Ishier Raote
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ishier.bsky.social
Ishier Raote
@ishier.bsky.social
Institut Jacques Monod, Paris
@ijmonod.bsky.social
https://www.ijm.fr/raote-lab/

Collagen secretion, membrane trafficking

Formerly @crg.eu
Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...
November 25, 2025 at 4:22 PM
Reposted by Ishier Raote
Congratulations to Celia Municio-Diaz in the lab for this new publication, showing that Cell Wall mechanosensors taken from distant yeast species can still function and detect forces in the foreign cell wall of fission yeast cells!

@ijmonod.bsky.social @cnrsbiologie.bsky.social
November 25, 2025 at 3:00 PM
Reposted by Ishier Raote
Oh wow! An excellent engaged review of I Dream of Theresa May. I couldn't be happier!

⭐ ⭐ ⭐ ⭐ “A whip-smart piece of queer political satire.“

www.thestage.co.uk/reviews/i-dr...

On until the 29th @taratheatre.com:
taratheatre.com/whats-on/i-d...

(Spoilers in the review- you have been warned)
I Dream of Theresa May at Tara Theatre, London: dark, absorbing comedy
Read our review of I Dream of Theresa May at Tara Theatre, London: astute new political satire exploring British culture under a hostile-environment policy
www.thestage.co.uk
November 21, 2025 at 10:38 AM
A long-standing question in cell biology: why are Golgi cisternae flattened? A biophysical model from Jensen group (Manchester) suggests this architecture may directly influence glycosylation.
Morphological determinants of glycosylation efficiency in Golgi cisternae
www.biorxiv.org/content/10.1...
Morphological determinants of glycosylation efficiency in Golgi cisternae
The Golgi apparatus has an intricate spatial structure characterized by flattened membrane-bound compartments, known as cisternae. Cisternae house integral membrane enzymes that catalyse glycosylation...
www.biorxiv.org
November 19, 2025 at 7:45 PM
Reposted by Ishier Raote
New Article: "A combined biochemical and computational approach provides evidence for membrane remodelling by the structural scaffold of the endocytic TPLATE complex" rdcu.be/eP4fX

... to generate a comprehensive structure of the multisubunit endocytic TPLATE complex.
November 15, 2025 at 12:03 PM
Reposted by Ishier Raote
Happy to share our new protocol in @cp-starprotocols.bsky.social: CATCH—Covalent Anchoring of Tethered Ligands to Chemogenetic Handles!

This method enables precise, long-lasting, and pharmacologically specific inhibition of brain receptors in vivo.

👉 www.sciencedirect.com/science/arti...
Covalent anchoring of tethered ligands to chemogenetic handles for targeted in vivo neuropharmacology
Covalent anchoring of tethered ligands to chemogenetic handles (CATCH) is a chemogenetic approach that enables sustained, localized, and pharmacologic…
www.sciencedirect.com
November 15, 2025 at 11:29 AM
Reposted by Ishier Raote
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
November 9, 2025 at 6:04 PM
Reposted by Ishier Raote
Environmental stiffness regulates neuronal
maturation via Piezo1-mediated transthyretin activity.

My main postdoc paper is finally online!

Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab.
@franzelab.bsky.social

www.nature.com/articles/s41...
Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity - Nature Communications
How the environment regulates neuronal maturation during brain development is poorly understood. Here, Kreysing et al. identify brain stiffness as a key factor and determine a mechanotransduction path...
www.nature.com
November 7, 2025 at 11:48 AM
Reposted by Ishier Raote
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.

Beautiful tomography and microscopy - congrats all 🤩
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:56 AM
Reposted by Ishier Raote
Under two weeks before my #play hits the stage @taratheatre.com ! Can't wait!
Come see it if you're in London- it'll be great to have tons of people there.

Book here: taratheatre.com/whats-on/i-d...

