Ishier Raote
@ishier.bsky.social
Institut Jacques Monod, Paris
@ijmonod.bsky.social
https://www.ijm.fr/raote-lab/
Collagen secretion, membrane trafficking
Formerly @crg.eu
@ijmonod.bsky.social
https://www.ijm.fr/raote-lab/
Collagen secretion, membrane trafficking
Formerly @crg.eu
Reposted by Ishier Raote
New PhD alert! We'll be applying animal welfare ideas to look at how stress affects bees, looking at the effect on bee brains with @lenariab.bsky.social, and working with @sensibee.bsky.social developing new monitoring methods.
Please spread the word! #bees #PhD 🧪
www.findaphd.com/phds/project...
Please spread the word! #bees #PhD 🧪
www.findaphd.com/phds/project...
The effect of stress on pollinator behaviour at Newcastle University on FindAPhD.com
PhD Project - The effect of stress on pollinator behaviour at Newcastle University, listed on FindAPhD.com
www.findaphd.com
February 3, 2026 at 1:21 PM
New PhD alert! We'll be applying animal welfare ideas to look at how stress affects bees, looking at the effect on bee brains with @lenariab.bsky.social, and working with @sensibee.bsky.social developing new monitoring methods.
Please spread the word! #bees #PhD 🧪
www.findaphd.com/phds/project...
Please spread the word! #bees #PhD 🧪
www.findaphd.com/phds/project...
Reposted by Ishier Raote
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
January 30, 2026 at 9:22 AM
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
Today at 17:00 CET - the first #MembraneTrafficking seminar of 2026.
Giovanni D’Angelo (EPFL) and Sean Munro (MRC-LMB), explore protein trafficking, retention, and sorting at the Golgi.
Join us for exciting discussions about the best organelle!
Details at felixcampelo.wixsite.com/membranetraf...
Giovanni D’Angelo (EPFL) and Sean Munro (MRC-LMB), explore protein trafficking, retention, and sorting at the Golgi.
Join us for exciting discussions about the best organelle!
Details at felixcampelo.wixsite.com/membranetraf...
MEMBRANE TRAFFICKING | Membrane Trafficking
felixcampelo.wixsite.com
January 29, 2026 at 8:36 AM
Today at 17:00 CET - the first #MembraneTrafficking seminar of 2026.
Giovanni D’Angelo (EPFL) and Sean Munro (MRC-LMB), explore protein trafficking, retention, and sorting at the Golgi.
Join us for exciting discussions about the best organelle!
Details at felixcampelo.wixsite.com/membranetraf...
Giovanni D’Angelo (EPFL) and Sean Munro (MRC-LMB), explore protein trafficking, retention, and sorting at the Golgi.
Join us for exciting discussions about the best organelle!
Details at felixcampelo.wixsite.com/membranetraf...
Reposted by Ishier Raote
Join us this Thursday (Jan 29) at 5pm CET for the first #MembraneTrafficking seminars of 2026, featuring two outstanding scientists, Giovanni D'Angelo (EPFL) and Sean Munro (@cellbiol-mrclmb.bsky.social), and the shared topic of protein trafficking, retention & sorting at the #Golgi 🥞
January 27, 2026 at 7:51 AM
Join us this Thursday (Jan 29) at 5pm CET for the first #MembraneTrafficking seminars of 2026, featuring two outstanding scientists, Giovanni D'Angelo (EPFL) and Sean Munro (@cellbiol-mrclmb.bsky.social), and the shared topic of protein trafficking, retention & sorting at the #Golgi 🥞
Reposted by Ishier Raote
Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social
www.biorxiv.org/content/10.6...
@ijmonod.bsky.social
www.biorxiv.org/content/10.6...
January 26, 2026 at 3:45 PM
Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social
www.biorxiv.org/content/10.6...
@ijmonod.bsky.social
www.biorxiv.org/content/10.6...
Reposted by Ishier Raote
Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.
Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis - FocalPlane
Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis -
focalplane.biologists.com
January 26, 2026 at 2:51 PM
Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.
Reposted by Ishier Raote
Please share🙏:
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
www.upf.edu
January 26, 2026 at 11:53 AM
Please share🙏:
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
Reposted by Ishier Raote
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS
Intracellular transport of macromolecules is crucial for the proper functioning of
most cellular processes. Although intracellular crowding is know...
www.pnas.org
January 26, 2026 at 9:42 AM
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Reposted by Ishier Raote
Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
rdcu.be
January 24, 2026 at 8:20 PM
Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
I replied “unsubscribe” to a predatory journal email. They thanked me for my interest in submitting.
