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Benoit Ladoux

@bladoux.bsky.social

780 followers 210 following 57 posts

Biophysics / Cell Migration / Active matter / Mechanobiology https://mpzpm.mpg.de/research/benoit-ladoux https://ladoux-mege-lab.cnrs.fr

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Benoit Ladoux @bladoux.bsky.social · 24d

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...

Regulation of epithelial tissue homeostasis by active trans-epithelial transport

Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

www.biorxiv.org

Benoit Ladoux @bladoux.bsky.social · 1d

Although our time working together at the MPZPM was far too short, I deeply valued our scientific exchanges and the beginnings of a friendship that I am sure would have grown even stronger. I will profoundly miss you as a colleague and as a person.

Max Planck Institute for the Science of Light (MPL) @mpi-scienceoflight.bsky.social · 3d

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg

Professor Jochen Guck, Director at the Max Planck Institute for the Science of Light (MPL), He headed the division “Cell Physics” at MPL and the Max-Planck-Zentrum für Physik und Medizin (MPZPM).

Benoit Ladoux @bladoux.bsky.social · 1d

Looks very interesting!

Reposted by Benoît Ladoux

Assaf Zaritsky @assafzaritsky.bsky.social · 1d

Excited to announce the first @cshlnews.bsky.social meeting on Cell Modeling in Space and Time, June 2026 💫

meetings.cshl.edu/meetings.asp...

Bringing together experiments, computation and theory to explore dynamic, multi-scale cellular organization and function!

1/3

Reposted by Benoît Ladoux

Max Planck Institute for the Science of Light (MPL) @mpi-scienceoflight.bsky.social · 3d

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg

Professor Jochen Guck, Director at the Max Planck Institute for the Science of Light (MPL), He headed the division “Cell Physics” at MPL and the Max-Planck-Zentrum für Physik und Medizin (MPZPM).

Reposted by Martin Tomko, Benoît Ladoux

Margaret Harris @drmlharris.bsky.social · 5d

Ahead of tomorrow’s #NobelPrize announcement, I went on a deep dive in search of the most obscure physics Nobel Prizes in history. That means it's time for a thread on...🧵

PHYSICS NOBEL PRIZES YOU’VE NEVER HEARD OF – PART 1

(1/n)

A photo of the Matterhorn rising above an Alpine landscape. The colours are a little washed out, but do not appear artificially tinted

Reposted by Benoît Ladoux

Adrian Liston @labliston.bsky.social · 5d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

Reposted by Benoît Ladoux

Daniel J. Cohen (Princeton) @djcohen.bsky.social · 11d

So: can a cell hold hands with itself…and do we care? YES and YES! Read on to learn WHY, HOW, and what this has to do with…PARIS (and tree-hugging)? Swansong of Dr. Anamika; Hannah Kim on drums; and fantastic undergrads (Margaret/Lauren) ! 1/n
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Reposted by Benoît Ladoux

Max Planck School Matter to Life @mattertolife.bsky.social · 11d

📣 Last chance to apply!
Applications for our URO program close tomorrow, October 1st.

Don't miss this opportunity:
mattertolife.maxplanckschools.org/uro-research...

👉 Funded 10-week research internship
👉 Learn from esteemed scientists
👉 No prior research experience required

Reposted by Benoît Ladoux

Sara Wickstrom @sarawickstrom.bsky.social · 12d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

Reposted by Benoît Ladoux

Guillaume Charras @gcharras.bsky.social · 12d

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...

elifesciences.org

Reposted by Benoît Ladoux

David Brückner @davidbrueckner.bsky.social · 14d

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

Reposted by Benoît Ladoux

epithelial mechanics fan club @epimechfc.bsky.social · 16d

Grata, A., & Levayer, R. (2025). Epithelial cell extrusion at a glance. Journal of Cell Science, 138(8), #EpithelialMechanicsReview doi.org/10.1242/jcs....

Reposted by Benoît Ladoux

Lennart Hilbert @lennarthilbert.bsky.social · 18d

What a great doctoral defense by Tim Klingberg @fau.de

Based in the group of our collaborator @vasilyzaburdaev.bsky.social Tim decisively contributed to at least 3 of our own lab’s foundational projects, which he showed today at “Max Planck Zentrum Physik und Medizin”

Some impressions

Benoit Ladoux @bladoux.bsky.social · 18d

Exciting science in Leipzig at the Physics of Cancer Meeting.
conference.uni-leipzig.de/poc/2025/

Reposted by Benoît Ladoux

Max Planck Institute for the Physics of Complex Systems @mpipks.bsky.social · 22d

IG Nobel Prize in #Physics 2025 to @mpipks.bsky.social researchers for elucidating the phase behaviour of cacio e pepe sauce. The work highlights how physics can also be applied to solve daily-life problems!

nature.com/articles/d41586-025-03045-0

Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research

The annual awards are a celebration of weird but thought-provoking science.

