Gabriele Zaffagnini
@gzaffagnini.bsky.social
Group Leader at CECAD, University of Cologne.
Interested in reproductive aging, protein homeostasis in oocytes, and super-organelles.
Interested in reproductive aging, protein homeostasis in oocytes, and super-organelles.
Pinned
Here we go again! Our paper on #proteostasis in human oocytes appeared on the latest @embojournal.org cover! A great collaboration with Dexeus Mujer @bokelab.bsky.social ! 🥂👏🏻💪🏻
Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
November 23, 2025 at 8:01 AM
Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
It's Sunday again and a new issue of #cebooc is out!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41223274/ on the maternal #mitochondria selection
Runner-up: pubmed.ncbi.nlm.nih.gov/41210958/
Thanks @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41223274/ on the maternal #mitochondria selection
Runner-up: pubmed.ncbi.nlm.nih.gov/41210958/
Thanks @biomednews.bsky.social for preselecting!
November 16, 2025 at 8:27 AM
It's Sunday again and a new issue of #cebooc is out!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41223274/ on the maternal #mitochondria selection
Runner-up: pubmed.ncbi.nlm.nih.gov/41210958/
Thanks @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41223274/ on the maternal #mitochondria selection
Runner-up: pubmed.ncbi.nlm.nih.gov/41210958/
Thanks @biomednews.bsky.social for preselecting!
After leaving Italy I always thought that the best thing Europe could do for its future stability would be establish a mandatory year of school abroad for all citizens. Now even scientific evidence suggests that it would be a good idea in the long term.
Yet another great reason to live in Europe!!
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
November 10, 2025 at 9:16 PM
After leaving Italy I always thought that the best thing Europe could do for its future stability would be establish a mandatory year of school abroad for all citizens. Now even scientific evidence suggests that it would be a good idea in the long term.
Reposted by Gabriele Zaffagnini
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
November 9, 2025 at 9:24 AM
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima
and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social
Read the full issue here: biomed.news/bims-cebooc/...
#cebooc
@biomednews.bsky.social
Reposted by Gabriele Zaffagnini
And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
November 6, 2025 at 4:35 AM
And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!
Reposted by Gabriele Zaffagnini
I have two open positions @ALMU @crg.eu:
1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...
Reposts appreciated.
1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...
Reposts appreciated.
November 3, 2025 at 2:01 PM
I have two open positions @ALMU @crg.eu:
1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...
Reposts appreciated.
1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...
Reposts appreciated.
Happy Sunday egg-ficionados! Here comes a new issue of #cebooc!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41173887/ on the role of mechanical forces in ovarian follicles development.
As always, thanks to @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41173887/ on the role of mechanical forces in ovarian follicles development.
As always, thanks to @biomednews.bsky.social for preselecting!
November 2, 2025 at 8:41 AM
Happy Sunday egg-ficionados! Here comes a new issue of #cebooc!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41173887/ on the role of mechanical forces in ovarian follicles development.
As always, thanks to @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41173887/ on the role of mechanical forces in ovarian follicles development.
As always, thanks to @biomednews.bsky.social for preselecting!
Happy Sunday ovo-lovers! A new issue of #cebooc is here!
biomed.news/bims-cebooc/...
This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/
Thanks @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/
Thanks @biomednews.bsky.social for preselecting!
October 26, 2025 at 8:04 AM
Happy Sunday ovo-lovers! A new issue of #cebooc is here!
biomed.news/bims-cebooc/...
This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/
Thanks @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/
Thanks @biomednews.bsky.social for preselecting!
Happy Sunday egg-ficionados! The latest issue of #Cebooc is here!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41102564/
Thanks @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41102564/
Thanks @biomednews.bsky.social for preselecting!
October 19, 2025 at 8:23 AM
Happy Sunday egg-ficionados! The latest issue of #Cebooc is here!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41102564/
Thanks @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41102564/
Thanks @biomednews.bsky.social for preselecting!