January 24, 2026 at 7:32 PM
I replied “unsubscribe” to a predatory journal email. They thanked me for my interest in submitting.
I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.
January 23, 2026 at 10:59 AM
I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.
Reposted by Ishier Raote
New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 23, 2026 at 10:31 AM
New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Ishier Raote
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
January 23, 2026 at 6:41 AM
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
Reposted by Ishier Raote
It's out! Our new study (led by @pierrelemerre.bsky.social & @weltgeischt.bsky.social @carlenlab.bsky.social) challenges classical cytoarchitectonic borders in the prefrontal cortex, showing that connectivity better explains its functional organization.
Read the open-access paper here: rdcu.be/eZUkh
Read the open-access paper here: rdcu.be/eZUkh
January 20, 2026 at 4:16 PM
It's out! Our new study (led by @pierrelemerre.bsky.social & @weltgeischt.bsky.social @carlenlab.bsky.social) challenges classical cytoarchitectonic borders in the prefrontal cortex, showing that connectivity better explains its functional organization.
Read the open-access paper here: rdcu.be/eZUkh
Read the open-access paper here: rdcu.be/eZUkh
Reposted by Ishier Raote
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
January 20, 2026 at 10:01 AM
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Reposted by Ishier Raote
🥳🥳🥳 Pretty fab start to 2026!!
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
www.nature.com
January 19, 2026 at 4:51 PM
🥳🥳🥳 Pretty fab start to 2026!!
Reposted by Ishier Raote
The growth of Paris from 250 AD to the present day in 3 minutes.
🔎 CITY 3D TIMELAPSE
🔎 CITY 3D TIMELAPSE
January 17, 2026 at 8:15 AM
The growth of Paris from 250 AD to the present day in 3 minutes.
🔎 CITY 3D TIMELAPSE
🔎 CITY 3D TIMELAPSE
Reposted by Ishier Raote
We made nanobodies that make your heart🫀 stop 🛑beating. Keep reading to learn how this taught us about how large membrane proteins like ion channels are folded and assembled in human cells. Beyond excited to share my lab's first preprint: Please 🔄 bit.ly/49A0PtD
January 16, 2026 at 10:57 PM
We made nanobodies that make your heart🫀 stop 🛑beating. Keep reading to learn how this taught us about how large membrane proteins like ion channels are folded and assembled in human cells. Beyond excited to share my lab's first preprint: Please 🔄 bit.ly/49A0PtD
Reposted by Ishier Raote
0/10
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
Continuum architecture dynamics of vesicle tethering in exocytosis
Data from complementary imaging techniques were integrated into a model that resolves
the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential
cellular pathway. Sec18 med...
www.cell.com
January 16, 2026 at 5:28 PM
0/10
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
Asahi Super Dry: helping people through Dry January since 1987.
January 15, 2026 at 8:46 PM
Asahi Super Dry: helping people through Dry January since 1987.
Exciting preprint from @felixmendu.bsky.social and Yuichi Wakana! A TGN carrier whose budding is driven by ER–Golgi lipid transfer, PKD activity, and a caveolin-based oligomeric coat!
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...
January 14, 2026 at 4:20 PM
Exciting preprint from @felixmendu.bsky.social and Yuichi Wakana! A TGN carrier whose budding is driven by ER–Golgi lipid transfer, PKD activity, and a caveolin-based oligomeric coat!
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...
A PKD-caveolin axis drives secretory carrier biogenesis at the TGN
www.biorxiv.org/content/10.6...
Reposted by Ishier Raote
Have you ever heard that women have more chances than men of getting grants or positions in academia? Of course you have, and here are my personal views on this. With the shocking revelation that no, it is NOT TRUE ! (1/n)
January 13, 2026 at 6:36 PM
Have you ever heard that women have more chances than men of getting grants or positions in academia? Of course you have, and here are my personal views on this. With the shocking revelation that no, it is NOT TRUE ! (1/n)
Fun preprint from @marius-lemberg.bsky.social! TMED9 drives Golgi-bypass secretion of proTGFα via a RHBDL4-independent pathway requiring GRASP65, autophagy machinery and ALIX.
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...
January 13, 2026 at 8:08 PM
Fun preprint from @marius-lemberg.bsky.social! TMED9 drives Golgi-bypass secretion of proTGFα via a RHBDL4-independent pathway requiring GRASP65, autophagy machinery and ALIX.
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...
Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles.
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
January 13, 2026 at 7:46 PM
Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles.
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...