Benoit Ladoux
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bladoux.bsky.social
Benoit Ladoux
@bladoux.bsky.social
800 followers 220 following 65 posts

Biophysics / Cell Migration / Active matter / Mechanobiology
https://mpzpm.mpg.de/research/benoit-ladoux
https://ladoux-mege-lab.cnrs.fr

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Biology 50%
Engineering 28%
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bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · 14d
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...

Reposted by Benoît Ladoux

fletcherlabucb.bsky.social
Fletcher Lab @fletcherlabucb.bsky.social · 5h
Check out our latest published manuscript: SurFlex microscopy, a new technique to measure molecular flexibility. Congrats to Aymeric, @sid592.bsky.social, @blenackmon.bsky.social, and Andres! www.pnas.org/doi/10.1073/...
SurFlex microscopy: Measuring flexibility of surface-tethered biomolecules | PNAS
The flexibility of tethered molecules, such as those bound to biological membranes, is an important property that can influence molecular height, m...
www.pnas.org

Reposted by Benoît Ladoux

ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · 9h
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article

📖 @jcb.org
📃 Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis

🔗 rupress.org/jcb/article-...

Reposted by Benoît Ladoux

minclab.bsky.social
Nicolas Minc @minclab.bsky.social · 10h
Congratulations to Celia Municio-Diaz in the lab for this new publication, showing that Cell Wall mechanosensors taken from distant yeast species can still function and detect forces in the foreign cell wall of fission yeast cells!

@ijmonod.bsky.social @cnrsbiologie.bsky.social

Reposted by Benoît Ladoux

ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · 16h
📢 PhD Thesis defense

📅 November 26th
📍Institut Jacques Monod

Tomorrow, Fanny Wodrascka ( @fanny-wodrascka.bsky.social @bladoux.bsky.social @rmmege.bsky.social ) will defend her PhD thesis "Mechanical control of epithelial cell extrusion via RhoA-dependent contractility "

➡️ buff.ly/f5VaVah

Reposted by Benoît Ladoux

mattertolife.bsky.social
Max Planck School Matter to Life @mattertolife.bsky.social · 1d
There's only one week left to apply to our Integrated MSc/PhD program - apply now! mattertolife.maxplanckschools.org/application

Reposted by Elizabeth Saunders, Alan Richardson, Anders Sundnes Løvlie , and 3 more

theatlantic.com
The Atlantic @theatlantic.com · 1d
Over many interviews, Robert F. Kennedy Jr. told Michael Scherer about how he plans to remake America’s public-health system. Can he lead the scientific establishment he’s spent much of his life crusading against?

Read more in our new cover story: theatln.tc/q9hXxlbM

Reposted by Benoît Ladoux

cecileleduc.bsky.social
cecileleduc.bsky.social @cecileleduc.bsky.social · 1d
is there a direct crosstalk between actin and vimentin intermediate filaments? Our work shows that vimentin promotes actin assembly by stabilizing ATP-subunits at the barbed end.
Fantastic work done by @lilianpaty.bsky.social with @romet-jegou-lab.bsky.social

www.biorxiv.org/content/10.1...

Reposted by Benoît Ladoux

thomaslecuit.bsky.social
Thomas Lecuit @thomaslecuit.bsky.social · 1d
Very happy to share video of 1st lecture @college-de-france.fr on Biological computation 😊. I defend the necessity to access Algorithmic & Computational levels of analysis in cell & developmental biol. proposed by David Marr in neuroscience. Logic & Function matter 🤩.
Video: tinyurl.com/55yejk5f
Qu’est-ce que l’information biologique (suite) ? (1) - Thomas Lecuit (2025-2026)
Enseignement 2025-2026 : Qu’est-ce que l’information biologique (suite) ? Cours du 20 décembre 2025 : Introduction : approche computationelle du vivant Professeur : Thomas Lecuit Chaire Dynamiques du vivant Retrouvez les enregistrements audios et vidéos du cycle : https://www.college-de-france.fr/fr/agenda/cours/qu-est-ce-que-information-biologique Tous les enseignements du Pr Thomas Lecuit : https://www.college-de-france.fr/chaire/thomas-lecuit-dynamiques-du-vivant-chaire-statutaire https://www.youtube.com/playlist?list=PLOj9pZ2YNGZ84uMY6DhPnqpL1rq5qNAVJ Le Collège de France est une institution de recherche fondamentale dans tous les domaines de la connaissance et un lieu de diffusion du « savoir en train de se faire » ouvert à tous. Les cours, séminaires, colloques sont enregistrés puis mis à disposition du public sur le site internet du Collège de France. Découvrez toutes les ressources du Collège de France : https://www.college-de-france.fr Soutenir le Collège de France : https://www.fondation-cdf.fr/faire-un-don Suivez-nous sur : Threads : https://www.threads.net/@collegedefrance Bluesky : https://bsky.app/profile/college-de-france.fr Facebook : https://www.facebook.com/College.de.France Instagram : https://www.instagram.com/collegedefrance LinkedIn : https://fr.linkedin.com/company/coll%C3%A8gedefrance
tinyurl.com