Tried it on a few papers that I know very well, including one that contains highly improbable data, and the comments were always spot-on. Undoubtedly a great tool to assist in reviewing and to benchmark one’s own manuscripts
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 17, 2025 at 10:03 AM
Tried it on a few papers that I know very well, including one that contains highly improbable data, and the comments were always spot-on. Undoubtedly a great tool to assist in reviewing and to benchmark one’s own manuscripts
Happy Sunday!! Ready for a new spectacular issue of #cebooc?👇🏽
biomed.news/bims-cebooc/...
Highlight: PMID 41066539 on the comparison between human and mouse ovarian aging
Special mention to PMID 41066576 by @frisophagy.bsky.social on mitochondrial selection by mitophagy in the early embryo
biomed.news/bims-cebooc/...
Highlight: PMID 41066539 on the comparison between human and mouse ovarian aging
Special mention to PMID 41066576 by @frisophagy.bsky.social on mitochondrial selection by mitophagy in the early embryo
October 12, 2025 at 6:41 AM
Happy Sunday!! Ready for a new spectacular issue of #cebooc?👇🏽
biomed.news/bims-cebooc/...
Highlight: PMID 41066539 on the comparison between human and mouse ovarian aging
Special mention to PMID 41066576 by @frisophagy.bsky.social on mitochondrial selection by mitophagy in the early embryo
biomed.news/bims-cebooc/...
Highlight: PMID 41066539 on the comparison between human and mouse ovarian aging
Special mention to PMID 41066576 by @frisophagy.bsky.social on mitochondrial selection by mitophagy in the early embryo
Reposted by Gabriele Zaffagnini
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 8:45 AM
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Reposted by Gabriele Zaffagnini
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
www.nature.com
October 8, 2025 at 3:51 PM
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Happy Sunday egg-ficionados! Here come the latest papers on #oocyte cell biology:
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41027914/
Thanks @biomednews.bsky.social for preselecting! #cebooc
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41027914/
Thanks @biomednews.bsky.social for preselecting! #cebooc
October 5, 2025 at 8:08 AM
Happy Sunday egg-ficionados! Here come the latest papers on #oocyte cell biology:
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41027914/
Thanks @biomednews.bsky.social for preselecting! #cebooc
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41027914/
Thanks @biomednews.bsky.social for preselecting! #cebooc
Reposted by Gabriele Zaffagnini
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:00 AM
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
Reposted by Gabriele Zaffagnini
👏Congratulations to the #CECAD Cologne's Escobar-Henriques lab and Reichert lab at the @hhu.de for their latest paper in #MolecularCell: a newly discovered #ubiquitin precursor, CxUb, plays a key role in #stress resistance and #longevity.
uni.koeln/7ET86
@unicologne.bsky.social #agingresearch
uni.koeln/7ET86
@unicologne.bsky.social #agingresearch
A quiet ally: a ubiquitin precursor promotes stress resistance and longevity
In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and...
uni.koeln
October 2, 2025 at 11:28 AM
👏Congratulations to the #CECAD Cologne's Escobar-Henriques lab and Reichert lab at the @hhu.de for their latest paper in #MolecularCell: a newly discovered #ubiquitin precursor, CxUb, plays a key role in #stress resistance and #longevity.
uni.koeln/7ET86
@unicologne.bsky.social #agingresearch
uni.koeln/7ET86
@unicologne.bsky.social #agingresearch
Reposted by Gabriele Zaffagnini
Human skin cells can be used to produce fertilizable eggs, according to research in Nature Communications. The study provides evidence that cell reprogramming could be a viable route in humans for addressing infertility, although further research is needed. go.nature.com/4nEbkAv 🧪
October 1, 2025 at 1:07 PM
Human skin cells can be used to produce fertilizable eggs, according to research in Nature Communications. The study provides evidence that cell reprogramming could be a viable route in humans for addressing infertility, although further research is needed. go.nature.com/4nEbkAv 🧪
Happy Autumn! Here comes a very rich issue of #cebooc, read all the latest #papers on oocyte cell #biology here:
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40993317/
Kudos to @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40993317/
Kudos to @biomednews.bsky.social for preselecting!
