John Greally
@greally.bsky.social
Using genomic information to improve medicine
Pinned
John Greally
@greally.bsky.social
· Oct 10
Epigenetics: History, Molecules, and Diseases
Buy Epigenetics: History, Molecules, and Diseases on Amazon.com ✓ FREE SHIPPING on qualified orders
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My book on Epigenetics: History, Molecules and Diseases
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
The US health system. So in need of innovation, so refractory to innovation. But we should keep trying to fix this broken system.
Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.
Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.
States could adopt single-payer laws that would create state-based Medicare-for-All–style systems."
Time For State-Based Single Payer: The New York Health Act | Health Affairs Forefront
There is an alternative to the One Big Beautiful Bill’s approach of kicking millions of people off their health care and closing rural hospitals: States could adopt single-payer laws that would create...
www.healthaffairs.org
February 9, 2026 at 8:43 PM
The US health system. So in need of innovation, so refractory to innovation. But we should keep trying to fix this broken system.
Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.
Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.
Reposted by John Greally
I'm going to do a thread of all the references and context behind Bad Bunny's performance and what it means for Puerto Ricans to see this on the biggest stage.
The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts.
Follow along!
The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts.
Follow along!
February 9, 2026 at 5:08 PM
I'm going to do a thread of all the references and context behind Bad Bunny's performance and what it means for Puerto Ricans to see this on the biggest stage.
The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts.
Follow along!
The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts.
Follow along!
Is the @nytimes.com trolling Gina Kolata?
Relentlessly negative about the medical profession, her headline asks what we physicians are really good for?
The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.
Relentlessly negative about the medical profession, her headline asks what we physicians are really good for?
The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.
February 9, 2026 at 6:58 PM
Is the @nytimes.com trolling Gina Kolata?
Relentlessly negative about the medical profession, her headline asks what we physicians are really good for?
The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.
Relentlessly negative about the medical profession, her headline asks what we physicians are really good for?
The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.
And we’re the outliers with peculiarities?
February 7, 2026 at 3:05 PM
And we’re the outliers with peculiarities?
Reposted by John Greally
The NYTs comment section for our feature yesterday got so heated, they shut it down immediately. However, people want to donate to #IDSov. Here’s ours: www.bonfire.com/store/native... donorbox.org/help-to-empo... www.bonfire.com/store/native... Here’s the movement’s indigenousdata.org nativegov.org
Native BioData Consortium | Official Merchandise | Bonfire
Check out Native BioData Consortium on Bonfire and shop official merchandise today! Featuring limited edition custom apparel, printed with care in the USA just for you.
www.bonfire.com
February 6, 2026 at 8:47 PM
The NYTs comment section for our feature yesterday got so heated, they shut it down immediately. However, people want to donate to #IDSov. Here’s ours: www.bonfire.com/store/native... donorbox.org/help-to-empo... www.bonfire.com/store/native... Here’s the movement’s indigenousdata.org nativegov.org
Gift link www.nytimes.com/2026/02/06/o...
Opinion | The Finance Industry Is a Grift. Let’s Start Treating It That Way.
www.nytimes.com
February 6, 2026 at 2:10 PM
Gift link www.nytimes.com/2026/02/06/o...
A conservative economist writing about capitalism today. Fascinating perspective.
www.nytimes.com/2026/02/06/o...
www.nytimes.com/2026/02/06/o...
Opinion | The Finance Industry Is a Grift. Let’s Start Treating It That Way.
www.nytimes.com
February 6, 2026 at 2:08 PM
A conservative economist writing about capitalism today. Fascinating perspective.
www.nytimes.com/2026/02/06/o...
www.nytimes.com/2026/02/06/o...
Solid genomics and statistical analyses involved, plus some innovative machine learning designed to bring FNCV information to clinical diagnostics.
The postdoc will be embedded with the @newyorkcrd.bsky.social group, who have an interest in getting FNCVs into translational use.
The postdoc will be embedded with the @newyorkcrd.bsky.social group, who have an interest in getting FNCVs into translational use.
February 5, 2026 at 10:49 PM
Solid genomics and statistical analyses involved, plus some innovative machine learning designed to bring FNCV information to clinical diagnostics.
The postdoc will be embedded with the @newyorkcrd.bsky.social group, who have an interest in getting FNCVs into translational use.
The postdoc will be embedded with the @newyorkcrd.bsky.social group, who have an interest in getting FNCVs into translational use.
This position has 2 years of funding from SFARI to test our findings that indicate an accumulation of functional non-coding variants (FNCVs) in regulatory loci of glutamatergic neurons causing neurodevelopment disorders.
February 5, 2026 at 10:49 PM
This position has 2 years of funding from SFARI to test our findings that indicate an accumulation of functional non-coding variants (FNCVs) in regulatory loci of glutamatergic neurons causing neurodevelopment disorders.
Please share this with your network: Postdoctoral position available in my group.
www.linkedin.com/jobs/view/43...
www.linkedin.com/jobs/view/43...
Albert Einstein College of Medicine hiring Postdoctoral position studying functional non-coding variants in neurodevelopmental disorders, Bronx, New York City, USA c in New York City Metropolitan Area...
Posted 9:40:20 PM. A postdoctoral fellow position is open with 2 years of funding from the Simons Foundation Autism…See this and similar jobs on LinkedIn.
www.linkedin.com
February 5, 2026 at 10:47 PM
Please share this with your network: Postdoctoral position available in my group.
www.linkedin.com/jobs/view/43...
www.linkedin.com/jobs/view/43...