Reposted by Benoît Ladoux

ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · 1d
📢 Institut Jacques Monod Seminar

📅 November 25th
📍 Institut Jacques Monod

Tomorrow, Magali Suzanne will present the Institut Jacques Monod seminar « Spatio-temporal control of nuclear Mechanotransduction during Epithelial-to-Mesenchymal transition »

➡️ buff.ly/ajrwbxo

Reposted by Benoît Ladoux

ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · 5d
📢 PhD Thesis defense

📅 November 26th
📍Institut Jacques Monod

Next week, Fanny Wodrascka ( @fanny-wodrascka.bsky.social @bladoux.bsky.social @rmmege.bsky.social ) will defend her PhD thesis "Mechanical control of epithelial cell extrusion via RhoA-dependent contractility "

➡️ buff.ly/f5VaVah

Reposted by Benoît Ladoux

cerbino.bsky.social
Roberto Cerbino @cerbino.bsky.social · 7d
🔬 PhD or Postdoc Position in Experimental Biophysics — University of Vienna

We are hiring for the WWTF-funded project MechanoSynth — focused on decoding and engineering multiscale mechanoresponses in synthetic and biological tissues.

PhD (48 months) or Postdoc (24 months). Vienna, Austria.

Reposted by Benoît Ladoux

pjsaez.bsky.social
Pablo J. Sáez @pjsaez.bsky.social · 11d
I guess it never gets old...bc we love #CellMigration

ATP has many roles: energy currency, hydrotrope, and *danger signal*

Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!

www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬

Reposted by Benoît Ladoux

ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · 11d
✍️ The @bladoux.bsky.social / @rmmege.bsky.social Lab published a new article

📖 @pnas.org
📃 Regulation of epithelial tissue homeostasis by active transepithelial transport

🔗 www.pnas.org/doi/10.1073/...

Reposted by Alan McNally, Benoît Ladoux

jlsteenwyk.bsky.social
🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 12d
Just gonna put this here for now
www.science.org/doi/10.1126/...
bsky.app/profile/jlst...

Reposted by Benoît Ladoux

labspagnoli.bsky.social
Spagnoli_Lab. @labspagnoli.bsky.social · 12d
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social

➡️ doi.org/10.1126/scia...

short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org

bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · 12d
It’s time for French researchers to upload their publications to HAL, the National Open Repository used by the @cnrs.fr !
Not unhappy that I don’t have to do this anymore!

Reposted by Benoît Ladoux

ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · 12d
📢 Institut Jacques Monod Seminar

📅 November 25th
📍 IJM

Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab, Magali Suzanne will present the IJM seminar « Spatio-temporal control of nuclear Mechanotransduction during Epithelial-to-Mesenchymal transition »

➡️ buff.ly/ajrwbxo

Reposted by Benoît Ladoux

pauguillamat.bsky.social
Pau Guillamat @pauguillamat.bsky.social · 13d
Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps.

@pnas.org @ub.edu

www.pnas.org/doi/10.1073/...

#ActiveMatter #Microfluidics #SoftMatter
Active nematic pumps | PNAS
Microfluidics involves the manipulation of flows at the microscale, typically requiring external power sources to generate pressure gradients. Alte...
www.pnas.org

bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · 14d
Thanks Elias

Reposted by Benoît Ladoux

leanhphuong.bsky.social
Anh Phuong Le @leanhphuong.bsky.social · 14d
When amnion and belly skin are from similar background but end up at different fates 😂
My latest story on building amnion and skin organoids with tweaks of signalings with @krkoehler.bsky.social . Mechanics and molecular cues interplay to control tissue architecture.
www.biorxiv.org/content/10.1...
Lateral plate mesoderm directs human amnion and ventral skin organoid formation
Engineering organoids that faithfully replicate the intricate architecture and region-specific features of bodily organs and extraembryonic tissues remains a significant scientific challenge. Previously, we demonstrated that craniofacial skin organoids (cSkOs)—containing epidermis, dermis, and hair—could be generated by co-developing epidermal progenitors with cranial mesenchyme. Building on this approach, we precisely adjusted cellular composition and signaling environments to generate ventral skin organoids (vSkOs) with lateral plate mesoderm (LPM) progenitors, successfully recapitulating features of abdominal or groin skin. Modulating early BMP and FGF signaling redirected these vSkOs toward an extraembryonic fate, producing human amnion-like tissues, termed Amnioids. Like native human amnion, Amnioids rapidly expanded into large, avascular, hairless cysts, in sharp contrast to the primitive vasculature and abundant hair follicles of vSkOs. Single-cell RNA sequencing identified divergent molecular signatures and developmental trajectories, highlighting key roles for NOTCH, WNT, and YAP/Hippo signaling pathways. Functional studies further underscored mesenchymal-epithelial interactions and mechanical forces as critical regulators of epithelial expansion. Together, these models provide potent tools to investigate human development at the embryonic-extraembryonic interface, offering critical insights into congenital skin and amniotic disorders and opening new avenues for precision regenerative therapies. ### Competing Interest Statement K.R.K. and J.L. are inventors of a patent relating to the skin organoid technology discussed in this article (WO2017070506A1). A.P.L. and K.R.K. with Childrens Hospital Corporation have applied for a patents relating to Amnioid (PCT/US2024/033843 Priority Date 6.13.2023) and ventral skin technology. K.R.K. is a consultant to STEMCELL Technologies that has licensed the skin organoid technology. National Institute of Arthritis and Musculoskeletal and Skin Diseases, https://ror.org/006zn3t30, R01AR075018 National Institute on Deafness and Other Communication Disorders, https://ror.org/04mhx6838, R01DC017461 National Institutes of Health, R01HD113792 National Institutes of Health, R01HD085121 National Institutes of Health, R24HD000836
www.biorxiv.org

