John Greally
@greally.bsky.social
Using genomic information to improve medicine
Pinned
John Greally
@greally.bsky.social
· Oct 10
Epigenetics: History, Molecules, and Diseases
Buy Epigenetics: History, Molecules, and Diseases on Amazon.com ✓ FREE SHIPPING on qualified orders
www.amazon.com
My book on Epigenetics: History, Molecules and Diseases
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
The US health system. So in need of innovation, so refractory to innovation. But we should keep trying to fix this broken system.
Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.
Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.
States could adopt single-payer laws that would create state-based Medicare-for-All–style systems."
Time For State-Based Single Payer: The New York Health Act | Health Affairs Forefront
There is an alternative to the One Big Beautiful Bill’s approach of kicking millions of people off their health care and closing rural hospitals: States could adopt single-payer laws that would create...
www.healthaffairs.org
February 9, 2026 at 8:43 PM
The US health system. So in need of innovation, so refractory to innovation. But we should keep trying to fix this broken system.
Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.
Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.
Reposted by John Greally
I'm going to do a thread of all the references and context behind Bad Bunny's performance and what it means for Puerto Ricans to see this on the biggest stage.
The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts.
Follow along!
The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts.
Follow along!
February 9, 2026 at 5:08 PM
I'm going to do a thread of all the references and context behind Bad Bunny's performance and what it means for Puerto Ricans to see this on the biggest stage.
The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts.
Follow along!
The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts.
Follow along!
Is the @nytimes.com trolling Gina Kolata?
Relentlessly negative about the medical profession, her headline asks what we physicians are really good for?
The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.
Relentlessly negative about the medical profession, her headline asks what we physicians are really good for?
The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.
February 9, 2026 at 6:58 PM
Is the @nytimes.com trolling Gina Kolata?
Relentlessly negative about the medical profession, her headline asks what we physicians are really good for?
The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.
Relentlessly negative about the medical profession, her headline asks what we physicians are really good for?
The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.
Reposted by John Greally
The NYTs comment section for our feature yesterday got so heated, they shut it down immediately. However, people want to donate to #IDSov. Here’s ours: www.bonfire.com/store/native... donorbox.org/help-to-empo... www.bonfire.com/store/native... Here’s the movement’s indigenousdata.org nativegov.org
Native BioData Consortium | Official Merchandise | Bonfire
Check out Native BioData Consortium on Bonfire and shop official merchandise today! Featuring limited edition custom apparel, printed with care in the USA just for you.
www.bonfire.com
February 6, 2026 at 8:47 PM
The NYTs comment section for our feature yesterday got so heated, they shut it down immediately. However, people want to donate to #IDSov. Here’s ours: www.bonfire.com/store/native... donorbox.org/help-to-empo... www.bonfire.com/store/native... Here’s the movement’s indigenousdata.org nativegov.org
A conservative economist writing about capitalism today. Fascinating perspective.
www.nytimes.com/2026/02/06/o...
www.nytimes.com/2026/02/06/o...
Opinion | The Finance Industry Is a Grift. Let’s Start Treating It That Way.
www.nytimes.com
February 6, 2026 at 2:08 PM
A conservative economist writing about capitalism today. Fascinating perspective.
www.nytimes.com/2026/02/06/o...
www.nytimes.com/2026/02/06/o...
Please share this with your network: Postdoctoral position available in my group.
www.linkedin.com/jobs/view/43...
www.linkedin.com/jobs/view/43...
Albert Einstein College of Medicine hiring Postdoctoral position studying functional non-coding variants in neurodevelopmental disorders, Bronx, New York City, USA c in New York City Metropolitan Area...
Posted 9:40:20 PM. A postdoctoral fellow position is open with 2 years of funding from the Simons Foundation Autism…See this and similar jobs on LinkedIn.
www.linkedin.com
February 5, 2026 at 10:47 PM
Please share this with your network: Postdoctoral position available in my group.
www.linkedin.com/jobs/view/43...
www.linkedin.com/jobs/view/43...
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
Albert Einstein College of Medicine | Medical Education | Biomedical Research
faculty-einstein.icims.com
February 5, 2026 at 10:14 PM
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
Please spread the word — a 2-year postdoctoral fellowship is available in my group funded by the Simons Foundation Autism Research Initiative (SFARI) to perform a study testing the contribution of functional non-coding variants in glutamatergic neurons to autism. 1/3
January 30, 2026 at 8:00 PM
Please spread the word — a 2-year postdoctoral fellowship is available in my group funded by the Simons Foundation Autism Research Initiative (SFARI) to perform a study testing the contribution of functional non-coding variants in glutamatergic neurons to autism. 1/3
We're testing AlphaGenome.