A video of me wittering on about the play in the post below ⬇️

#theatre #newWriting #immigration
I Dream of Theresa May – Tara Theatre
taratheatre.com
November 5, 2025 at 5:58 PM
Nice preprint from Gerard Cantero @gercrcat.bsky.social! Loss of ClC-5 function causes Dent’s Disease type 1. In a renal proximal tubule epithelial cell line, ClC-5 mutations disrupt endolysosomal pH and the Golgi via TMEM9 and SEC22B, interesting pathophysiology.
www.biorxiv.org/content/10.1...
TMEM9 and SEC22B interact with ClC-5 to shape renal proximal tubule function and Dent's Disease type I pathogenesis
Cl-/H+ antiporter ClC-5 is a key regulator of renal proximal tubule function, primarily by controlling endosomal acidification. Loss-of-function mutations in ClC-5 cause Dent's Disease type 1 (DD1), a...
www.biorxiv.org
November 5, 2025 at 8:42 AM
Reposted by Ishier Raote
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
November 3, 2025 at 8:24 AM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
Reposted by Ishier Raote
I have two open positions @ALMU @crg.eu:

1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...

2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...

Reposts appreciated.
November 3, 2025 at 2:01 PM
The new Outlook app has achieved peak academic design: less functional, but somehow more confident.
November 3, 2025 at 7:45 AM
Reposted by Ishier Raote
Interested in intracellular organization and membrane trafficking? 🥞 Join us at @melisupf.bsky.social in Barcelona! We’re looking for postdocs to apply for a Juan de la Cierva fellowship (PhD between Jan’24–Dec ’25). If you’d like to work with us, get in touch! www.aei.gob.es/en/announcem...
Ayudas para contratos Juan de la Cierva 2025 | Agencia Estatal de Investigación
Las ayudas Juan de la Cierva tienen como finalidad fomentar la incorporación de jóvenes, en posesión del grado de doctor, con objeto de que completen su formación investigadora postdoctoral en centros...
www.aei.gob.es
November 2, 2025 at 11:08 AM
Nice preprint from Mondira Kundu lab! Glucose starvation blocks SEC24C-dependent ER-to-Golgi export of some proteins like E-cadherin, reshaping the surface proteome - via AMPK-ULK1-Sec31A signalling. Controls cell migration and metastasis under nutrient stress.
www.biorxiv.org/content/10.1...
ER-to-Golgi Trafficking is a Nutrient-Sensitive Checkpoint Linking Glucose Starvation to Cell Surface Remodeling
Cancer cells adapt to nutrient stress by remodeling the repertoire of proteins on their surface, enabling survival and progression under starvation conditions. However, the molecular mechanisms by whi...
www.biorxiv.org
November 1, 2025 at 5:54 PM
Reposted by Ishier Raote
🚨 #PhD Opportunities 🚨
🧵

How does plasma membrane structure underpin tissue development?
Let’s find out!

Opportunity to do a PhD with me, co-supervised by Darius Koester, at Warwick.
Fully funded studentship by #MIBTP.

🔬✨🐟

More info:
www.findaphd.com/phds/project...

Interested? Reach out!
October 31, 2025 at 1:33 PM
Reposted by Ishier Raote
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
Should I be worried if I can't solve many of the 'are you human' puzzles on the internet?
October 31, 2025 at 5:25 PM
Reposted by Ishier Raote
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM url: rupress.org/jcb/article-...
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM
Nair et al. show an abundance of vesicular ERES in mammalian cells imaged by volume-focused ion beam EM. These findings reconcile diverging models of ERES
rupress.org
October 31, 2025 at 3:03 PM
Reposted by Ishier Raote
Had the pleasure of working with @mohannad-dardiry.bsky.social to rethink what it means to develop for life. Many thanks to @dev-journal.bsky.social! @embl.org #LifelongDevSI
October 31, 2025 at 11:24 AM
Reposted by Ishier Raote
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Reposted by Ishier Raote
📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
October 30, 2025 at 1:15 PM
Reposted by Ishier Raote
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
#JobOffer

💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod

➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
October 28, 2025 at 1:51 PM