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sarahlempriere.bsky.social
Sarah Lempriere
@sarahlempriere.bsky.social
1.1K followers 2K following 79 posts
Senior Editor at Science. I handle Perspective articles in neuroscience, genetics, biochemistry and plant science. Views are my own.
Posts Media Videos Starter Packs
Reposted by Sarah Lempriere
science.org
Science Magazine @science.org · 2d
This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi
Medicine Nobel goes to three researchers who identified immune system’s security guards
Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease
scim.ag
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Reposted by Sarah Lempriere
science.org
Science Magazine @science.org · 2d
In a new Science study, researchers show that lysosomes, degradative organelles activated by food limitation, stimulate epigenetic changes that contribute to transgenerational longevity in C. elegans.

📄: https://scim.ag/4gOlR9N
#SciencePerspective: https://scim.ag/3IOqNyH
From lysosome to longevity: Overexpression of the lysosomal lipase LIPL-4 in Caenorhabditiselegans results in methylation of lysine 79 on histone H3 (H3K79),which increases transcription of the gene encoding histone variantHIS-71. HIS-71 is shuttled from intestine to oocytes through association with yolk particles. On arrival, it is methylated and becomes associated with germ line DNA. These events promote longevity in wild-type descendants for several generations.
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 4d
I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...
Hidden networks in the brain
Dendritic nanotubes extend brain connectivity beyond synapses
www.science.org
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 4d
The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...
The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
www.science.org
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Reposted by Sarah Lempriere
us.theconversation.com
The Conversation U.S. @us.theconversation.com · 5d
#SCOTUS starts a new term on Monday, and it has it all: race, gender, money and power.

Cases on voting rights, transgender sports, conversion therapy and campaign finance will test how far the court’s originalist “course correction” will go.

buff.ly/1iGFqBy
#polisky
Supreme Court opens with cases on voting rights, tariffs, gender identity and campaign finance to test the limits of a constitutional revolution
With partisan advantage, clashing perceptions of reality and revolutionary readings of the Constitution all in play, the Supreme Court’s cases this year reach far into American politics and culture.
buff.ly
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 5d
Getting to the root of the pattern | Science www.science.org/doi/10.1126/...
Getting to the root of the pattern
Root barriers and metabolite leakage shape microbial colonization of plants
www.science.org
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Reposted by Sarah Lempriere
jeremymberg.bsky.social
Jeremy Berg @jeremymberg.bsky.social · 12d
This paper does a great job with a "It's a Wonderful Life" scenario about NIH, supposing the consequences of the bottom 40% of the funding NIH grants never existed.

www.science.org/doi/10.1126/...

tl:dr The world would lose a lot, but directly and indirectly
What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
www.science.org
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 12d
An inheritance of long life | Science www.science.org/doi/10.1126/...
An inheritance of long life
Parental lysosomes modify epigenetic signaling to influence offspring life span
www.science.org
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 12d
I found this fascinating! Termites build and tend a fungal garden. www.science.org/doi/10.1126/...
Gardening strategies of termite farmers
Termites use microbe-infused soil to protect a fungal symbiont
www.science.org
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Reposted by Sarah Lempriere
ocasapiens.bsky.social
Oca sapiens @ocasapiens.bsky.social · 19d
#evolution
#adaptation

Science just published two important (imo) #genomics papers about the origin, mobility and pesticide resistance of Aedes aegypti, funestus and formosus mosquitoes - and the increased risk of dengue and malaria.

Links in Tamar Carter's perspective:
Genomic clues into the spread of deadly mosquitoes
Ancient and more recent human interactions shape mosquito vector evolution
www.science.org
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Reposted by Sarah Lempriere
petrathepostdoc.bsky.social
Petra Korlević @petrathepostdoc.bsky.social · 19d
also really fun to share an issue and a commentary with a big paper on Aedes aegypti 🦟🥂🦟

