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brozlab.bsky.social
Broz Lab
@brozlab.bsky.social
220 followers 120 following 19 posts
Lab of Petr Broz @ UNIL. Cell death, innate immunology and pathogen defense
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Reposted by Broz Lab
embojournal.org
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 21, 2025 at 12:59 PM
brozlab.bsky.social
The week of publications continues for the lab with a @currentbiology.bsky.social piece on ninj1 by @elliottbernard.bsky.social and @ehartenian.bsky.social check it out to have all your pressing ninj1 questions answered :)

www.cell.com/current-biol...
November 21, 2025 at 9:12 PM
Reposted by Broz Lab
ehartenian.bsky.social
Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.
November 20, 2025 at 3:29 PM
brozlab.bsky.social
Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social @embojournal.org

link.springer.com/article/10.1...
You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal
The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...
link.springer.com
November 20, 2025 at 3:17 PM
brozlab.bsky.social
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.

www.embopress.org/doi/full/10....
NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports
imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...
www.embopress.org
November 20, 2025 at 3:15 PM
brozlab.bsky.social
It’s DIB day! The annual conference for our department @dib-unil.bsky.social. Lovely day (and view!) at the Lausanne Olympic museum exchanging with our colleagues. Plus a stellar presentation on NINJ1 by our own @elliottbernard.bsky.social 🔬!
November 11, 2025 at 1:21 PM
brozlab.bsky.social
The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.
October 2, 2025 at 8:09 AM
Reposted by Broz Lab
dib-unil.bsky.social
Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne!

@brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social
October 1, 2025 at 9:30 AM
Reposted by Broz Lab
rebsamenlab.bsky.social
Full room at the start of the 2nd Immunobiology symposium on pattern recognition receptors!
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social

#ImmunoSky
October 1, 2025 at 7:51 AM
Reposted by Broz Lab
eckerleisabella.bsky.social
Are you an excellent researcher in the field of genomics of infectious diseases of intracellular pathogens (viruses, intracellular parasites or bacteria)? The apply for this chair of excellence at the University of Geneva, Faculty of Medicine:
jobs.unige.ch/www/wd_porta...
Professeur-e ordinaire, professeur-e associé-e (6460)
en génomique des maladies infectieuses intracellulaires Chaire dexcellence / Full Professor or Associate Professor in Genomics of Intracellular Infectious Diseases Chair of Excellence
jobs.unige.ch
July 7, 2025 at 3:51 PM
brozlab.bsky.social
Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!

www.embopress.org/doi/full/10....
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal
imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...
www.embopress.org
July 19, 2025 at 11:18 AM
brozlab.bsky.social
Here is the latest review from the lab on co infections 🥳. Following up on Philipp’s previous work, Philipp and Petr address what is known and all the open questions in this field :

www.embopress.org/doi/full/10....
Molecular mechanisms of co-infections | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
July 19, 2025 at 11:11 AM
brozlab.bsky.social
A big congratulations to Dr. Alexandra Boegli for very successfully defending her PhD on listeria activation of the elusive NLRP6! Very well deserved and very well celebrated! 🥳
June 24, 2025 at 10:26 AM
brozlab.bsky.social
Registration opens soon for the second Pattern Recognition receptor symposium in Lausanne Switzerland in October 2025. Check out the link for the great list of speakers.

wp.unil.ch/immunobiolog...
February 26, 2025 at 8:11 PM
brozlab.bsky.social
Congrats to lab member Elliott for winning the poster prize at the Swiss LS2 conference for his work on the activation mechanism of Ninj1 during cell death!! 🥳 @dib-unil.bsky.social @lifesciswitzerland.bsky.social
February 25, 2025 at 8:07 PM
brozlab.bsky.social
Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!

www.biorxiv.org/content/10.1...
Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells
NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...
www.biorxiv.org
January 28, 2025 at 1:42 PM
Reposted by Broz Lab
rebsamenlab.bsky.social
Very happy to share our latest work just published in @jexpmed.bsky.social! #Firstpost

rupress.org/jem/article/...

Our amazing PhD student @lbernaleau.bsky.social shows that CCDC134 controls TLR biogenesis through the ER-chaperone Gp96. #ImmunoSky #innateimmunity #inflammation

Quick summary here:
CCDC134 controls TLR biogenesis through the ER chaperone Gp96 | Journal of Experimental Medicine | Rockefeller University Press
A loss-of-function genetic screen identifies the ER-resident protein CCDC134 as an essential regulator of Toll-like receptor (TLR) responses. CCDC134 binds
rupress.org
December 10, 2024 at 3:48 PM
Reposted by Broz Lab
inflammasomelab.bsky.social
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
December 9, 2024 at 1:39 AM
Reposted by Broz Lab
dib-unil.bsky.social
New manuscript by Sina Bohnacker and Julia Esser-von Bieren published in Science Immunology!

www.science.org/doi/10.1126/...
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis
H. polygyrus glutamate dehydrogenase drives parasite chronicity by epigenetically and metabolically reprogramming host macrophages.
www.science.org
December 9, 2024 at 10:08 AM
Reposted by Broz Lab
lozanzi.bsky.social
#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
www.nature.com
December 5, 2024 at 4:55 PM
brozlab.bsky.social
First real bluesky post 🥳 Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a News & Views, @elliottbernard.bsky.social and Petr describe new results from Dixit & Deshpande, including a resting structure of NINJ1 with 3 helices! Check it out here: rdcu.be/d2nqH
December 4, 2024 at 8:50 PM
Reposted by Broz Lab
drnatsampaio.bsky.social
I’ve made a Starter Pack of #innateimmunity and #inflammation researchers to follow! Please contact me to get added or to suggest others to add. We are just getting started 😎
#immunosky
#academicchatter
go.bsky.app/QqJ9AgB
November 16, 2024 at 10:10 PM
Reposted by Broz Lab
protinnimmunity.bsky.social
go.bsky.app/221DCXf
November 18, 2024 at 9:02 AM