Simon Fisher
@profsimonfisher.bsky.social
Director of Language & Genetics at Max Planck Institute, Nijmegen.
Tracing the complex connections between genes, brains, speech & language.
Website: https://www.mpi.nl/people/fisher-simon-e
ORCID: https://orcid.org/0000-0002-3132-1996
Tracing the complex connections between genes, brains, speech & language.
Website: https://www.mpi.nl/people/fisher-simon-e
ORCID: https://orcid.org/0000-0002-3132-1996
Pinned
Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n
Reposted by Simon Fisher
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
What enables human language? A biocultural framework
Explaining the origins of language is a key challenge in understanding ourselves as a species. We present an empirical framework that draws on synergies across fields to facilitate robust studies of l...
www.science.org
November 23, 2025 at 11:54 AM
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
Reposted by Simon Fisher
This overview dovetails very nicely with the complementary, more historical and theoretical (albeit short) review of the study of language evolution in this entry in the Open Encyclopedia of Cognitive Science (open access for all): oecs.mit.edu/pub/18miikqb/
Language Evolution
oecs.mit.edu
November 23, 2025 at 11:07 PM
This overview dovetails very nicely with the complementary, more historical and theoretical (albeit short) review of the study of language evolution in this entry in the Open Encyclopedia of Cognitive Science (open access for all): oecs.mit.edu/pub/18miikqb/
If you are unable to download the full version of our newly published language evolution article in Science, there is a link for direct free access on the Max Planck Institute website here:
November 23, 2025 at 7:09 PM
If you are unable to download the full version of our newly published language evolution article in Science, there is a link for direct free access on the Max Planck Institute website here:
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
What enables human language? A biocultural framework
Explaining the origins of language is a key challenge in understanding ourselves as a species. We present an empirical framework that draws on synergies across fields to facilitate robust studies of l...
www.science.org
November 23, 2025 at 11:54 AM
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
Reposted by Simon Fisher
Current me: It's only one more project/talk/paper/review...
Future me: Don't do this, I beg you.
Current me: Super interesting, could find a way to fit it in...
Future me: C'mon, remember the rule, just say no!
Current me: & loads of time before the deadline...
Future me: Wait, can you even hear me?
Future me: Don't do this, I beg you.
Current me: Super interesting, could find a way to fit it in...
Future me: C'mon, remember the rule, just say no!
Current me: & loads of time before the deadline...
Future me: Wait, can you even hear me?
January 17, 2025 at 4:02 PM
Current me: It's only one more project/talk/paper/review...
Future me: Don't do this, I beg you.
Current me: Super interesting, could find a way to fit it in...
Future me: C'mon, remember the rule, just say no!
Current me: & loads of time before the deadline...
Future me: Wait, can you even hear me?
Future me: Don't do this, I beg you.
Current me: Super interesting, could find a way to fit it in...
Future me: C'mon, remember the rule, just say no!
Current me: & loads of time before the deadline...
Future me: Wait, can you even hear me?
Advances in genomics are giving exciting new perspectives on biology of speech, language & reading. My latest peer-reviewed paper is a tutorial, guiding readers from different backgrounds through the history of the field, current state-of-the-art, & where we’re heading. A taster in this thread.🧪
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Genomic Investigations of Spoken and Written Language Abilities: A Guide to Advances in Approaches, Technologies, and Discovery
Purpose: The aim of this tutorial is to show how the rise of molecular technologies
and analytical methods in human genetics yields exciting new ...
pubs.asha.org
November 17, 2025 at 5:54 PM
Advances in genomics are giving exciting new perspectives on biology of speech, language & reading. My latest peer-reviewed paper is a tutorial, guiding readers from different backgrounds through the history of the field, current state-of-the-art, & where we’re heading. A taster in this thread.🧪
1/n
1/n
There must be some fundamental law of the universe that no matter how many times you go over the galley proofs, no matter how intensively you & your coauthors examine them, a glaring typo will sneak its way through in plain sight. I just caught one at the final hurdle, next time may not be so lucky.
November 14, 2025 at 7:13 PM
There must be some fundamental law of the universe that no matter how many times you go over the galley proofs, no matter how intensively you & your coauthors examine them, a glaring typo will sneak its way through in plain sight. I just caught one at the final hurdle, next time may not be so lucky.