congrats @mariloumercedes.bsky.social and Jacob E. Crawford

www.science.org/doi/10.1126/...
#SciArt doodle of two mosquitoes holding papers and drinks highfiving eachother, an anopheles on the left (orangey brown with dots on her wings) and an aedes on the right (dark brown with white stripes on body and legs).
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 19d
@amygoldberg.bsky.social @katherinemcvay.bsky.social
sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 19d
Trade-offs and human adaptation at the extremes | Science www.science.org/doi/10.1126/...
Trade-offs and human adaptation at the extremes
Genomic analyses of Turkana pastoralists identify variants that increase water retention
www.science.org
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 19d
Genomic clues into the spread of deadly mosquitoes | Science www.science.org/doi/10.1126/...
Genomic clues into the spread of deadly mosquitoes
Ancient and more recent human interactions shape mosquito vector evolution
www.science.org
Reposted by Sarah Lempriere
venkatesh-lab.bsky.social
The Venkatesh Lab @venkatesh-lab.bsky.social · 22d
We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature
Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...
www.nature.com
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 22d
Burning questions on wildfire | Science www.science.org/doi/10.1126/...
Burning questions on wildfire
Fire heat may change how wildfire affects air pollution in the United States
www.science.org
Reposted by Sarah Lempriere
cedricboeckx.bsky.social
Cedric Boeckx @cedricboeckx.bsky.social · 26d
Very cool study by @oyiz.bsky.social using optogenetics to shed light on how oxytocin signaling regulates vocalization to maintain maternal bonds (with nice write-up by @bellonec.bsky.social, “Cries into ties” indeed) 🧪

www.science.org/doi/10.1126/...
Cries into ties
Oxytocin neurons in mouse pups regulate vocalization to maintain maternal bonds
www.science.org
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 26d
Gene flow stops sooner in plants than in animals | Science www.science.org/doi/10.1126/...
Gene flow stops sooner in plants than in animals
Genomic data indicate when species became reproductively isolated
www.science.org
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sarahlempriere.bsky.social
Sarah Lempriere @sarahlempriere.bsky.social · 26d
Cries into ties | Science www.science.org/doi/10.1126/...
Cries into ties
Oxytocin neurons in mouse pups regulate vocalization to maintain maternal bonds
www.science.org
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Reposted by Sarah Lempriere
science.org
Science Magazine @science.org · 27d
The photosystem I and light-harvesting proteins of marine coccolithophores assemble into a huge molecular machine that efficiently captures, transfers, and converts light energy, demonstrating the evolutionary diversity of photosynthesis.

Learn more this week in Science: https://scim.ag/4mZBkpy
The photosynthetic proteins of marine coccolithophores capture green light underwater and appear orange-red. Their photosystem I and light-harvesting proteins assemble into a huge molecular machine that efficiently captures, transfers, and converts light energy, demonstrating the evolutionary diversity of photosynthesis and the ultimate pursuit of light.
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Reposted by Sarah Lempriere
mishaahrens.bsky.social
Misha Ahrens @mishaahrens.bsky.social · Sep 8
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
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Reposted by Sarah Lempriere
fullfact.org
Full Fact @fullfact.org · Sep 8
At the Reform UK conference, Dr Aseem Malhotra made a number of claims about Covid vaccines, some of which were misleading or simply not backed by any credible evidence.

We’ve fact checked a few of his claims 👇
Covid vaccine claims at the Reform UK conference: fact checked – Full Fact
A cardiologist called Dr Aseem Malhotra, who we have fact checked before, made unevidenced and misleading claims at the event in Birmingham.
fullfact.org
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Reposted by Sarah Lempriere
pestilence4all.bsky.social
Pestilence @pestilence4all.bsky.social · Sep 7
Science Sunday. A very easy read filled with facts.
#Science

“Although clean water, sanitation, improved nutrition, and advances in neonatal and perinatal care have all played crucial roles in this progress, the greatest single contributor has been the development and widespread use of vaccines.”
Unraveling the arc of vaccine progress
The philosopher Thomas Hobbes famously described life in 1651 as “nasty, brutish, and short.” He was undeniably correct, with estimates of average life expectancy in the UK at the time ranging from 37...
www.science.org
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Reposted by Sarah Lempriere
joannabagniewska.com
Joanna Bagniewska @joannabagniewska.com · Sep 4
❄️ Common shrews shrink their brains in winter.

🧠 The process is reversible and occurs because brain cells shrink, rather than die off. As a result, neuronal numbers stay constant and preserve brain function.

I can defo relate to seasonal brain shrinkage.

🧪🦊🌍
Paper: www.cell.com/current-biol...
Image of a shrew in summer (left) and winter (right), with brain cells containing more (L) and less (R) water. Young common shrews, photo WWalas from Wikimedia Commons
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Reposted by Sarah Lempriere
friedemann.bsky.social
Friedemann Weber @friedemann.bsky.social · Sep 5
Serious setback in the fight against malaria:
"opposition to the project has grown, fueled in part by false accusations...social media...disinformation campaigns in the region often linked to Russian networks, says Mark Duerksen, a security expert"
After ‘humiliating’ raid, Burkina Faso halts ‘gene drive’ project to fight malaria
Disinformation campaign may have triggered “brutal” shutdown of mosquito lab
www.science.org
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