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Cutting-edge research, news, commentary, and visuals from the Science family of journals. https://www.science.org
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New research reveals that paperbarks, among other trees, host abundant, specialized, and metabolically active bark-dwelling microbial communities that modulate climatically relevant gases, including methane, hydrogen, and carbon monoxide.
Learn more this week in Science: https://scim.ag/4bp9hgl
Learn more this week in Science: https://scim.ag/4bp9hgl
Scientists have identified a protein that acts as a brake on the breakdown of lipids in the liver that’s regulated by both feeding and the circadian rhythm, according to new #ScienceSignaling research involving mice. https://scim.ag/4bkWSKf
The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modification
m6A modification of mRNAs promotes hepatic lipid metabolism and is blocked by HRD1-mediated ubiquitination.
scim.ag
January 9, 2026 at 11:46 PM
Scientists have identified a protein that acts as a brake on the breakdown of lipids in the liver that’s regulated by both feeding and the circadian rhythm, according to new #ScienceSignaling research involving mice. https://scim.ag/4bkWSKf
Researchers have discovered a periodic scaffold in the epidermis adjacent to the nervous system of C. elegans. The find may indicate similar structures in other organisms.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4qaC6BF
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4qaC6BF
January 9, 2026 at 10:07 PM
Researchers have discovered a periodic scaffold in the epidermis adjacent to the nervous system of C. elegans. The find may indicate similar structures in other organisms.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4qaC6BF
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4qaC6BF
Reposted by Science Magazine
@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...
Deep contrastive learning enables genome-wide virtual screening
Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...
www.science.org
January 9, 2026 at 6:55 PM
@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...
Two new Science studies on lizard coloration reveal how a delicate interplay of genetics, environment, and social dynamics can either preserve or erase polymorphic diversity in species.
📄: https://scim.ag/4srYKHi
📄: https://scim.ag/4qCcsWn
📄: https://scim.ag/4srYKHi
📄: https://scim.ag/4qCcsWn
January 9, 2026 at 8:56 PM
Two new Science studies on lizard coloration reveal how a delicate interplay of genetics, environment, and social dynamics can either preserve or erase polymorphic diversity in species.
📄: https://scim.ag/4srYKHi
📄: https://scim.ag/4qCcsWn
📄: https://scim.ag/4srYKHi
📄: https://scim.ag/4qCcsWn
Hunter-gatherers in southern Africa laced their stone arrow tips with poison roughly 60,000 years ago, a new #ScienceAdvances study finds.
The discovery pushes back the timeline for poison weapon use from the mid-Holocene to the Late Pleistocene. https://scim.ag/4aQDXqI
The discovery pushes back the timeline for poison weapon use from the mid-Holocene to the Late Pleistocene. https://scim.ag/4aQDXqI
Direct evidence for poison use on microlithic arrowheads in Southern Africa at 60,000 years ago
Earliest proof of plant poisons on arrows reveals complex Pleistocene hunting in southern Africa.
scim.ag
January 9, 2026 at 7:20 PM
Hunter-gatherers in southern Africa laced their stone arrow tips with poison roughly 60,000 years ago, a new #ScienceAdvances study finds.
The discovery pushes back the timeline for poison weapon use from the mid-Holocene to the Late Pleistocene. https://scim.ag/4aQDXqI
The discovery pushes back the timeline for poison weapon use from the mid-Holocene to the Late Pleistocene. https://scim.ag/4aQDXqI
Just before the holidays, a website that offered the world a window into the evolution of SARS-CoV-2, the virus that caused the COVID-19 pandemic, went dark. https://scim.ag/3NlkHrr
Fresh conflicts erupt around giant database for flu and COVID-19 sequences
Critics say “autocratic” behavior by GISAID could hamper response to a future pandemic
scim.ag
January 9, 2026 at 5:30 PM
Just before the holidays, a website that offered the world a window into the evolution of SARS-CoV-2, the virus that caused the COVID-19 pandemic, went dark. https://scim.ag/3NlkHrr
Reposted by Science Magazine
In @science.org this week:
The interaction between flavonoids and rhizobial Nod factors during legume symbiosis
www.science.org/doi/10.1126/...