It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.
Congrats to @avsecz.bsky.social and the team for this landmark publication.
www.nature.com/articles/s41...
It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.
Congrats to @avsecz.bsky.social and the team for this landmark publication.
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 28, 2026 at 6:05 PM
We're testing AlphaGenome.
It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.
Congrats to @avsecz.bsky.social and the team for this landmark publication.
www.nature.com/articles/s41...
It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases.
Congrats to @avsecz.bsky.social and the team for this landmark publication.
www.nature.com/articles/s41...
RIP Sly Dunbar, hopefully back to jamming with Robbie Shakespeare somewhere beyond the clouds
youtu.be/o_PNL3djy54
youtu.be/o_PNL3djy54
Grace Jones - Pull Up To The Bumper
YouTube video by breathinthefreshair360
youtu.be
January 28, 2026 at 12:32 AM
RIP Sly Dunbar, hopefully back to jamming with Robbie Shakespeare somewhere beyond the clouds
youtu.be/o_PNL3djy54
youtu.be/o_PNL3djy54
Interested in the genetic history of the island of Ireland?
From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland.
youtu.be/m5AwYzzCAF4
From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland.
youtu.be/m5AwYzzCAF4
The Irish DNA Atlas: providing a map of Irish genetics in and out of Ireland - Dr Edmund Gilbert
YouTube video by National Monuments Service
youtu.be
January 26, 2026 at 3:08 PM
Interested in the genetic history of the island of Ireland?
From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland.
youtu.be/m5AwYzzCAF4
From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland.
youtu.be/m5AwYzzCAF4
Geneticist John Greally fears above all that the tests could exacerbate existing inequalities. “I work in the Bronx, where 26 percent of the population lives in poverty and 40 percent receive food assistance,” says Greally,...
www.zeit.de/2026/04/kuen...
www.zeit.de/2026/04/kuen...
Künstliche Befruchtung: Ein Kind mit hohem IQ und niedrigem Alzheimer-Risiko, bitte!
Start-ups wollen bei der Auswahl optimierter Superbabys helfen. Ein Paar aus Hessen zahlt zehntausende Euro für Gen-Screenings in den USA und muss sich dann entscheiden.
www.zeit.de
January 22, 2026 at 4:52 PM
Geneticist John Greally fears above all that the tests could exacerbate existing inequalities. “I work in the Bronx, where 26 percent of the population lives in poverty and 40 percent receive food assistance,” says Greally,...
www.zeit.de/2026/04/kuen...
www.zeit.de/2026/04/kuen...
Reposted by John Greally
📺 OMG—who made this?! Noah Wyle has a message for all you—vaccine skeptics…
Share with a friend who needs to hear it.
Share with a friend who needs to hear it.
January 15, 2026 at 8:06 PM
📺 OMG—who made this?! Noah Wyle has a message for all you—vaccine skeptics…
Share with a friend who needs to hear it.
Share with a friend who needs to hear it.
I appreciate these authors publishing a well-powered, entirely negative epigenome-wide association study (EWAS).
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Multi-ancestry epigenome wide association study of generalized anxiety disorder
Epigenetic studies face persistent challenges related to small sample sizes, particularly when using epigenome-wide array technologies. This limitation has likely hindered the discovery of replicable ...
www.medrxiv.org
January 15, 2026 at 11:12 AM
I appreciate these authors publishing a well-powered, entirely negative epigenome-wide association study (EWAS).
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Rare Disease Day 2026 at the New York Center for Rare Diseases (NYCRD) @newyorkcrd.bsky.social
This year we are focused on rare disease therapeutics, where there is unprecedented hope for our patients.
www.linkedin.com/posts/john-g...
@einsteinmededu.bsky.social
This year we are focused on rare disease therapeutics, where there is unprecedented hope for our patients.
www.linkedin.com/posts/john-g...
@einsteinmededu.bsky.social
#rdd26 #raredisease #iddrc | John Greally
Rare Disease Day 2026 #RDD26 at the New York Center for Rare Diseases, this year focused on the justifiable excitement to do with rare disease therapeutics.
