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Jonathan Kagan @jkagan1.bsky.social · 20d

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria

Jonathan Kagan @jkagan1.bsky.social · 20d

This work derives from prior studies on the structure-function relationship between Bacteroides LPS and TLR4 endocytosis and signaling.
www.sciencedirect.com/science/arti...

Microbe-induced receptor trafficking has emerged as an essential means to promote innate immune signal transduction. Upon detection of bacterial lipop…

Structure of gut microbial glycolipid modulates host inflammatory response

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Jonathan Kagan @jkagan1.bsky.social · 20d

TLR4 endocytosis continues to be the centerpiece of TRIF-Interferon signaling. Kasper et al report diverse structures of Bacteroides LPS and their impact on TLR4 endocytosis and signaling. Functional consequences on Treg induction in the gut.
www.cell.com/cell/abstrac...

Structural variations in the number of acyl chains and phosphate groups of gram-negative microbial lipid A differentially modulate DC-derived IFN-β responses, which are mechanistically regulated by TL...

Towards a molecular and structural definition of cell death

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Jonathan Kagan @jkagan1.bsky.social · 21d

What is cell death?
Honored to participate in this article where the question was posed to a dozen experts.
Thanks to the fantastic team at Nature Structural & Molecular Biology for organizing this discussion.
rdcu.be/eG1Nm

Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...

rdcu.be

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Reposted by Jonathan Kagan

Kevin Bonham @kevinbonham.com · 23d

More than a decade ago, I started making tutorial videos on how to use Adobe illustrator, targeted at scientists that needed to make figures and cartoons for talks or papers.

Now I'm getting started again, but this time with the free and open source vector editor Inkscape 🧪

youtu.be/E7n6SDni28Q

Inkscape for scientists 1 - simple shapes

YouTube video by Kevin Bonham

youtu.be

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Jonathan Kagan @jkagan1.bsky.social · 27d

Coming early 2026: Conference on Gene Expression & Signaling in the Immune System

A world-class lineup of interesting and interested scientists will convene at the historic Cold Spring Harbor Lab to discuss all things immunology. share.google/m7eZmUxm0TVh...

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Reposted by Jonathan Kagan

Ivan Zanoni @lozanzi.bsky.social · 29d

💥 #ImmunometabolismPower! Excited to have this officially out @cp-immunity.bsky.social 💥 We show that pathogens induce the host to produce oxidized lipids which rewire the #metabolism of #macrophages, causing #epigenetic modifications which dampen anti-inflammatory IL-10, exacerbating #inflammation!

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…

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Jonathan Kagan @jkagan1.bsky.social · Sep 9

Thank you. Yes, we believe the same approach would be effective for other viruses and cancers.

Jonathan Kagan @jkagan1.bsky.social · Sep 8

Thanks Ivan!

Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors

Jonathan Kagan @jkagan1.bsky.social · Sep 8

Kudos to the brilliant Jon Chow and Kelsey Finn, who led this study.
@lozanzi.bsky.social @synth-immune.bsky.social
#universalflu #NLRP3 #vaccine #influenza

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Jonathan Kagan @jkagan1.bsky.social · Sep 8

But the question remained, are hDCs important to generate T cells in animals other than mice? The discovery that hDCs improve/diversify the immunogenicity of the influenza vaccine Afluria validates the hDC hypothesis, and raises the possibility of improved therapies towards infection and cancer.

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Jonathan Kagan @jkagan1.bsky.social · Sep 8

Dania Zhivaki then discovered that these cells were not just viable, but were hyper-migratory. These hyper-migratory and IL-1 producing “hyperactive” DCs have been found to protect young and old mice from implantable tumors, in a T cell mediation fashion.
www.sciencedirect.com/science/arti...

Defective host defenses later in life are associated with changes in immune cell activities, suggesting that age-specific considerations are needed in…

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

Jonathan Kagan @jkagan1.bsky.social · Sep 8

This finding led to the discovery by Charlie Evavold that gasdermin D pores in the membrane of living cells serve as a conduit for IL-1 secretion, independent of cell death.
www.sciencedirect.com/science/arti...

The interleukin-1 (IL-1) family cytokines are cytosolic proteins that exhibit inflammatory activity upon release into the extracellular space. These f…

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

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Jonathan Kagan @jkagan1.bsky.social · Sep 8

Background on this discovery in a thread:
Over a decade ago, when he was a postdoc in my lab, Ivan Zanoni made the surprising discovery of an NLRP3 stimulus induced IL-1 production from viable cells.
www.science.org/doi/10.1126/...

Oxidized phospholipids released from dying cells shape dendritic cell immunity.

www.science.org

Jonathan Kagan @jkagan1.bsky.social · Sep 8

Using the commercial influenza vaccine Afluria from Seqirus, hDC stimuli induced robust T cells in non-human primates, and antibodies that target every strain of influenza virus in Afluria.

An NLRP3-stimulatory adjuvant improves the immunogenicity of influenza virus vaccines in mice and non-human primates | mBio

Jonathan Kagan @jkagan1.bsky.social · Sep 8

An NLRP3 stimulatory universal influenza vaccine.
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...

The generation of vaccines that stimulate T cell activities is an unmet need for the scientific community, as T cells are the primary mediators of immune memory. In this study, we report a new vaccine...

journals.asm.org

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Reposted by Jonathan Kagan

Ivan Zanoni @lozanzi.bsky.social · Sep 3

Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Interferons in health and disease

The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

Interferons in health and disease

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Reposted by Jonathan Kagan

Cheri Sirois @cherisirois.bsky.social · Sep 3

If you've been looking for a big, juicy, up-to-date review on interferons, incorporating the latest understanding about how IFN-lambda fits into the picture... well, here it is!👇 (Thanks to
@lozanzi.bsky.social and @danielboehmer.bsky.social
for writing it!)

Ivan Zanoni @lozanzi.bsky.social · Sep 3

Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...