#plantscience
The interaction between flavonoids and rhizobial Nod factors during legume symbiosis
www.science.org/doi/10.1126/...
#plantscience
The molecular basis of the binding and specific activation of rhizobial NodD by flavonoids
The specific partnership between legumes and rhizobia relies on a chemical dialogue. Plant flavonoids activate the bacterial transcription factor NodD, which triggers production of Nod factors that ar...
www.science.org
January 9, 2026 at 4:07 PM
In @science.org this week:
The interaction between flavonoids and rhizobial Nod factors during legume symbiosis
www.science.org/doi/10.1126/...
#plantscience
The interaction between flavonoids and rhizobial Nod factors during legume symbiosis
www.science.org/doi/10.1126/...
#plantscience
A new #ScienceSignaling analysis has elucidated the structure and activation mechanisms of the receptor HCAR1, which is involved in many metabolic and inflammatory conditions, and could inform research into therapies that target the receptor. https://scim.ag/4juCaK9
Structural insights into the activation mechanism of the human metabolite receptor HCAR1
How the lactate receptor HCAR1 becomes self-activated and is activated by ligands is revealed.
scim.ag
January 9, 2026 at 4:00 PM
A new #ScienceSignaling analysis has elucidated the structure and activation mechanisms of the receptor HCAR1, which is involved in many metabolic and inflammatory conditions, and could inform research into therapies that target the receptor. https://scim.ag/4juCaK9
Reposted by Science Magazine
Our Science Perspective on Ianni et al - neural control of facial expressions involves voluntary pathways
@jamiewhitehouse.bsky.social
www.science.org/eprint/EKJTZ...
@jamiewhitehouse.bsky.social
www.science.org/eprint/EKJTZ...
Making faces
Facial expressions are produced through a coordinated system of voluntary and emotional pathways
www.science.org
January 8, 2026 at 9:37 PM
Our Science Perspective on Ianni et al - neural control of facial expressions involves voluntary pathways
@jamiewhitehouse.bsky.social
www.science.org/eprint/EKJTZ...
@jamiewhitehouse.bsky.social
www.science.org/eprint/EKJTZ...
Reposted by Science Magazine
Ex–Google CEO funds private space telescope bigger than Hubble | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...
Ex–Google CEO funds private space telescope bigger than Hubble
Schmidt Sciences announces investments in orbiting observatory and three ground-based instruments
www.science.org
January 7, 2026 at 10:15 PM
Ex–Google CEO funds private space telescope bigger than Hubble | Science | AAAS 🔭🧪 @science.org www.science.org/content/arti...
Reposted by Science Magazine
The January 2026 issue of #Science #Immunology is out now!
Thanks to Rioka Hayama for another fantastic cover!!!
Thanks to Rioka Hayama for another fantastic cover!!!
The January 2026 issue of #ScienceImmunology is out!
This month's cover depicts the repopulation of resident cardiac macrophages after chemotherapy, protecting the heart against subsequent injury. Learn more about this research and more: https://scim.ag/3NsLjqu
This month's cover depicts the repopulation of resident cardiac macrophages after chemotherapy, protecting the heart against subsequent injury. Learn more about this research and more: https://scim.ag/3NsLjqu
January 8, 2026 at 11:14 AM
The January 2026 issue of #Science #Immunology is out now!
Thanks to Rioka Hayama for another fantastic cover!!!
Thanks to Rioka Hayama for another fantastic cover!!!
Reposted by Science Magazine
"For centuries, the life of Leonardo da Vinci has been pieced together from paint, ink, and paper—the fragile traces of a singular mind. That could be about to change."
Richard Stone for @science.org: www.science.org/content/arti...
Richard Stone for @science.org: www.science.org/content/arti...
Exclusive: Have scientists found Leonardo da Vinci’s DNA?
Inside the decadeslong quest to reveal the genes of a genius—and revolutionize art authentication
www.science.org
January 8, 2026 at 5:23 PM
"For centuries, the life of Leonardo da Vinci has been pieced together from paint, ink, and paper—the fragile traces of a singular mind. That could be about to change."
Richard Stone for @science.org: www.science.org/content/arti...
Richard Stone for @science.org: www.science.org/content/arti...
Reposted by Science Magazine
Can we design mutations that bias proteins towards desired conformational states?
Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
Computational design of conformation-biasing mutations to alter protein functions
Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...
www.science.org
January 8, 2026 at 7:08 PM
Can we design mutations that bias proteins towards desired conformational states?
Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
Reposted by Science Magazine
Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
Ontogeny of the spinal cord dorsal horn
The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...
www.science.org
January 8, 2026 at 7:59 PM
Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
Reposted by Science Magazine
In @science.org for chemsky this week, Michael Willis’ group make beta-lactam analogues with S=O in place of C=O, using energy-transfer reactivity of N-silyl sulfinylamine precursors.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Access to four-membered cyclic sulfinamides by energy transfer catalysis
Synthetic transformations that advance through excited states proceed by unconventional mechanistic pathways and deliver products not accessible using ground-state chemistry. The breadth of these synt...
www.science.org
January 8, 2026 at 8:03 PM
In @science.org for chemsky this week, Michael Willis’ group make beta-lactam analogues with S=O in place of C=O, using energy-transfer reactivity of N-silyl sulfinylamine precursors.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Science Magazine
Also this week for chemsky in @science.org Peiyuan Yu’s and Zhe Dong’s groups contract cyclohexyl epoxides into a versatile range of cyclopentanes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Leveraging triatropic rearrangements for stereoselective skeletal reshuffling
Pericyclic reactions transform simple precursors into architecturally complex products with exquisite stereocontrol, making them central tools in synthesis. Here, we report a class of pericyclic react...
www.science.org
January 8, 2026 at 8:10 PM
Also this week for chemsky in @science.org Peiyuan Yu’s and Zhe Dong’s groups contract cyclohexyl epoxides into a versatile range of cyclopentanes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Science Magazine
In this week’s @science.org cover article, we discover tree bark is a hidden habitat for abundant, diverse, and specialized microbial life that actively regulate our climate 🦠. Bark isn't just an inert armor of tree but an active interface for climate and biodiversity
www.science.org/eprint/7H9PX...
www.science.org/eprint/7H9PX...
Bark microbiota modulate climate-active gas fluxes in Australian forests
Recent studies suggest that microbes inhabit tree bark, yet little is known about their identities, functions, and environmental roles. Here we reveal, through gene-centric and genome-resolved metagen...
www.science.org
January 8, 2026 at 8:37 PM
In this week’s @science.org cover article, we discover tree bark is a hidden habitat for abundant, diverse, and specialized microbial life that actively regulate our climate 🦠. Bark isn't just an inert armor of tree but an active interface for climate and biodiversity
www.science.org/eprint/7H9PX...
www.science.org/eprint/7H9PX...
Reposted by Science Magazine
You don't need a brain to appreciate a good night of sleep!
New research revealed that jellyfish and sea anemones sleep for around 8 hours a day—the same amount as humans—and even get groggy! 🪼
Latest for @science.org with a great edit from @david-grimm.bsky.social
www.science.org/content/arti...
New research revealed that jellyfish and sea anemones sleep for around 8 hours a day—the same amount as humans—and even get groggy! 🪼
Latest for @science.org with a great edit from @david-grimm.bsky.social
www.science.org/content/arti...
Jellyfish sleep a lot like us—and for the same reasons
Study adds to evidence that sleep likely evolved among ancient animals as a means of repairing neurons
www.science.org
January 8, 2026 at 9:34 PM
You don't need a brain to appreciate a good night of sleep!
New research revealed that jellyfish and sea anemones sleep for around 8 hours a day—the same amount as humans—and even get groggy! 🪼
Latest for @science.org with a great edit from @david-grimm.bsky.social
www.science.org/content/arti...
New research revealed that jellyfish and sea anemones sleep for around 8 hours a day—the same amount as humans—and even get groggy! 🪼
Latest for @science.org with a great edit from @david-grimm.bsky.social
www.science.org/content/arti...
Reposted by Science Magazine
My first editorial in @science.org was published today: what to do (and, importantly, what NOT to do) when your grants are suddenly cut or research funding is uncertain. Please read and share!
#AcademicSky #Science #Astronomy
www.science.org/doi/10.1126/...
#AcademicSky #Science #Astronomy
www.science.org/doi/10.1126/...
