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Science Magazine @science.org · 3m

Octopus #DNA reveals that the West Antarctic Ice Sheet collapsed during the Last Interglacial ~129,000 to 116,000 years ago—when temperatures were only about 1°C warmer than preindustrial levels.

Learn more: https://scim.ag/4nFJ94k #WorldOctopusDay

Genomic evidence for West Antarctic Ice Sheet collapse during the Last Interglacial

Genetic analyses of a type of octopus found around Antarctica show that the West Antarctic Ice Sheet collapsed during the last interglacial period.

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Science Magazine @science.org · 1h

New findings in mice cast light on the pathways behind the growth of painful bone tumors in hereditary multiple osteochondroma and suggest that these mechanisms could be targeted to slow the disease’s progression.

Learn more in #ScienceSignaling: https://scim.ag/46VRSIp

An ectopic Hedgehog signaling axis drives directional tumor outgrowth in a mouse model of hereditary multiple osteochondromas

Redeployment of a developmental program drives the outgrowth of bone tumors in an inherited disease.

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Science Magazine @science.org · 2h

This year’s #NobelPrize in Chemistry has gone to the architects of molecular “cages” that could be used for everything from carbon capture to drug delivery. https://scim.ag/4mTE1Z6

Architects of molecular cages win Chemistry Nobel
Susumu Kitagawa, Richard Robson, and Omar Yaghi honored for developing metal-organic frameworks

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Jake Yeston @jakeyeston.bsky.social · 5h

Here’s a @science.org review Omar Yaghi published about 10 years ago

🧪 chemsky

www.science.org/doi/10.1126/...

The Chemistry and Applications of Metal-Organic Frameworks

www.science.org

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Keith Smith @drkeithsmith.bsky.social · 3h

Editor's choice: little red dots (LRDs) are compact distant galaxies with unusual properties, of uncertain origin. Taylor et al. have found an LRD at redshift 9.2, and show it contains a supermassive black hole >5% of the stellar mass in the galaxy. ☄️ #extragalactic
www.science.org/doi/10.1126/...

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Hannah Richter @hannah-richter.bsky.social · 18h

For essentially every supermassive black hole that astronomers have studied, they've spotted powerful winds blowing out from the event horizon to shape the surrounding galaxy. Except for the one in the Milky Way. 🌟 ⚫ 🌬️

The case may now be closed. @science.org tinyurl.com/5y99b7az #space #astronomy

Missing wind from Milky Way’s giant black hole finally found

Astronomers may have glimpsed a long-predicted wind of gas blowing out from Sagittarius A*

tinyurl.com

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Science Magazine @science.org · 17h

A new generation of radiotherapies promises a more targeted attack on cancer.

Learn more: https://scim.ag/3IwH8YW

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Science Magazine @science.org · 19h

Researchers delineate how a pathway drives the growth of bone tumors in a painful inherited bone disorder, new experiments in mice show how an enzyme inhibits the leakage of calcium ions in skeletal muscle cells, and more this week in #ScienceSignaling. https://scim.ag/4obBkmM

$The image is a scanning electron micrograph of a freeze-fractured mammalian skeletal muscle fiber.$

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Science Magazine @science.org · 20h

#NextGenSci gave young scientists this prompt: In the form of a haiku, assess the strengths and weaknesses of science in your home country or a country in which you have lived.

Read a selection of the responses here: https://scim.ag/46HsE1D

NextGen Voices
National assessments in verse

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Science Magazine @science.org · 21h

New research in #ScienceAdvances finds automated texts for California defendants reduced warrants issued for missed court dates by 20%. https://scim.ag/48FSnIX

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Science Magazine @science.org · 23h

Neurons in the mouse brain bypass synapses by communicating with one another via tiny nanotubes. https://scim.ag/4pOH6fL

Neurons can communicate via hidden network of nanotubes, study finds

Tubes in mouse and human brains may also influence spread of brain disease

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James Dinneen @jamesdinneen.bsky.social · 1d

Scary news for West Coast friends in my latest for @science.org. Disturbed ocean sediments off California suggest big earthquakes on the Cascadia fault can trigger big quakes on the San Andreas. The "Big One" could well become the "Big Two"...

Big U.S. West Coast earthquakes could come as a one-two punch

Cascadia and San Andreas fault zones appear to generate synchronized earthquakes

www.science.org

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Maddy Seale @maddyseale.bsky.social · 1d

Wonderful to see this beautiful image on the cover of Science this week highlighting a paper that uses high resolution imaging to show the spatial patterns of bacterial attraction to glutamine from roots.
Paper here: www.science.org/doi/10.1126/...
Perspective here: www.science.org/doi/10.1126/...