“Critically assessing the literature, we found it beset by conceptual & methodological flaws & limitations, undermining claims that the gut microbiome is causally involved in etiology/pathophysiology of autism”
Crucial PSA from @wiringthebrain.bsky.social @statsepi.bsky.social @deevybee.bsky.social🧪
Crucial PSA from @wiringthebrain.bsky.social @statsepi.bsky.social @deevybee.bsky.social🧪
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in
the scientific literature and popular press. Mitchell et al. critically examine influential
studies underpinning these...
www.cell.com
November 13, 2025 at 9:18 PM
“Critically assessing the literature, we found it beset by conceptual & methodological flaws & limitations, undermining claims that the gut microbiome is causally involved in etiology/pathophysiology of autism”
Crucial PSA from @wiringthebrain.bsky.social @statsepi.bsky.social @deevybee.bsky.social🧪
Crucial PSA from @wiringthebrain.bsky.social @statsepi.bsky.social @deevybee.bsky.social🧪
With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven
with population-based datasets used to quantify musical achievement.
www.cell.com
November 13, 2025 at 11:26 AM
With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇
Unboxing Schrödinger's cat.
November 3, 2025 at 9:57 PM
Unboxing Schrödinger's cat.
Reposted by Simon Fisher
“Bonferonni correction”, an invaluable method in #statistics, refers to the act of repeatedly correcting misspellings of the word Bonferroni at multiple places in a draft manuscript.
#science #academia
#science #academia
November 11, 2024 at 2:52 PM
“Bonferonni correction”, an invaluable method in #statistics, refers to the act of repeatedly correcting misspellings of the word Bonferroni at multiple places in a draft manuscript.
#science #academia
#science #academia
If you're interested in how advances in human genomics are transforming our understanding of the biology of spoken & written language abilities, please do check out my new peer-reviewed "tutorial" article, just published.
🗣️🧬🧪
[Will also make a Bsky explainer 🧵 on it next week when I get some time🙂.]
🗣️🧬🧪
[Will also make a Bsky explainer 🧵 on it next week when I get some time🙂.]
Genomic Investigations of Spoken and Written Language Abilities: A Guide to Advances in Approaches, Technologies, and Discovery
Purpose: The aim of this tutorial is to show how the rise of molecular technologies
and analytical methods in human genetics yields exciting new ...
pubs.asha.org
October 30, 2025 at 3:49 PM
If you're interested in how advances in human genomics are transforming our understanding of the biology of spoken & written language abilities, please do check out my new peer-reviewed "tutorial" article, just published.
🗣️🧬🧪
[Will also make a Bsky explainer 🧵 on it next week when I get some time🙂.]
🗣️🧬🧪
[Will also make a Bsky explainer 🧵 on it next week when I get some time🙂.]
More than two decades have passed since we discovered that rare disruptions of the FOXP2 gene disturb development of proficient speech/language skills. Today we know of multiple FOXP genes that are directly implicated in distinct brain-related conditions with differences in symptoms & severity.🧪 1/n
October 29, 2025 at 5:09 PM
More than two decades have passed since we discovered that rare disruptions of the FOXP2 gene disturb development of proficient speech/language skills. Today we know of multiple FOXP genes that are directly implicated in distinct brain-related conditions with differences in symptoms & severity.🧪 1/n
A haunted house for academics but it's just a continual stream of ominous "decision on your manuscript" emails that you can never work up enough courage to open & read.
October 24, 2025 at 7:54 AM
A haunted house for academics but it's just a continual stream of ominous "decision on your manuscript" emails that you can never work up enough courage to open & read.
Come join us for a 4-year PhD on effects of rare gene disruptions involved in speech disorder, investigated in human neuronal models (via gene-editing, tissue culture, brain organoids, high-res microscopy, transcriptomics, epigenomics).
More info: www.mpi.nl/imprs-phd-fe...
#AcademicJobs #PhDJobs
🧬🧪
More info: www.mpi.nl/imprs-phd-fe...
#AcademicJobs #PhDJobs
🧬🧪
October 22, 2025 at 3:43 PM
Come join us for a 4-year PhD on effects of rare gene disruptions involved in speech disorder, investigated in human neuronal models (via gene-editing, tissue culture, brain organoids, high-res microscopy, transcriptomics, epigenomics).
More info: www.mpi.nl/imprs-phd-fe...
#AcademicJobs #PhDJobs
🧬🧪
More info: www.mpi.nl/imprs-phd-fe...
#AcademicJobs #PhDJobs
🧬🧪
Help spread the word about developmental language disorder, a common yet often hidden condition that makes it hard for children to understand what's said to them & to articulate thoughts & feelings. Lots of helpful resources & information at radld.org.
#DLDday #DevLangDis @radld.bsky.social
#DLDday #DevLangDis @radld.bsky.social
October 17, 2025 at 9:34 AM
Help spread the word about developmental language disorder, a common yet often hidden condition that makes it hard for children to understand what's said to them & to articulate thoughts & feelings. Lots of helpful resources & information at radld.org.