Weathering budget cuts: Lessons from NASA
The current uncertainty and cuts to science funding affect universities, research facilities, and laboratories across the United States, but this situation is not unprecedented. Under pressure to fund...
www.science.org
January 8, 2026 at 11:28 PM
My first editorial in @science.org was published today: what to do (and, importantly, what NOT to do) when your grants are suddenly cut or research funding is uncertain. Please read and share!
#AcademicSky #Science #Astronomy
www.science.org/doi/10.1126/...
#AcademicSky #Science #Astronomy
www.science.org/doi/10.1126/...
A lawsuit by Alzheimer’s disease drugmaker T3D Therapeutics accuses five South Florida testing sites of falsification of data and other fraud in a test of an experimental compound, T3D-959. https://scim.ag/3Lu2pDP
Alzheimer’s drug developers accuse clinical trial sites of faking data
T3D Therapeutics alleges that contract researchers delivered “medically impossible” results on its candidate drug
scim.ag
January 9, 2026 at 2:23 PM
A lawsuit by Alzheimer’s disease drugmaker T3D Therapeutics accuses five South Florida testing sites of falsification of data and other fraud in a test of an experimental compound, T3D-959. https://scim.ag/3Lu2pDP
Reposted by Science Magazine
When did humans up their hunting game by adding poison to arrows? This week on the @science.org podcast, Sven Isaksson joins to discuss evidence for this toxic technology from 60,000 years ago
Listen here: www.science.org/content/podc...
Listen here: www.science.org/content/podc...
January 8, 2026 at 7:56 PM
When did humans up their hunting game by adding poison to arrows? This week on the @science.org podcast, Sven Isaksson joins to discuss evidence for this toxic technology from 60,000 years ago
Listen here: www.science.org/content/podc...
Listen here: www.science.org/content/podc...
Reposted by Science Magazine
In a new study, researchers from @uab.cat claim people have been whaling for almost 5,000 years – and that the earliest evidence comes from the warm coastal waters of Brazil, not the Arctic. www.science.org/content/arti... @science.org
World’s oldest whale harpoons discovered in Brazil
Far from the icy Arctic, ancient South Americans hunted whales using whalebone tools
www.science.org
January 9, 2026 at 1:30 PM
In a new study, researchers from @uab.cat claim people have been whaling for almost 5,000 years – and that the earliest evidence comes from the warm coastal waters of Brazil, not the Arctic. www.science.org/content/arti... @science.org
Reposted by Science Magazine
Scholars are on a quixotic quest to identify Leonardo da Vinci’s DNA—what could they learn from the real 'da Vinci' code? This week on the @science.org podcast with @richardastone.bsky.social
www.science.org/content/podc...
www.science.org/content/podc...
January 9, 2026 at 1:30 PM
Scholars are on a quixotic quest to identify Leonardo da Vinci’s DNA—what could they learn from the real 'da Vinci' code? This week on the @science.org podcast with @richardastone.bsky.social
www.science.org/content/podc...
www.science.org/content/podc...
Gut bacteria protect mice infected with influenza A virus from secondary bacterial lung infections such as bacterial pneumonia.
Learn more in #ScienceImmunology: https://scim.ag/4jgo7HS
Learn more in #ScienceImmunology: https://scim.ag/4jgo7HS
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia
SFB colonization phenotypically alters alveolar macrophages, maintaining their antibacterial functions in inflamed interferon-rich lungs.
scim.ag
January 8, 2026 at 10:00 PM
Gut bacteria protect mice infected with influenza A virus from secondary bacterial lung infections such as bacterial pneumonia.
Learn more in #ScienceImmunology: https://scim.ag/4jgo7HS
Learn more in #ScienceImmunology: https://scim.ag/4jgo7HS
"Rejecting evidence-informed infectious disease strategies and undermining vaccine-based interventions will not make us healthy again," argues Seth Berkley in a new #ScienceExpertVoices article. https://scim.ag/3YJRA3P
January 8, 2026 at 8:23 PM
"Rejecting evidence-informed infectious disease strategies and undermining vaccine-based interventions will not make us healthy again," argues Seth Berkley in a new #ScienceExpertVoices article. https://scim.ag/3YJRA3P