Speakers include Alex Kentsis, Greg Newby,...
www.linkedin.com
January 14, 2026 at 12:19 PM
Rare Disease Day 2026 at the New York Center for Rare Diseases (NYCRD) @newyorkcrd.bsky.social
This year we are focused on rare disease therapeutics, where there is unprecedented hope for our patients.
www.linkedin.com/posts/john-g...
@einsteinmededu.bsky.social
This year we are focused on rare disease therapeutics, where there is unprecedented hope for our patients.
www.linkedin.com/posts/john-g...
@einsteinmededu.bsky.social
Reposted by John Greally
Reposted by John Greally
Read our full statement by AAP President Dr. Andrew Racine on today’s HHS announcement about the childhood immunization schedule: www.aap.org/en/news-room...
January 5, 2026 at 9:16 PM
Read our full statement by AAP President Dr. Andrew Racine on today’s HHS announcement about the childhood immunization schedule: www.aap.org/en/news-room...
There is always so much more to learn about Albert Einstein as a person. Such a good guy. Hopefully this link will allow sharing of this fondly-written piece about his life in Princeton.
www.theatlantic.com/culture/2026...
www.theatlantic.com/culture/2026...
Albert Einstein’s Brilliant Politics
The physicist fought for the promise of a diverse, meritocratic America. We need his optimism today.
www.theatlantic.com
January 4, 2026 at 2:42 PM
There is always so much more to learn about Albert Einstein as a person. Such a good guy. Hopefully this link will allow sharing of this fondly-written piece about his life in Princeton.
www.theatlantic.com/culture/2026...
www.theatlantic.com/culture/2026...
I finally got around to putting together a quick overview of what my book is all about.
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
Epigenetics: History, Molecules, and Diseases -- Book overview
YouTube video by John Greally
youtu.be
January 2, 2026 at 7:26 PM
I finally got around to putting together a quick overview of what my book is all about.
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
Reposted by John Greally
Ending 2025 w/ our new paper @natcomms.nature.com which shows that the immediate early gene Egr1 induces sex-dependent changes in ventral hippocampal (vHIP) structure and in anxiety- & depression-related behavior, via direct regulation of chromatin structure 🧵👇 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour - Nature Communications
Molecular drivers of sex-specific brain plasticity are unknown. Here, authors show estrogen-driven Egr1 controls chromatin accessibility sex-dependently, driving gene expression, structural plasticity...
www.nature.com
December 31, 2025 at 8:57 PM
Ending 2025 w/ our new paper @natcomms.nature.com which shows that the immediate early gene Egr1 induces sex-dependent changes in ventral hippocampal (vHIP) structure and in anxiety- & depression-related behavior, via direct regulation of chromatin structure 🧵👇 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In Galway this week. Shop Street and Quay Street looking festive.
Being home is good for the soul.
Being home is good for the soul.
December 18, 2025 at 8:29 PM
In Galway this week. Shop Street and Quay Street looking festive.
Being home is good for the soul.
Being home is good for the soul.
I couldn't resist using the very festive-looking cover art from my book as a holiday card (image attribution to follow).
December 18, 2025 at 3:01 PM
I couldn't resist using the very festive-looking cover art from my book as a holiday card (image attribution to follow).
Reposted by John Greally
Incredible piece on Oliver Sacks. If you were ever awed at his supposedly true stories (I remember being stunned by the account of the autistic twins who rattled off large prime numbers), read this. He told wonderful stories, but they were in large part fiction.
www.newyorker.com/magazine/202...
www.newyorker.com/magazine/202...
Oliver Sacks Put Himself Into His Case Studies. What Was the Cost?
The scientist was famous for linking healing with storytelling. Sometimes that meant reshaping patients’ reality.
www.newyorker.com
December 12, 2025 at 10:33 PM
Incredible piece on Oliver Sacks. If you were ever awed at his supposedly true stories (I remember being stunned by the account of the autistic twins who rattled off large prime numbers), read this. He told wonderful stories, but they were in large part fiction.
www.newyorker.com/magazine/202...
www.newyorker.com/magazine/202...
Make it stop
NEW: Five years of social media history is only a fraction of what the US Government will shortly demand of overseas visitors.
The full requirements will end tourism in the United States.
Below is the full, mind-blowing list.
🚨THEY. WANT. YOUR. DNA.🚨
1/
The full requirements will end tourism in the United States.
Below is the full, mind-blowing list.
🚨THEY. WANT. YOUR. DNA.🚨
1/
December 12, 2025 at 10:39 AM
Make it stop