#DLDday #DevLangDis @radld.bsky.social
#DLDday #DevLangDis @radld.bsky.social
“NOVA1 is a gene distinguishing modern humans from extinct hominids but evolutionary pressures that selected the modern allele remain elusive...Lead exposure on human brain organoids carrying the archaic NOVA1 variant disrupts FOXP2 expression, a gene crucial for human speech/language abilities.”🤔🧪
Impact of intermittent lead exposure on hominid brain evolution
Lead exposure, as influenced by NOVA1 expression, affected brain function in multiple hominid species.
www.science.org
October 16, 2025 at 3:46 PM
“NOVA1 is a gene distinguishing modern humans from extinct hominids but evolutionary pressures that selected the modern allele remain elusive...Lead exposure on human brain organoids carrying the archaic NOVA1 variant disrupts FOXP2 expression, a gene crucial for human speech/language abilities.”🤔🧪
There should be a word for that strange mix of naive optimism & existential dread that you experience in the brief period between submitting your scientific manuscript & having it desk-rejected by the journal editor.
October 16, 2025 at 10:53 AM
There should be a word for that strange mix of naive optimism & existential dread that you experience in the brief period between submitting your scientific manuscript & having it desk-rejected by the journal editor.
"Returning manuscript without review."
In honor of spooky month, share a 4 word horror story that only someone in your profession would understand
I'll go first: Six page commercial lease.
I'll go first: Six page commercial lease.
October 12, 2025 at 7:04 PM
"Returning manuscript without review."
New paper alert! Rare DNA changes in the SETBP1 gene are linked to speech problems & diverse syndromes affecting brain development. Work led by ace postdoc @maggiemkwong.bsky.social uncovered impact of different gene variants, coupling clinical/speech evaluation to molecular & cellular readouts.🧬🗣️🔬🧪
SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder - Nature Communications
Different types of SETBP1 variants cause variable developmental syndromes with only partial clinical and functional overlaps. Here, the authors report that SETBP1 variants outside the degron region impair DNA-binding, transcription, and neuronal differentiation capacity and morphologies.
www.nature.com
October 10, 2025 at 5:36 PM
New paper alert! Rare DNA changes in the SETBP1 gene are linked to speech problems & diverse syndromes affecting brain development. Work led by ace postdoc @maggiemkwong.bsky.social uncovered impact of different gene variants, coupling clinical/speech evaluation to molecular & cellular readouts.🧬🗣️🔬🧪
Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350....
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪
October 4, 2025 at 1:34 PM
Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350....
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪
Not gonna lie, just tried swiping to scroll to next page of a thesis that I'm reading, was surprised by lack of response, & only then did brain kick in to remind me it's a printed copy, & that's not how books work. Time for a break perhaps. 😬
October 3, 2025 at 5:33 PM
Not gonna lie, just tried swiping to scroll to next page of a thesis that I'm reading, was surprised by lack of response, & only then did brain kick in to remind me it's a printed copy, & that's not how books work. Time for a break perhaps. 😬
Unique opportunity to direct your own innovative long-term research programme on the psychology of language at @mpi-nl.bsky.social, a leading interdisciplinary Max Planck Institute in Nijmegen, the Netherlands. Nominate yourself or a colleague by 19 December 2025. Please help us spread the word. 👇🧪
We're seeking the next Director of the Max Planck Institute for Psycholinguistics! Lead cutting-edge research in language & cognition. Nominations (incl. self) due 19 Dec 2025.
mpi.nl/career-education/vacancies/vacancy/nominations-and-self-nominations-sought-position-director-max
mpi.nl/career-education/vacancies/vacancy/nominations-and-self-nominations-sought-position-director-max
October 3, 2025 at 8:18 AM
Unique opportunity to direct your own innovative long-term research programme on the psychology of language at @mpi-nl.bsky.social, a leading interdisciplinary Max Planck Institute in Nijmegen, the Netherlands. Nominate yourself or a colleague by 19 December 2025. Please help us spread the word. 👇🧪
"Earlier- & later-diagnosed autism have different developmental trajectories & genetic profiles. The findings have important implications for how we conceptualize autism & provide a model to explain some of its diversity." @vw1234.bsky.social & an international team report today in @nature.com: 👇🧪
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
www.nature.com
October 1, 2025 at 3:35 PM
"Earlier- & later-diagnosed autism have different developmental trajectories & genetic profiles. The findings have important implications for how we conceptualize autism & provide a model to explain some of its diversity." @vw1234.bsky.social & an international team report today in @nature.com: 👇🧪
New analysis of a 1-million yr old fossil skull captured worldwide media attention this week, with many headlines saying it requires a complete rewrite/rethink of human evolution. This is an intriguing study & it's brilliant to see so much public enthusiasm for deciphering our origins, but....1/n 🧪
September 27, 2025 at 12:40 PM
New analysis of a 1-million yr old fossil skull captured worldwide media attention this week, with many headlines saying it requires a complete rewrite/rethink of human evolution. This is an intriguing study & it's brilliant to see so much public enthusiasm for deciphering our origins, but....1/n 🧪