Examples of Departmental strengths include model organism researchers (including Hannes Bülow, Bernice Morrow, Meelad Dawlaty, Julie Secombe), ageing research (Jan Vijg) and population genetics (Srilakshmi Raj), and is the home for the research arm of the @newyorkcrd.bsky.social.
February 5, 2026 at 10:15 PM
Examples of Departmental strengths include model organism researchers (including Hannes Bülow, Bernice Morrow, Meelad Dawlaty, Julie Secombe), ageing research (Jan Vijg) and population genetics (Srilakshmi Raj), and is the home for the research arm of the @newyorkcrd.bsky.social.
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
Albert Einstein College of Medicine | Medical Education | Biomedical Research
faculty-einstein.icims.com
February 5, 2026 at 10:14 PM
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
The goal is to understand how non-coding sequence variation may cause intellectual disability, improving our ability to give families answers when they have a child with this condition.
Anyone interested should reach out to me directly. We will officially post the position soon.
Anyone interested should reach out to me directly. We will officially post the position soon.
January 30, 2026 at 8:01 PM
The goal is to understand how non-coding sequence variation may cause intellectual disability, improving our ability to give families answers when they have a child with this condition.
Anyone interested should reach out to me directly. We will officially post the position soon.
Anyone interested should reach out to me directly. We will officially post the position soon.
The applicant should have the ability to work with large genomic datasets, and learn/apply statistical and machine learning approaches. They will be co-mentored by Srilakshmi Raj. Start date May 1 2026, we need to fill the position soon. 2/3
January 30, 2026 at 8:00 PM
The applicant should have the ability to work with large genomic datasets, and learn/apply statistical and machine learning approaches. They will be co-mentored by Srilakshmi Raj. Start date May 1 2026, we need to fill the position soon. 2/3
Please spread the word — a 2-year postdoctoral fellowship is available in my group funded by the Simons Foundation Autism Research Initiative (SFARI) to perform a study testing the contribution of functional non-coding variants in glutamatergic neurons to autism. 1/3
January 30, 2026 at 8:00 PM
Please spread the word — a 2-year postdoctoral fellowship is available in my group funded by the Simons Foundation Autism Research Initiative (SFARI) to perform a study testing the contribution of functional non-coding variants in glutamatergic neurons to autism. 1/3
The term 'junk DNA', used by Susumu Ohno in 1972, has no modern validity over a half century later. This 98.8% of the genome is what regulates gene expression, it's fascinating.
January 28, 2026 at 7:27 PM
The term 'junk DNA', used by Susumu Ohno in 1972, has no modern validity over a half century later. This 98.8% of the genome is what regulates gene expression, it's fascinating.
We're using it. Nobody should expect a step forward to complete a long journey, but this is a significant step forward and should be celebrated.
We only understand the 1.2% of the human genome that encodes genes. AlphaGenome is a tool towards understanding the remaining 98.8%.
We only understand the 1.2% of the human genome that encodes genes. AlphaGenome is a tool towards understanding the remaining 98.8%.
January 28, 2026 at 6:07 PM
We're using it. Nobody should expect a step forward to complete a long journey, but this is a significant step forward and should be celebrated.
We only understand the 1.2% of the human genome that encodes genes. AlphaGenome is a tool towards understanding the remaining 98.8%.
We only understand the 1.2% of the human genome that encodes genes. AlphaGenome is a tool towards understanding the remaining 98.8%.
We're testing AlphaGenome.
It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.
Congrats to @avsecz.bsky.social and the team for this landmark publication.
www.nature.com/articles/s41...
It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.
Congrats to @avsecz.bsky.social and the team for this landmark publication.
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 28, 2026 at 6:05 PM
We're testing AlphaGenome.
It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.
Congrats to @avsecz.bsky.social and the team for this landmark publication.
www.nature.com/articles/s41...
It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.
Congrats to @avsecz.bsky.social and the team for this landmark publication.
www.nature.com/articles/s41...
RIP Sly Dunbar, hopefully back to jamming with Robbie Shakespeare somewhere beyond the clouds
youtu.be/o_PNL3djy54
youtu.be/o_PNL3djy54
Grace Jones - Pull Up To The Bumper
YouTube video by breathinthefreshair360
youtu.be
January 28, 2026 at 12:32 AM
RIP Sly Dunbar, hopefully back to jamming with Robbie Shakespeare somewhere beyond the clouds
youtu.be/o_PNL3djy54
youtu.be/o_PNL3djy54
You're not ready for grant applications yet, right? Just manuscripts?
January 26, 2026 at 3:31 PM
You're not ready for grant applications yet, right? Just manuscripts?
A reminder that history is rewritten every day. There is no Irish genome. Irishness is not genetic.
www.bbc.com/sport/athlet...
www.bbc.com/sport/athlet...
January 26, 2026 at 3:12 PM
A reminder that history is rewritten every day. There is no Irish genome. Irishness is not genetic.
www.bbc.com/sport/athlet...
www.bbc.com/sport/athlet...
Interested in the genetic history of the island of Ireland?
From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland.
youtu.be/m5AwYzzCAF4
From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland.
youtu.be/m5AwYzzCAF4
The Irish DNA Atlas: providing a map of Irish genetics in and out of Ireland - Dr Edmund Gilbert
YouTube video by National Monuments Service
youtu.be
January 26, 2026 at 3:08 PM
Interested in the genetic history of the island of Ireland?
From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland.
youtu.be/m5AwYzzCAF4
From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland.
youtu.be/m5AwYzzCAF4
Plus this commercial prenatal testing to create "superbabies" is all unapologetic eugenics, disgusting and vile
January 22, 2026 at 4:55 PM
Plus this commercial prenatal testing to create "superbabies" is all unapologetic eugenics, disgusting and vile