Jonathan Kagan
@jkagan1.bsky.social
800 followers 30 following 130 posts
Scientist at Boston Children's Hospital, Professor at Harvard Medical School, Husband, Father
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Reposted by Jonathan Kagan
jordanjastrab.bsky.social
Now that I am no longer dealing with an infant with an infection (non-staphylococcal), time for a proper 🧵! If you’re interested in some combination of Staphylococcus aureus, innate immune sensing of bacteria, inflammasomes, and cell wall modifications, read on…
jkagan1.bsky.social
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Reposted by Jonathan Kagan
jkagan1.bsky.social
TLR4 endocytosis continues to be the centerpiece of TRIF-Interferon signaling. Kasper et al report diverse structures of Bacteroides LPS and their impact on TLR4 endocytosis and signaling. Functional consequences on Treg induction in the gut.
www.cell.com/cell/abstrac...
Structure of gut microbial glycolipid modulates host inflammatory response
Structural variations in the number of acyl chains and phosphate groups of gram-negative microbial lipid A differentially modulate DC-derived IFN-β responses, which are mechanistically regulated by TL...
www.cell.com
Reposted by Jonathan Kagan
kevinbonham.com
More than a decade ago, I started making tutorial videos on how to use Adobe illustrator, targeted at scientists that needed to make figures and cartoons for talks or papers.

Now I'm getting started again, but this time with the free and open source vector editor Inkscape 🧪

youtu.be/E7n6SDni28Q
Inkscape for scientists 1 - simple shapes
YouTube video by Kevin Bonham
youtu.be
jkagan1.bsky.social
Coming early 2026: Conference on Gene Expression & Signaling in the Immune System

A world-class lineup of interesting and interested scientists will convene at the historic Cold Spring Harbor Lab to discuss all things immunology. share.google/m7eZmUxm0TVh...
Reposted by Jonathan Kagan
lozanzi.bsky.social
💥 #ImmunometabolismPower! Excited to have this officially out @cp-immunity.bsky.social 💥 We show that pathogens induce the host to produce oxidized lipids which rewire the #metabolism of #macrophages, causing #epigenetic modifications which dampen anti-inflammatory IL-10, exacerbating #inflammation!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…
www.sciencedirect.com
jkagan1.bsky.social
Thank you. Yes, we believe the same approach would be effective for other viruses and cancers.
jkagan1.bsky.social
Kudos to the brilliant Jon Chow and Kelsey Finn, who led this study.
@lozanzi.bsky.social @synth-immune.bsky.social
#universalflu #NLRP3 #vaccine #influenza
jkagan1.bsky.social
But the question remained, are hDCs important to generate T cells in animals other than mice? The discovery that hDCs improve/diversify the immunogenicity of the influenza vaccine Afluria validates the hDC hypothesis, and raises the possibility of improved therapies towards infection and cancer.
jkagan1.bsky.social
Dania Zhivaki then discovered that these cells were not just viable, but were hyper-migratory. These hyper-migratory and IL-1 producing “hyperactive” DCs have been found to protect young and old mice from implantable tumors, in a T cell mediation fashion.
www.sciencedirect.com/science/arti...
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors
Defective host defenses later in life are associated with changes in immune cell activities, suggesting that age-specific considerations are needed in…
www.sciencedirect.com
jkagan1.bsky.social
Background on this discovery in a thread:
Over a decade ago, when he was a postdoc in my lab, Ivan Zanoni made the surprising discovery of an NLRP3 stimulus induced IL-1 production from viable cells.
www.science.org/doi/10.1126/...
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Oxidized phospholipids released from dying cells shape dendritic cell immunity.
www.science.org
jkagan1.bsky.social
Using the commercial influenza vaccine Afluria from Seqirus, hDC stimuli induced robust T cells in non-human primates, and antibodies that target every strain of influenza virus in Afluria.
Reposted by Jonathan Kagan
cherisirois.bsky.social
If you've been looking for a big, juicy, up-to-date review on interferons, incorporating the latest understanding about how IFN-lambda fits into the picture... well, here it is!👇 (Thanks to
@lozanzi.bsky.social and @danielboehmer.bsky.social
for writing it!)