates pleural fibrosis by increasing extracellular matrix stiffness and activating integrin/PI3K-AKT/JUN signaling: doi.org/10.1172/JCI1...
Wan-Li Ma & team show excessive collagen type VII mediates pleural fibrosis by increasing extracellular matrix stiffness and activating integrin/PI3K-AKT/JUN signaling: doi.org/10.1172/JCI1...
December 30, 2025 at 5:15 PM
Unwinding the mysteries of fibrosis
Wan-Li Ma & team show excessive collagen type VII mediates pleural fibrosis by increasing extracellular matrix stiffness and activating integrin/PI3K-AKT/JUN signaling: doi.org/10.1172/JCI1...
Wan-Li Ma & team show excessive collagen type VII mediates pleural fibrosis by increasing extracellular matrix stiffness and activating integrin/PI3K-AKT/JUN signaling: doi.org/10.1172/JCI1...
Count down: Our top 5 most-accessed manuscripts of 2025!
#2:Bacteriophage Therapy for Multidrug-Resistant Infections: Current Technologies and Therapeutic Approaches: doi.org/10.1172/JCI1...
#2:Bacteriophage Therapy for Multidrug-Resistant Infections: Current Technologies and Therapeutic Approaches: doi.org/10.1172/JCI1...
December 30, 2025 at 2:02 PM
Count down: Our top 5 most-accessed manuscripts of 2025!
#2:Bacteriophage Therapy for Multidrug-Resistant Infections: Current Technologies and Therapeutic Approaches: doi.org/10.1172/JCI1...
#2:Bacteriophage Therapy for Multidrug-Resistant Infections: Current Technologies and Therapeutic Approaches: doi.org/10.1172/JCI1...
Profound statin intolerance was previously described in a patient with a mutation in RyR1.
Here, Gunnar Weninger & team provide structural and functional insights into how simvastatin affects calcium release channels and causes statin-associated muscle symptoms: doi.org/10.1172/JCI1...
Here, Gunnar Weninger & team provide structural and functional insights into how simvastatin affects calcium release channels and causes statin-associated muscle symptoms: doi.org/10.1172/JCI1...
December 29, 2025 at 5:15 PM
Profound statin intolerance was previously described in a patient with a mutation in RyR1.
Here, Gunnar Weninger & team provide structural and functional insights into how simvastatin affects calcium release channels and causes statin-associated muscle symptoms: doi.org/10.1172/JCI1...
Here, Gunnar Weninger & team provide structural and functional insights into how simvastatin affects calcium release channels and causes statin-associated muscle symptoms: doi.org/10.1172/JCI1...