September 28, 2025 at 7:40 AM
Happy Autumn! Here comes a very rich issue of #cebooc, read all the latest #papers on oocyte cell #biology here:
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40993317/
Kudos to @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40993317/
Kudos to @biomednews.bsky.social for preselecting!
It was great to attend and give a talk at the Groningen-Jena Aging Meeting (G-JAM)! Very nice conference in a great historical location! Thanks a lot to the organisers @mariaermolaeva.bsky.social and Alessandro Cellerino for the invitation! @leibnizfli.bsky.social @uni-jena.de
September 26, 2025 at 11:02 AM
It was great to attend and give a talk at the Groningen-Jena Aging Meeting (G-JAM)! Very nice conference in a great historical location! Thanks a lot to the organisers @mariaermolaeva.bsky.social and Alessandro Cellerino for the invitation! @leibnizfli.bsky.social @uni-jena.de
Happy Sunday! Ready for the latest papers on #oocyte cell biology?
Here they come! biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40973727/ by @abalboula.bsky.social and @ejsm9.bsky.social
Thanks @biomednews.bsky.social for preselecting!
Here they come! biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40973727/ by @abalboula.bsky.social and @ejsm9.bsky.social
Thanks @biomednews.bsky.social for preselecting!
September 21, 2025 at 7:25 AM
Happy Sunday! Ready for the latest papers on #oocyte cell biology?
Here they come! biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40973727/ by @abalboula.bsky.social and @ejsm9.bsky.social
Thanks @biomednews.bsky.social for preselecting!
Here they come! biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40973727/ by @abalboula.bsky.social and @ejsm9.bsky.social
Thanks @biomednews.bsky.social for preselecting!
Happy Sunday! Here is a new issue of #cebooc, featuring the latest papers on #oocyte cell biology, enjoy!
biomed.news/bims-cebooc/...
Thanks to @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Thanks to @biomednews.bsky.social for preselecting!
September 14, 2025 at 9:28 AM
Happy Sunday! Here is a new issue of #cebooc, featuring the latest papers on #oocyte cell biology, enjoy!
biomed.news/bims-cebooc/...
Thanks to @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
Thanks to @biomednews.bsky.social for preselecting!
Great to see our work featured in @natsmb.nature.com!! Thanks editor @dimitristypas.bsky.social for your coverage! @bokelab.bsky.social
New online: A snapshot of proteostasis in human oocytes
A snapshot of proteostasis in human oocytes
Nature Structural & Molecular Biology, Published online: 09 September 2025; doi:10.1038/s41594-025-01679-2A snapshot of proteostasis in human oocytes
go.nature.com
September 10, 2025 at 10:14 AM
Great to see our work featured in @natsmb.nature.com!! Thanks editor @dimitristypas.bsky.social for your coverage! @bokelab.bsky.social
Happy Monday eggficionados, #cebooc is back! Ready for a new year of exciting papers on oocyte cell biology? Start now! 👇🏽
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40902605/
Thanks @biomednews.bsky.social for preselecting
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40902605/
Thanks @biomednews.bsky.social for preselecting
September 8, 2025 at 6:52 AM
Happy Monday eggficionados, #cebooc is back! Ready for a new year of exciting papers on oocyte cell biology? Start now! 👇🏽
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40902605/
Thanks @biomednews.bsky.social for preselecting
biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/40902605/
Thanks @biomednews.bsky.social for preselecting
Reposted by Gabriele Zaffagnini
Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!
Full Professorship in Molecular Mechanisms of Disease
The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...
www.maxperutzlabs.ac.at
September 4, 2025 at 10:25 AM
Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!