Ishier Raote
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ishier.bsky.social
Ishier Raote
@ishier.bsky.social
Institut Jacques Monod, Paris
@ijmonod.bsky.social
https://www.ijm.fr/raote-lab/

Collagen secretion, membrane trafficking

Formerly @crg.eu
Reposted by Ishier Raote
New PhD alert! We'll be applying animal welfare ideas to look at how stress affects bees, looking at the effect on bee brains with @lenariab.bsky.social, and working with @sensibee.bsky.social developing new monitoring methods.

Please spread the word! #bees #PhD 🧪

www.findaphd.com/phds/project...
The effect of stress on pollinator behaviour at Newcastle University on FindAPhD.com
PhD Project - The effect of stress on pollinator behaviour at Newcastle University, listed on FindAPhD.com
www.findaphd.com
February 3, 2026 at 1:21 PM
Reposted by Ishier Raote
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
January 30, 2026 at 9:22 AM
They were fun seminars - I'm glad you enjoyed the session!
January 29, 2026 at 5:27 PM
They're just runaway domains of the Golgi.
January 29, 2026 at 1:27 PM
Today at 17:00 CET - the first #MembraneTrafficking seminar of 2026.
Giovanni D’Angelo (EPFL) and Sean Munro (MRC-LMB), explore protein trafficking, retention, and sorting at the Golgi.
Join us for exciting discussions about the best organelle!
Details at felixcampelo.wixsite.com/membranetraf...
MEMBRANE TRAFFICKING | Membrane Trafficking
felixcampelo.wixsite.com
January 29, 2026 at 8:36 AM
Reposted by Ishier Raote
Join us this Thursday (Jan 29) at 5pm CET for the first #MembraneTrafficking seminars of 2026, featuring two outstanding scientists, Giovanni D'Angelo (EPFL) and Sean Munro (@cellbiol-mrclmb.bsky.social), and the shared topic of protein trafficking, retention & sorting at the #Golgi 🥞
January 27, 2026 at 7:51 AM
Reposted by Ishier Raote
Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social

www.biorxiv.org/content/10.6...
January 26, 2026 at 3:45 PM
Reposted by Ishier Raote
Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.
Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis - FocalPlane
Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis -
focalplane.biologists.com
January 26, 2026 at 2:51 PM
Reposted by Ishier Raote
Please share🙏:

Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona

Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...

Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
www.upf.edu
January 26, 2026 at 11:53 AM
Reposted by Ishier Raote
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS
Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is know...
www.pnas.org
January 26, 2026 at 9:42 AM
Reposted by Ishier Raote
Excited to share a new story that transformed how we think about membrane domains in the ER!

rdcu.be/eR7Cn

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export

Wondering what’s so new and exciting? Skytorial below!

1/9
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
rdcu.be
January 24, 2026 at 8:20 PM
I thought "corresponding author" meant recognition from the field. I didn’t realise the field was predatory publishing.
January 24, 2026 at 7:39 PM
I replied “unsubscribe” to a predatory journal email. They thanked me for my interest in submitting.
January 24, 2026 at 7:32 PM
I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.
January 23, 2026 at 10:59 AM
Reposted by Ishier Raote
New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization.

www.biorxiv.org/content/10.6...
www.biorxiv.org
January 23, 2026 at 10:31 AM
The Life of Brian seems great - lots of smiling and laughing there. He must have a tendency to always look on the bright side of life.
January 23, 2026 at 9:39 AM
Reposted by Ishier Raote
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
January 23, 2026 at 6:41 AM
Reposted by Ishier Raote
It's out! Our new study (led by @pierrelemerre.bsky.social & @weltgeischt.bsky.social @carlenlab.bsky.social) challenges classical cytoarchitectonic borders in the prefrontal cortex, showing that connectivity better explains its functional organization.
Read the open-access paper here: rdcu.be/eZUkh
January 20, 2026 at 4:16 PM
Reposted by Ishier Raote
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.

🔗 doi.org/10.64898/202...

#CryoET
January 20, 2026 at 10:01 AM
Reposted by Ishier Raote
🥳🥳🥳 Pretty fab start to 2026!!
January 19, 2026 at 4:51 PM
It's OK! He made it to the bus on time!
January 19, 2026 at 3:03 PM
Colleague’s PhD paper was repeatedly rejected unless she added a Western blot on mouse 1-cell embryos. After a year of resisting, she gave in and spent months collecting them. Carrying all the embryos to the equipment room, a first-year PhD student running to catch a bus knocked them onto the floor.
January 19, 2026 at 12:24 PM
Reposted by Ishier Raote
The growth of Paris from 250 AD to the present day in 3 minutes.

🔎 CITY 3D TIMELAPSE
January 17, 2026 at 8:15 AM
Reposted by Ishier Raote
We made nanobodies that make your heart🫀 stop 🛑beating. Keep reading to learn how this taught us about how large membrane proteins like ion channels are folded and assembled in human cells. Beyond excited to share my lab's first preprint: Please 🔄 bit.ly/49A0PtD
January 16, 2026 at 10:57 PM
Reposted by Ishier Raote
0/10
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology

Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
Continuum architecture dynamics of vesicle tethering in exocytosis
Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...
www.cell.com
January 16, 2026 at 5:28 PM