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Jake Yeston @jakeyeston.bsky.social · 1d

Quantum mechanics of a macroscopic variable, published by today’s laureates in @science.org in 1988. In addition to the science, it’s remarkably lucid writing

www.science.org/doi/10.1126/...

🧪

ARE MACROSCOPIC DEGREES OF FREEDOM GOVERNED BY quantum mechanics? Our everyday experience tells us that a classical description appears to be entirely adequate. The trajectory of the center of mass of a billiard ball is predicted wonderfully well by classical mechanics. Even the Brownian motion
of a tiny speck of dust in a drop of water is a purely classical phenomenon. Until recently, quantum mechanics manifested itself at the macroscopic level only through such collective phenomena as
superconductivity, flux quantization, or the Josephson effect. However, these "macroscopic" effects actually arise from the coherent superposition of a large number of microscopic variables each
governed by quantum mechanics. Thus, for example, the current through a Josephson tunnel junction and the phase difference across it are normally treated as classical variables.

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Science Magazine @science.org · 1d

"… I carry the lesson with me that good mentors are not born—they are built through reflection, training, and community." #ScienceWorkingLife https://scim.ag/4q6ea31

An iIllustration of man looking in mirror with his reflection and students' reflections looking back, with text: I didn't think I needed mentorship training—but it reshaped my approach.

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Maddy Seale @maddyseale.bsky.social · 1d

Out First Release in @science.org this week:
The development of a directed evolution strategy with proof of concept in plant immune protein engineering.

www.science.org/doi/10.1126/...

Engineered geminivirus replicons enable rapid in planta directed evolution

Directed evolution can rapidly generate genetic variants with new and enhanced properties, yet efficient platforms for performing such evolution directly in plant cells have been lacking. We developed...

www.science.org

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Science Magazine @science.org · 1d

This year’s #NobelPrize in Physics honors researchers who demonstrated quantum mechanical effects in electric circuits on a chip. https://scim.ag/46T4qQK

Physics Nobel awarded for macro demonstration of quantum effects

John Clarke, Michel Devoret, and John Martinis honored for work demonstrating quantum mechanical tunneling in electrical circuits

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Science Magazine @science.org · 1d

The October issue of #ScienceImmunology is out!

This month's cover highlights a Review that delves into brain tumor development and examines factors contributing to the immunosuppressive brain tumor microenvironment. Learn about this and more: https://scim.ag/46HgHcl

This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain.

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Christie Wilcox @nerdychristie.bsky.social · 1d

It took decades for the work of Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi—the winners of this year's Nobel Prize in Medicine or Physiology—to have clinical relevance. That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

Continued support for blue-sky research is essential to fuel the breakthroughs of tomorrow.
Carola Vinuesa, Francis Crick Institute

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Science Magazine @science.org · 1d

In a 2020 #ScienceReview, researchers investigated how systematic racist practices such as residential segregation have led to an unequal distribution of “nature” within cities.

Learn more on #WorldHabitatDay: https://scim.ag/3KQnEir

The ecological and evolutionary consequences of systemic racism in urban environments

Cities create challenging environments for many nonhuman species, and the presence of nonhumans in cities influences the health and well-being of the humans with which they share the environment. Dist...

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Science Magazine @science.org · 1d

A new trivalent vaccine based on chimeric alphaviruses shields mice and macaques from infection and CNS pathology when exposed to aerosolized forms of Venezuelan, Eastern, and Western equine encephalitis viruses.

Read more in #ScienceTranslationalMedicine: https://scim.ag/4gSP2Z3

An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques

Two doses of an inactivated trivalent vaccine protect mice and macaques against disease caused by encephalitic alphaviruses.

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Science Magazine @science.org · 1d

“It’s really a tour de force to get such high-quality data out of something so degraded and old.” https://scim.ag/3Ku8SxQ

Ancient DNA from horses slaughtered by Neanderthals sheds light on equine evolution

200,000-year-old genes are oldest ever recovered from open-air site

www.science.org

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Sarah Lempriere @sarahlempriere.bsky.social · 4d

I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...

Hidden networks in the brain

Dendritic nanotubes extend brain connectivity beyond synapses

www.science.org

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Kilian Schober @kischober.bsky.social · 4d

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

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CortésLab @corteslab.bsky.social · 4d

Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...

A comprehensive genetic catalog of human double-strand break repair

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

www.science.org

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