Benoit Ladoux @bladoux.bsky.social · 23d

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.

mikeinmemoriam.sciencesconf.org

Reposted by Benoît Ladoux

Biophysical Paris @parisseminar.bsky.social · 23d

Forces at Play: emerging themes in Mechanobiology - In memoriam of Pr. Michael Sheetz,
In Paris, at the Institut Jacques Monod, from January 19th to January 21st 2026.

The registration is now open, and the rates are quite low.

Dead line: end of November

mikeinmemoriam.sciencesconf.org

In memoriam of Prof. Michael P. Sheetz – Forces at Play: emerging themes in Mechanobiology - Sciencesconf.org

mikeinmemoriam.sciencesconf.org

Reposted by John De Vos, Benoît Ladoux

Denis Duboule @denisduboule.bsky.social · 24d

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

Benoit Ladoux @bladoux.bsky.social · 24d

www.biorxiv.org/content/10.1...

SCHEPHERD: A universal platform for high-throughput, high-resolution, and programmable control of cell behavior through bioelectric stimulation

Spanning frogs, fish, and humans, direct-current (DC) bioelectric cues play critical roles beyond neuro-muscular function, such as modulating morphogenesis, immune response, and healing through electr...

www.biorxiv.org

Reposted by Dominique Bourg, Benoît Ladoux

Vincent Lemire @vincent-lemire.bsky.social · 25d

🔥 "Gaza brûle !" annonce fièrement ce matin le ministre de la Défense Israël Katz, qui confirme le début de l'offensive terrestre sur Gaza-ville, avec l'engagement de 2 divisions (environ 30.000 hommes). Quelques données factuelles pour y voir clair, dans le flot des informations du moment:

Reposted by Benoît Ladoux

Nature @nature.com · 26d

Nature research paper: Energy deficiency selects crowded live epithelial cells for extrusion

go.nature.com/42tmu2l

Energy deficiency selects crowded live epithelial cells for extrusion - Nature

Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.

Reposted by Benoît Ladoux

epithelial mechanics fan club @epimechfc.bsky.social · 29d

Hoffmann, L. A., Carenza, L. N., Eckert, J., & Giomi, L. (2022). Theory of defect-mediated morphogenesis. Science advances, 8(15), eabk2712. #EpithelialMechanics
buff.ly/wUYJE0s

Reposted by Nicole Dubilier, Benoît Ladoux

Sara Wickstrom @sarawickstrom.bsky.social · 29d

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Computational image analyst (m/f/d)

The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

jobs.mpi-muenster.mpg.de

Benoit Ladoux @bladoux.bsky.social · Sep 10

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...

The complex microscopic dynamics of cells in high-density epithelial tissues

Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...

www.biorxiv.org

Benoit Ladoux @bladoux.bsky.social · Sep 10

🤔Altruism versus selfishness: impact on collective dynamics?
journals.aps.org/prl/abstract...

Hydrodynamics of Cooperation and Self-Interest in a Two-Population Occupation Model

Socioeconomic systems, where individualistic and altruistic agents coexist and interact, can be analytically characterized through state-of-the-art tools from active matter at the hydrodynamics scale.

journals.aps.org

Benoit Ladoux @bladoux.bsky.social · Sep 10

Very nice work! Congrats.

Reposted by Benoît Ladoux

Institut Jacques Monod @ijmonod.bsky.social · Sep 10

📢 PhD Thesis defense

📅 September 11th
📍 Institut Jacques Monod

Tomorrow, Andreas Schoenit @andreasschoenit.bsky.social will defend his PhD thesis "Mechanical forces in cell competition and epidermal stratification"

➡️ buff.ly/yhtJMsu

Reposted by Benoît Ladoux

Thibaut Brunet @thibautbrunet.bsky.social · Sep 9

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

Flagellar gliding in choanoflagellates

Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates, the closest relatives of animals. Under mild confinement, choanoflagellate move over surfaces without cell deformat...

Benoit Ladoux @bladoux.bsky.social · Sep 9

Erlangen?