Reposted by Renaud Epstein, Benoît Ladoux

vincent-lemire.bsky.social
Vincent Lemire @vincent-lemire.bsky.social · 16d
⚠️🇵🇸🇮🇱 Ça pue. Ça enfle et ça pue. Un mois après l'annonce du cessez-le-feu à Gaza, les rages se libèrent au lieu de s'apaiser, les censures se déchainent au lieu de se calmer:
www.lemonde.fr/education/ar...
Le Collège de France annule un colloque sur la Palestine « en réaction à la polémique entourant » l’événement
Le Collège de France « ne prône, ni n’encourage, ni ne soutient aucune forme de militantisme », a affirmé l’établissement qui assure de sa « stricte neutralité (…) au regard des questions de nature po...
www.lemonde.fr

bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · 16d
Great study on human skin and amnion organoids through the interplay of signaling and mechanics. Congrats to @leanhphuong.bsky.social and the team!
www.biorxiv.org/content/10.1...
Lateral plate mesoderm directs human amnion and ventral skin organoid formation
Engineering organoids that faithfully replicate the intricate architecture and region-specific features of bodily organs and extraembryonic tissues remains a significant scientific challenge. Previous...
www.biorxiv.org

Reposted by Benoît Ladoux

ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · 18d
📢 PhD Thesis defense

📅 November 26th
📍Institut Jacques Monod

Fanny Wodrascka ( @fanny-wodrascka.bsky.social @bladoux.bsky.social @rmmege.bsky.social ) will defend her PhD thesis "Mechanical control of epithelial cell extrusion via RhoA-dependent contractility "

➡️ buff.ly/f5VaVah

bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · 19d
Congrats!!!👏

Reposted by Benoît Ladoux

gdrimabio.bsky.social
GdR ImaBio @gdrimabio.bsky.social · 19d
Lecture online : youtu.be/ye-i6deGO1Q 😜👇
Pierre NASSOY : formation, morphometrics and mechanics of epiblast models
YouTube video by GDR Imabio - CNRS
youtu.be

Reposted by Benoît Ladoux

mpi-muenster.bsky.social
Max Planck Institute for Molecular Biomedicine @mpi-muenster.bsky.social · 19d
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
Portrait of Sara Wickström standing in a modern building. The image is part of a turquoise graphic with the Max Planck Society logo above and the text “Sara Wickström, Max Planck Institute for Molecular Biomedicine – ERC Synergy Grant 2025” below.

Reposted by Benoît Ladoux

fabricearfi.bsky.social
Fabrice Arfi @fabricearfi.bsky.social · 20d
Sidérant.
À voir, absolument.

www.mediapart.fr/journal/fran...
« Faut leur tirer dans la gueule ! » : la manifestation de Sainte-Soline vue par les gendarmes
Mediapart et « Libération » révèlent des images inédites du 25 mars 2023, filmées par les caméras-piétons des gendarmes. Elles montrent des consignes prohibées et dangereuses données par la hiérarchi…
www.mediapart.fr

Reposted by Benoît Ladoux

gdrimabio.bsky.social
GdR ImaBio @gdrimabio.bsky.social · 21d
If necessary Pierre NASSOY's talk 😜 :
👉 youtu.be/ye-i6deGO1Q?...

@univbordeaux.bsky.social @cnrs.fr

#Mifobio2025 #GDRimabio

Reposted by Benoît Ladoux

mpi-scienceoflight.bsky.social
Max Planck Institute for the Science of Light (MPL) @mpi-scienceoflight.bsky.social · 21d
Our aftermovie shows some impressions of #NdW25 at #MPL & #MPZPM: from exciting insights into current #research projects and inspiring conversations to curious glances into our laboratories. It was truly a night, where #science came to life.

🎥 Billmann Event GmbH

#physics #medicine #light #matter